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Monocytes/macrophages upregulate the hyaluronidase HYAL1 and adapt its subcellular trafficking to promote extracellular residency upon differentiation into osteoclasts

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Academic year: 2021

Partager "Monocytes/macrophages upregulate the hyaluronidase HYAL1 and adapt its subcellular trafficking to promote extracellular residency upon differentiation into osteoclasts"

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Figure

Fig 1. The protein and activity levels of HYAL1 are upregulated during osteoclastogenesis.
Table 1. Relative mRNA expression levels of hyaluronidases and lysosomal hydrolases in osteo- osteo-clasts collected at day 2 or 5 of the differentiation process, compared to RAW264.7 precursor  macro-phages (day 0).
Fig 2. The mature form of HYAL1 co-distributes with lysosomal markers after osteoclast fractionation by differential centrifugation
Fig 3. HYAL1 and cathepsin K co-distribute in a self-forming Percoll™ density gradient
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