HAL Id: inserm-00474713
https://www.hal.inserm.fr/inserm-00474713
Submitted on 27 Apr 2010
HAL is a multi-disciplinary open access
archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.
L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Evidence for a positive role of PtdIns5P in T-cell signal
transduction pathways.
Geoffrey Guittard, Eva Mortier, Hélène Tronchère, Guylène Firaguay, Audrey
Gérard, Pascale Zimmermann, Bernard Payrastre, Jacques Nunès
To cite this version:
Geoffrey Guittard, Eva Mortier, Hélène Tronchère, Guylène Firaguay, Audrey Gérard, et al.. Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways.: PtdIns5P and T cell signaling. FEBS Letters, Wiley, 2010, 584 (11), pp.2455-60. �10.1016/j.febslet.2010.04.051�. �inserm-00474713�
95 60 35 60 60 60 47 35 CD3 PH Dok-5 GFP - - + + pY pSrc pErk1/2 pAkt Akt GFP pSrc Src GFP PH Dok-5 GFP GFP CD3 2’ 5’ 2’ 5’ IpgD WT IpgD CS PH Dok-5 GFP GFP 60 40 20 0
IL-2 promoter activity (%)
80 100 101 102 103 CD3 pSrc NT CD3 CD3 PH Dok-5 A B C D + + - -Counts Figure 3
