potential therapeutic target
MT2A is an early predictive biomarker of response to chemotherapy and a potential therapeutic target in osteosarcoma
... valuable therapeutic target to improve osteosarcoma sensitivity to ...a potential therapeutic target to develop novel treatment strategy to prevent or de-escalate chemo-resistance in ...
13
LOX and LOX-Like Proteins as Potential Therapeutic Target for Atrial Fibrillation
... In the current study, the main findings were the following: (a) upregulation of LOX, LOXL-1, LOXL-3 and LOXL-4 in LA myocytes and LOX and LOXL-2 in LA fibroblasts isolated fr[r] ...
276
Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells -high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation
... the potential tumor suppressor gene TSC22 and genes encoding the growth factor receptor KIT, the cytokine Angiopoietin 1 and the selenium-containing glycoprotein Selenoprotein ...
19
Potential therapeutic target in a murine model of eosinophilic airway inflammation
... ADAM28 is soluble and a multipotent membrane-bound or secreted proteinase expressed by epithelial cells in human normal tissues. ADAM28 influences lymphocytes adhesion and migration, and cleaves the low affinity IgE ...
1
en fr Autophagy, a potential therapeutic target in acute myeloid leukaemias expressing FLT3-ITD Autophagie, une cible thérapeutique potentielle dans les leucémies aiguës myéloïdes exprimant FLT3-ITD
... Zinc finger protein 428 Zinc finger protein 30;Zinc finger protein 461;Zinc finger protein 30 homolog;Zinc finger protein 82 homolog;Zinc finger protein 14 homolog.. Zinc finger protein [r] ...
227
Potential Therapeutic Target Discovery by 2D-DIGE Proteomic Analysis in Mouse Models of Asthma
... discover potential new target proteins with a molecular weight >20 kDa by using two-dimensional differential in-gel electrophor- esis (2D-DIGE) on lung parenchyma extracts from control or allergen-exposed ...
11
TRPV4: new therapeutic target for inflammatory bowel diseases.
... a potential target for the treatment of inflammation? Several features should be associated with the molecular signature of this ...a potential therapeutic target to treat intestinal ...
21
The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease
... In line with the latter epidemiological and neuropathological observations, compelling experimental evidence, both in vivo and in vitro, give reliable proof-of-concept that caffeine has a strong potential toward ...
10
Proteoglycans as Target for an Innovative Therapeutic Approach in Chondrosarcoma: Preclinical Proof of Concept
... Marie-Melanie Dauplat 4 , Mercedes Quintana 1,2 , Fran ¸coise Degoul 1,2 , Fran ¸coise Redini 5 , Jean-Michel Chezal 1,2 , and Elisabeth Miot-Noirault 1,2 Abstract To date, surgery remains the only option for the ...
12
en fr Iron as a therapeutic target: New horizons Le fer comme cible thérapeutique : nouveaux horizons
... 2. Brissot P, Pietrangelo A, Adams PC, de Graaff B, McLaren CE, Loreal O. Haemochromatosis. Nat Rev Dis Primers. 2018;4:18016. 3. Loreal O, Cavey T, Robin F, Kenawi M, Guggenbuhl P, Brissot P. Iron as a ...
3
Computational analysis of biochemical networks for drug target identification and therapeutic intervention design
... The same procedure to examine 14 potential targets was carried out on the three cancer variant models, and the general target behavior along the signaling cascade[r] ...
137
View of Novel therapeutic targets in sepsis — Triggering receptor expressed on myeloid cells-1: a novel therapeutic target in inflammatory disease
... Ces données suggèrent ainsi un rôle de TREM-1 dans l ’amplification de la réponse inflammatoire au cours de la PR et que la modulation de TREM-1 pourrait réduire cet excès d ’inflammatio[r] ...
7
The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders.
... on target cells have been reported for modafinil, even though diffuse expression of immediate early gene c-fos [41], or enhanced histamine release [42] occurred with high doses of ...
21
New Potential Therapeutic Approaches by Targeting Rad51-Dependent Homologous Recombination
... Halenaquinone modulates the recombinase activity by inhibiting the binding of the Rad51- ssDNA complex with dsDNA. The hypothesis is that the presence of halenaquinone desta‐ bilizes the Rad51-ssDNA binding or the ...
23
Iron as a Therapeutic Target in HFE-Related Hemochromatosis Usual and Novel Aspects
... not target the biological mechanisms involved in the iron metabolism ...the target of hepcidin, if devoid of significant secondary effects, should be useful to better control iron parameters and symptoms, ...
15
Protein arginine methyltransferase 5: A novel therapeutic target for triple-negative breast cancers
... putative target for cancer ...the therapeutic efficacy of PRMT5 targeting in TNBC has not yet been ...the therapeutic potential of pharmaco- logical inhibition of PRMT5 in ...
16
Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential.
... a potential role for eIF4E2 in ...This potential role of eIF4E proteins in tumor biology is also supported by studies confirming that eIF4E is involved in cell proliferation and tumor growth [ 32 , 33 ...
29
Glycine and hyperammonemia : potential target for the treatment of hepatic encephalopathy
... Studies have also shown a beneficial effect on lowering blood ammonia and HE events by administering the glutamine scavenger phenylacetate (as glycerol phenylbutyrate, pro-drug for phenylacetate) (McGuire et al. 2010; ...
8
The immune landscape of chondrosarcoma - potential for therapeutic targeting of CSFR1+ macrophages
... mammalian Target Of Rapamycin; PD1, Programmed death 1; PDL1, Programmed Death Ligand 1; SIRPa, Signal regulatory protein alpha; SMO, Smoothened Homolog Precursor; TAMs, Tumor Associated Macrophages; TILs, Tumor ...
12
HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours
... METHODS: We used transgenic mouse models to determine the role of Hoxb9 in adrenal tumour development. Patient transcriptomic data was analysed for the expression of HOX genes and their association with disease. Drug ...
13