HAL Id: hal-02268730
https://hal.archives-ouvertes.fr/hal-02268730v2
Submitted on 21 Aug 2019
HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci- entific research documents, whether they are pub- lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.
L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Xanthine-based gold(I) N-heterocyclic carbene complexes: synthesis and anticancer evaluation
Benoit Bertrand, Geny M M Groothuis, Angela Casini, Stefan Loic, Ewen Bodio, Richard Philippe, Pierre Legendre, David Monchaud, Michel Picquet
To cite this version:
Benoit Bertrand, Geny M M Groothuis, Angela Casini, Stefan Loic, Ewen Bodio, et al.. Xanthine- based gold(I) N-heterocyclic carbene complexes: synthesis and anticancer evaluation. XVIth Interna- tional Conference on Biological Inorganic Chemistry (ICBIC16), Jul 2013, Grenoble, France. pp.S589,
�10.1007/s00775-014-1095-8�. �hal-02268730v2�
;9, WK ,QWHUQDWLRQDO
&RQIHUHQFH RQ%LRORJLFDO ,QRUJDQLF &KHPLVWU\
-XO\
*UHQREOH$OSHV&RQJUªV )UDQFH
KWWSZZZLFELFFRP
&21752/,'
7,7/(;DQWKLQHEDVHGJROG,1+HWHURF\FOLF&DUEHQHFRPSOH[HVV\QWKHVLVDQGDQWLFDQFHUHYDOXDWLRQ
$87+256,167,787,216%%HUWUDQG*0*URRWKXLV$&DVLQL5HVHDUFKLQVWLWXWHRI3KDUPDF\5LMNVXQLYHUVLWHLW
*URQLQJHQ*URQLQJHQ1(7+(5/$1'6_/6WHIDQ(%RGLR35LFKDUG3/H*HQGUH'0RQFKDXG03LFTXHW ,QVWLWXWGH&KLPLH0RO«FXODLUHGHOಬ8QLYHUVLW«GH%RXUJRJQH8QLYHUVLW«GH%RXUJRJQH'LMRQ)5$1&(_
&855(17&$7(*25<0HWDOVLQ0HGLFLQHDQG+HDOWK
$%675$&7%2'<
$EVWUDFW%RG\*ROGFRPSRXQGVKDYHEHHQXVHGLQPHGLFLQHIRUPDQ\\HDUVWKHHDUOLHVWXVHGDWLQJEDFNWRDQFLHQW
&KLQD,QPRUHPRGHUQWLPHVJROGFRPSOH[HVKDYHEHHQLQYHVWLJDWHGIRUWKHLUDFWLYLW\DJDLQVWWXEHUFXORVLVDQG VHYHUDOJROGFRQWDLQLQJDQWLDUWKULWLVGUXJVKDYHVXEVHTXHQWO\HQWHUHGWKHPDUNHWDQGUHPDLQLQFOLQLFDOXVHWRGD\
*ROGFRPSOH[HVERWKLQR[LGDWLRQVWDWH,DQG,,,KDYHDOVRDSSHDUHGLQWKHODVW\HDUVDVSURPLVLQJFDQGLGDWHVDV QHZSRVVLEOHDQWLFDQFHUDJHQWV>@
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ಬSRVVLEOH DQWLFDQFHUHIIHFWVKDYHEHHQWHVWHGRQYDULRXVFDQFHUFHOOOLQHVLQFRPSDULVRQWRKHDOWK\FHOOVLQYLWURDQGWKHLUWR[LFLW\
DJDLQVWKHDOWK\UDWSUHFLVHGFXWOLYHUDQGFRORQVOLFHVKDYHEHHQHYDOXDWHGH[YLYR
,QLWLDOPHFKDQLVWLFVWXGLHVKDYHKLJKOLJKWHGWKHSURSHUWLHVRIVRPHRIWKHQHZFRPSRXQGVDV'1$*TXDGUXSOH[
VWDELOL]HUVE\)5(7PHOWLQJDQDO\VLVDQGFLUFXODUGLFKURLVPVSHFWURVFRS\)LJXUH
5HIHUHQFHV
>@1RELOL$HWDO0HG5HV5HY
>@2WW,&RRUG&KHP5HY
>@<DQJ+HWDO&OLQ([S0HWDVWDVLV