Incidence of ulnar nerve entrapment at the elbow in repetitive work.
17
0
0
Texte intégral
(2) HAL author manuscript Scand J Work Environ Health 06/2004; 30(3): 234-40. HAL author manuscript. Incidence of ulnar nerve entrapment at the elbow in repetitive work.
(3)
(4) !#"$%&%'!(*)+ -,%. 0/213'4. 65708 :9; 44. =<0)> *?
(5) @
(6) AB7=C(D>ED '!( GFH IB J=D I=K:L '!7(D0M#7= NAOPM>QR4E@S-TU7'2VNWX Y Z 44RD\[:47= &\IH]^J (4_H IHE`AO 'Q. #a_I&cbE[d%476 6& Z 44RD!#e!7'gfN(R2h. I IE& AB P('!6ikj
(7) ll/ Z 13Anm0o J (G (Q/pD '!]013'4 & q J '4@ E&rIsM %S77=<HMS't7=e! P E7= O9O .2'QHf:7 !M RQ&E76/2jB E@S%' R4(E'Qub4jg 68@ %' R4KpfN7 !MS 2(EiQ < 't 1>'4. 6&. inserm-00141238, version 1. v )3'Q'!1w'Q. 6Sx. IH13.y 'QE(
(8) z{7&D '2< 7 Pw|< (B[:47= &E
(9) M 7&D 'B~}8 #_7='!%4E7= rI0( 9\7= SIR47= . I $'4@(E>)3DS3'QD> Z 44RDk[:4E7& 6&kI AB%. 'QS$I:J>_%DS'QRQ_&>z{'! 6&'QI #7(!39\& P 9\ (4'Q&EIE uD~D (ERQ_J 7=(E( <'!(7=&('2K@ 7= 0 L
(10) 7(DS'4 K p('!]/49OED I( ]E&'QI 7=#E C(D>OD> (!7= u9\%'!E A{7= SI%.DI&D[7=K 't| -7&D '! . I9\_ (E.K %' Z 0 tM P4 7= a_I=(I&D$'4@(E9;6'! 44E $K P %'/49\7! 7DM 4E7= ( %=R IM ('# (Q z{ 5(76 #jB E@ 't R2Kf:7 !M R4(4X (303 >& ¡.g¢63 c&3£S¤t.¥("$%&'QO#X Z P'!jlSl/ Z 1wAnmo= f7&M R4&[:4E7= (SI JS(G (Q/.D 'QE& YP¦ '4D OI(D (SI }§| Bo ¦¦*Y¨ J (G (Q/pD'QE(B9\©* |©kªN=1w'4 ( !X &%'!(«a 4Q/:DS'QE(=X E P'!sX e4' 13
(11) =D
(12) y>%' v0v¬Y-¦ ¨Y l v l
(13) lo ® >>£3¯d° =¢= *¥=jBE ('k S%'2@ B .2'QM0# .k ~ {Gy>7=±²8 #'QM t!R4E@ O±7='2V+X.
(14)
(15)
(16) !" # $ %
(17) & ' )(* + & , - .(/ &01. (¡¤t£65 (&¥w !M> !~ HE<ue4'C(D> K7=eB±7='!V /'QE%2I¬:D D>]7 V 4(\I08 7='QI't :bET A{ |iQ3> 'QE%4 7= Oy 2± `±7='4VSE <`(7= SIR!7= B. 6ID>E (' 6'!@ : (4'Q.M# (\% :Gy 7=±b2j\[:©*©*i 6= O 7$y . ¬7&8y 7PP
(18) 7e
(19)
(20) D 4D>I=K3X3T¬ 4D>I Ir2 HM 'I=P4E@Sre4&P47='t e47=':j;[d©*©E `'/K ('
(21) M '!7 !M PQE@>. !D '2@K#7ewDM0M %'/4EE:yTAO G :'QM QR48@ O±7='4V3X 77&y H8 @ 7G@ ¬'QM ! !E@ ±7='!V 9 ¤t°> >.¥ Y o0o v / Y oo ¦ . Ir~6'K ('t E%2%' ¨ oSl¬±7='2V %' ± 7 Z ±' &#E I yK 4 E' 7=DM 47= ( (R2 MK &E . I &7=M>QI ]eQ/=I=#8 4Q'Q&I C&D 44 7= (E'X+)3'QIEP!E@ :e4(P!7='t | P 7E4I`±
(22) 2cSc76 0 B7eBj\[:©*© ±
(23) %'# 4D>I=I¬±R`y>E@('!E%4:. I :D R!E@('QE4{. 6&GK0 X ( ® : ¤t¥+ =D &*G (EI S(:± = 44E:%!IH%# ;+Xl <M '{MS%' 7= `K ('+y I¬7= Y%¨ S± |I(DS'QE S< $4' /~K ('$M>%'!]70I X6fN70I=E <c !77=kE #M>7 PR4 7= H±g= $
(24) 7= EKM 'I P4E@ |y 7=#.( &3e4&P47='{b4§B> A = A = ¦ X v -9 Z Y X q / Y m>X q iQ*= :I=EI¬M ' (`70e ¦ X Y $9 Z Y X ¦ / YPq X ;6itX*§OyS R2KE '%= I`4Sc'! !V 7=e
(25) j;[d©-©b4§B? #IE=-M &7& I=K R4 P ('4M&3D = - K= I='7=# 'Q(I=E(wD $ !K I='Q76#(k I`&%'!@ E(7&y '!(E( D 'Q&<S]SX 6
(26) 7=(E%4 7= O±RA @ 70IE =<`4707E HM 7 PR476) B
(27) . I`7&y> R2K`±' D S6& <SIH±B #4 |M ' P (:70e 74S%'*I=E&<= 7 P $± k2V N8 .!7
(28) (7&D (PX =3¡ : ® £>(¥ !M> !` pE#R447= ¬7=e2 4DSI=K \4Su't !D RQ ¬ !DS<< 4
(29) %j;[d©*©E (I0 (p8. 7=]4I ± R47= Sy>7=#.6. E(p'Q Ve4&P47=' b 7 I8 <477=G M 7 R!7& 0^'PM>t!R4E@ 8K6iQ^±R2 7=@ '!±E<=(Q:. I ±
(30) 2 72 '¬DMM 't/8:y T A{
(31) : !M E(8K #I0]&HPM>E(7= I6K R4 p IU7 2 '¬ 'Q@> (4'Q.M# (kI P7='!I%' \b('4@ E&7(yS'Q(S]& SPD '!(E<E0('MS(. 6I
(32) 'Q&I=]&~D > !K I='!7=#( iPX 2
(33) 34. HAL author manuscript inserm-00141238, version 1. ¤Q(E`&¥¬y>7=±u'!PM>QR!@S ±7='4V ¬D>E (' '4@S .2'QM0# .!¬±7='4V>/'QE%4I D D 7 V 4= I 7='I'%X C D.
(34) j{M0M 't/2]8:y ±7='4V /'%E%!ID D 7 V 4( I= P7='QI0%' bETA{p i &'Qe4'QC&D> ( E E I&D 44'!E( (&I 7&D (4'! Pw !M>(E&]8Kd! I=E R! B IH '4@S: .2'QM0# .! X>jBE (' %'2@ : (4'Q.M# (\%:y>7=± b4j\[:©©*iQ ( 7&> I @.Dy R4& D S# K SI'!7=# B
(35) ¬D tD (8K (7= I0%'I n (7= I #7 4`&7=##7= U 'Q@> (4'Q.M# (kI P7='!I%'&e4'*'4M(=D = > !K SI'!7=# b Y iPX T B P76# .D 7=' \b q ik(7= ]I0%'$j\[:©*©I0]e!e4D R>!7:IE< 7 S@S :±R4:©*L
(36) Ie!E RQ76 0 yS I:70 . !K
(37) M!7=# & I E< &'Q @(E.y e47='PM>I#707=< E 4DSI b q v iPXH[:76 t2 P Pp= z\7 ( (4V # 4 7= I:E : MSK 7 7=<(> 4D I6K#7e$j\[:©*©-SM I0c7=7=<S] 4~D I=( 7e7&DM 4E7= (>j\[:©*©p('QOC&D R 'Q'!Nb ¦ iPX p7 4{7=e$ #7=&DM %2]76 6&- 4DSI B('!: :'!PM>7=' Q B8 tM (EeQ #7=DM 47= |7'B PP!7' Pk !D `. I='QE@S 0<^b ¨ iQ ! 7
(38) E I&D 42'4Khb4m =iQxy
(39) y 707#Q76Kre4(P47='!Kb!l(iQ* !D '2<]&- !D~D 'Q 2't(Ie4(P!7'2Khb4o=iQ ±7='4V 't. M 7 I#!7` SI /7&M 'Q4I`@SyS'Q%2 0<cQ707 :b Y ;0 Y0Y iQk IM 'Q7=e! P 7= (:D ]&E b Yq iPX>a7 4{7=e\ IS7 7kE (GD>I{. N= P P # .k7=e*M>7 !D 'Q$47|y 7=#.6& E& e4&P47='t X * ` 4DSI=K± yS I7= I=%4pe4'Q7= u 4E7= ( !D '2@ K%:e47D> PI7& ±
(40) 7'2V /'QE4IpDMM>%'/4EE#y I 7='I't $E :< S%'!(=±
(41) ~g2±7
(42) #I&>PS(#8 647= $e!7'*(:±7='4VS%'-b Y oo v / Y o0o ¦ I Y oo0m/ Y oo 6iPX( . !D '2@Kn sy I 'QGy>InE M 'Q@ 7(D> `&'4E yS7(D=H('4M&{D = tK I='Q7=#(g± 'Q 4
(43) 4 IG R! `. I M E(76 I=K ERQ b Y%v / Y%¨ iPX T &EK PI j\[:©*©±R 76 <S ~D I=E (MM '!7=( . I776V I%^@('!]7&D. M '!%IEP!E@ Oe4(P47='t $e47='*RQ $7& tQ0E (GD>I=E < \MS't 6&B7ek7 ~ %'wTA{p #X . HAL author manuscript. . . inserm-00141238, version 1. . Subjects and methods . ® 3 4(¡¤t. * (
(44) M aE u 4~D I=K 6= y I P'!Gy I E M 'Q@ 7(D> M M 't ub Yv / Y%¨ iPX Z Y oo v / Y o0o ¦ YP¦0q ; ±7='4VS%' :±| 7 P¬7=DM %27= :'C&D E'Iu'tM>t4R!E@ ±7='4Va I vv u±| 7I Iu 7BM>'QeQ7='!'PM>t!R4E@ ±7='!V 7=:M>QI:: eQ/(I=#8 4Q'%IC&D 4!]76 (E' . I
(45) ±' PS(#8 I
(46) y K~ 7=DM 47= (SS%=R:MSK E& 0. E H('2< 7ek
(47) #IE=x tD '4@ E. 6&:7=exS
(48) ±7='4V 't OE # E'\7=:MS X0* P tDy 7%PQ ±%' PQ&I (7='!IE <n47U7=DM %27= (:'! !'QE XO*7 a±R 'PM>QR4E@Sa±7='4Vy>7= <SI47 7= S7=e# e!7=7=±8 < (P2@S ~K PP!7' ¥¬ P
(49) y EKE b M &V(<E 0< (GD>II=iQp(7268 < SI 7 G I&D 44'2Kb M &V6&<E S< GD>IIiQ e477I E I&D 42'4K b M &V< 8 < (GD>II=iQM &V< G < !DM>'Q:('2V t 't Xa©kS(M >. !DMS%'!:('4VSt ! %' P= K#±' (E= P Ee4I#8 YYY IEe4eQ'! .$ @±7='2V G <c PRDS%4E7= B+I%e!E I:= { !Dy0<6'!7&DM+. M 'Q (E 0<s E# ]&'\± 7='!V68 <`(7= IR!7= O%$:7=:#7= `±
(50) 7'2V`7=%476 b~#7 4\7=eQ 0 : &# ±7='!V ! 7=M 7='3 &#O P y>EK#8 %iPX&6'OK (' $]4't Y l7=e>4S v o|MK PE&]. \7e>2 BE R4E(> !D '2@ K#(7&D>I'M % R SKr(IP &#E SI ;;s±7='4V 't gE r'QM>t!R4E@ d±7='4VrE Y lHIEe4eQ' (\eQE'!d .X §ge*4 );;H±
(51) 7'2V 't P Y ; q b Y%¨ <si$±%'
(52) (7=:M>Q8Ks7=' M ('4GKs 76 2*47HeQ7E76±N/ DMxXS|M ' ({ 4D I6Ks OyS I`76 d~ ¨ oSl#±
(53) 7'2V 't B O7= <S ~D IE (> 4DSI=K3X(p76 2w6&I ~ .#B7'g EN ]&' 77&y#%wy E S{ SI '!{KS%&'t $E%4'%X . . .
(54) ( >£¡(¢ : 5 ¢=.£ ¢3 : ( 9. BL D IEE S( BM '!PMS('QIeQ7='\ # !D '2@ K¬±%'
(55) D I¬E c H 44. 6I=&'QI= (I¬(EE E=- &:E %476 `M 'Qe!7='Q#&I yKu ¬7DM 47= ( MK ]&E %B Hy><E 8 <7eB ¬ 4D I=Ka Ip<=G h26'K ('t E%2%'XkE 4:70e 'QR4'QEue!7' ~ uIE< S76 #'!(7='QI0I 8 h2 ¬#I& C&D> 2Q7& &]'± dM 'QM &'QIaeQ7=' H !D '4@SK+X*> <=D EI E {&7=@ 'I vv IE<0 7 P O%kBy><68 E <H7=ex2 4~D I=Kc. I v0¨ $e47E76±|/ D0MbE2 E<($( =< (. y 4±
(56) ^2 H±7E 4Q c±%'¬E#R!Ih!7 7&D I0%' ! IE S 28 iPX-§g u7=' ±7a'Q< 7= (O#(Q8 < ±R4u4> 7=(DMS%4E7= (MSK E(E B!77&VrM>E((dy eQ7='~ :y = E Sc 4DSI=K3X3$'4(G G <ueQ7='{Sc 44. I=('!I I`MS=K PE= &#E %476 c± = BG (GD IIE # P
(57) #P!E < X0* |M '! (447= `7=e*
(58) <=D>IG
(59) ± = BE (GD>IIH<(E ` O'Q< 7= (S#QE 0<0 $7='2<6. PI|y>%e!7'$ (7= I: !D '2@K+X *BI=]&< 7 8 $7=e*j\[:©©u± y ( I DMS7= g~ {e!7E7=±E 0<N'! 2%'!]S¥ J 7='!KN. 6I
(60) #7!7='- !K
(61) M!7=d $8 gS\D>E ('k '4@ BI 44'!GyD4E7= • Ee4eQED R! $E :#7=@E < BGy 76±| • §BI# S{Gy 76±| • T7='t 68 <N70e ~ !K0:MQ76d yK:(76:M 'Q P ]76 #7e>S{Dy>R4(=D = • T V S P $. I&DS# PE S P $70e ~ \& I>X • ©*
(62) M ± < E@S Q7U4±7 'QRQ'QES¥# P 7='4K K:M47=# E D G ('p '4@S I08 24'QGyD2]76 >I ±7='t E <r7=e$ # KM=Q7=# OySKr(76M ' P 76 r7e* :DSy R4& ~D 4XS E.< 7 P g±%':E EeQI`8 d2'( %2< 7='Q ¥-b2Ei M '!7=@ IaI=E(<0 67 #8 h #I&BP &#E 47= b(E{'! !'QEu#4iQ{b ]i|M '!7=@ II0].< 7 8. y e47=' d#I($ &#E %4E7= hbe!7=' &
(63) M wM '!@7&D+ |I=].< 7 8 gyKr` !MS%E( 8 24iQk Irb2EEi !D tM PQ&I IE<0 7 b~ 7$(E 2 '! !'QE:#$E N2 |#I(k &N8 647= H7='\IE< 7 y = IH7= NSI 'QGM476 s70e. !K
(64) M!7=# $ 7
(65) 7= <S%'kMS'Q (k%>-2E#B7ekP &#E 47= iPX §OD '$Ie48 RQE7= H7e= PB7ekDSE (' %'2@ (4'!M# ($E (EDSII
(66) M 'Q76@ I> !D !M P!I: SI
(67) M 'Q7='$I=]&< S76 X @)>'!E7'BI=E< S76 B:8 c # (7= I¬C&D 4!]76 (E':E (GD I0Ir= O% (I`.MM ('!%I¬I&D 'QG <c~ 4'/K (' E (!%'2@6&4X Z 2 & (8K0 8 ^7eM 'QI0]P!E@ ae4&P47='t ¬7=er76 0 tQO &
(68) M ± = ¬'Q 44'QEP!I !7 ±7='!V 't 7( IE<0 7 PI¬±Rj\[:©©%Oy = % E =X3
(69) %e!E R476 0 N±'tdy %Iu &GD E@ 8K7= s~ #' !D RQ
(70) 7=e\2 #I= &#E %476 +XkH ±
(71) %' 47`Sc&'4IE<'!(. 6I`2 `I0 '!GMQ 7= 7=e K0M!7=# E r M '!@ 7&D # #7= (20
(72) P tD I`e4'!7=2 # eQ/(I6#E 4!%'I¬C(D> 447= 0 6&E'Q±'td 7-2V uE (47¬(7&D (BE H4 :& (8K0 X f7=±
(73) @ %'=4S ±'t ±'tB. V IeQ7='k @& !D !M P2I BB PSE `7='QI'x!7:@S%'!eKN2%3~ !K:M=Q7=c. ±'{(76 0 8 2Q (w±R2gS I=E<0 7 P X . HAL author manuscript inserm-00141238, version 1. . ¤t(0¤t£¢ : £Q¢¡ ¤t. * ¬ 4:(76M '! PIpM>%' 7= (O( SI 7=&DM %2]76 6&B@('!].y E $M>76 2D 'Q & Iuy>7=#.6. E(B(76 0 24'Q& (Q. b4 Eet/= P P Ii( SI
(74) M !K . 7 7E=>±7='4V#e4&PQ7=' X Z k± ;y %IH7& NS 'Q !D> ! \e4'Q7672 %'\ 4DSI ( {76 #±7='4V / 'QE%!I D0MM 't/E:y#I08 7='QI't =± R4: !MS%E(>
(75) MS6= $7= :'Q !V:e4(P47='t $e47='*Gy 76± I 7='tI0%' X
(76) !" # !$"%. ¥.
(77) . HAL author manuscript . . . inserm-00141238, version 1. L I' < E :eQ7&D '%4< 7='Q \b v ; v ;/ v o ¦ ;/ ¦ o= ¨ ;gK6(' i §BDM 4E7= (k@('!Ey &¥ &P4E@R4Kr P47=' b27e*2 :mM>76 PEyS%i\& Is DS
(78) y 'B7e K ('t g7= # #77(y b Y Y /4o= Y ;&K('t i J#7=V 8 <db S7= /4 #7=VS%' N76V %' /4 #7=V 'i z\7I=K: P E Ib4z\ Z i%¥d 7='!N&hb2z\ Z qS¨ V< F iQ7=@ 'Q±
(79) E<=.bz\ Z qS¨ V< F >I v ;&V= < #F4iQ7&y> R2Kdbz\ Z v ;=V0 < #Fi "* !D 'QB&PQE@R! &¥= ±'x47 2 C&D> 2Q7& x¥ @&I=7:KS7(D`7=e! c !M SI 4E#BM &' 4EGM 4E <HE c !M 7=' ! P M EK E =<:
(80) D ](07= :I7 /RQ/~K 7&D 't % e3S7(D> P M 'Q7 7PPQ
(81) 8BE ±7
(82) %2< 7='Q (¥.K \7='k 7 )3'Q &7euM> !K 7 7=N4U7'aIM ' P E@ MS'Q7&y c PH(7='!I8 < !7 . 0 ±'t p47 > e477=± E 0<rC&D 4!]76 0 &¥>I7sK67&Du7=eQ `.@ : (I=& kI7sK 7&Dr7e! `@ : P PMuI 7='I%' 3' K 7&Dr7e! cyS7 2 '%IySKcKS7(DS'\ ('$y %4G <`&'QIS3I=7HK 7&D¬6.@ |M 't 76 6&k±7='Q'!E \~6$< \K7=D I7=± M K (EEK>>('Q|K 7&DrE H7=±7='\@ '4K`76± !M>E'QRQ O#7 4$7ek B4E#=>('! KS7(DHy>7 'tIdy>K %'2@ 7&D 3I7HKS7(D¬7eQ `e! ~6$ 7 8 <r@ '-DS'4 B7&D*S
(83) ±g.K`K7&Dr± (OR*47S3I7K 7=D. 7=#QE#( g±7= SI%'BEe{. K(4E 0<r |±7=' ±B : K0#7'XS6'!Q<S7'! B±'#IeQ8 I3¥S >7 M 'Q7&y #S 7=#OM 'Q7&y># \b Y 7' q M 7 R4E@ O ±
(84) %' iQ=MS'Q7&y # \b v 47lBM 7 RQE@S{ ±'t iPX. X#"77(y I&D4 # .!7= SIE ]eQ/=I=#8 4Q'Q&I C&D 44 7= (E'G &GD II:
(85) eQ7=76±E <H(P476 0 .¥ @S7IHE HM 7 RQ 7= B @P~D '4 H Ic '!± B @ ±7='4VH±RHeQ7='Q& B b =KH(P!]76 #M>%'!eQ7='!#I#±
(86) 2ce!7='Q(iQ @ D
(87) Gy 7=± OeQ7='{ !D0MM 7=' B+ I @ 7EI# 277kE #MS76 R47= Bb D 4707 % I $47:y>B IE #M>7 RQ 7( SiPX=*±7:Q<S7'! \±
(88) %' &7= I'I3¥=± St2 'x2 B(P4 7= H±g= $M>%'!e47='Q#&I 'QM>t4R!E@ EK7='a S7 X @.jg E <@ Gy 'Q4G =< !77, BU± & 7 &7= PEI'I = ± 7%2< 7='4K@('!].y E'Q'! !M>P4E@ `7=eBe4'C&D K3Xw
(89) eQ7=' 72 'C&D> 427=
(90) y 76DO±7='4V 8 <&7= I=RQ 7= P3~ #. 0 ±'t B47¬MS76 2D 'Q(. I|y 7=#.( & &7& 0 24'Q& (Q ±
(91) %'{. VSI ±R2g~ \MSK E& 3X ! %. . $" "%. !
(92) ! . P, 7&yn(76 .2'Q7=b4 &7'!Ie4'Q76 ;u47 l(i:± = H(ED>]4I= : u !DS 7e 4> e47 7=± E <#KS 7' 7:R!d &¥& 7:S7E(BeQ7='348#E <c7=ewy 'V =DS 0 I&D>IN 7=' wyS'QV 67 M 7 P PGy ==M (= IEP44I:ySKNS :(. E SyKH(7 %.<=D PSy0Ks72 '\7= 4Q'!(G (Q S 7#&7= (4'Q7w7=@ '*
(93) C&D (! ~Ks7=e$±7='2V + 7 7= (4'!7-76@ %'\S:M &(#7=eO±7='4V>*E(Vu7eO@('!]2Kh7=eB±7='2V+X+ 76±@S\7e 7P7&yu(7= (4'!7±g= I0e4E I¬ |. 7='{7=e ¨ 7='k#7='t=X 7=±@ B7e: %4 e4&P47= a± Ie48 Ia ¬ <%48@ r. ±':yS7(D=:R '# %4 e4&P47= a±R> ±7='4V 42%4E7= #7='k< S%'!( 7t7&yc 4 e4(P27& +X % ! ! . >X HI P7='QI0%' :(76 0 I'tIu8 r4 ` 4~D I=K±
(94) %': 7 c&e4eQP48 <r4S`Gy 7=±$. 6I^ 'Q@> 7=:M '! P76 I08 7='QI't .¥:E%4'Q&c. I#IE=`PMS7= I=KSR4 P('4@ E(7&y '!( E&# SPD '!(E<Ec#IE 'Q@>. !K SI'!7=## y>7=±
(95) 'Q&I=]& D S# K SI'!7=## y>7=±
(96) ('2M ( ~D = # K0 I='Q7=#X
(97) J0 7&D I0%' 4 I0E ! B± = B( 7`&7= P I%'!Ix E (d±7='4V 't g(e4eQP!I`yKr 7&D EI'\MS(E ¬N&K`#70IeKc2 E'O#7 27= B% . .
(98) ±7='4V3XBLBDSK 7= 3} p &# K SI'!7=#±g= u&7= PI0%'I PM>('44%8K0|y>D R¬8 ^(7 EK 7=(E%4IU±R2 j\[:©*©{X. HAL author manuscript. 9. ¤t°> >. inserm-00141238, version 1. J 4P4 42]&| 6&EK P OJS7e2± ('! b!J:JSi3@S%' 7= Hl X q ± D !I
(99) eQ7='3 O (QE'QB 4D I6K+X A{E%4E7= Ny 4±
(100) j\[:©© 8 Y oom/ Y oo u. Iu'Q V e4&P47='t :8 Y oo v / Y oo ¦ ±'t` 4~D IIpeQ7=' ~ ¨ >l. !Dy7P%P! ¬e4'tpe4'7= j{[:©*©y E S gy K y>@&'QE%4a= P 7=E%476 0 ub. /4 PC&D &'Qp I 1k8 t %'Q 44iPXO*> @('!].y $ P 7E4I
(101) ±R4:j\[:©*©uk )k/@ ;>X Y%¨ ±' 4D I=IB :±R2g~±7N M ('!%4O]76< 44EB#7I P 7= ±R2< I0%'\<S I¬TA{p MS'Q P (
(102) %|y ( E S 72 %':76 `±
(103) 2<S I't\.< \ SIr 'Q V e4(P27' $7 '34. gTAO #X Z : E 2* 44M |e4E (>7&< 44 B#7I=Q707=VN8 .!7
(104) ((7&DS (Q8 N&IIR47= !7
(105) < I' I`.< kH]8# !I DS
(106) y 'B7eOe4(P!7='t g#76 2 42'Q7& <EKr= P 7=(E%2I`±Ruj\[:©*© (7='I=E <c474
(107) MS'Q@ 7&D. &K .X Z $± OM E& I:!7H .Vd2 := P 7=(E%2]76 0 y 4±
(108) hj\[©*© I`LgD K 7& x} g = K= I='7=#X0f:7=±@ 'P aI=E&< S76 ¬7eHLBDK 76 +} ¬. : !K SI'!7=#a± ¬.y (He4'Q7= 4 p#I (
(109) C(D>( 44 7= (E'Q u7=eH( > E ( I (k $7=e*j\[:©*©{X Z #I=IR!7= 0± 77=V I%3~ Be4'tC&D> Kc7=ek±7d@6&'QEyS( \= P 7=E%4Id±R42 E &I (
(110) 7=e-j\[:©*©a peQE &
(111) D>RQE@&'QE%4p#7I0= =<4 ^M '@( (H ^E ~ a .!E'<'!7(D0M 7=e Y ¨ = ub Y¦q ; M 7 Iu47a'tM>t4R!E@ ¬±7='2V0 vv pD M 7 Ii:E Y oo v / Y oo ¦ X\§OD'7(y 7P%P!E@ ¬± = :47a7&y4(G (I0IR47= = E eQ7='!:%4E7= y 7&D¬2 = P 7=(E%2]76 0 y>4± 7 '!8 tVe4&PQ7='t Ij\[:©*©$` !M>]&EK E ( 4> M '!P@( .k. I
(112) E I (k= ;±'tO(7=
(113) M>t!EK# M ('!%4 <6'!7&DM X . . . . . =¢ ¡¤t\¢=PP0¡£ ¢.¤Q £G¤° : ¤t ~ : : ® "*7 P {27`eQ7 7=±DM¬±
(114) E< e4 (QGKr= P 7EQI± 2r.< : I(P4E@S 2Kh %P!7='%X Z ± g#7='Q#e4'!C&D #76 <Hy 72d2 7
(115) K 7&D <S%'$( v ;sK (' B I#S76 :% %= 4 ¨ ;sK (' B7=e{<S w SI`( 0<h !DM>%'!:('2V t t6 %' XS*'t
(116) ± = O 7s P4 7= reQeQP\&(7='QI8 <#47H#IE(7= IR476 0 g%$y = E k (M** 7 7 4O47ueQ7=76±DMa#7'H7e! (7=
(117) M>]&E Ip7e
(118) 7&D I%'
(119) MS(G ±Rh tDy 44. (4E(\7= (4'!y0D47= e4'!7=> 'QE%48@ EK
(120) K 7&D <S%'- tDy<'Q7&DM#7=e* !DM>%'!:('2V tk= !'t X §BDM 4E7= (>MSK E& O7(D>IH7&y4& `E e!7'!:%4E7= `7= : ' 76 ce47='\7 P $47#e!7E7=±UDM`eQ7=' ¦ 7=ex> Y ; q E7 4\47¬eQ70E7=± D0MxX3 #7 4Be4'QC&D> (B'Q 7= N±%'dM ('! .2($7'|:%4'! 6R2Kh %&@ *'! E< 4E7= *. I I #8 (4X.f%&R4:'Q 76 0 ±
(121) %'{'!PM>7=' 4I
(122) ( P $e4'!C&D (4EK3X . Results. #7= <`4S ¨ oSl±7='4V 't :b ¦0q ;¬±76# 0 Y Sl# i E `2 H7= <RD>IE (\ 4D I6K0 q ;ub Y%¨ ±7=# u& I ¨ # ik&I
(123) I=]&< S76 8 7=e*j\[:©*©u%wyS EE & :70e ~ ±'{(e4e!PQI:7& S '!G<(* PI0 +l 7= 4 Be!. I ¨ y E%2%'!(EEK3X*'Q¬K (' #E4%' Y lp7eB2 q ; = P &I'!(7&@ 'tI>X* ¬eQ8@ `±
(124) 7'!V 't c±gR2y>E%4'Q& . .
(125) j\[:©*©^6=I
(126) 'Q&7=@ 'tI>X Z Y oom0/ Y oo & 'O±%' Y |M '@( (*= (¥ Y ;
(127) (e4e!PQI:76 g2 {'!E<(* I0 v > eQ>. I ¦ y>73X §Bek4S Y Y%¨ ±'E &I ($ P+N&VE <H `E ( I (|'Q%27=e$y 7&D;>XGl < M>%' M 't 76 K ('%X J @ 7e ~ ±'rE= P EeQIa= @M'Q7&@ IE ¬#I& &# 47= B¬ SI @ . @( tD !M PQI B
(128) IE.< 7 P XS:]= 4\7& w(E P ]e4 Ic= @MS'Q7&@ I`IE.< 7 Oy>%e!7'B
(129) #I (* &#E %4E7= B (IpDS I'4< 7= S !D '4<S%'2Ke!7='cj\[:©© 4±
(130) 7aK ('t s%&'QE'%X #7= <a @ n !D !M>%P!I= -~6'¬=I M &'4( 4 PE= \ (GD E@ EK#8 4 |eQ7&D ' ~# I:e!]e2cI0E< (&7'!I=E <!7 4 Eet/(I6#E 4!%'I#C&D ( 247= &]'!X 6'!O6&I
(131) M ('! 2 PE $& P7BQ7:72 '-I=E< RQ eQ7='3 2 7=DM 47= &MSK PE&]. $(Id<68@ #I0].< 7 . 7=ek('4MS(=D = > !K I='Q76# 8 N&II0 !7& Q7
(132) j\[:©*©{X=§O O(I|M (G :%>BGy 76±dX *± 7|MK PE&]. 6=IB'QBE ( I (k P&'QO(IB±7: P&'QO(I
(133) 7= O X #7= <4S Y%¨ E (I (a= P P Y ; ±'t
(134) M 7=K IE P y>EKEE 7=eaS7(D> P7I P4'QE= M0M E]. ( b ¦ iQk&'\y '4.V
(135) b v = iQkP4'!7= :&MM EE& 6&
(136) b q = P i{7='B V k&( P P7='!
(137) b Y = PiPX 6'!O±%'OE g~ 7OE I&D 44'2K (±
(138) 7E
(139) M &V6&<E <:E 4S{eQ707I8 I&D 44'2Kdb M &V(<E 0<#7ewy '!%&IS 44EV 8 <N70e Ey $E O#%kE SI(D> 44'4KiPX *
(140) e4(P47='t O= P 7=(E%2IH±R`E I0 (
(141) ±' 4D>I=I`E #S <'7&DMr7=e ¨ Sl:±
(142) 7'2V 't O± S7cI0I 7$(@> j\[:©*©%|y = E =X #7= <u4 sM 7! .2]&\M>%' P76 6&{. Ia7D0M %4 7= (\MS'QIEP!E@ `e4&PQ7='t *Hy>E@('!]4 &K bE4y Y iG IE%!Iu%
(143) < SI%' M 'Q &u7edM !KS76 7=NQEp7'IM 'Q P E@ M 'Q7&y c {z\ Z @D> sy>7=± eQ7='# !DM0M 7=' B I @ 7=IE <a`Q707| aM>7 R476) Bh±'t P 7=&]4Ia±RE SI &X* @('!].y Pk47&< 4S%'
(144) ±R&< H. Iu(P48@ RK PP!7='t±'QE (GD I0IuE r 7=< 44#7I4Xk H#7I0{b 7( < E@S 6iE IE%!I%7&y R4K . > I @7 IE < a47=7=#E UM 7 R47= B ±%' E<0 EeQE (!EK P 7EQI ±R2 E ( I (#7=eBj\[:©*©{X @6JDMMS7'\7& c Gy 7= ± Bd'Q:8 I`E #2 :#7I0*± R4`& r§BA7=e v X v w. 6IHHo ¨ < 7= eQ I (OE (Q'4@& ,;>X Y / Y o+X m ¦ X *{= P 7=(E47= y 4±
(145) g2 \MS'Q P &B7e7 ~ %'wTA{p Y oo v / Y oo ¦ . I:E (I & 7=e*j\[:©©u±'P. 4DSI I PM &'Q%2%EK3X
(146) a%I0]&rM>]&7= I=KR! P('4@ E(7&y '!( E&H D 'Q&E<]= I'Q&I=]&` SI('2M (:D = &. !K SI'!7=#(
(147) ±
(148) %'c E< EeQE. .!EKu P 7EQI¬±Rj\[:©© E ( I (`bE4yS q iPXST s2 PeQ7&D ' I08 7='QI't. ±'4VS E (47(&7(DS (u E:D> 2 7&D 8K 8 7=< 44 #70I:( c70ec2 't:(8 I PE<= Ee!]& (4 K 7=]4Ip±Rj\[:©*©G &]I0 (=X*1w7' ~6 '!%= 7= *@('QE.y #4.VE < 8 .!7&7&D (B HMS'Q P &r70e 74S%'3T A{ G Oe4E (S#7IS± = k\M '! (B7=ek%w 4k7& B7=e> ( {e47&D '*I 7='I't X *
(149) eQE (k76<6 4!E
(150) #7I*8 6&GD IIwE H(IIR!E7= #47H< I0'\ I#&< S 2'Q
(151) @('!].y O#7 4{ 42'Q7& < K 7=]4I±R4`j\[:©*©B¥z\ Z S 70IE <H 47=7kE #M>7 RQE7= H IdM ' (
(152) 7=e-& 7 '*TAO #X0* P{2'( 'Q !V:e4(P27' $'Q:(E SI= P 7=E%!I ±R2N8 6&I (B7=e*j\[:©$©-== $ IEQI:E 4y E v X T . VSI26k
(153) e4'tC&D> K`7e @ 7 I8 <#477kE M 7 27= B:>7=@S%'!±E<0.$. IM 'Q P S(
(154) 7e\. 74S%' TAO U± E<H%y = % E
(155) (#7& <#S: S(EI (\ BEek4S:I%e!E R476 s7=e\E &I & ± O'! 42'QEPQI
(156) 7 @MS'Q7&@ IaIE< S76 HE ^#IE= PS(:E %27= B=X$* ue4'!C&D ( s±'t ¨ < eQ7=' @ 67=I0E <r47=7|E M 7 R!7= #b vkY <E 4 O± S7 &MSiQ q o <e!7'7(y> PR2Kdb < E g± 7 .M>iPX& I Y < eQ7='kM '! = 7=ek 7 '3TAOJ#G O 4*b v ;
(157) < G g~ O± 7= (
(158) M>iPX f7I=E <H 477kE M 7 PR4 7= c. IHz\ Z ±' ( 7c &#E I
(159) Q7H P|± 2 %'OR '\± O 7=]QI± R! M 'Q@& (O7ekj\[:©*©G 4S (4E'
(160) M OE Y oo v / Y oo ¦ X* M 'Q@( (O± q X Y <b v
(161) $#76 < . . . HAL author manuscript inserm-00141238, version 1. . . . . . . .
(162) Y ¨ r !D0y87PPQ iPX> : 7=(E%4 7= r±
(163) ~hz\ Z ± |7eOy =7 'I'Q8 c 8< EeQE S(#b M = ;>X ; ¨kY i 2
(164) M '@( = ± Bo>X v ;<e47='\7&y P tDy87PPQ q X YY < e47='*76 8:M E K`7=@ '!±E<=(-. I q X ¦0q <e47'*~67 ± R2c
(165) 7='Q:= ±E<0.X)3'!P@& (
(166) ± =. E<= EeQ. .2EKH E< '{b v XGl ¨ < # `Y X ¦ <H M =;>X ;; q i*#76 <N2 7 P|± 7(I
(167) 7 7EI
(168) {47=7SE
(169) M 7 PR476 +X . . . HAL author manuscript. Discussion.. inserm-00141238, version 1. O§ D ' 4D I&Kh tD<< 4!I#4{j\[:©*© | P 7&E%4I±Ru7(DMS%4E7= ('Q V¬e4(P47='t w#7='t
(170) MS'Q P8Kr±R2 @7 IG <#4770\E rM>7 RQ 7= B±RuM 't 7= ($e4(P!7' :b7=y PRKSiQ*. I¬±RuM '! (H7e|7 ~ %'gDMM>%'/4EE#y I 7='I't P0 tM EEEK:#I0]&>PM>E(7= SI=K ERQ $ I:7 'k '!@ B (4'Q.M# (Q X&* 2D I=K
(171) (I: P7=#B8# 2%4E7= . 7=±
(172) @ %'
(173) ±B
(174) D 4sy u4.V E (47(&7(DS (%¥\2 a'RQ'QE eQ7='rj\[:©©±
(175) %' C(DS !n 8#E('H4747 'Q(76:# I I E n'( (dM M>%' rb v ¦ iQO7=±@ ':4 'u± s 7 (7& e4E'!N47='4K 'Q@S(76 6I&D>P47= 4D I0K M 'Qe!7'!#Ie!7='N~ Y%¨ E I ( B I2 u'QR!%'!Ee47=/ ' @& !D !MS%P!I BI0].< 7 ±'u 7HM E(R M 7 4DS'Q $ I|y 7=# S]&>(7= 42'Q(G (Q ±' eQ/ IS S7 2 '*E#R447= :± = k : S DS
(176) y '-70e X * 2D I=K:± yS I: (QE'Q8K#7= N E E(>I=E&< 7 X&*OM 'Q P !DS'Q\MS'Q7&@ 7=%48@ -! 2Q=±| E:± $7= S{7Se :'!RQ'QE II`e!7='{MS'Q7&@ I`= P Pw |c tM % e4R4Ku7=e ;>XRoSlw&7'!IE <H47`` 4D I&Kr7=e$ # 0 R4E@ R2K I# !M>e4R2Kc7=ekM '!7=@ 74G@ {! 2Q \e47='\j\[:©*©ab Y m=iPX @=J=D> !M PQI B|I=E(<0 67 {7=e$j\[:©*©p± $yS I7= 4> @(GD 47= :ySK4S{MSK E& > 7d#E E:DS DS
(177) y '\7=e-&'QR4'QE
(178) ± $<S@S sG : |<DSIE SX&f:7=±@ 'tSe47=' 7 H B4Ss K
(179) M!7=d I '!y>IuE rSs Eet/&I=#E 4!%'!IC&D> 427= (E'!H±'tH&7= 4Q (g±R4`4> IE<0 7 < E@
(180) y K MK ]&E 3XEX Z h26 H 4DSI=KM>7 4D '! I^y 76# E&{(76 0 24'Q& (Q d±'r ]eQ/= P P I6;yDB ±
(181) %' :±
(182) %'P .V Iu±Rr2 MSK E& +X Z &IIR476 0k~ He4'tC&D> K 7=e
(183) %&&7= 44'Q&G .g± :&ED E%2IueQ7='(& @± 7='!VE <c RD 4E7= B0 IB2 B'Q !D RQ ;±'tBI D> P PI
(184) ±
(185) 2 4 |7D0M %4 7= (0M K E(E \8 #('2<6|7e>2 . !D '2@E]& (BE ~ BeQE'!d P0E H7'!I'347
(186) y> !D '$4%!e47='*&]=2 O±7='QVE 0<c RD %2]76 0 (2 BI P'!M=47= #7e>2 ±7='4VSE <(7= SIR47= y = PI7= 4 uC&D>( 4476 (E'Q ± H&7= 4Q (d±R S @(M>%':7&M 8 6 7= Bu7=e
(187) 7=(DMS%4E7= (0MK E(E 3X =Kr7=DMS%476 6&wM K ]& g±%'!:E @ 70E@ I`G #4SN 42D I=K> ~ B#E<0.;6&@ :8 I&D (I`7&y '4@ '\y>E P (RS7(D0<n '± = u !M (Ee!]u4'!(G E 0<²e!7' 4D I6K0|E (! IIaQ7E
(188) M '!7=@ u4S(76:M ('!y EER4K 7=e:4> #I& &#G %476 0 .X\* ¨ o l±7='2V %' `8 7& < RD I8 6& 4DSI=K±'u 7H P!I(7='QI0E < !7 (R2h'! !'QE IH4 H P %P!7= ueQ7='B (R2h'!%= 7= |y>P± `4 eQE't 2B Ih (7= IuC&D> 2QE7= &]'
(189) ± . #E 8N={b Y%¨ iPXkp7 4BM '4EGM (Q P$@ r2 7 Ps± 7 !D e4eQ'Iue4'Q7= DM0M 't/8:y I 7'!I't :G Y o0o v / Y oo ¦ ±'P0M 7 IQ7 8#E('¬7= 44'Q&G .! u%sy %G IU%`e47= 7=±/ DMxX\[@ %' P PB~ 7DMS%4E7= = MK ]& %pe4]'!# ± R4 E<@ ¬7e^DMM>%'/E:yI 7='I't @ 7GD (!%'I #7='t7=e! e47='u4> 7= =< RD>I=E (> 4D I6K j;[d©*©n |I 'QGy>I#ySKHf&<=y '4<r\&~XS= \ : P(76 IHc7 4 (7=:#7= u7=DM 47= (wDM0M 't/8:yr '4@> (4'Q.M# (Qk&e4%'B&'4M(3~D = - K I='Q7=#Hb Y iQk. 6I¬7&D ' 4D I&Kr&7= eQE'!#I#26 |'Q. VSE <3X>6 |I P7='!I%'B.
(190) HAL author manuscript inserm-00141238, version 1. =7 St2 P \8 6e4'!C&D (Q0± S].MS(' 2K#M>E(E k2 B]&Vc7=e*M I#776< E>I=4 7& #7=(DM 4E7= (>e4&P47='t X Z uM 7&MDS]47= M>76 Iu47a'QM ! !E@ ¬ SI e47='!(eD B#76@ # Q PO)w% PD0²:(4X$ 44E:%!Ia ! H = =D = E ( I (:'Q4
(191) % q XRm <>y= I`7= `(E&Ec BeQ7='O7DM 47= (I P |b4o=iPX0fNE<= '\MS't@& (# @ B@> y H7(y> P'4@ I:8 d 7=# 4D I0 7='kM 7&MD>]47= ¥ ¦ ;< E #B<'Q7&DM#70e m0o
(192)
(193) D PE&]. \b YPq iQ ¦q X ¨ < tDy EE E= j\[:©*©b48 6' I#7!7'\&7& I&D P4 7= `7eD E &'$ %'2@ x~ Gy>7=± i-= 0< Y m d±7='2V %' O± 7dD I I/ 7&M 'Q4I|@ Gy 'Q4G <g277=8 \b Y ;=iPX *`7= SEKuy 7=#.( &\e4(P47='
(194) E r2 HeQE (\ 7=< 44#7I ± @ 7IG <H477\8 uM 7 27= B=Xk*> ±7='4VS%' |± 7`'! !M>7= I0I#4-SKr±'#'!C(D>E'QI#!7 7I`:4707-G ¬M 7 PR4 7= k'QM ! !E@ 8K0xD I@6&'Q7&D. 477= # tD a
(195) MS] %' P$D48 <uM %' P\ !7`'!E@ Q P\ !MS%D E¬ I '±I='Q8@ %' X @AOPMSt!R4E@ EK B`E
(196) M>Iu& E (! 0 E@ :D> P- E (
(197) HK&!E#±
(198) ( P B~6. v ;u P&7= I6
(199) e!7='B(eB7e\ ±7='!V 't P7& #E D!#7=' #7=' e!7='-7= SK q l <7ew b YP¦ iPX=* B= P 7=E%476 #±R @7IG <#B477=wE :M 7 PR4 7= B $ S7 # (!7= I: 74S%'{ 4~D I= g7= `j;[d©*©-Sy0Dk76 4~D I OeQ7D I#7='Q
(200) 7= NS'!7 7e@ Gy '!%4E7= P+E (GD I=E 0<c@SyS'Q%2]7& . e4'Q76 ±G <UN& E S pbE n 7 uE I&D 24'4KiQO4 76 n a'PM>t!R4E@ pD a7=e#Q7=7 X Z 7&D 'r 4DSI=K @M 7 !DS't$47|@ Gy 'Q4G <g277 B ± $'Q 44'!EPQIB47|6. I / IB477 P0
(201) I @7I8 <NO47=7SE
(202) M 7 R!7& BB P#&I 47y
(203) #7='8:M 7=' 2 (\e47='{j\[:©*©p rM 7 !D 'B47@ Gy 'Q4E7= B P !D>IHe4'Q7=c ±
(204) 0<`N& 8 Nb~± E`. #POySKh&E#7 4B(k s±7='4V 't
(205) E u( 7 2E <u& 6Iu 7 :E I&D 24'4KiPXw*:'c8 6&I (B
(206) E s2 H 7S E I&D 24'4K6&I47 7=I 47=738 #M>76 !7= +'QM %QI0K +E c&IIR47= :47:D> E <H# ± E <HN& 8 X Z #y>G@6&'QE%! &K 3j\[:©©a± O( 7 P 7=&]QIH± R4 @D IcGy>7=±N Oe47='{ !DMMS7' B=Xp =Kc.D7='t O'QM>7'k%$Gy 70± e4 7= n SIn!P 7= n&'QuE @78@ In8 n7=(D '!'Q (p7eHj\[:©*©b ¦ Y / qY iPX$* ¬DSE (' %'2@ (!%' #> Dy R4&>D wySKHM P 0<cM>7 4!%'!7='-47:
(207) #I0]=*M &7= I=K=XS*S y>7&D I=&'QE |7=e\eQGy '!76/27 P P7&D gDy R4& D = |E @ 78@ IaE 4 @D0y R4(\DS = (4'Q.M # ( B^E nGy>7=±b(RQ'4 4E@ ¬ &#ue47='cj\[:©©*i:('!c> 7'Q. 7= : IB2 \D>E ('*70]EQ'Q& 8<6&# (kE%!%'!(EEK & B#IE&>M (76 6I6K B± R4 2 \D>E ('k S%'2@ !D ED+. (4'Q 7'!EK ¬ I~ Dy R4&`D Su'QQE &D GD b& P7&I§ !y>7='4 8<6&# (4i. I Uy '!I=< 8 < MS7( SPD '7 u70eN2 ¬4±7 S%=I ue4S7'sD E &'`('2M
(208) D3 b47= S 70eN2 a#I0]&#M E&7= I=Ka:D> ( i #IE=EEK b q*Y / q ¨ iPXw %47=# s 2D I :0M E(E rS`%e!eQPt
(209) 7=e '!PM>QR4E@Ss 24'Q& 76 s2 :D>E ('g %'2@ H%\> Gy 76±|;± Ea GM E pD SI%' 44. 6I0E <h~ HMSK P7&M 77=<=K7=e 2 I P7='!I%'#b qS¨ q m=iPXk6 P 70]470 7&y %'2@ IHy>t2± 7&y ~Kr I¬j\[:©*© :&K`y P0M E(8 IHySKr#.6. #
(210) PE# ]&'\47#7 PE @ 70E@ I` ('2M(=D = > !K I='Q76#(I( E <
(211) ±R4 OE 'Q {7=eke4%k. I7I0# E {D0y R4(=D S~X *B P 7&E%4E7= :y>t2± Hj;[d©*©u I
(212) DSE ('k '!@ B (4'Q.M# k%>~ B± 'Q 4*bLBDSK 7= 3} \ K I='Q76#i*(7&D I 7dy a 4D I Iay .D ¬ uD>G (' 'Q@S ¬E @ 70E@ I E y>7 ~ I 7='QI't X * u= P 7=(E47= ±R474S%' TAO ± dPM>P!I6$ !M>%&E(EKu#I0]=\M (7& I=K 2
(213) Iu('2M (kD 0 ; K I='!7=#Xk P 70]470 ±Ra7 ~ %'| '!@ ` (4'Q.M# ( I 7='I't P$ !D u
(214) &'4M &x~D \ K0 I='Q7=#`7='{2 7='Q&E`7&D4 !K0 I='Q7=H b <'Q7&DM>I
(215) ±R4:('4@S]&7&y 'Q& E(S D 'Q&G< E E Y oo v / Y oSo ¦ &#E %4E7= #8 N7&D '- 2D I=Kik± $& 7:P0M PQ&I b Y ; Y 6iPX6
(216) 7=(E%4 7= Hy 4±
(217) rj{[:©*© IH('!@(7&y '!(E(k D '!(G< E# BIEe!e4D R*!7c= P P ¥=2 Kr& 8Ky>ON 44.V :eQ7='*7= O 7S%' G &-S KM=Q7=# \'!\M '4GKg~ .#X *¬'Q !D RQ !D<< 4 ~6
(218) ±7='4VS%' ±Rn7= ScTAO S@ ¬ E '%= Ia'Q !VeQ7=' 74 'tB !DS=. j\[:©*©-0 !M &E(EEK:ek7&DM 4E7= (S'Q V:e4(P27' *&'QO( 7|M 'Q P (PX.* K:'tC&D E' tM E(S%4 (4 7= 3X . . .
(219) Acknowledgments. * r 4~D I&Ka± (7= SI(DSPQIp±RaeQE S]& !D0MM 7='e4'!7& Z [HJS©*A{ X3T Vu4 Y l7=DM 47= = (R2M0K0 E(E ± S7 4707=VMS(' wG g~ B7& < RD>I8 6& 2D I=K3X HAL author manuscript. References. inserm-00141238, version 1. f.<y>'4< OJSEE@ 't 448 z\kT 8 dA OJ0NR2nX ,(XRf %'2y ' |A f I='QEVufHX T X* (4X YX T7='4Va'%E%!IpD> D 76 tV 4={I 7'!I't HbETJS iPX 'QeQ'Q S(Hy 707=V e!7'
(220) MS'Q@ (Q76 +X q I Xz\'Q 4470Q¥ *.K6 7' I1w'4 P Y oo >X J GD R!%'¬,
(221) AO 2 a
(222) 13'QG =< P/ ' P ^f TX 9\'!R4%'!EI7=D # eQ7='u@(GD 4G <²> qX ±7='4V /'E%4I6
(223) 7e DMM>%'/44'!# 2K¬:D D>7 !V P4&-I08 7'I't .XkJ . 6I, T7='!Vr©k 0@ E'Q7= `f:R q ;; Y q J0DMM Y ¥ Y / Y ; q X )3E8<6E& #L0f:%'2y ' A 0f('2 \ S |'Q7&M VS H,%S"*. I !y '4<S8 )x>9; %'2 E(.V#nX=©@6&GD %4E70 vX I:( .< # $7e$6'7& E
(224) ±7='4V /'E%4I
(225) D D>7 VSt2(kI=8 7='QI't O7=ek4 |I 44(+DMM '{4'!#R4K3X=
(226) , Z IaI q ;;; v b Y iP¥ ¨ /4o v X z\7 & .2VH ,(X>9$DyS 2(3D0 S- !K I='!7=#:M 7&MSK 776<K3X39\EE h§g' 7&M Y ooSl0]b v¨kY iP¥Ro ;0/ ¦X o¦X By I08/!JS(E& |©kK' . dJ $9\('2Kh,(Xw '!@S%' >Gy 7=±H¥k`D #7=eOD E &'B D 'Q7&M K3X3, ¨X f. 6IJDS'4< Ez\' BY oo Y Y mb ¦ iP¥ ¦Sv m/ ¦ v +X m>X < S BA O (g 7 "${$7I='Q7 s J0M ('J ( (!E 1-Xk[:D '7&M %4EpIB '!@ 7 D E &'Q
(227) #EE@ 7`Iw< 7=#R!7`E `(II0t!
(228) ( D 7`I=k:(& E S M>%'OD (E'!(7=7= S¥ = 4!]:eQ7=76±|/ D0MxX Ej E &'{ SPD '!7&M %=Kr-~ #Gy 7=±E ¬±7='4V 't gD G <¬(7GDS: h P±
(229) E <¬N& E S &¥> :'QM 7=' ! . 6IeQ7=7=±/ DM X&I
(230) "*@ Y oo v >l ¦ b q iP¥ YP¦ 0/ Y m Y X >X )3'4ySG "$u
(231) L '! I U up('!6 7'!"-p§BE@47 ^z{' !7=]= "OX#[PD '!7&M %4 M 'Qe!%'!E I=M 7 4~D 'Q8 6&7= <'4DSE E.@ 7='Q%27'!( %~D 'QE'Q GM>'QGM S%'!( SPD '!7&M %0K D Iy>K E (76 <'4D 7&D M 7 4~D 'QOE d t 7ON& =D e4&PD 'Q ±7='!V %' X&I"*.@ Y oSloS>l ;0b q iP¥ YP¦ ;/ YP¦ >X lX z\7= e48< 7=kA w"*70Ikw*y . ] -J>+7=E( (!1JxX Z (4'4MM 7=E&# (Q7`I0k 'Q@S7#DSE ('Q
(232) = < 7=#R!7#I=
(233) #7=@ 8# .!3'!GM 4RQ8@6!¥I P'! (7= S ISDS c 7#E &7>X wj G (' 'Q@S (4'Q.M # (*. I:'PM>QR4E@> #7=@ H (Q (¥&I( '!GM47= :7ek ( X&I
(234) "*@ Y oom >l b q iP¥ YP¦ / Y%¨ Y X o>X )3E PDaJ 137&D C&D Oz{k"* e4'4<=D L#X JK= I='Q7=#HI&D¬ %'!e\D 8 6&E't:.Dh7&D I0#ON=E(I M '!7e! 7= S=Xp (EK I M &'4 4'Q 7=(7&M '!7e! P76 S8 M0K0 C&D> X j 8 6&' S%'2@ D &. !K SI'!7=## Gy 76± IU7DM 47= (I P XB
(235) 'QGM27= 7=eu 77S/ M 'Q7=eQ P 7& :. I MSK PE= M &'4#Q't X.B :'Q(I=M2%4E7= :a%I
(236) )>K q ;); Y ¦¦ b ¦ iP¥ qY%v / qq ;+X Y ;>X .V67 K# X&D = 3 !K I='!7=#( O7ew ODMM>%'\4'!#RQ OE :±7='!V 't $D> G <# SI6/27&M 'Q4I @ Gy '!%4G =<g!7=7 X&I
(237) "*@ Y oo ¦ >l ¨ b4m=iP¥ ¦ ¦ / ¦ l ;>X . . . . . . . . . . . . . . .
(238) Y Y X $7I=&'Q7:S$7=: E S> S
(239) 39\('!E7# >9 7= P7= 0 6w S&'4E >©{X[D '7(MS%4E
(240) I: 44'2D# ( @ Gy '! (44¥ 4~D I7&E (7/2IE< 7 42]&7 E UD <'4DMMS7 IH 7=<< 4H E (!7=N44X R[#DS'Q7&M %~6 pD> PI ySK @ Gy '!%4G =<I@ & &¥ 8 E(7/4IE.< 7 P a 4DSI=K7e¬ <'Q7&DSM 7=eu K0M!7=:%4 ² !D0y87PPQ X|IU"*@ q ;;;S o Y b v iP¥ qY / qq ¨ X YPq X 9$&'4
(241) ©-A{7 P
(242) ^fN\J0%e2 %'|,PnXwj E ('g 6D '!7(MS%Ku SIuI=K 447= EHeQ P>7= 7=e\4> e47&D ' ~N. Ie4Ee2NI0E< RQ ¥&(EE E& &7'!'QE%2]76 NE :
(243) D E(E X=^D E-[%'2@ Y oomS Y o0b ¦ iP¥ ¦ vkY / ¦ v >X Y%v X {[:9 ; Z 0 'Q j
(244) ll Z [:A JkXk e4eQP4 7= :M>_'QE('4ED E( 'Q HI #
(245) y ' H !D0M _'QD ' Ht 7='4< S8 %476 I(Du4'Q.@(E4XkA{_ !D R4Q :I=` C&D !r_M I_#7=7=< C(D>H %27& 6==X jOMM>%'
(246) EE:yI=8 7='QI't d >I ±7='4Va7='4<& 6 47= 3XkAO !D>RQ :e4'!7= %476 6&{M I#776< E({ 4DSI=K Xk 7DS# (Q
(247) M>7&D '
(248) H#_I&E I=D 4'4.@6&E Y o0omS m ¨ ¥ Y%v / vkY X YP¦ X "*'Qd31w'Q. 6Sx)kk9$'Q 447=e4('!k1xw #7( Q
(249) z{w'tD¬)x>$K0 P't/49 7Q:9Ut (4X 9\'2M(3D0 S- K0 I='Q7=# I±7='4Vu7='4< 4E7= uE r'QM>t!R4E@ d±7='4Vx¥>H'!76 P27= (- 2D I=KuG r13'! (=X J~D I&KNL '!7&DM#7= :A{M QR48@ -TU7='4V3X§gDM#©k @ E'!7= NaI Y ooSl0 ¨¨ b v iP¥ Y l ;0/ Y l >X Y%¨ X "*'Q$"* SI'H /1k\9$ 24 =<,%/1kk[:I=&:#%' Z $AO7=C(D>ED '!#? & I` ¬ 4D I0K L '!7(D0M7= hABM ! 2E@ :T 7='2V+XkjOMM>'t/E
(250) y I08 7='QI't
(251) 8 h'!PM>t!RQG@ s±7='4V3X*JS I¬, TU7'2Vh© @ E'!7= rf:(R! q ;; Y q b ¦ iP¥ q m l/ q Sl X Y m>X [:7=@.V9\z{ "-L{T \p(VE S7= nJS©-\"*.K "{Xk)>'!7&@ 7=(%2@S#Q 448 < e!7':D0y R4($D &. !K SI'!7=#=X(,$f. I#J0D '4< G BY o0o ¦ Y ob ¨ iP¥l Y /!l q ;+X Y >X z\ 8 *L#X+ !M 4( 47=#7 /eDS (7= &]\I¬E C&D &I='Q# (!7rI=E&< 7 4QE&7rI
(252) M %277=< I=`4'4D0NO'QGM D2{<S]O('4 !D0M %'!7='Q G %47=#7S/eD P27= (O !M PQ IaIE<0 7 #&E<7='QR407=e|DMM>%' EE:y#'QM>%QIB4'4D0N X&L Z (SI"@:©*'4<7= q ;; Y q v b q iP¥Roo/ Y ; ¦ X Y l X )>D 7t70 X{)w%7E7=< MS'Q7=eQ P 7= EI K=M>%' 7ER447= 3XO{4E (!uM>_%'E('4ED E(E'QaI=D #:yS'Q tDM _'Q PD ' §O@ '4D !K0 I='Q7=#=X=jOMM '*EE:y#I 7='QI't X&= 7& 00)3'! ¥ Y oo v X Y o>X $%'!'Q7& 7 g"$`p] I'"kfcX. <# a7ep±7='4V>/4'QE%!ID0MM 't/44'!#K '4@> (4'Q.M# (Q X=§B' ~67&Mc9 ]8 g[7='
(253) Y oomS q 0b ¦ iP¥ Sl v / So v X q ;>X $7(y0Kc©$z{Sf. ±7=' ~c #XSj E &'$ %'!@
(254) 44'Q&G 0 Ox~ :Ey 7=±#X0,{f
(255) I¬JDS'4< 8 :Y ooSl q v b4m6iP¥ o0o q /4oo +X q*Y X 9\.M0y =TTX&j E ('k D 'Q7&M K:%>BGy 7=±#X&uD ;[d%'2@ q ;);;S q v b ¦ iP¥ ¦S¨ ;/ ¦ ¨=q X qq X 9\7& (4''Q OpLg0T'4 '\u39;('4yS7( S%.DdT ,%39 E3
(256) AX6 47=:K`7=ex2 BD>E ('$ '4@> %#Gy 76±c¥0M 7! .2]&*'QE47= 6GM7=e\(D=Q|D 8 6&'\ D>'Q7&M %~K#!7H< I0%'BIEeQe!%' ( X>9\ E ` % Y ooSl YY b4m6iP¥ v q / v SlSX q v X $t4'!7pgaO)3E 7='! A
(257) X;9;D=y R4(\D 0 !K I='Q76#u( SIh2 M (8 6eD>ODMM>%'H4'!# 2K3X f. 6I:9\ E Y oomS YPq b ¦ iP¥Rmm ¨ /4m >X |j (± X{9$D0y R & D 0 '!%&7= 44'2D P47& eQ7='HD G (' q¦ X \ !8D 7G 7 Z 47&n?:gfK t6 D 'Q7&M K:E #7 4!%7=(''QR4E Gy>7=± X(,\z\7& O,%70E ($JD'4<:z\' Y oo S 0ob v iP¥ v o ;/ v o v X . HAL author manuscript. . inserm-00141238, version 1. . . . . . . . . . . . . . . . . . &.
(258) q ¨ X T'!<0. xT wL E7&± &±| V
(259) 1xw,'%X 39 7(±
(260) E ` ST '{ "OX jBE &'\ %'2@ : D ' E7= ` >I. 44'4&G n%
(261) Gy>7=± SIa± 'Q 4 P 7=&]4I±gR2DMM>'c4'#R2Kn#7476 +X ,`f. IJD '2< G #q ;; Y q mb ¦ iP¥ m ¨¨ /4mm q X q m>X L '! N,PAB,'%XR=A{.K :L nX&*BDy R4&D SQ¥(& %27=#E66 4!77&< (. I y>E7=#& E=. 4DSI(K3X&,BJ7&D I'*©*Gy>7=±JD '2< Y o0ooSSlb ¨ iP¥ ¦ mm/ ¦ ;>X . HAL author manuscript. . inserm-00141238, version 1.
(262) # 0. '.
(263) . . HAL author manuscript.
(264) ® E 3w(B
(265) ® E 3w(B ® E ® : ¢¤t£65 2 !* ® 34¡¤t £3¡£ S&S¤¡&¢=( £3 ¡£ S&3¡ " # \+¤Q°> (' ) *+ , 1.-. $ 2 $ % & /:3 S=. .
(266) . inserm-00141238, version 1. T7=# . Y v ¦;¨. v ;|K('t. v ;/ v o|K ('. ¦ ;/ ¨ ;|K ('. ¨ ;|K('t. YY%¨ q*Y o Yoq ¨=q. q. | P:y 8KN8 JDM '!N&'4V !'t. 9\E74 8 <: SI. ! 7 $E I&D 42'4K 137=7I
(267) E I&D 44'2K )3(V.<68 < Y Y 4 7 Y ; Y ;. q;v v; mSl. ¨. [:7= /4 #76V %' J#7=V ' ©k /4 #7(VS%'. q;q v=q ¨ ¨kY. ¨. [:7='Q:( §O@ 'Q±
(268) E<( §Oy PR2K. vo Y%v l ¦v. [:7 ? . :. qlY qo. m. [ 7 : (&3¡ J 7='Q Y 7' q 3 D ¡.° 0PE`¢&¤£¡ 0 Sx(6£ 5 B3 3 : EH J 7='Q v 4 7#l. v=q v Y ¦ lY. ¨ q. M : £3£¤£. [:7 ? . :. q ;m v q. [:7 ? . :. % ¯= % ¡¤Q£65>£¤ Dc (¡¤t .
(269) ® E 3w(B D ( ¢\= ¤t°S4P3 c >£>¯. E . G#9 & £ ® . ¢¡ ¤Q£65 £G¤t£E(. . . N 0
(270) £¤°~S¡ O B : 33 N ~ 0 ® >3S¤. Y m>X Y m ,;SXGl ; / ¦ +X qkY . ¨. YX q Xv q XRm ¨ XGl. Y Y X v=q ,;SX q ¨ /4m>XRo Y Y X ¨kY ,;SX q o/ >XRo q v X ¦ m ,;SX ¨ m/ q*Y X v m . qvm ¦q. Y; ;. ¦ Xq ;>X ;. 021 43 5687 :9(5<;=. m Y v. ¦ XRo. 04> @? 56A3 BC5<;=. ;. ;. ; ;. YP¦. Y ;. Y¦. . ¨ v. oo. . . . . >X. . q X¨ q Xv ¦ X¦. . . v o Y. . Y. >XRo q ,;SX q o / q XRom Y XGl v ,;SX ¦ v / >XGlm. . ;. . . q X¨ q XGl q X;. Y X YPq ,;SX v / v X ¦ ; >X o ,;SX ;o/4m>XRo;. Y . . ;. . . H 1 " I2* 1 H"H"JA*K' 1 L ,. q XY v X;. Y X ¦ v ,;SX ¨ ; / ¦ X ;Sl. Y XRm ¦ RX m q X¨. Y v X ; ,;SXRoo/4o>X ¨=q Y XRm Y ,;SX vkY /!l X ¦ ¨ . ¨ Y;. q X¦ qX. Y X YY ,;SX v / v X q o. ¦*Y m Ymq. Y0Y ¦. q XRm q X¨. [:7 ? . :. q¦ l vv ; o. m. q X¦ qX. [:7. ¨¨v. Yv. q X¦. . l. . 04? @D 56E> :F(5<;=. q Xq. q. . q X; q Xq o>X v. . $\® `¢=3 HP¡. . >XRm v X¨. . v ¦ o. . . . l. Y. Y X ;Sl ,;SX q l/ ¦ X Y%v. . Y . . . Y . . Y. >XRo v ,;SX q o / q XRo . ;. . . Y Y X Y%v ,;SX ¦ ; / v X qq Y.
(271) ?:. q¨. £3P£G¤£80. [:7 ? . :. ¦; Y Y. O ¢ 5 £ 3x¢&¤Q£ 3¯|¤t :. [:7 ? . :. ¢g¤t : M :H HAL author manuscript. `¡0¤t. 3. :. 3¢.¤Q£Q¢¡¤t£0s¢.¤ N . . l X;. v XRm Y ,;SX / Y m+X o ¨. o. m. Y X¨ ¨ XY. L 1 L 2* 1 ,"H"JA* 1 -. ¦ ¨ Y;v. Y0Y ¦. q Xv v XRo. Y X ; ,;SX ¨v / ¨ X ¦ m. "*7=±@ fE<:@ . v mo q ;o. Y; ¨. qX. fE<:@ "*7=±@ . ¨v ; ¦l. Yv q. q X¨ ¦ Xq. . . q. . . Y Y . . Y >XGll ,;SX v ; / q XRm Y . q X¦. ;. Y X v ,;SX v l/ >XRo; . . inserm-00141238, version 1.
(272)
(273) ! "$#&%(' *)+,
(274) - .,/
(275) 0.
(276). Y .
(277) $ ¢&3 : , (&3¡g N $ 2 $ % &. 9. ¢.¤3x¢= : £ S¢=3 £3¡£ S&x¡ O
Documents relatifs
To test whether the vesicular pool of Atat1 promotes the acetyl- ation of -tubulin in MTs, we isolated subcellular fractions from newborn mouse cortices and then assessed
Néanmoins, la dualité des acides (Lewis et Bronsted) est un système dispendieux, dont le recyclage est une opération complexe et par conséquent difficilement applicable à
Cette mutation familiale du gène MME est une substitution d’une base guanine par une base adenine sur le chromosome 3q25.2, ce qui induit un remplacement d’un acide aminé cystéine
En ouvrant cette page avec Netscape composer, vous verrez que le cadre prévu pour accueillir le panoramique a une taille déterminée, choisie par les concepteurs des hyperpaysages
Chaque séance durera deux heures, mais dans la seconde, seule la première heure sera consacrée à l'expérimentation décrite ici ; durant la seconde, les élèves travailleront sur
A time-varying respiratory elastance model is developed with a negative elastic component (E demand ), to describe the driving pressure generated during a patient initiated
The aim of this study was to assess, in three experimental fields representative of the various topoclimatological zones of Luxembourg, the impact of timing of fungicide
Attention to a relation ontology [...] refocuses security discourses to better reflect and appreciate three forms of interconnection that are not sufficiently attended to
