HAL Id: tel-00774836
https://tel.archives-ouvertes.fr/tel-00774836
Submitted on 14 Jan 2013
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Premières pharmacomodulations de la meiogynine A, un
sesquiterpène dimère inhibiteur de l’interaction
Bcl-xL/Bak, régulant l’apoptose
Jérémy Dardenne
To cite this version:
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! ! !Directrice de thèse : Mme Françoise Guéritte , directrice de recherche INSERM (ICSN-CNRS)
Co-directrice de thèse : Mme Fanny Roussi, chargée de recherche CNRS (ICSN-CNRS)
Composition du jury :
Rapporteurs : Mme Pascale Moreau Professeur (Université Blaise Pascal) Mr Pierre van de Weghe Professeur (Université Rennes 1)
Examinateurs : Mr Jean-Daniel Brion Professeur (Université Paris Sud XI) Mr Laurent Micouin Directeur de recherche (Université Paris V)
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1 http://www.helmo.be/esas/mapage/euxaussi/sante/cancer.html
2 Calvo, F. ; Bruzzoni-Giovanelli, H. ; Nouvelles Cibles moléculaires dans les traitements des cancers, l’actualité chimiquee, n°269-270 novembre-décembre 2003, 150-155
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4 Carter P. ; Improving the efficacy of antibody-based cancer therapies, Nat. Rev. Cancer, 2001, 1, 118-129 5
Rang, H. P., Pharmacology, 2003, 241
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7 Kerr, J. F. R ; Willie, A. H. ; Currie, A. R., Br. J. Cancer, 1972, 26, 239-257 8
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9 http://medidacte.timone.univ-mrs.fr/webcours/biocell/biopath_cell/prion/apoptose.html 10 Zimmerman, K. C. ; Bonzon, C. ; Green, D. R., Pharmacol. Ther., 2001, 92, 52-70
11 (Poly (ADP-ribose) polymérases, protéines réparant les dommages de l’ADN et qui déclenchent la mort cellulaire si besoin)
12
Yu, S. W. ; Andrabi, S. A. ; Wang, H.; Kim, N. S.; G. G.; Dawson, T. M.; Dawson, V. L., Proc. Nat. Acad.
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14 Ashkenazi, A., Nat. Rev. Cancer 2, 2002, 420-430
15 Hinz, S. ; Trauzold, A., Boenicke, L., Oncogene, 2000, 19, 5477-5486 16
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18 Zamani, N. ; Kroemer, G., Curr. Biol., 2003, 13, R71-R73 19 Green, D. R. ; Kroemer, G., Science, 2004, 304, 626-629 20
Nika, N. D., Clin. Cancer Res., 2007, 13, 7254-7262
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25 Rutledge, S. E. ; Chin, J. W. ; Schepartz, A., Curr. Opin. Chem. Bio., 2002, 6, 479-485 26
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27 Muchmore, S. W. ; Sattler, M. ; Liang, H. ; Meadows, R. P. ; Harlan, J. E. ; Yoon, H. S. ; Nettesheim, D. ; Chang, B. S. ; Thompson, C. B. ; Wong, S. L. ; Ng, S. C. ; Fesik, S. W., Nature, 1996, 381, 335-341 28 Petros, A. M. ; Olejniczak, E. T. ; Fesik, S. W., Biochimica et Biophysica Acta, 2004, 1644, 83-94
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Liu, Q. ; Moldoveanu, T. ; Sprules, T. ; Matta-Camacho, E. ; Mansur-Azzam, N. ; Gehring, K., J. Biol. Chem.,
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35 Derenne, S. ; Monia, B. ; Dean, N. M. ; Taylor, J. K. ; Rapp, M. J. ; Harousseau, J. L. ; Bataille, R. ; Amiot, M., Blood, 2002, 100, 194-199
36 Alvi, A. J. ; Austen, B. ; Weston, V. J. ; Fegan, C. ; MacCallum, D. ; Gianella-Borradori, A. ; Lane, D. P. ; Hubank, M. ; Powell, J. E. ; Wei, W. ; Taylor, A. M. ; Moss, P. A. ; Stankovic, T., Blood, 2005, 105, 4484-4491 37
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38 Snyder, E. L. ; Meade, B. R. ; Saenz, C. C. ; Dowd, S. F., PlOS Biology, 2004, 2, 141-147
39 Shen, C. ; Dirk Rattat, D. ; Buck, A. ; Mehrke, G. ; Polat, B. ; Ribbert, H. ; Schirrmeister, H. ; Mahren, B. ; Matuschek, C. ; Reske, S. N., Cancer Biother. Radiopharmac., 2003, 18, 17-26
40 Broch, S. ; Hénon, H. ; Debaud, A. L. ; Fogeron, M. L. ; Bonnefoy Bérard, N. ; Anizon, F. ; Moreau, P.,
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43 Tse, C. ; Shoemaker, A. R. ; Adickes, J. ; Anderson, M. G. ; Chen, J. ; Jin, S. ; Johnson, E. F. ; Marsh, K. C. ; Mitten, M. J. ; Nimmer, P. ; Roberts, L. ; Tahir, S. K. ; Xiao, Y. ; Yang, X. ; Zhang, H. ; Fesik, S. ; Rosenberg, S. H. ; Elmore, S. W., Cancer Res, 2008, 68, 3421-3428
44 Trudel, S. ; Li, Z. H. ; Rauw, J. ; Tiedemann, R. E. ; Wen, X. Y. ; Stewart, A. K., Blood, 2007, 109, 5430-5438
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45 Petros, A. M. ; Dinges, J. ; Augeri, D. J. ; Baumeister, S. A. ; Betebenner, D. A. ; Bures, M. G. ; Elmore, S. W. ; Hajduk, P. J. ; Joseph, M. K. ; Landis, S. K. ; Nettesheim, D. G. ; Rosenberg, S. H. ; Shen, W. ; Thomas, S. ; Wang, X. ; Zanze, I. ; Zhang, H. ; Fesik, S. W., J. Med. Chem., 2006, 49, 656-663
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Zhou, H. ; Chen, J. ; Meagher, J. L. ; Yang, C. Y. ; Aguilar, A. ; Liu, L. ;Bai, L. ; Cong, X. ; Cai, Q. ; Fang, X. ; Stuckey, J. A. ; and Wang, S. , J. Med. Chem., 2012, 55, 4664!4682
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2008, 64, 2192-2197 53
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