B-cell malignancies
Bispecific, T-Cell-Recruiting Antibodies in B-Cell Malignancies.
... are B-cell malignancies that are primarily located in lymph ...from B-cell precursors ( 69 ...tumor cell proliferation rates, but potentially curable when responding to high-dose ...
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Targeted Therapies in Adult B-Cell Malignancies
... cited. B-lymphocytes are programmed for the production of immunoglobulin (Ig) after antigen presentation, in the context of T- lymphocyte control within lymphoid ...process, B-lymphocytes exhibit different ...
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Chimeric antigen receptor T-cells: a new therapeutic option for relapsed/refractory B-cell malignancies and beyond
... B-CELL PRECURSOR ALL The phase II ELIANA trial investigated the CD19-directed genetically modified autologous T-cell product tisagenle- cleucel as a single infusion for r/r paediatric and young adult ...
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Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice
... hematological malignancies; (2) despite their similar catalytic activities in oxidi- zation of 5mC, Tet1 is required for the Tet2-deletion-mediated HSC dysregulation, myeloid skewing, and myeloid malignancy ...
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Increased activation of PI3 kinase-δ predisposes to B cell lymphoma.
... Furthermore, B cell lymphoma has been reported for several patients not included in these cohort studies - thus further highlighting the risk of B cell lymphoma in patients with APDS1 or APDS2 ...
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The Chromatin Regulator CHD8 Is a Context-Dependent Mediator of Cell Survival in Murine Hematopoietic Malignancies
... of B-ALL cells, but loss-of-function is selected for in T-ALL [ 38 ...the B cell lineage [ 37 ...the B cell malignancies ...T cell malignancy, consistent with results of a ...
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Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies : An Update of the Pivotal Clinical Trial Center
... tumor cell surface) ...r/r B-ALL patients experiencing an antigen-negative relapse after CD19-targeted CAR-T-cell therapy can be rescued by using CAR-T cells targeting an alternative antigen: CD22 ...
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Gene expression-based risk score in diffuse large B-cell lymphoma.
... the current study highlights pathways that could be involved in poor prognostic DLBCL. Among the 12 prognostic genes used to build GERS, the BSPRY gene encodes B-box and SPRY domain containing protein. A high ...
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SOS: online probability estimation and generation of T-and B-cell receptors
... 4 Fred Hutchinson cancer Research Center, 1100 Fairview ave N, Seattle, WA 98109, USA Recent advances in modelling VDJ recombination and subsequent selection of T and B cell recep- tors provide useful tools ...
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CD4-positive T-helper cell responses to the PASD1 protein in patients with diffuse large B-cell lymphoma
... large B-cell lymphoma; DLBCL(t): diffuse large B-cell lymphoma trans- formed; TCR: T-cell rich B-cell lymphoma; # subtyped according to expression of CD10, BCL-6 and MUM1; ...
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Regulation of B cell responses by distinct populations of CD4 T cells
... Tfr cell differentiation but reduces their suppressive ability [79] ...Tfr cell formation, a small Id3 expression at the initial step of Tfr cell differentiation was essential to induce the specific ...
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GZMB+ B cells, a key factor of cell immunity in human?
... specific B cell population with suppressive regulatory functions in the blood of transplanted patients with long- term graft ...These B cells inhibit an effector T cell response through a ...
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Identification of a New Stromal Cell Type Involved in the Regulation of Inflamed B Cell Follicles
... colorless B cells would express the ...of B cells in the LNs of treated mice (Figure ...remaining B cells were not evenly distributed in the areas formerly occupied by the enlarged B ...
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Cytolytic T-cell response to the PASD1 cancer testis antigenin patients with diffuse large B-cell lymphoma
... large B-cell lymphoma Diffuse large B-cell lymphoma (DLBCL), representing 40% of non-Hodgkin lymphoma (NHL), is heterogeneous with respect to morphology, clinical features and immunopheno- ...
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Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling.
... across B-NHL, we included patient samples from DLBCL, FL, MCL and CLL (Supplemental Table 1), as well as samples from healthy donors (tonsils and peripheral ...tumor cell levels of p-SYK and p-PLCγ (Figure ...
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Quantification of the relative importance of CTL, B cell, NK cell, and target cell limitation in the control of primary SIV-infection.
... cells, B cells cytolytic activity and target cell limitation in controlling acute SIV ...each cell population to predict viral load variation across the ...target cell and immune cell ...
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Probe-based confocal laser endomicroscopy for pleural malignancies diagnosis.
... was characterized by the presence of heterogeneous and pleomorphic cells with distorted intercellular gaps and indistinct cell borders. Those cells could be orga- nized in clusters or nodules or take a papillar, a ...
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Genetic background and immunological status influence B cell repertoire diversity in mice
... www.nature.com/scientificreports www.nature.com/scientificreports/ The gene subgroup distribution study shows that, within a given murine strain, immunization led to a slight shift in the B cell ...
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BOB.1 controls memory B-cell fate in the germinal center reaction
... B cells to enter Bmem pool. Activated B cell factor-1, ABF1, was reported to be induced by T follicular helper cell-mediated signals and facilitate Bmem in vitro and in vivo by re- pressing ...
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Origin of public mMemory B cell clones in fish after antiviral vaccination
... Vaccination induces “public” antibody clonotypes common to all individuals of a species, that may mediate universal protection against pathogens. Only few studies tried to trace back the origin of these public ...
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