SN38
HCT116-A2 HCT116-SN50 Sora
+ + + + + + + + NT 0.5 1 2
HCT116-A2 HCT116-SN50 NT 0.5 1 2 Sorafenib
ABCG2 Tubulin
SN38 intracellular accumulation (%)
0 10 20 30 40 50 60 70 80 90
S SN6 SN50 G7 A2
SN38
SN38 intracellular accumulation (%)
0 10 20 30 40 50 60 70 80 90
HCT116SW48 SW620 HT29 SN38
SN38 SN38+Sora
0 2 4 6 8 10 12 14 16
S SN6 SN50 G7 A2
SN38 intracellular accumulation (relative to SN38)
0 1 2 3 4 5 6
HCT116 SW48 SW620 HT29 SN38 intracellular accumulation (relative to SN38)
SN38 SN38+Sora
HCT116 SW48
HT29 SW620
ABCG2 GAPDH
B
C D
E F
s SN6 SN50 G7 A2 HCT116
ABCG2 GAPDH