Is malaria vector control still useful despite insecticide resistance?

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https://hal.inrae.fr/hal-02788777

Submitted on 5 Jun 2020

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Is malaria vector control still useful despite insecticide

resistance?

Haoues Alout

To cite this version:

Haoues Alout. Is malaria vector control still useful despite insecticide resistance?. 2018 Institut Pasteur International Network Symposium, Nov 2018, Paris, France. �hal-02788777�

Haoues ALOUT

Is vector control still useful despite

insecticide resistance?

2018 I

NTERNATIONAL

P

ASTEUR

I

NTERNATIONAL

N

ETWORK

S

YMPOSIUM

Combating resistance: microbes and vectors

Malaria prevalence: 50% reduction in 15 years

Control of disease

Control of transmission

21%

79%

Contribution of control methods

H

ALOUT /

I

?

Is vector control still useful despite

insecticide resistance?

Bhatt et al. 2015

???

Is vector control still useful despite

insecticide resistance?

Is vector control still useful despite

insecticide resistance?

Cost of resistance

Modifications of several

physiological and

metabolical processes

Resistance genes – Infection – Insecticides

Susceptible / Resistant

Infected / Control

Exposed / Control

Is vector control still useful despite

insecticide resistance?

Transmission

Interactions between:

Is vector control still useful despite

insecticide resistance?

H

ALOUT /

I

?

Records identified through database searching

(n = 933) Sc re en in g In cl ud ed El ig ib ili ty Id en tif ic at io n

Records screened after duplicates removed

(n = 677)

Full-text articles assessed for eligibility

(n = 75)

Studies included in qualitative synthesis

(n = 17)

Studies included in quantitative synthesis (meta-analysis)

(n = 10)

Systematic review:

Criteria :

- Experimental studies only

- At least 1 resistant strain/pop

- Known mechanism of resistance

- Appropriate control

Is vector control still useful despite

insecticide resistance?

Proportion of treated mosquitoes

EIR Insecticide resistant Insecticide susceptible

A

B

In resistant populations, insecticides remain partially efficient to

reduce malaria transmission

Is vector control still useful despite

insecticide resistance?

H

ALOUT /

I

?

And thank you

Thanks to

Anna Cohuet

Benjamin Roche

Fréderic Jourdain

Roch Dabiré

TransMalariaBlock (FP7)

Marie Sklodovska Curie (H2020)