Innate immune cells
Innate immune cells and their contribution to T-cell-based immunotherapy
... T cells in controlling and killing tumor ...the innate immunity orchestrating complex interactions within the tumor ...microenvironment. Innate immunity plays a central role in cancer development and ...
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Epigenetic regulation of innate immune responses to infection
... and innate immunity 1.5.1 Innate immunity Classically, innate immunity is characterized by a rapid, nonspecific response to an invading pathogen (Medzhitov and Janeway ...adaptive immune ...
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Trained Immunity Carried by Non-immune Cells
... NK cells (Ly49C-I+) (O’Leary et ...mast cells, there is no published study related to immunological ...mast cells, like the other innate immune cells, could adopt a memory ...
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Diversity of innate immune cell subsets across spatial and temporal scales in an EAE mouse model
... infiltrated immune cells during disease, among which the most critical populations were neutrophils, monocytes (P1), moDCs (P2, P3 matu- ration states), macrophages (P4, P5 maturation states) as well as ...
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TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.
... dendritic cells (DCs) of the small intestine ( 23 ...of immune cells expressing CD127 but not CD3 that resembles LTi cells, LTi-like or NK-like innate ...CD127 innate ...
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Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression
... pathogenesis, innate immune cells have an important role not only by directly inducing inflammation and bone erosion but also by recruiting and activating different cells from the adaptive ...
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Innate-like T cells in children with sickle cell disease
... other innate immune cells, a role for chronic hemolysis and inflammation may be suspected [ 3 ...antigen-presenting cells (APC) would be more physiologically relevant than stim- ulation with ...
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Innate Immune Response to Streptococcus pyogenes Depends on the Combined Activation of TLR13 and TLR2
... human innate immune cells, we employed the human monocytic cell line ...THP-1 cells respond only poorly to TLR ligands, unless differentiated into more mature macrophage-like cells [ 35 ...
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Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes.
... ACKNOWLEDGMENTS We thank R. Bartenschlager (University of Heidelberg), C. Rice (Rockefeller University), T. Wakita (University of Tokyo), and J. Ball (University of Notting- ham) for plasmids for HCVcc and HCVpp ...
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The mitochondrial respiratory chain: A metabolic rheostat of innate immune cell-mediated antibacterial responses
... The mitochondrial respiratory chain: A metabolic rheostat of innate immune cell-mediated antibacterial responses... 7 8 2 INSERM U1211, Rare Diseases, Genetics and Metabolism, Universi[r] ...
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Altered innate functions of myeloid dendritic cells in ANCA-associated vasculitis
... Altered innate functions of myeloid dendritic cells in ANCA-associated vasculitis Cécile Braudeau 1,2 , Antoine Néel 2,3 , Marie Rimbert 1,2 , Mohamed Hamidou 2,4 , Régis Josien 1,2,4* From 7th European ...
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β2-adrenergic signals downregulate the innate immune response and reduce host resistance to viral infection
... regulate immune cell functions in infectious diseases ( Moriyama et ...including immune cells ( Elenkov et ...endothelial cells ( Scheiermann et ...T cells in the liver or NK cell ...
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Immune checkpoints on innate lymphoid cells
... combination therapies with antibodies that block several negative regulators, with the expectation of their additive or synergistic effects on antitumor re- sponse. As highlighted by the expres- sion of PD-1 on NK ...
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MicroRNA-29b Modulates Innate and Antigen-Specific Immune Responses in Mouse Models of Autoimmunity
... + cells in spleens and PLNs was assessed by flow cytometry in the CD3 + CD8 + T-cell ...+ cells was observed in the spleen of miR-29b-injected mice, compared to miR-127 and HBS controls ...+ cells ...
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Modulation of innate immune signaling by a Coxiella burnetii eukaryotic-like effector protein
... Modulation of innate immune signaling by a Coxiella burnetii eukaryotic-like effector protein.. Melanie Burette, Julie Allombert, Karine Lambou, Ghizlane Maarifi, Sébastien Nisole, Eliza[r] ...
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Deficiency in Either 4E-BP1 or 4E-BP2 Augments Innate Antiviral Immune Responses
... infected cells (16 hpi) confirmed the difference in infection observed by fluorescence between 4E-BP1 2/2 MEFs and cells rescued with 4E-BP1 ( ...control cells when assessed by Western blotting ...
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Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia
... B Cells Results in Enhanced Th1 Responses We next sought to determine the bio- logical relevance of endosomal TLR signaling in B cells during ...moral immune responses to the ...T cells in the ...
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A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system
... We then investigated the impact that lack of PG N-deacetylation might have on the inflammatory response. Because the Nod proteins detect PG and PG fragments such as muropeptides (19, 20), we first analyzed the ability of ...
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Tissue Infiltrating LTi—Like Group 3 Innate Lymphoid Cells and T Follicular Helper Cells in Graves' and Hashimoto's Thyroiditis
... Tfh cells displayed an activated phenotype that is usually observed in ...Tfr cells. These cells were significantly decreased in Group 2 ...ILC3 cells and Tfh ...
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Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-defensin 14 Expression in Pancreatic Endocrine Cells Preventing Autoimmune Diabetes
... These data support that the inflammatory environment in the PLN and MLN in NOD mice may influence the cytokine expression of ILCs towards an inflammatory profile regardless of the subtype of ILCs as already described in ...
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