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Submitted on 1 Jan 1987
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ACTION MECHANISMS AND DESIGN OF
PHOTOSENSITIZERS IN PHOTOCHEMOTHERAPY
D. Brault
To cite this version:
D. Brault. ACTION MECHANISMS AND DESIGN OF PHOTOSENSITIZERS IN PHO- TOCHEMOTHERAPY. Journal de Physique Colloques, 1987, 48 (C7), pp.C7-296-C7-296.
�10.1051/jphyscol:1987766�. �jpa-00227070�
JOURNAL DE PHYSIQUE
Colloque C7, supplément au n°12. Tome 48, décembre 1987
ACTION MECHANISMS AND DESIGN OF PHOTOSENSITIZERS IN PHOTOCHEMOTHERAPY
D. BRAULT
Laboratoire de Biophysique, INSERM U-201, CNRS UR-481, Muséum National d'Histoire Naturelle, 61, Rue Buffon, F-75005 Paris, France
Photochemotherapy i s based on the s e l e c t i v e r e t e n t i o n of a photo- s e n s i t i z e r by sons p r o l i f e r a t i n g t i s s u e s which can then be i n a c t i v a t e d upon local i r r a d i a t i o n by v i s i b l e l a s e r l i g h t . The process involves the photosen- s i t i z e d generation of r e a c t i v e intermediate s p e c i e s , such as s i n g l e t oxygen, with d e l e t e r i o u s effects on the diseased t i s s u e s . This method i s relevant to treatment of tumors and atheromatous plaques which have been shown to r e t a i n porphyrins and r e l a t e d p h o t o s e n s i t i z e r s . The chemical nature of the curren- t l y used p h o t o s e n s i t i z e r s , HpD and r e l a t e d commercial compounds, will be considered. Basic problems r e l a t e d t o the development of more e f f i c i e n t molecules will be examined. The need of well characterized p h o t o s e n s i t i z e r s strongly absorbing l i g h t in the red region where t i s s u e s are the most t r a n s - parent i s s t r i k i n g . Our current research on chlorins will be presented in t h i s r e s p e c t . Studies on membrane models shed l i g h t on the i n t e r a c t i o n s of porphyrins with l i p i d i c s t r u c t u r e s and provide some clues to the mechanism of porphyrin r e t e n t i o n by tumors. The i n t e r a c t i o n of components of HpD with experimental atheromatous plaques shows i n t e r e s t i n g parallelism with what i s observed for tumors suggesting t h a t some common mechanisms are involved.
Article published online by EDP Sciences and available at http://dx.doi.org/10.1051/jphyscol:1987766
