helper cells
en fr Improvement of the anti-tumoral effects of T follicular helper cells (Tfh) by the targeting of the intercellular cross-talk between Tfh and Th2 cells. Améliorer les effets anti-tumoraux des lymphocytes T folliculaires helper (Tfh) en ciblant la communication intercellulaire entre Tfh et Th2.
... Page | 186 5. Cibler l’axe PGD2-CRTH2 limite la croissance tumorale Nos données suggèrent que la PGD2 produite par les cellules Tfh favorise le recrutement et « booste » les fonctions des cellules Th2. Pour tester la ...
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CD4+ T Helper Cells Play a Key Role in Maintaining Diabetogenic CD8+ T Cell Function in the Pancreas
... 200 µm) (Video S1 in Supplementary Material). Green, CD8 + ; blue, CD4 + ; red, beta cells. Islet is circled. (e) T cells tracks from field in (D), color-coded as function of time. Total duration: 18.3 min. ...
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Tissue Infiltrating LTi—Like Group 3 Innate Lymphoid Cells and T Follicular Helper Cells in Graves' and Hashimoto's Thyroiditis
... ILC3 cells could be correlated with specific humoral or clinical phenotypes of ...these cells are involved in TLS and in the formation of GCs, which leads to antibody production by B ...
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HIV-1 and SIV Predominantly Use CCR5 Expressed on a Precursor Population to Establish Infection in T Follicular Helper Cells
... T cells, with their increased expression of Bcl6 and CXCR5, are able to migrate to the interfollicular area, also known as the T:B border, where they encounter B cells ( 3 ...B cells via ICOS and ...
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en fr Study of mast cell degranulatory response dynamic and analysis of eicosanoid influence during mast cell and Helper cells cooperation Etude de la dynamique de dégranulation des mastocytes et analyse de l'effet des éicosanoïdes dans la coopération entre mastocytes et lymphocytes T Helper
... (phospholipase C J 1) [137]. Cet énorme complexe macromoléculaire génère de nombreuses voies de signalisation comme les kinases MAP ou un flux calcique intracellulaire. Malgré l’importance de LAT dans la transduction du ...
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Definition of B cell helper T cells in rheumatoid arthritis and their behavior during treatment
... B cells play a crucial role by producing autoreactive antibodies such as anti-citrullinated peptide antibodies (ACPA), which are pathognomonic of ...+ helper T-cell homeostasis dysregulation. Infiltration ...
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T helper cell mediated-tolerance towards fetal allograft in successful pregnancy
... T helper cells, but rather a microenvironmentally oriented ...T cells [20,23] could be at least in part responsible for a Th2 switch at feto-maternal interface and IL-4 produced by the effector CD4+ ...
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Follicular helper T cells: implications in neoplastic hematopathology.
... FH cells has begun to be better understood, several questions have ...FH cells are heterogeneous comprising at least the GC- T FH cells subset described above and non-GC T FH including CD4+ T ...
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Human Lymphoid Stromal Cells Contribute to Polarization of Follicular T Cells Into IL-4 Secreting Cells
... reticular cells, follicular T cells, T follicular helper cells, follicular lymphoma INTRODUCTION T follicular helper cells (Tfh) have been described as a specialized mature CD4 ...
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Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells
... CONFLICT OF INTEREST The authors declare no con flict of interest. ACKNOWLEDGEMENTS We would like to thank Robert Weinberg for providing HLMER cells; James Riley and Mai Ping Tan for plasmids; Andrew Thomas for ...
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Corrective GUSB transfer to the canine mucopolysaccharidosis VII cornea using a helper-dependent canine adenovirus vector.
... Fig. 1. Intrastromal injections of CAV-2 and HAd5 vectors in vivo in mice, nonhuman primates and ex vivo in human cornea. The transduction efficacy of a CAV-2 vector harboring a GFP cassette (CAVGFP) was compared to a ...
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Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell–derived lymphomas
... A detailed description is provided in the supplemental Material. Brie fly, we performed site-directed mutagenesis of RHOA, PLCG1, and CARD11 mutations on cloned cDNAs into pcMV6-MycFlag (RHOA, PLCG1) (Origene, C-terminal ...
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HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation
... plasma cells [ 13 , 14 , 18 , 19 , 45 ]. Of note, loss of memory B cells during HIV infection is also due to apoptosis [ 46 ...B cells accumulated while further differentiation was rerouted to plasma ...
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CD4-positive T-helper cell responses to the PASD1 protein in patients with diffuse large B-cell lymphoma
... Discussion Previous reports have described limitations in using short peptide sequences from tumor-associated antigens to elicit long-lasting CTL responses to the target molecule. Repeated boosting with peptides may be ...
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en fr Mechanisms implicated in follicular helper T cells polarization and mucosal immunity initiation after intradermal immunization with particles-based antigen Mécanismes impliqués dans la polarisation des lymphocytes T CD4+ folliculaires et l'initiation de l'immunité muqueuse après immunisation intradermique par un antigène particulaire
... 94 Materials and methods. Mice. Female C57Bl/6 mice (6–8 week old) were purchased from Charles River Laboratories (L’Arbresle, France). Langerin–DTR black/6 mice from the Transgenesis, Archiving and Animal Models (CNRS ...
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Deformability of Tumor Cells versus Blood Cells
... 4T1-ZSGreen cells to confirm presence of metastatic ...tumor cells having green fluorescence, and then measured in the ...control cells kept in culture after the initial injection were run through ...
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Human mucosal associated invariant T cells detect bacterially infected cells.
... MAIT Cells We next performed phenotypic analyses of Mtb-reactive MR1- restricted T-cell clones to determine if they shared properties of previously characterized MR1-restricted MAIT ...MAIT cells is the ...
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Regulation of Human T Helper Cell Diversity : From In Vitro Dendritic Cell-Based Mechanisms to Candidate Biomarkers in Atopic Dermatitis
... 18 from such an extended range of observations, we anticipate that it should be able to predict behaviors in situations not necessarily covered in our original dataset, as confirmed in our computational and experimental ...
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On cells and sound
... 5007 Bergen, Norway Abstract Ultrasound as a therapeutic means is increasing in popularity, owing to its non-invasiveness and low cost. Biomedical applications include surgery, cyanobacteria eradication, and drug and ...
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Innate lymphoid cells
... T cells) et sécrètent de l’IFN(interféron)- ; les ILC2 et les lymphocytes Th2 expriment le facteur de transcription GATA-3 (GATA binding protein 3) et sécrètent les interleukines 5 (IL-5) et 13 (IL-13) ; et les ...
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