Hepatitis B Virus Core Protein Domains Essential for Viral Capsid Assembly in a Cellular Context

We have developed a model based on Semliki forest virus (SFV) replicon vectors, in which the production of the HCV core protein in mammalian cells leads to the

Core protein domains involved in hepatitis C virus-like particle assembly and budding at the endoplasmic reticulum membrane.: HCV core protein domain involved in viral

Modeling of protein structure using Voronoi tessellation had already been shown in previous studies to be a very efficient tool for the optimization of accurate scoring function

Phosphorylation of the Arginine-Rich C-Terminal Domains of the Hepatitis B Virus (HBV) Core Protein as a Fine Regulator of the Interaction between HBc and Nucleic

However, early studies of cells infected with the JFH-1 virus showed that the core protein was detected at the surface of lipid droplets or in association with the ER membranes

25-27 Although this cellular model is based on HCV core protein production from a genotype 1a virus, it also displays the accumulation and clustering of lipid droplets

Moreover, an absence of core protein at the LD sur- face was associated with higher levels of virus secretion for the C10M-JFH-1 construct than for the wt-JFH-1 construct,

By combining the highly replicative and cell culture-selected gt3 p6 strain 19 and a highly transfectable subclone of PLC/PRF/5 cells (PLC3 cells), we recently developed an