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Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown adipocytes.: Adipocyte mitochondrial toxicity of antiHIV drugs

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(1)Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown adipocytes. Say Viengchareun, Martine Caron, Martine Auclair, Min-Ji Kim, Paule Frachon, Jacqueline Capeau, Marc Lombès, Anne Lombès. To cite this version: Say Viengchareun, Martine Caron, Martine Auclair, Min-Ji Kim, Paule Frachon, et al.. Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown adipocytes.: Adipocyte mitochondrial toxicity of antiHIV drugs. Antiviral Therapy, International Medical Press, 2007, 12 (6), pp.919-29. �inserm-00148353�. HAL Id: inserm-00148353 https://www.hal.inserm.fr/inserm-00148353 Submitted on 15 Oct 2007. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

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(29) ”¾ ·]g"j"fWŒVkgAlOfh i]tukEg»ƒ]g"j"kcUh f’9ƒ_’§m'h › gl9}Wdfh iT}LfŒw›dV’utul9w Œ kd3kcK’Iˆg"g"h`›ˆf´y´f!jm0})tˆg"jcam’9gRw ´0tuk g › f´u´yfLjam'})tudTfh`wtc"fh fh i`Œcatufg"hKt­’9c"ƒ3Œ}Lg’9qtuk gR›fW¤gl’9f)td]wV´ cig"hKt9’®ch ›`}!g"h ituk`wˆ´ chtyf~œ¤f¼l9c"}. inserm-00148353, version 1. tul9g"c”tuƒ`g"hKtqKtukEglywmtufhEg‡m’9gRw ´§j<wVƒ3fhctyfw h«tukEgl9cŒ dEqEtukEgfƒ`Œ'c"jat w ´0tuk g‡¤fWlÄc"}fh ´gjatfwˆh`f)t9’€g"}´¸c"h › tuk ghEg"g"›«tuwµcK’”’€gK’”’ tuk gR› f´u´gl9g"hKtfc"}0fƒ`Œ0c"jt wˆh&Ç3k f)tgRcAh ›]El9wÇ3h`c<›ˆfWŒwjdtgK’¾ vgU}}Wm'}!cAl¬ƒ`w› g"}’ k c¤ˆg‡tuk gl9g"´uw l9g‡g<gUh3¤ˆglyd«m’Äg"´!m'}ˆtw w }!’§t{wTg})m'j"fL› catg«’€wˆƒ`gRw ´0tuk gK’€g»ƒµg"j"kEcUh f’ă_’¾ ¿ kEgR™ ¿ ™KŽ&¦ wl ™ ¿ ™ œ{†    ¡ | ƒ&mlOfhgRj"g"}L}V}Lfhg’€qEÇk fLjUkl9g"j"cŒf)tm'}catgƒ`w0’ t¸w ´0tuk g‡Çk f)tgRc"› fWŒwVjdtgR› f´u´gl9g"hKtfcatfw h Œ l9w il9cAƒ m0hE› gl1’yŒg"j"fL´ fLjRjam'})tml9gRj"w h › f)tfw h0’9q k c¤gRƒµwY’t w ´!tgh«ˆg"g"h«m tyf}f’Äg"›0¾|«})tk wmi k`g"c<jUk]›l mi k c<›,cR› f´y´gl9g"hKt Œc”t!tglyhw ´§g"´u´yg<jat9’9q  ¿ •9q gK’Ä’9g"hKtufc"}L}d I·3e wl­›  ¿ q › g"jl9g<cK’9g"›`c"› fWŒwjdKtg › f´u´gl9g"hKtfcatfw h qÇ`gl€gŒ lywœycŒEwˆŒtuwKtufj"qgh kEcUhEjg"›`gaŸ Œ lÄgK’Ä’9fwVh`c"h ›T’€g"jl9gatfw h`w ´=•uŽ— qˆ• Ž&¦ β chE› ¿ ]† αqch ›`fh›Km'j<g"›,ƒ`f)twjk w h ›l9fLc"} Œ l9wV}f´ygAl9catfwˆh]cUh›`› gŒw }cl9f  catuf~wˆhL¡¨ œ ¡ ¡”¾b wˆƒ]g •1’um'jk`cK’ • ·e6wˆl h g"}´yfhc<¤fl§Ç]gl9gŒ l9w œcŒ w ŒKt{wKtufjRc"h ›`c"})tgl9g"›`c"› fWŒwjdKtgR› f´ ´gl9g"htyfctyfw h!¡I¦Aœu¡0©

(30) ”¾"|«}²tuk wmi k  l9fh ifh iTfLƒ,Œw ltchKtl€gK’ m'})t9’9qj"g"}})m'}!cAl¬ƒ`w› g"}’¬kEc¤gR´ucUfL}Lg"›«tuwTc<› ›l9gK’”’’9ga¤ˆgl9c"} ŒwVfhKt9’Š¾ ¿ k gRƒ«t·,| › gŒghE›Vg"htIc<jŠtufW¤f)tfLgK’­À l9g’yŒfWlÄcatufw h q | ¿¸ ’yd htykEgK’9f’yÁ­kca¤gRh wt0g<gUh]›ˆfWl€g"jat}~d]ƒTgcK’uml9g"›`› gK’ŒVf)tg‡tukEg Œw0’”’9fW}LgRj"wˆƒŒ0g"hV’€catw l d`g"´u´yg<jat¸wˆ´0tuk g wE'’9gly¤ˆg"›3Œ l9wˆ}fL´ygl€catufw h`wV´§ƒ`f)twjkEwˆhE›lOfLc¾ ¿ k gRg"´ ´g"jat=wˆ´ ›l mi0’IkEcK’­h wt0g<gh`c’”’€gE’Ä’9g"›`j"w h j<wVƒ`f)tc"hKt}~d]w h`c"› fŒ'wjadtgR›ˆf´u´ygl€gUhtyf~catyf~wˆh`cAh ›,ƒµf)twjk w h ›l9fc"} ´m0hEjatyf~wˆh`› g’yŒf)tg‡tuk g‡tufWikKt ´!m'h jatfw h c"}}!fh 3'gatÇ`g<gh«'wKtuk`j"g"}}Wm0}Lcl­c’yŒg"jat9’ !¡— œ ¡¢ 9¾¥Rh }Wd`w h g chEcU}d0’Äf’¬kEcK’Ig"g"h`j<wˆhE›Km'jatg"›3fh]El9wÇ3h`c<›ˆfWŒwjdtgK’”¦A˜ ”¾"·]gK’yŒ f)tg‡tukEg´uc"jattuk ct  ¿ •IchE› •­cAl9g l9wmtufWhg"}Wdµj"wƒ]fhg"›`fh`j"}!fhVfLj"c"}Œ l9c"jatufLj"g<qEtukEgRg´ ´g"jat9’®wˆ´0tuk g’9gR›l mi0’IkEc¤gig"h gl€cU}L}d3ˆggUh chEcU}d  "g ›T’9gAŒcl9catg"}WdEqVg¤g"h«tukEwEmi k&tuk gRj"w ƒ3fhg<›,g"´u´9g"jat9’¸ƒ`cd3Ç`g"}L}›ˆfL´y´ygAl¬´l9w ƒ tuk w0’9gRg"}fLj"f)tg"›« d g"c"j"k`j"}c’Ä’­wˆ´ ›l mi0’®cU}~wVh g¾.

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