BIOFUTUR 254 • AVRIL 200561
SI VOUS SOUHAITEZ PARTICIPER À CETTE RUBRIQUE, MERCI
de contacter José Fernandez au 01 55 81 14 72 ouj.fernandez@
mediakom.fr
Nouveaux produits
Mini-Mill “pulverisette 23”
In the past there was the legendary (East German)
“Ardenne” mill, which was absolutely unique in the entire world. We are now able to offer an alternative minimal quantity mill, which still allows adequate recovery for forensic applications.
The special field of the NEW Mini-Mill “pulverisette 23” of FRITSCH is the fine comminution of very small- quantities of dry laboratory samples or solids in suspension. For mixing and homogenisation of emul- sions. Sample quantity up to 5 ml.
This mill is ideal for sample preparation, for example, for chemical analysis, chromatography, mass spectro- metry or X-ray structural analysis. Can be used for preparing samples for genetic research, for homoge- nising of active ingredients, preparation of extracts in the forensic analysis and milling of pigments or other precious materials.
Method of operation :
Vertical oscillations of the grinding bowl with high amplitude generates a particle-size reduction through
the impact of the grinding ball and friction between ball and grinding bowl wall.
Features of performance:
• smallest sample quanti- ties < 5 ml
• grinding in tube contai- ners PCR for 6 tubes à.
0.5 or 2 ml volume
• simple handling
• easy cleaning of the grinding elements
• rapid, reproducible grinding
• small grinding bowl volume
• low contact surface area with grinding elements
• quick fastening of the grinding bowl
• oscillation amplitude 9 mm
• adjustable and reproducible grinding time
• adjustable stress frequency
• compact and affordable
Veeco Introduces New NanoMan II
High-Resolution Imaging and Nanoscale Pulling Capability Aids in Nanoscience Research.
Veeco Instruments Inc. (Nasdaq: VECO) has announ- ced the release of the new NanoMan“ II Atomic Force Microscope (AFM). The NanoMan II features a new, patented Hybrid XYZ scanner, offering the scientific research community the highest resolution imaging available on a large sample microscope. NanoMan is also able to perform highly accurate force curves, nanoindenting and “pulling techniques,” all of which are critical to today’s advanced nanoscience research applications. This new state-of-the-art AFM operates in closed-loop mode in all three axes, enabling a single instrument solution for nanolithography, nanomani- pulation, and imaging for material and life science applications.
“The NanoMan II’s unique design offers up to six times lower Z sensor noise than any other commer- cial AFM system,” explains Ken Babcock, Ph.D., VP of Research and Development for Veeco Resear- ch AFM. “This superior performance sets a new standard for AFM imaging, and also allows true closed-loop in Z for more accurate pulling and nanoindenting. The NanoMan II uses our proven X/Y closed-loop design for the best imaging, litho- graphy, and manipulation. And it is uniquely able to do all of this while maintaining the high band- width, scan speed, and noise immunity expected of our world-leading AFMs.”
Closed-loop feedback in the NanoMan II with Hybrid XYZ head provides precise X/Y control for nanomanipulation, with scans that are accurate and independent of X-Y offset and scan size/angle. The unique, integral flexure design ensures that the Z- axis remains orthogonal to the XY plane. With the latest in advanced engineering, the increased Z- height accuracy and repeatability require less fre- quent and less extensive calibration than is necessa- ry with other scanners. The instrument also sup- ports the full spectrum of AFM modes, as well as Veeco’s electrical testing application modules, making this a highly flexible scanner for a wide range of advanced research applications.
To learn more about the NanoMan II:
http://www.veeco.com/namoman2.
© D.R. © D.R.
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BIOFUTUR 254 • AVRIL 2005 62
Veeco Introduces New High Performance Optical Profiler for Printed Electronics Applications.
Veeco Instruments Inc. (Nasdaq: VECO) today intro- duced a new, high-performance optical profiler to ad- dress metrology challenges in the rapidly growing prin- ted electronics industry, which includes organic light emitting diode (OLED) displays, radio frequency identification tags (RFID), biosensors, and other flexible circuit devices.
The Wyko®NT4800 combines high-speed, high-resolution op- tical profiling with large format staging, and is ideal for criti- cal R&D and production me- trology applications in flexible printed electronics, such as sur- face shape and texture measu- rement.
"The printed electronics indus- try, also known as 'semicon- ductors-on-plastic', is beginning to deliver new exciting growth products, from printed batteries to biosensors, with many more products still in the development stage", said Lloyd LaComb, Ph.D., Senior Vice President and General Manager of Veeco's Optical and Industrial Metrology group. "Extremely low power and rollable flexible display technologies such as OLEDs and electronic ink (E-ink) are being developed using novel printed electronics. Many other innovative devices will emerge as well. For example,
radio frequency identification tags that can be printed directly into packaging materials are expected to re- volutionize product tracking and inventory control."
Industry forecaster Intertech Corp. estimates that the total available market for printed electronics will reach over $15 billon in 2005 and will double by 2010.
"Our new high performance Wyko NT4800 addresses R&D and production metrology requirements to mea- sure these novel device features," continued Dr. La- Comb. "The feature sizes of typical semiconductor- on-plastic devices are on the order of tens and hundreds of microns – an excellent fit for optical and stylus pro- filing. The NT4800's combination of speed, repeata- bility, resolution and range enables customers to move new products quickly from development to full-scale production using a single metrology platform."
The automated Wyko NT4800 utilizes Veeco's pa- tented Vertical Scanning Interferometry (VSI) and Phase Shifting Interferometry (PSI) to obtain accurate 3D data of surface features from nanometer-scale rough- ness through step heights up to 2mm. An ergonomic operator interface and automated controls enable ra- pid production measurement and minimize opera- tor-to-operator variability. The NT4800 also includes industry-leading Vision software for advanced 2D and 3D data analysis and visualization. Vision provides over 200 analysis tools, as well as automated mea- surement sequences and data logging for real-time pro- cess feedback and statistical process control.
To learn more about the Wyko NT 4800 : http://www.veeco.com/nt4800
Nouveauté technologique de Promega pour l’imagerie cellulaire : HaloTag™
Interchangeable Labeling Technology
HaloTag™ Interchangeable Labeling Technology est une nouvelle technolo- gie pour visualiser intracellulairement les protéines, suivre leurs transports, réaliser des « pulse chase », les purifier et les analyser ensuite sur gel SDS PAGE.
Cet outil pour l’imagerie cellulaire est basé sur l’utilisation de la protéine reporter HaloTag™, une dehydrolase bactérienne génétiquement modifiée, codée par le vecteur pTH2, qui a été développée pour permettre le clonage et l’expression de protéines.
La technologie utilise la propriété de la protéine de fusion HaloTag™ de former une liaison covalente avec un ligand spécifique. Ce ligand peut porter une grande variété de fonctionnalités tel que des composés fluorescents ou des molécules ayant une affinité avec une phase solide pour une purification rapide de la protéine de fusion liée au ligand. Ce ligand pénètre de façon passive dans les cellules vivantes (en culture) et va se fixer dans les conditions physiologiques sur les protéines de fusion HaloTag™.
Caractéristiques
Réalisation de multiples applications avec une seule construction :en utilisant les ligands HaloTag™ avec différents groupes fonctionnels vous pouvez réaliser de nombreuses applications sans avoir à créer une nouvelle construction.
Imagerie sur cellules vivantes ou cellules fixées :les ligands sont perméables à travers la membrane cellulaire et leurs liaisons covalentes sont stables, permettant l’imagerie de cellules vivantes ou fixées (ce qui n’est pas le cas du dsRED, sensible à la fixation).
Marquage spécifique de la protéine de fusion : la protéine HaloTag™ n’existe pas de façon endogène chez les cellules de mammifères. Les ligands HaloTag™
se lient à la protéine HaloTag™ ou à la protéine de fusion avec une haute af- finité et spécificité.
Réalisation de marquage en « Pulse-Chase » :enregistrer en temps réel l’ex- pression et les mouvements de protéines en utilisant des ligands marqués avec dif- férents fluorophores.
Analyse rapide depuis la cellule jusqu’au gel :Des liaisons covalentes fortes per- mettent que les cellules soient visualisées puis lysées et analysées sur gel SDS PAGE.
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