Tumor development
Osteoprotegerin inhibits bone resorption and prevents tumor development in a xenogenic model of Ewing's sarcoma by inhibiting RANKL
... ES tumor model was due to direct synthesis by tumor ...a tumor (Fig. 1C). Therefore, it suggests that during tumor development, the stroma may in fluence tumor cells to produce ...
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Macrophages of distinct origins contribute to tumor development in the lung
... during tumor development (A) tSNE dimension 1 and 2 plots of the lung myeloid compartment show relative expression intensity of each indicated phenotypic marker at different time point after TC-1 cell ...
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ADAMTS-1 metalloproteinase induces a stromal reaction and propotes tumor development in mice.
... promote tumor development (3,4, ...on tumor invasion and angiogenesis require the shedding of the transmembrane precursors of HB-EGF and amphiregulin ...
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The Prosurvival IKK-Related Kinase IKK« Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine
... Wnt-driven tumor development in the intestine relies on Ikk « We investigated whether Ikke inactivation impacts on tumor formation in the Apc þ/min mouse model, which spontaneously develops ...
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NVP-BEZ235, a dual PI3K/mTOR inhibitor, inhibits osteosarcoma cell proliferation and tumor development in vivo with an improved survival rate
... bone tumor, originates from mesenchymal stem cells and has a common origin with Ewing’s sarcoma and chondrosarcoma ...residual tumor cells in the resected tumor tissue ...the development of ...
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Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization
... the tumor microenvironment and its role in favoring CCR7+ carcinoma cell movement and mediating ...primary tumor site, might thus be attracted to CCL21+ sites such as peripheral lymph nodes, where the ...
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New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors
... the tumor and stromal ...the tumor development by the supply of bioactive molecules, such as growth factors produced by the microenvironment immune ...in tumor-associated macrophages [ 89 ...
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Capturing the Driving Role of Tumor-Host Crosstalk in a Dynamical Model of Tumor Growth
... 2. Benzekry, S., Lamont, C., Beheshti, A., Tracz, A., Ebos, J. M., Hlatky, L. and Hahnfeldt, P. (2014). Classical mathematical models for description and prediction of experimental tumor growth. PLoS Comput Biol ...
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Ontogeny of Tumor-Associated Macrophages
... the tumor microenvironment in most ...the tumor microenvironment and their implication in therapy ...the tumor microenvironment than once thought and raise the question of their respective ...
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Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression
... 2.2. Tumor-Associated Macrophages Within tumors, macrophages can be in between or off the spectrum of the M1/M2 states depending on the tumor stage [ 18 ...the tumor site thanks to the CCL2 (MCP-1) ...
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Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression
... 2.2. Tumor-Associated Macrophages Within tumors, macrophages can be in between or off the spectrum of the M1/M2 states depending on the tumor stage [ 18 ...the tumor site thanks to the CCL2 (MCP-1) ...
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New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors
... the tumor and stromal ...the tumor development by the supply of bioactive molecules, such as growth factors produced by the microenvironment immune ...in tumor-associated macrophages [ 89 ...
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Characterization of Plasma Cell-Free DNA Integrity Using Droplet-Based Digital PCR: Toward the Development of Circulating Tumor DNA-Dedicated Assays
... Quantitative PCR (qPCR) analysis based on the measurement of the relative amount of DNA amplicons of different sizes has long been the reference method for DNA integrity assessment ( 16 – 18 ). A wide range of strategies ...
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The role of ERα36 in development and tumor malignancy
... The impact of this variant on the physiological development of the murine male germ line was also studied. Since the sequence encoding ERα36 is not present in the mouse genome, a C57BL/6J transgenic line ...
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Tumor Stiffening, a Key Determinant of Tumor Progression, is Reversed by Nanomaterial-Induced Photothermal Therapy.
... the tumor stiffness following ...(b) tumor over 9 ...residual tumor. (c) Quantitative analysis of the normalized mean tumor stiffness for 9 days for control tumors (n=8) and CNT-injected ...
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Acoustic separation of circulating tumor cells
... circulating tumor cells (CTCs) pro- vides physicians a minimally invasive way to monitor the response of cancer patients to various ...the development of an acoustic-based device that successfully ...
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Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anti-cancer therapies
... This work is supported by grants from the FNRS (FRSM - Télévie) , the J. Maisin Fundation and the Belgian Federation against Cancer. Influence of intermittent hypoxia on the vascular and tumor cell compartments: ...
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A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy
... The P2RX7 receptor (also called P2X7R) is an ATP-gated ion channel composed of three protein subunits (encoded by the P2RX7 gene), which is expressed predominantly in immune cells and in some tumor cells 2 . ...
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Design Considerations for Tumor-Targeted Nanoparticles
... Intraoperative fluorescence imaging of tumor-bearing mice An intraoperative fluorescence imaging system optimized for animal surgery has been described in detail previously. 30 For fluorescence excitation, LEDs ...
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Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site
... Immunofluorescence Tumor pieces were fixed overnight with Periodate-Lysine-Paraformaldehyde [48] at 4°C and Immunofluorescence on tumor slices was performed as previously described [17, ...
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