DNA repair and recombination
Escaping the immune system by DNA repair and recombination in African trypanosomes
... 4. DNA repair, recombination and VSG switching Despite intense study, we still do not fully understand what leads to VSG switching in a natural ...[47], and no such enzyme has yet been ...
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Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining
... A DNA double strand break (DSB) is a highly toxic lesion, which can generate genetic instability and pro- found genome ...instability and its consequences on ...DSB repair: homolo- gous ...
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RAD50 promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes
... is considered a minor reaction 25 . In trypanosomes both transcriptionally active and silent 78 (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without ...
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Xrcc1-dependent and Ku-dependent DNA double-strand break repair kinetics in Arabidopsis plants.
... of DNA involves loss of information on the two strands of the DNA fibre and thus cannot be repaired by simple copying of the complementary strand which is possible with single-strand DNA ...
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Coupling DNA Damage and Repair: an Essential Safeguard during Programmed DNA Double-Strand Breaks?
... formation and repair steps both take place in a specific chromosome compartment, the chromosome axis, from which chromatin loops emanate, and which will be the place where the homologs become fully ...
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The roles of bacterial DNA double-strand break repair proteins in chromosomal DNA replication
... genetic and biochemical experiments, carried out during this period, have revealed intricate details of their enzymatic functions, requirements in the cell, and mutant ...DSB repair mutants on genome ...
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Oxidative DNA damage and repair in the radioresistant archaeon Thermococcus gammatolerans
... TGAM_1653 and TGAM_1277 Are Slightly Upregu- lated after Heavy Radiation ...TGAM_1653 and TGAM_1277 in nonirradiated and irradiated ...The DNA damage analysis reported here shows the presence ...
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Differing requirements for the Arabidopsis Rad51 paralogs in meiosis and DNA repair.
... Keywords: DNA repair, meiosis, recombination, RAD51B, RAD51C, ...Homologous recombination (HR) and non-homologous end-joining (NHEJ) are the two major pathways for DNA ...
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Weaving DNA strands: structural insight on ATP hydrolysis in RecA-induced homologous recombination
... Homologous recombination is a fundamental pro- cess in all living organisms that allows the faith- ful repair of DNA double strand breaks, through the exchange of DNA strands between ...
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Homologous Recombination is Involved in the Repair Response of Mammalian Cells to Low Doses of Tritium mologous Recombination is Involved in the Repair Response of Mammalian Cells to Low Doses of Tritium
... HR, and since HR protects against genome instability, we speculate that HR may participate in the adaptive ...water, and the question arises as to the potential effect of low radiation doses from tritiated ...
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Chromatin Regulation of DNA Damage Repair and Genome Integrity in the Central Nervous System
... active DNA repair pathways in nervous system [1, 5], each corresponding to particular types of DNA lesions (Figure ...the DNA damage must be detected, the lesion removed or the ends processed, ...
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Ph2 encodes the mismatch repair protein MSH7-3D that inhibits wheat homoeologous recombination
... in recombination rate between these divergent ...homologous recombination rate by 97% relative to wild-type at the subtelomeric 420 genetic interval as assessed using a fluorescent seed reporter line 52 ...
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Cdk12 regulates DNA repair Genes by suppressing intronic polyadenylation
... TOPO and Gateway cloning kits (Thermo ...piggybac recombination sites, A.W. Cheng) and mPBase (piggybac transposase expression plasmid, ...Fisher) and 200 ug/mL G418 (Sigma) to select stable ...
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CDK12 regulates DNA repair genes by suppressing intronic polyadenylation
... homologous recombination (HR) repair promote tumorigenesis and sensitize cells to chemotherapeutics that cause replication fork collapse, a phenotype known as ...inhibitors, and that Cdk12 ...
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Ph2 encodes the mismatch repair protein MSH7-3D that inhibits wheat homoeologous recombination
... removed, and a coverslip placed on the ...chromosomes and aceto-carmine solution replaced by acetic acid ...chiasmata) and quadrivalents (four chromosomes linked by three or four chiasmata) were ...
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Survivin contributes to DNA repair by homologous recombination in breast cancer cells
... DNA damage Breast cancer Homologous recombination Introduction In the last decade, Survivin has attracted considerable attention as a therapeutic target for anticancer strategies because of its dual ...
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Complex Chromatin Motions for DNA Repair
... of repair sites to the nuclear periphery is also a response to damaged CAG repeats in budding yeast ( Su et ...yeast and mammalian cells ( Nagai et ...), and damaged telomeric or subtelomeric ...
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Human RAD52 Captures and Holds DNA Strands, Increases DNA Flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination
... extension and relaxation curve ( Figure S4 D), signature of the force-induced melting of the DNA strands ( Gross et ...smooth and the hysteresis between extension and relaxation curves is much ...
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Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation
... Introduction DNA damage can be caused by radiation, by organic and inorganic chemical agents and by enzymes that have the roles of promoting natural methylation and deamination, such as ...
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Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.
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