lung tumor
Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance
... alters tumor fate and compromises maintenance To perform the converse experiment, lung tumors were generated, and at 12 weeks post-Ad- FLPo administration, TAM administration produced acute autophagy ...
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Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression
... silence tumor-suppressor genes and thus contribute to ...intestinal tumor formation ...intestinal tumor formation ...prognosis. Lung cancer is the leading cause of cancer death in the United ...
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en fr Alternative splicing of ATGL16L1 : a role in lung tumor escape to anti-EGFR therapies Epissage Alternatif d'ATG16L1b : un rôle dans l'échappement des tumeurs pulmonaires aux thérapies anti-EGFR
... 2.2. EGFRvIII EGFRvIII is the most common EGFR splice variant. It skips exons 2–7 and encodes a protein of 145 kDa that is devoid of the extracellular ligand-binding domain. As a consequence, EGFRvIII is unable to bind ...
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VEGF165b, a splice variant of VEGF-A, promotes lung tumor progression and escape from anti-angiogenic therapies through a β1 integrin/VEGFR autocrine loop
... Cell Lung Carcinoma (NSCLC) and 17 matched normal lung parenchymas were included in this study (Supplementary Table 1 and Supplementary Figures 1 and ...
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A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy
... some tumor cells 2 ...and tumor microenvironments (TMEs) 3 ...present tumor antigens to T cells 6 ...Lewis lung carcinoma (LLC) tumors grew faster in line with the findings of Adinolfi et ...
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Orthotopic model of lung cancer: isolation of bone micro-metastases after tumor escape from Osimertinib treatment
... orthotopic lung tumor models, the major explored routes consist of intrathoracic or intra- tracheal cell ...NSCLC tumor cell development takes place at the injection site and also mainly around the ...
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Impact of pemetrexed chemotherapy on the gut microbiota and intestinal inflammation of patient-lung-derived tumor xenograft (PDX) mouse models
... cell lung cancer, can induce significant side effects in ...the tumor graft on the gut microbiota composition in immunodeficient ...The tumor graft induced some variations in the microbiota ...a ...
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Anti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer
... of lung cancer ...combinational lung cancer ...three-dimensional lung adenocarcinoma cell cultures, we observed that the nanoparticles were mostly found at the periphery of the CD44-expressing ...
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BMI1 is a context-dependent tumor suppressor that is a barrier to dedifferentiation in non-small cell lung adenocarcinoma
... autochthonous lung adenocarcinoma, driven by oncogenic Kras and Tp53 loss (KP LUAD), and subsequent deletion of Bmi1 specifically within the tumor cells once more than half the tumors progress to grade 3 or ...
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“Sentinel” Circulating Tumor Cells Allow Early Diagnosis of Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease
... for lung cancer. Migration of circulating tumor cells (CTCs) into the blood stream is an early event that occurs during ...detectable lung cancer as a first step to identify a new marker for early ...
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Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer
... with lung tumor stroma activation To explore the association of PAR-1 expression with the NSCLC stroma, we correlated PAR-1 gene expression levels with specific markers of different stromal cell types, ...
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RhoB Determines Tumor Aggressiveness in a Murine EGFRL858R-Induced Adenocarcinoma Model and Is a Potential Prognostic Biomarker for Lepidic Lung Cancer
... of lung cancer induced by an activating EGFR muta- tion, which is known to lead to adenomas and adenocarci- nomas (20) crossed with Rhob WT, heterozygous, or null mice ...of tumor tissue consistent with an ...
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Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression
... restraining tumor progression correspond to fibroblasts resistant to irreversible conversion into CAFs, or to distinct CAF subsets remains ...their tumor-suppressing ...with tumor progression. ...
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Base-Position Error Rate Analysis of Next-Generation Sequencing Applied to Circulating Tumor DNA in Non-Small Cell Lung Cancer: A Prospective Study
... from tumor FFPE DNA and from circulating free DNA using Ion AmpliSeq Colon and Lung Cancer Research Panel v2 (Life Technologies–Thermo Fisher Scientific), following the manufacturer’s ...
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NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells
... Groups of ten, strain 250, 6 weeks-old, male Fox Chase SCID−/− Beige mice from Charles River™ were anaesthe- tized according to the manufacturer’s recommendations for xenografting. ShControl (shRNA Control, Sigma-Aldrich ...
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Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression
... restraining tumor progression correspond to fibroblasts resistant to irreversible conversion into CAFs, or to distinct CAF subsets remains ...their tumor-suppressing ...with tumor progression. ...
35
In-House Implementation of Tumor Mutational Burden Testing to Predict Durable Clinical Benefit in Non-Small Cell Lung Cancer and Melanoma Patients
... Abstract: Tumor mutational burden (TMB) has emerged as an important potential biomarker for prediction of response to immune-checkpoint inhibitors (ICIs), notably in non-small cell lung cancer ...
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Interstitial Lung Disease Associated with Lung Cancer: A Case–Control Study
... Based on a few series, most of them from Japan and surgical series, ILD frequency in LC populations ranged between 2.4% and 10.9% [ 6 ]. Only one of three studies on European patients considered all LC stages and ...
11
Tumor exposed-lymphatic endothelial cells promote primary tumor growth via IL6.
... of tumor cells and stromal cells including lymphatic endothelial cells (LEC), which are mainly viewed as cells forming lymphatic vessels involved in the transport of metastatic and immune ...which tumor ...
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Modeling Primary Tumor Dynamics of Human-to-Mouse Xenografted Non-Small Cell Lung Cancer in Response to Administration of Bevacizumab and Pemetrexed-Cisplatin
... Primary Tumor Dynamics of Human-to-Mouse Xenografted Non- Small Cell Cancer in Response to Administration of Bevacizumab and Pemetrexed-Cisplatin Benjamin K Schneider 1 , Arnaud Boyer 2 , Joseph Ciccolini 2,3 , ...
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