HAL Id: inserm-00656367
https://www.hal.inserm.fr/inserm-00656367
Submitted on 4 Jan 2012
HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci- entific research documents, whether they are pub- lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.
L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
PRDM1 is a tumor suppressor gene in natural killer cell malignancies.
Can Küçük, Javeed Iqbal, Xiaozhou Hu, Phillip Gaulard, Laurence de Leval, Gopesh Srivastava, Wing Yan Au, Timothy Mckeithan, Wing Chan
To cite this version:
Can Küçük, Javeed Iqbal, Xiaozhou Hu, Phillip Gaulard, Laurence de Leval, et al.. PRDM1 is a tumor suppressor gene in natural killer cell malignancies.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2011, 108 (50), pp.20119-24.
�10.1073/pnas.1115128108�. �inserm-00656367�
Fig. 5
(A)
TNFα 1.2
1 0.8 0.6 0.4 0.2 0
MYC 1.2
1 0.8 0.6 0.4 0.2 0
12 10 8 6 4 2 Relative fold mRNA expression 0
Time (d): 0 2 4 6
(C)
CCNG2
TNFα
2.5 2 1.5 1 0.5 0
3.5 3 2.5 2 1.5 1 0.5 0
(B)
1 0.8 0.6 0.4 0.2 0
1.2 1 0.8 0.6 0.4 0.2 0
3 2.5
2 1.5
1 0.5
0 CCNG1
TNFβ 1.4 1.2 1 0.8 0.6 0.4 0.2 0
MYC
Vector PRDM1
siRNA
Relative fold mRNA expression
Vector PRDM1 4-1BBL
Relative fold mRNA expression