Is the intersection syndrome is an occupational disease?
Texte intégral
(2) HAL author manuscript Joint Bone Spine 2008;75(3):329-31 2007;:epub ahead of print.
(3)
(4) !"$# %'&(#&) *+,
(5) .-/(01#2#+.3 4!5.62798;:=<68>"5?8@A62:CB1<5+DE<FG>?BHI8;:J5*K<IB@@ALMKA62:=B9<9KNF9:J5"8K5?8PO HAL author manuscript. Q NR8S:J5)TU8E5V@KA627EKXWZYZ[ \+]_^G`IaN=b<98 c 8dM9>?BEL.526WZYZ]e^f79:=NZ:=M9M8XgBEL>?8XWih]j^kB9N=8A6J680gB9<9K<lWnm+]_^9oqp185)gBrLs8N=K/L>?8XWjt2]. inserm-00222731, version 1. u /v Q xf wy`zfx^X{|<9:e6a}F98~MKA627EB1NCB1:=8}M9>?B128G5"5?:=B<9<98NRNZ8^`9M9:n6KNXgKDEHIB<9FfxB1:=<@K>Va^ dGFgKDHIB<EF fxB1:=<E@K>?a^Gw+GIK>?@7E8G5! u 9v 4JGg^{U9^K:=<P6wyKAL>?:=@8^(w+G9 dI{I<9:jp8d>!5?:n6afxK>?:J5}z4V^ 4$sg;99^¡ |:=NZNR8+¢+L:=^(w+G9( {l<9:Cps8d>!5?:n6aX l8>!5?K:RNZNR8G5?w!K:=<6x£Ls8d<6:¤<E^E(K@ALsNn6a;F98 aF98@¥:=<8 fxK>?:Z5Vw$4?N=8w+F98w$.>VK¥<E@8w+¦XLs8526? u Gv {l>+8<@8P5§K¥:=<5¨ IKN©F98ª8:=<8^«k `f F8¬B1<P62K>?F9ad^'Gª>$Ls8®FL¯B9<62Kd>?F9a^°(w+P d Q L±8>+8<Gp:RNZNR8G u 9v Q 4$gl²^ dz>$Ls8;F985f)NCK¥<P685?^Gw+99zK¥:R5?B9<9wyc0K$:n6268 u´³ v kB9<5$LsNn6KA6:=B9<µF98'MKA627EB1N=B9:=8'M9>?B928E5"5?:=B<9<E8¥NRNR8^c *² ^k`z{ Q <G8>"5?^¡§>2Ls8c K>+>?8DE^(w$)d9 Q <G8>!5·¶ ¸I¹.ºd»¼"¼!»G½ Tl> Q NZ8S:J5)TU8G5?@KA627EK^G{|<9:n6a;F98XMK/6279B9N=B1:=8;M9>?B9285!5?:=B<9<98NZNR8;8A6xF98z5?Kd<6a;KAL|62>VKApK:=N=^G`I9M:e6K¥N g;KDEHIB<9FzfxB:=<9@K>?a^ Q fxwy`zfx^GIzK>V@7985V^E>?K<9@P8G¶ w$HUK¥:RN¾GKNZ8S:J5/¶eF985V@PKA6279KP¿~>+M@G¶eKM97M.¶nJ>/¶²*8¥Ny¾À9ÁEÁdI9 ³ .¶(KAS¾À9ÂÂdÃ9l Ä*Å ¼¹.»;ÆÇ9ÈÉ+ÊRˤÌ*¹)Í=ËRÈÌVκÏdÌ?Ð.
(6)
(7)
(8) !"$# %'&(#&) *+,
(9) .-/(01#2#+.3. HAL author manuscript inserm-00222731, version 1. Î ¼ Î ;:=8<¡rLs8Fa@>?:n6*F98dMGL:J5NR8z4+ 5?:RbP@NZ8^NR8Ã5+DE<FG>?B9H8FL@d>?B:Z5V8¥H8<6 85$6L<E8qMK/6279BN=B9:=8zM8ALJ>"arLs8<68^ NZ:Ra8KALµJ>?BG6Z68dHI8<6Á8<62>?8N=85 N=B< K±FLs@/68AL> 8A6@BGL>J6 8AS68<5V8AL> FL MBGLs@8 u 68<EF9B1<5 FL M9>?8HI:R8> @B1HlMK>$6:¤H8<6qF98 N=KÂK@8F9B1>!5VKNZ8FL@K>+M8vlKps8@ NJ8P5|@BEL>$6q8·6N=B9<G8SG68<5?8AL>"5IFL@K>+M8 u F98ALS:ZbH8 @B1HlMK>$6:¤H8<62v·¶c 85;N=:R8¥<5Kp8@¡NR8U62>?K/pK:ZN*B9<6 a/6aÃM98/L F9a@>?:n6?5;HK:J5|5?8H|±sNZ8<P6 8AS:J5$68>V^ @8F KAL96K<6 rLs8 F985:=<9F8HI<9:y5"K/6+:=B9<5 5?B9<6xMB5"5+:j±NR8E5 8<HKNRKF9:Z8;M9>?B85"5?:=B<9<98NRNZ88<Ã.>VK¥<E@8G¶BGL.5>VKM9MB1>J62B9<5 L<@KG5 FL 5+D9<9FG>VBHI8 FL@d>?B1:R5"8¥H8<6U@7E 8 ÂL<7EE68ÂF98 @Kd:y5"5"8~F98 ³ K<5·¶ Q M9>?b5|Ls<98 @Kd>+>?:=b>?8~5?aF98¥<P6K:j>?8^<9BG62>?8 MKA62:=8<6 K©aA6a©@B9<6 >?K:=<6 F9862>?K/pK:=NZNR8>@BHIH8©79G68©F98©@K:Z5/5?
(10) 8 ³ µK<5?^¡MB5268©@B9H|M9>?8<EK¥<P6 L<8 7GD9M8>!5VBN=NZ:R@:n6KA6:=B9<¡:ZHIMB1>26K<68|F98P5X5$62>2Ls@·6JL>?8P568<EF1:=<8AL.5V85 FLMB:j<98A6"¶94+NK|Fa@NRK>?a|@8A6J68zMKA627EB1N=B9:=8|KL F9a@BGL>!5l F Ls<Â62>?KALsHIKA6:Z5?H8ÂH:=<9:ZH8G¶ ;> P@ 8 ÂNZK¡>?8P@B9<G<EK¥:J5/5VK¥<@8 8<}HKNZKF1:R8¡M9>?B285/5?:=B<9<98NZNR8^:=N K M9L ±a<9a+:R@:R8>* F L<IKd>+> A6xF98XN 8SEMB5?:e6+:=B9<|M9>?B9285/5?:=B<9<98N=NZ8¶ GÇ ÌV¼§ÆdÊZμ ¾62>?BGL9±9NR85 H|L5?@ALsN=Bw´5?rLs8NR8A6J62:=rLs8P5?^5+D<EFG>?BHI8 FLª@>VB:Z5?8H8<6^K °@>?aM:n6K<6^HIKNZKPF9:R8E5 M9>?B128P5!5?:=B<9<E8NZNR8G5 .
(11) ¼Ì.»;ËZÈÌ?»ºd¼!»ÆÌ?ËZÇ9ȼsÈ.¹.ºdÇ »;ËZ¼ Å ÈÇ9ÆÆ Å Ì?ËRÇ9È Å Ê¹.ËR¼!» Å ¼"». HAL author manuscript. ELsHIHK>+D ² 7E8 :=<68d>!5?8@/6+:=B9<}5+D9<FG>?B9H8^*F985?@>?:j±s8F~5?:=<@P8Ã62798~
(12) @8¥<P6JL>+D9^*:y5qK¥<ÂLs<9@BHÃHUB< F9:y5VB1>VF98>K5!5VB@:=K/68F :n627©>$L±9±:=<9 B¡6278K±FLs@A6B9> M9B9N¤NR:R@¥:J5}NCB<GGL.5 K<9F 8SG68d<5?B9> MB1N=NR:Z@:J5~±E>?8p:y5 ±8NZN=:R8G5 u 2:j>/5$6ÁF9B1>!5VKN @B1HlMK>$6HI8<62v K<EF 627E8 8ASG68<5?B9> @K>+M9:©>?KF1:RKNZ:J5 NCB1<GL.5 K<9F ±E>?8p:J5 68<9F9B9<5 u 5V8@B9<9F F9B9>!5?KPN @B1HlMK>$6HI8<62v/¶ Q 5"5?B@:=KA6:=B1< :e627'BGp8d>$L.5"8B@@AL>>?8F':=<«B@@ALMKA62:=B9<9KN5V8A6J62:=<G K5±K>V8¥N=D F985"@>?:j±8PF K¥Ne6279BGL97~:n6q@BELNCF±8 NR8KFÂ62B}@dB1HlM8¥<5VKA6:=B1<±9D .>"8<9@7~7E8KNn67~:=<5$L>?K<E@8G¶ 8¡>?8MB9>J68F~K@K5V8¡B1K¥< :¤<P68>!5V8@A6:=B1<}5+DE<FG>?BHI8¡:=< ³ ÂD18K>!5qBN=F~HK< 79B~>V8@8<P6+NjD ±s8@KH8 K 52LM8>?HK> 8A6@K5?79:R8>·¶)² 79:J5¢?B1± :¤<Gp1BNjps8F|>?8M8K/68FI8ASG68<5?:CB<IK<9FI$NR8S:=B<IB627E8 >?:J5$6"¶P² 798;F9:J5?B9>?F98>!5x>+B5?8;KZ68>*KXHI:=<:RHK¥N962>?KALHKA62:J5?H¶ 4+<2KpBGL> B1>?8@B99<9:n6:=B1<K5 K<B@@ALMK/6+:=B9<9KN.F9:J5?8KG5"8^s@85!5VKA6:=B1<BM9>?BGpB@K·62:jps8K@A6:jp:n6+:R85*±9D8¥<EF1:=<9B B@@/LMK·62:=B9<KN8S9MB5$L>?8;@BGLN=F|7Kp8 ±188<IBG±G6Kd:¤<E8F¶. inserm-00222731, version 1. l8D B9>?F5d¾~L.5?@/LN=B58NR8A6KNF9:y5VB1>VF98>?^G:=<68>"5?8@A6:=B9<5+D9<EFG>?BHI8^B@@ALMKA62:CB1<EK¥NF9:J5"8K5V8 .
(13) . HAL author manuscript inserm-00222731, version 1. Ð ÈÌVºÇ9¹.ÆÌ?ËRÇ9È TUa@>?:n6xF98MGLs:Z5*NR8q4+ 5?:Zb@¥NR8^N=8U5+DE<FG>?B9H8;FL@>VB1:J5"8HI8<6x8526(L<E8XMKA6279BN=B1:=8XM8ALJ>"arLs8<68^5?8 HK<9:R+8526K<6*MKd>L<E8|F9BGLNR8AL>8/6 L<|F9bH8|KAL <9:jps8PKAL%FL±B9>?F>?KF9:=KNFL F9B5FLMB:j<E8A6 |¡@H F98|N K 5$6JD9NCB F98>?KF9:RK¥NR8G¶k 85+D9<FG>?BHU8@B9>+>?8P5+MB9<9F ~Ls<'M9>?B@85"5$L.5Â:=<+NRKHHKA6B9:j>?8<EB1<«:¤<8@A6:=8ALS©FL @B1HlMK>$6:¤H8<6F985}8/SG68<5?8AL>!5·¶zTIK<5}@8d>$6K:¤<5}@KE5"^N B9>´:_:=<8M9>VB1285/5?:CB1<9<8N=NR8'F9B:n6 A6J>?8>?8@7E8>?@7EaP8 @B1HlMG6868<PLF98;N 7GD9M8d>A5VB1N=NR:Z@:n6K/6+:=B9<F985X5262>$Ls@!6JL>?85)6y8<9F9:=<8AL)5V85NCB1>!5 FL62>?KApK:=NR^@B9HIH8N :RNZNjL.5$62>V8z@8@K5 @¥N=:=<:ZrLs8¶. Ð Å ¼ÆÊRËZÈ.Ë . » B1<5?:R8AL>I|^ ³ }K<5?^ FG>?B1:e62:Z8d>?^XK a!6aKFG>?85!5Va 8<@PB1<5$LsNn6KA62:=B9<F98ÂMKA6279BNCB1:=8ÂM9>?B9285/5?:=B<9<E8¥NRNR8 MBEL> KAp:J5X52L> Ls<98;MK/6279B9N=B1:=8|B5$6adBw+K>J62:=@ALsNZK:=>?8;MK>;5?B9<HaF98@:=<FL62>VKApK:ZN ¶k8zMK/6+:=8<P6*KaA6azFL>VK¥<P65VK p:Z8XM9>VB185/5?:=B9<9<8N¤NR8^F98G5!5?:=<KA68AL>*8/6 KP5!5?:J5$6K<P6xKF1HI:=<:$5$62>VK·62:= F9K<5)L<8;8<P62>?8M9>+:J5?8;F :=<2B1>?HIK/6+:=rLs8XMs8<9F9K<6 MNnL.5UF98 p:¤<9G6lKd<5?^MGLs:J5IK>$62:J5VK¥< @BHIH8>
(14) K<P6M8<9FK<6I Kd<5/¶GLs:n68 L<E8ÁK:ZN=NZ:e68Â8A6;L<98Ma>?:=BF98%F98 @79HUK8^:=NsB@@/LM8 L<|MB5268; F 79G68;F98X@K:Z5/5V8;F9K¥<5 L<5$LM8>?HK>?@7Ea;F98MGL:J5 99¶ <5?8MG68H|±9>V8X9G^ :ZN*M9>?aG5?8<68ÃL<Â62>?KALHKA62:J5?H8¡HIBF9ad>?a F98¡N KpsK<6wy±E>?K5FG>VB1:n6N=B9>!5F Ls<~HUBELp8H8<6;2B9>?@a¡8<}5$LM:=<KA62:=B< u MBG>y6q F L<MK@ }F 8KALv/¶(TU8MGLs:Z5?^:=NX5"8¡MNCK¥:=<P6F98F9BELsN=8AL>!5M8>"5?:y526K<685lKAL <9:Cps8KALF98 NCK +K@8 MB5$6ad>+Bw NZK/6a>?KN=8 FLMB9:j<98A6UFG>?B9:n6 u 5$LMa>Bw+8ASG68d>+<98v·¶ c a@79B99>?KM979:R8Â>?aKN=:J5"a8H8A6U8<ap:=F8¥<E@8 L<E8ÂMB@7E8 F98 F9a@B9N¤NR8H8<6Á8<62>?8NR868<9F9B9< FLµHzL.5V@NZ8±9>?K@¥79:CBw$>?KFG:RKN u N=B<Gµ5$LM:=<KA68AL>+v 8!6ÂNCKN=B98MB526aA>+:R8AL>V8 K<6aA±E>?K@79:RKNZ8¶zf)>?:J58< @¥7EK>+8'MK> L< @79:=>$L>+:Z8<µF98'NRK'HK:=<^ÃL< 5+DE<FG>?BHI8«FL @>?B9:y5V8H8<P6 85$6 F1:=Kd<EB5262:=rLsaG¶{I<62>?K:n68HI8<6MK> Q 4 «8A6K<6KdNj: rLs85¡M8>B5K5"5?B@:=a L<«K>> A6F98Á62>?K/pK:=N|F98 5?8HK¥:=<85qKaA6a8¥28@/6JLsaÃMK>5?B9< @79:j>$L>+:R8¥<%F98¡NZKHK:=<¶TI8p1K¥<P6 NZKIM8>!5?:J5$6K<E@8¡F985|5?:=<98G5;@NR:¤<:RrLs8G5?^ L<98':=<9+:ZNe62>?KA6:=B1< F98'@B1>J62:=@B ¤F98E5 >?8A6Kd>?F5}8!6ÂL<E8':¤HHIB1±:RN¤:J5"KA6:=B9< MN A62>?a8B9<6 a!6a>VaKN=:J5?aP85/¶zKN¤9>Va N KHaNR:=B1>VKA6+:CB1<KAL%>?8MB5?^.NRKÃF9BGLsN=8AL> 8A6 N lFbH8|>?a@:JF9:jp8<60N=B1>"5 F98ÃN=K|>?8M9>?:J5?8¶1c B9>!5 F985?K@B1<5$LsNn6KA6:=B1< 8<ÂMsKA6279B9N=B9:=8¡M9>?B928G5!5?:=B<9<E8NZNR8^ ³ HIB:J5MNCL.5 6K>?F9^:=N*M9>?a5"8<68Ã6yBELd¢?BGL>!5XL<E86JLHa2KP@A62:=B9< |F9aHKA68AL.5V8.
(15) ³. HAL author manuscript inserm-00222731, version 1. ?5 :n6JLsa8 @H KALsw+F985"5$L5F98NRK~5$62D9N=B F98Â>?KF9:RKNZ8 Kp8P@ L<98 F9BGLNC8AL>KAL<9:jps8KAL°F98NRK 6JLHUa¥K@A6:=B9< N K M9>?B1<EB52LM9:=<9KA6:=B9< u 2:=GL>?8 /v·¶c 8SKH8<¡@NZ:=<9:RrL8zH8A6*8<ap:ZF98<E@8Ls<98F9BGLNR8AL>5+Ma@:R+:RrLs8 zN 8S68<5?:=B< 8A6 IN K±1FLs@A6+:CB1<FL%MBELs@8Ã8/6FLÁ@K>+M8^)Kp8@zLs<98FBGLN=8AL>;5?:n6JLsaP8IKAL <9:jps8PKALÁF98ÃNRKU6JLHIaK@A6:=B9<ÂN=B9>!5 FL 685J6 F98q:¤< 8Ny5268:¤ < JH:J5?8|8<aA6+:_>?8H8<P6*HIKS:ZHKN)8<¡2NR8S:CB<9w+KF9FLs@A6+:CB1<FLMBELs@8I5$L>L<MB1:j<8A6 z F 8S68<5?:=B<E^zKAp1K<6I±9>?KG58<M9>VB1<EKA62:=B9< u /v!¶K~MKA6279B9N=B9:C8}85$6F9a@NRK>?a8}8/6¡K}a/6a~>?8@dB1<<Ls8@B1HIH8. HKNRKF9:R8M9>?B9+85/5?:CB1<9<8N=NR8K/L©62:n62>?8FL©6KA±NC8KAL ³ @I¾ 6ad<9B5+D9<9BGp:n68F98P5 8S68<5V8AL>!5ÁFL @Kd>+M88A6%F98 N K±FLs@A68AL>*FLMBGLs@8;FG>?B9:n6"¶{|<IKd>+> A6.68H|MB9>?K:_>?8zF98;N 8S9MB5?:n6:=B9<8P5$6M9>?85V@>?:n6"¶¥c apBNnL962:CB1<8526 2KpB9>?KA±N 8 KAp8P@ L<E8 F1:J5+MsK>?:n6:=B9<F98~N |F9bH8 8A6UF985F9BELsN=8AL>"5>?a@¥:CF1:jpsK<6?5@8dM8¥<EF9K<6IN=B9>!5F98 62>?KAp1KALS8¥<2B1>?@8 u ¢VK>?F9:¤<EKs8^'@ALs:J5?:=< 8 }v·¶c 85¨K>> A6?5¨B9<6 a·6a®FGB9<9@ M9>?B9N=B9<Ga5«¢+L)5VrL ®NZK®@8G5"5?KA6:=B9<ªF KP@A62:jp:n6Va M9>?B128P5!5?:=B<9<E8NZNR8 u dÃHUB:Z5*KALI6yB6KN=^KM9>?b5*@B1<P6K@A6KAp18@;N=8qHaF98@¥:=<I@B1<5V8¥:RN=v/¶. Ð lËZ¼"Æ .¼!¼!ËRÇ9È Q =N B9>!5%rLs8NR85+D9<FG>?B9HI8FL @>?B9:J5?8H8<68P5$6@B9<G<GL F98dMGL:Z5%NR84+ 5?:Rb@NR8^|:=NI< 8S:J5$68rLs8}M8AL F98 F985?@>?:jMG6:=B9<¡F98|@8A6J68qMK!6279B9N=B9:C8|@798 INR8562>VKApK:ZNRNR8AL>!5HIK<Ls8NJ5/¶GfxBGL>y6K<P6 F9b5|d ³ ·^L<98|aA6JLsF98K<N=K:J5·8 5$L>;L<98Â@B979B9>J68 F9862>?KAp1K¥:=NRNZ8/L>!5lF98 N :¤<FL5$62>:=8 u @B1HIMK<9:R8 F98G5lHIBE68/L>!5 |KALS79KNRNjvz>V8A62>?BGL9p8@B1HIH8 aA62:=BN=B9:=8|KAL 5+D9<FG>?B9HI8|FL%@d>?B:Z5"8H8<6^MK> BG>?FG>?8|F98zJ>VarLs8<9@8¡¾NR85 @7EK¥<8H8<P6?5F98zMB5$68|8d<62>?
(16) K J<EK¥<P6 L< 62>VKApK:ZN :=<97K±:e6JLs8¥NC^ÁNRK >V8M9>?:y5V8 F L<µ62>?KAp1K¥:=N 7sKA±:n6JLs8N KM9>?b5}Ls<8 K±.5?8<E@8 K5/5V 8 M9>?B9N=B9<Ga8^ÂN 8 5$L>?HI8<9Ks8ÃNCB@KN.L<9:RrLs8IBEL%>?aMa/6a^(NR8z62>?KALHKA62:J5?H8N=B@KN 8<62>? K y<K<P6L<@79B@IF1:_>?8P@A6^(N=8G5 HIBGLp18¥H8<6?5 @B1<5$6KHIH8¥<P6 >?adMa·6a5 KAp18@8¥22B9>$6 :=<68d<5?88A6x>?KM9:=F9:n6a| F 8Sa@/L96+:=B9<@8E5 F9:=$a>?8<6?5 2K@A68AL>"5MBGL9pKd<6 !62>?8 K5!5VB@:=aG5 u 9v/¶Gc B1>!50 F L<8|aA6JLsF98|J>?K<
(17) K:J5?8I8<~d ³ ^f ¶ c ¶G;8d>+<9K>VF>?8N=bps8|aKNR8¥H8<6 rLs8l@8A6Z68lK$8P@A62:=B< :¤<P68>+p:R8¥<P6 F9Kd<5 @P8>$6K:=<5 @KG5 F9aA68d>+HI:¤<aG5¾q62>?K/pK:=NK<9B9>?HIKNZ8H8<6%Ma<9:j±NR8BGLµK<EB1>?HIKNR8H8¥<P6 N=B9<9 u 798AL>V85Â5$LM9MNRaH8<P6K¥:_>?85?^@BHIHK<9F98L>+8d<68^ 62>?K!pK:RNz:=<97K±:n6JLs8N=v u Gv/¶f)NeL.5¡>?a@8HIH8<6^XL<98}aA6JLsF98 6279 K RNZK<EF9K¥:J5"8ÂHIB<P62>?8ÂrLs8ÂNR8 62>?KAp1K:ZN 8<2B9>?@8ÂFLMsB9:j<E8A6lK5"5?B@¥:Ra F985HIBGL9ps8H8<P6?5|>?aMa/6a5I8526;L< +K@/68AL>2KpB9>+:J5?K<6 u 9v?^Â@dB9HÃH8 @8¥NRK KpK:n6a/6a Fa@>?:n6@798 @8>$6K:=<5«5+MB9>y62:=?5KM9>?bP5Ls<98 K@A6:Cp:e6a :¤<97K±:n6JLs8NRNZ8lBELM9NnL.5:=<P68¥<5?:jps8 u´³ ^=Gv/¶k8M8<9F9K<P6*N=K|>?aMK>$62:e62:=B1<F985M9>VB128G5!5?:CB<58526 FG:=$a>?8<68lF985MKD5 8AL>?B9Ma8<5B NR8U6KAL9SÁF K9>?:=@/LNn68/L>;8G5$6<E8A6Z68dH8<P6:=<9+a>?:R8AL> @8NjL:>?8A62>?BGL9pa8<%² 7 K RNRK¥<F98¶TIK<5Ls<8.
(18) HAL author manuscript inserm-00222731, version 1. 5?a>?:=8¡F98~dÂMKA6:=8<6?5|52L:jp:J5MK>;>$L<9FG±8>~8/6 g8KdK<9^5?8MG6FR8<62>?8¡8AL9S8¥28@A6JLs8<P6;F98P5zHUBEL9p18¥H8<6?5 >?aMaA6a5 K/L¡62>?KApK:=N u Gv/¶k798 |Ls<F98ÃNR8AL>MKA62:=8<6^)NC8 5+D9<EFG>?BHI8IFLÁ@>?B:R5?8H8¥<P68P5$6 5$L>$p18¥<PL±9>2L96K¥NC8¥H8<6 KM9>?b5L<62>?K/LHK/62:y5?H8IF9K<5 NRKU>Va:CB1<s¶1 <8¥28A6^(NR85+D9<EFG>?BHI8IFLÁ@>?B9:y5V8H8<P6M8AL96 adK¥NC8¥H8<6 5$L>2p8<9:=> KM9>?b5)L<62>?KALHKA62:J5?H8qN=B@KN.5$L>)L<|MB:_<E8A6xF9aV¢ z5?BN=NZ:R@:n6aXMK>*F98P5HUBEL9ps8H8<6?5 >?adMaA6a5?^9@B1HIH8;F9K<5*NR8 @K5*FLMKA6:=8<6xrLs8X<9BGL.5 >?KdM9MB1>J62B9<5*8/6 K;a!6a;F9a@>:n6xF9K<5*FRKAL962>?85*a/6JLsF985 u 9v/¶T K:=NZNR8AL>"5?^9MBEL> 4?FGNC8>*8A6xKN ^NR8q>?:J5?rLs8F98U52L>+p8<Ls88G5$6 MNnL966N=:Ra zNZ:=<62>?BFLs@A62:=BG<FCLs<98<9BGL9p8NZNR8K@A6:Cp:e6aqM7GD5?:RrLs8|8<62>V
(19) K J<9K<6 F98E5 HIBELp8H8<6?5lFL}MEB1:_<8A6x¢$L.5?rLs8wVN :=<97K±:n6JLs8NJ5MNnL626rL ÃL<E8¡8S9MB5?:n6+:CB<ÂM9>?BNCB1<a8 ÃLs<98K@A6:jp:n6Va >?aMaA6a8;F986yB1>!5:=B9<IFLMB1:j<98/6 u Pv/¶ c 8K¥:j±NR8~<9B9H|±9>?8 F8 F985?@>?:=MG6:=B1<FL«5+D9<FG>VBHI8 FEL°@>?B9:Z5V8¥H8<6U@798 NR8%62>VKApK:ZNRNR8AL>HK<Ls8N;F9K<5N K NZ:n6J6a>VK·6JL>?8 5 Z8S9MNZ:RrLs8µ<9B9< 5"8ALsNR8H8<P6MK>©5VK§>?8NRKA6:jp8µ>?K>?8A6aµHIK:J5©KAL.5/5?: MK>«F8P5©:=HÃM9>Va@:y5":=B<5 @B1<E@8>+<EK<6}5VK'F9a<9BHI:=<KA6:=B9<µ8A6}5VKM7GD5?:=B9MKA6279BNZB99:=8G¶zc 8 5+DE<FG>?BHI8«F98©@>?B9:J5?8H8¥<P6 K'a/6a'F9a@>?:n6 M9>?BE±1KA±NR8H8<P6;N=K¡M9>?8H:Rb>?82B:Z5MK> |8NjMs8KAL8<G 5?BGL.5zNC868>HI8 F98@8NZNjLsNZ:n68¡Ma>?:n68<EF1:=<8AL5E¶(< ³ ^B1< >?8/62>+BGL9p8L<8627Eb5"852L>|NRK5+D9<EB1p:n6868<9F9:=<8AL)5V8 @7>?B1<9:RrLs8^*MGL:J5INR868d>´HU8 F Z7GDFG>VB1M5?:=8%F98E5 K¥:=<E8E5 68<EF1:=<8AL.5V8G58P5$6*8H|MN=B1D1aqMKd> c Ls@ 88< G u Gv"¶ <9P^9c K>+8> H8<62:=B9<9<98N Q .F9BGLsN=BEL>V8ALS 8<9P^.>?8M9>?:n6 MK>fxKAL PKA608<GÂrLs:(L96:=NZ:J5?8@8N¤Ls :
(20) u 68>+HI8z6BGLd¢?BEL>"5 8¥HIMN=B1D1aÃF98<EB5 ¢?BEL>"5+v/¶Gc 8H|MN=B:FL¡68>HI8|F98Ã5+DE<FG>?BHI8|FL%@d>?B1:J5V8¥H8<6 BGLÂ5+DE<9FG>?B9HI8|F :=<P68>!5?8P@A62:CB1<8E526*M9NnL5>?a@8<6·¾:=N 85$6%:=<62>?BFL:n6Á8< d9'MKd>ÁTUBG±9D9<5 8/6 KN u Gv/¶lk 8/6Z68MK·627EB1NCB1:=885$6%>?8A62>BGL9pa8F9K<5~NRKNR:n6J6a>?K/6JL9>?8 aKN=8H8<P65VBEL.5F RKAL962>?85I<EB1H5|68¥NR5rLs8I¾ 6a<9B@8N=N¤LsN=:n68^Ma>?:n68<9F9:=<9:n6V8@d>?aM:n6K<68"^ !$#&% !$'')('$*,+
(21) /.& 01/23!$#$,4*5014d^zM8>?:RHÃDEB5?:e685?BGL.5%@AL96K<9aP8
(22) ^ '$,4,+
(23) 76 498:*;4<Z^Ã5+DE<FG>?B1H8FL N=B< K±1FLs@A68AL>%FL MBELs@8=^ 4>#?@=6 4A8:042¶G² >?b5xM8AL F a/6JLsF985*F98XM9>?aApsKN=8<E@8;B9<6xa!6aX>?8!62>+BGL9pa8P5*F9K<5*NRKqN=:n6J6a>VKA6JL>?8d^rLs8N=N 8 rLs8 5?B:n6¨NRK F9a<9BHI:=<KA6:=B9< @79B:Z5?:R8^ Kp8@ F85 6KAL9S >V8¥NCKA6+:jp18¥H8<6 2K:C±sNR85 @79 8 ªF98G5 MKA6:=8<6?5 5+D9HIMG6B1HUKA6+:CrLs8E5 J8<62>V8;9^CC B 8·6(9^¤9$ B u 9^+dGv ?¶ TI85 F9BEL685 M8>!5?:R5$68<P652L> N=KXM7GD5?:=B9MK/6279B9N=B1:=8;8SKP@A6y8;F98;@8z5+D9<EFG>?B9H8¶¥c 8z5+DE<FG>?B1HU8;FL¡@d>?B1:J5V8¥H8<6*5V8 5?:n6JLs8K<EKA6B1HI:RrLs8H8¥<P6KAL <9:jps8K/L FL©MKG5"5?Ks8F98G5%@BHlMB5VK<6?5%FL 0D @BH|MK>$6:=H8¥<P6F985¡68<EF9B1<5 8ASG68<5V8AL>!5 u ¢?B<9@A6:=B9<H|L5?@ALsN=Bwy68<EF1:=<98/L)5V8}FL N=B<9«K±FLs@A68AL>FL«MBGLs@8}8A6FL @BGL>y68AS68<5V8AL>FL.
(24) . HAL author manuscript inserm-00222731, version 1. MBELs@8dv|KALswF985!52L.5|F98%@8ALSFLF98/LS:RbH8Â@BH|MKd>$6+:=H8<6 u 68<9F9B9<5lFL@BGL>J68A6qFL}N=B9<G8SG68d<5?8AL>lFL @K>+M:=8<9^zM9>V8¥HI:R8>%8A6F98/LS:RbH8>?KF1:RKNjv u 9^+9/v/¶ ;:C8¥<«rLs8NRKMNnLMsK>$6 F985%KAL968AL>!5%KF9HI8A6J68<P6rLs8}NR8 J>?BE6R68HI8<6q8A6;N 7GD9M8>!5VBN=NZ:R@:n6KA6:=B9<5VB1<P6 ¡N B9>?:j:¤<8%FL}M9>B@8P5!5$L.5l:=<2NRK¥HHKA6B1:_>?8 FL @BHlMK>$6:¤H8<6 F9858SG68d<5"8AL>!5 u ^+/9v?^.@8>J6K:=<5apBrLs8<P6 L<98Ã7GDMs8>$6J>B1M979:C8|F8P5@B9>+M5HzL5?@ALsNRK:¤>V85 u Gv08A6 F KAL962>?85*L<E8 5$6a<EB5V8FL @BH|MKd>$62:=H8<P6 u 8AS68<5?8/L>!5%FL @K>?M8v%F9B9>!5?KN u Gv/¶c 85%aA6JLsF985>?a@8<P685MB1>J6K<6%5$L> NR:ZHKs8>?:=8XMK> >?a5VB1<EK<9@8;HK<EaA6:=rLs8z5?B9<6x8<I2Kp8ALs>* F L<98 6a<EB5+DE<9BGp:n68XMK> 7GDEM8>"5?BN=N=:R@¥:e6?KA62:CB1<IF98p1K¥<P6 NZKp:J5$LsKNR:y5"K/6+:=B9<©F jLs< lF9b¥H8Mad>´:68<9F9:=<8ALS KAL96BGL>ÂFL M9>?8dHÃ:R8>Á8A6%FL F98AL9S:=bH8@BHlMK>$6:¤H8<6?5 u d9^+d9^V/v?^}KAp18@§M9>?BG±K/±NZ8H8<6L<E8 KG5!5VB@:=K/6+:=B9< MNnL.5 BEL HIB:=<5©HK>?rLsa8¨8¥<P62>?8 N=8G5 F1:=+a>?8<6?5 M979a<9BHUb¥<E8G5?^IF apBNnL96+:CB1< K¥:=GL BGL @7G>?B9<9:RrLs8 u dGv/¶ Q :=<5?:=^:RN8E526¡62BGLG6 2K:n6%@B9<9@8psK±NR8rLs8@P8 5+D9<9FG>VBHI8Â5?B:n6qK5!5VB@:= a F85lHIBGLp18¥H8<6?5>?adMaA6a5lF98 2NZ8S:=B9<}8S68<5?:=B<~FL MB1:_<8A6M9>+B9285/5?:=B<9<98NJ5?^ KAp8P@ L<z62>?K/LHIKA6:y5?H8X>?a/paNRKA68AL>*@B9HIH8;@ 8526)NC8;@KG5*F98X<9BG6J>?8XMK!62:=8<6"¶ 4´N8G526<Ea@8G5!5VK:¤>V8F98~>?KdM9M8¥NR8>rLs8NZ8}F9:RK<9B5$62:R@8P5$6KApK<P6Ã6yBEL6@¥N=:=<9:RrL.8 u 2:=GL>?8'/v?^q±:R8<rLs8F98E5 :¤<Gps8G5262:jKA6:=B1<5¡52LM9MNRaH8<6K:j>?85 u a@79B99>?KM979:R8 8A6|:=HK8>?:R8ÂMK>I>?a5VB1<EK¥<E@8HK<9a/6+:=rLs8dvÃM8/L9ps8¥<P6 !62>?8 <9a@P85"5"K¥:_>?8G5¡8<@KG5F98~F9BGL968 KAp8@ÁL<F1:RK<9B5$62:=@}F9:=$a>?8<P6+:=8NJ5 u d9^+d9^V/9v·¶ c 85IM9>?:=<@:jMK/LS«5?B9<6INC8E5 6a<9B5+D9<EBEp:n68P5 F98E568d<9F9B9<5 8SG68<5V8AL>!5 FL%M9>?8H:R8>@B1HlMK>$6:¤H8<60F9BG>!5VK¥N u 5+DE<FG>?B9H8IF98zTU8ãXL8>$pK:=<^ F9B1<P6'NCK§6JLHIaK@A6:=B9<®85$6«MNnL.5 F9:J5$6KNR8v?^N=8G5'6ad<B52D9<9BGp:n68G5 F985«68<9F9B9<5 8SG68<5V8AL>!5 F98G5 K/L962>?85 @B1HlMK>$6:¤H8<6?5V^NR85;62>?KALsHIKA6:Z5?H8G5|N=B@KALS u rL:0Kp1K:n6aA6aaAp1BrLsa :=<9:n6:RKNZ8H8<6MBEL><9B6 >?8 MK!62:R8<62v?^NC8 5+D9<9FG>VBHI8¡F98 K>268<G±8> u @B1HlM9>?85/5?:=B<ÁF98 N=K±9>VK¥<E@798 5"8<5?:n6:jps8¡FL <98>?>?KF9:RK¥N F9B9>!5?KN*KAL <9:Cps8KAL F98 5?B9< a¥H8>8¥<E@8 5VBEL.5 NR8°68<EF9B1< FLµ±E>?K@79:=Bw$>?KF9:=KN=v?^ULs<98:¤<+NRKHHKA6:=B9< <EB1<µ5+Ma@:R+:RrLs8FL 6+:Z5/52L)5 @8N¤NjLsNRK¥:=>?8z5VBEL.5 @AL96K<9a u Pv/¶ c 8zF98><9:Z8d>MB9:=<6*F98F9:Z5?@AL5!5?:CB<85$6*N=K;MB5!5?:j±:ZNR:n6az8/6 N :=<6ad>A6*F98F9a@NRK>VKA62:=B9<8<HKNRKF9:R8qM9>?B9285/5?:=B<9<98NZN 8 F9K<5N=8 5+D526b¥H8¡J>?K<
(25) K:J5/¶TU8ALSÁMB5"5?:C±:RNZ:n6aP5zHaF9:R@PBw+KFGHÃ:=<9:J5$62>VKA62:jps858S:J5$68<P6XMBGL9>;NCK¡F9a@NZKd>?KA6:=B1<ÁF98 @8A6Z68IMK·627EB1NCB1:=8ÃMBGL>XNC85|5?KNRK>?:Ra5FLÂga:RH8Ãa<9a>?KN F98a@AL>?:n6a 5VB@d:=KNZ8E¾(N K@@:RF98<6 FL62>?KAp1K:¤N*8/6NRK HKNRKF9:R8 M9>?B928G5!5?:=B<9<98NZNR8G¶(c K¡Fa@NRK>?KA62:CB1< 8< K@@:RF98¥<P6FL62>VKApK:ZN 8G5$6 MB5!5?:j±NR8 8< @KG5F8Ã62>?KALsHIKA6:Z5?H8.
(26) HAL author manuscript inserm-00222731, version 1. u H ¥H8 H:=<8AL>+v?^HIK:J5I<9a@8E5"5?:n68 NRKÂ@B9<526KA6K!62:=B1< F¤L<~K:n6K@@:RF98<68N Kp1a>?aG¶sBG62>?8¡MK·62:=8<P6KApsK:n62K:j6 M9>?aKN=K±NR8¥H8<6x@8/6Z68;F9aHIK>?@7E8;rL:sK;aA6aX>?8ZL.5?aXMKd>N K;@K:y5"5"8;F98|a@AL>?:n6a|B@d:ZKNR8;KALHIBE6:=F98qN K±.5V8¥<E@P8 F98 6aHIB9:j<Kd8¬5$L>©NR8 +K:n662>?KALsHIKA6:=rLs8¬5$L>©NR8 N¤:R8AL F98 62>?KApK:RN$¶ {U<98 F9a@NRK>?KA6:=B9< F8 HKNZKF1: 8 M9>?B128P5!5?:=B<9<E8NZNR8I85$6 aKNR8H8¥<P6*MB5"5?:j±NZ8IKAL¡6:n62>?8lFL¡6KA±N=8KAL ³ ¡FLg;ad:RH8a¥<ad>?KN u BEL%9¡FL¡ga:ZH8 K9>?:=@BN=8dvÃMB9>J6K<65$L>IN=8G5?K+8@A6:=B1<5IMad>´:CK>$6:=@ALsNZK:j>"85IM9>VBEp1BrLsa8P5IMK>@8>$6K:=<5I8526858A6lMB5J6JL>?8 F98 62>?KApK:=Nd¾qN KNR:¤<aPKk®F98@8~6KA±NR8K/L @B9<@8>+<K<P6N=8MB9:j<8/6^zN=KHK¥:=< 8A6NR85 F9B:_G6?5?^|HI8<6:=B9<9<98?NR8E5 68<9F9:=<9:n685BELµ6a<EB52D9<EBEp:n68G58< >VKM9MB1>26}K/p8@©F98G5~62>?K/pKALS¨@BHlMB1>J6K<6 F98©2K
(27) B9<µ7K±:e6JLs8¥N=NR8 F98E5 HIBELp8H8<6?5 >VaMaA6a5*BGLM9>+B9N=B9<Ga5 F8568<9F9B9<5*F985 8AS68<5?8AL>"5*F98qNRK;HK¥:=<BGL¡F98P5*F9B:jG6?5V^5VBEL.5 >Va5?8>2ps8 F Ls<¡F9aNRK:.F98zM9>?:J5?8|8<@¥7EK>+8|F98lq¢?BGL>!58A6*rLs8zNC8E5 @d>+:n6b>?8P5F R8SEMB5?:e6+:=B9<>V8rL:J5 MK>N=8q6KA±NR8KAL 5VB:=8<6 >?8H|MN=:J5 u ³ v/¶ Q 62:n62>V8 F 8Ss8H|MNR8^I@86KA±NR8PKAL K:Z<EF98HÃ<:J5"a9 P©5?KNRK>?:Ra5 8<«9G y<EBH|±9>?8F98 HKNRKF9:R8E5 KAps8@zK>> A6?5 rL:NR85*MB1>J68<P6*KALMG>?8HI:R8>*>?K<9¡F985 HIKNRKF1:R8G5*M9>?B9285/5?:=B9<9<8¥N=NR8G5 u dGv +^FB1<P6x9G MBEL>|N aMKALsNR8 u KN¤:=<aPK Q v?^9 MBEL>IN=8 @BGLsF98 u KdNZ:=<aK v?^|9 ³ ~MBEL>IN Kp1K<6wy±E>?K5?w2MB:j<98A6w$HUK¥:R< u KN¤:=<aK¡kv?^*GÂMBELE>;N=8¡H8H|±>?8¡:=<9+a>?:R8AL> u KN=:=<aPKÃT|v8A6 99KP5!5?B@:RKA62:=B9<5 u ?H|LNe6+:=w?5+D9<FG>?BHU85+v/¶c 8E5 KAL962>?85 >Va9:=H8G5 M8/Lp18¥<P6xaKN=8H8<P6(±1a<9a+:R@:Z8d>*F98;@86JDM8;F98X>?8@B1<9<EK:y5/5VK<@8^HIK:J55?BGL.5*F985*@B1<EF1:n6:=B<5 F1:=2+a>V8¥<P685IM9>?B9M9>?85 @7KrLs8Â>?a:ZH8 u 5?BGL9p8<6UF98HK<9F98~F 8S9M8>$6:Z5V8v/¶)BG6J>?8 @8>262:¤2:R@PKA6IHI8<6:=B9<9<9K:j6 N KA6J68:=<68F985Â68d<9F9B9<5 F985}8S68<5"8AL>"5 FLµ@Kd>+M8 u K:=<5?:rLs8'@8NRNZ8F98'N K±1FLs@A68AL> FL MBGLs@88A6%NR8 5+D9<9FG>VBHI8 FL @>?B:Z5"8H8<P6MBGL> ·62>?8µ@B9H|MNR8A62v«8A6M9>Va@:J5?K:n6NR8G5«@PK>?K@/6a>+:J5$6:=rLs85 F98§N 8SEMB5?:n6:=B< M9>?B128P5!5?:=B<9<E8NZNR8G¶c K;HK¥NRKF9:R8qM9>VB128G5!5?:CB<9<98NZNR8;KK:¤<5?:aA6aX>?8@B9<G<PLs8;8<HIB:=<5*F98X62>B1:Z5 HIB:J5/¶c :=<6a> A6xF98 @8Ã6JDM8¡F98¡F9a¥HUK>?@798¡8G5$6 M9>+:=<E@¥:=MKNR8H8<P6X2:=<K<9@:R8>zMBGL9>;NC85;MKA6:=8<6?5V^KAp18@M9>?:Z5?8¡8< @7EK>+8¡F985J>?K:$5 HaF1:R@KALS^:=<F98HI<:J5"KA62:CB1<5¢?BGL>+<KN¤:Rb>V8E5 8< @K5 F K>+> /6ÂHIKNRKF9:R8 «@86+:e62>?88A6Â:=<EF98¥HI<:J5"KA62:=B9<5 F98E5 5?arLs8NZNR85·¶k 8lrL:.KlaA6azMK>$62:C@ALNR:Rb>?8H8¥<P6*:=HÃMB9>$6K<P6MBEL>*<9B62>?8MK·62:=8<P6^(@ a/6K:n6 F98zMBGL9pB9:j>:=<68>+>B9H|M9>"8 N 8S9MB5?:n6+:CB1<8<@KAL.5"8~5?K<5IM8>$68 $:=<K<9@:Rb>?8¶ <8¥28A6^XN=8ÂM9>?8H:R8>|62>?K:e68¥H8<6U@B9<5?:J5$68 8<N K>> A6UF98 N K@A6:jp:n6aq:=<@>?:RHÃ:=<aP8G¶:@P8A6xK>+> ·6<98z52L2+:n6MKG5?^GL<8;:ZHHUB1±:=NZ:J5"KA6:=B1<UFLMB:j<E8A6x85$6>?aK¥N=:J5?a8z8<|MB5?:n6:=B1< <98AL962>?8^K5!5VB@:=a8Âap8<6JLs8N=NR8¥H8<6 L< 62>?K:n68HI8<P6MK> Q 4 ^ L<E8 >VaaFL@KA62:=B9<~M9>?B99>?85"5?:jp8BEL L<E8 :¤<d¢"8@A6:=B9< F98 @B9>J62:=@B RF98G5 NCB1<GLs8 FL>?a8 F K@A6:=B9< u F9K<5NRK 6JLHUa¥K@A6:=B9< BGL F9K<5NR8 F98/LS:RbH8 @B1HlMK>$6:¤H8<62vV^0pB9:j>?8 Ls<~62>?K:n68HI8<6U@79:j>$L>+:R@KNR^;8<@K5F98ÂM8>"5?:y526K<9@P8 F98 F9BELsN=8AL>"5:=<GpsKNZ:RF9K<685.
(28) HKN=9>?a;K>>A6F98XN=K;@KAL.5"8;8A6.L<q62>VK:n68HI8<6HIaF9:R@PK¥N9±:J8d<I@B9<9FLs:n6 u ^=9^ ¥^+9/v!¶. HAL author manuscript. c 8Á5+DE<FG>?B1H8FL@>VB1:Z5"8H8<6q85$6qFGB9<9@L<98¡MKA6279BNRB99:=8¡M8ALJ>?arL8<68^HUK¥:J5MBGL9pK<6 A62>?8¡N¤:Ra8 L<E8 7GD9M8>!5VBN=NZ:R@:n6KA6:=B9< FL MB1:j<98/6 MB68d<62:=8NZNR8H8<G6 M>+B928G5!5?:=B<9<98NZNR8G¶ < 5?8 >?KA6J6K@79K<P6 KALS 68<9F9:=<9:n685 R6a<9B5+D9<EB1p:n685 F98P5 8S68<5"8/L>!5?^.8NZNR8zM8AL96 K¥:_>!8|N RBE±d¢"8A6 F CL<8lF9a@NZKd>?KA6:=B1<K/L¡6+:n62>V8|F98|HKNRKF9:R8 M9>?B128P5!5?:=B<9<E8NZNR8G¶. inserm-00222731, version 1. Ð » »ºÆËJ» »ÈÌV¼ BGL.5K:=H8>?:=B1<5 MK>$62:R@ALsN=:Zbd>?8H8<P6*>?8HI8>?@:R8>Tl>XLDgK:=HU±s8PKALs^.FL%k8<62>?8lF98UNCKUHK:=<F Q <8>!5 MBEL> 5?85*@B1<5?8:ZNJ5*8A6*5V85*@B9>+>?8@!62:=B9<5·¶ . . Ð ÎÉκ»È(ÆP»¼. ! NnLs:n68>)/^Gg85$6;^E.>?:=<G5VwyTl>?85"8<z~`¶k0>:n68>?:=KF9B@ALHU8¥<P62B1>*8Ap1KNCLsK/6+:=<G|627E8 BG>w >?8N=KA68FG<E8E5"5*B9LM9M8d>?w+8AS62>?8HÃ:e6$DIH|L5?@ALsN=B58NR8A6KNF1:J5"B9>?F98/>!5/¶/ '$,?
(29) /.&0'$ /25 9)/#2s¾JdwdG¶ Z ¨² E7 B1H¡5?B9< Q g^EfNR8 85)c ^.97K 0öfx8>+:n68d<9F9:¤<9:e6+:25*@>?8M:n6K<5*K<9F5?:ZHIMNR8 68<9B5+D9<EBEp:n6:J5 ¾GK @¥N=:=<:Z@K¥N.5$6JLsFGDUB1 ³ 9@K5V8E5*:=<I:=<9FL5$62>$Ds¶: * ~d ³ ¾y ³ 9w9¶ J ;8d>+<9K>VFlf.c ¶²8d<9B5+D9<9BGp:n6:J5*K<9F|M8>?:n68<EF1:=<:n6+:J5*@d>?8M:¤6K<5:=<I:=<9FL5$62>+:CK¥NMKA627EBN=B91Ds¶ d ³ !#"s¾e) ³9³ w+) ³ ¶. '$/ '#$,4. Z f Kd<6JL B5+:n6 ^fx8·6@7 9>$LsK °^(G62:=8<50 Q ¶P4+<68>"5?8@A62:CB1<¡5+D9<EFG>?B9H8;:=<zL>?:j>?KH `UB5+M:n6KN2¾GKXw$D> M9>?B5M8@!62:Cp18z5$6JLsFGDs¶, "+$%&'4( )"* !$;29),+s¾n ³ 9w+9)P¶ ³ f KN=H8>)T`I^Gc K<98wycKd>!5?8<Ikc ¶`I8N=:R@B1MG68d>59:=:=<9 +> :J5$6x:=</¢VL>?:=8G5·¶ Q @K5V8X>?8MB9>y6(B1 $±GLK±1BB.
(30) d 2B1>?8K>?H /¶ "+$ . '$<4! . d9G ¾J/w/¶. HAL author manuscript. J B9N=798:ZH©c ^G`IKd8¥<g|¶k7G>?B9<9:R@;@B9H|MKd>$62HI8<6KN5+D9<sFG>?B9HI8;B9627E8;KA±FLs@/6B1>M9B9N¤NR:R@¥:J5*N=B<GL.5*K<9F 8ASG68<5VB1> MEB1N=NR:Z@:J5 ±9>?8/p:y5*H|L5?@NR85d¾>V8MB1>J6B9K;@K5?8 6 >+8KA68F :e627Ã2KG5V@¥:CBE6B9H|D¶ "* /' /#$+ /#$ %d99 .¾n)d9w)¶ J¨q>$L<EFE±18>+ Q ;^Gg8KK<T¡.¶f K/6279B9N=B19:R@;K<K/62B9HUDÃB162798;2B9>?8K>?H¾G:=<68>"5?8@A6:=B9<5+D9<EFG>?BHI8¶ /#$% "+ Âd ³ +s¾i99w+9G¶. inserm-00222731, version 1. $ µ4?F1NC8>)gl^.6 >+:=@ NRK¥<EF ^k>?8:¤76B9< /^ ! >/¶4+<P68A>"5?8@A6 :=B<5+DE<FG>?B9H8¶ , /1 .¾n ³ w+ ³ ¶. . d99. J TIBG±9D9<5?`I^.9:=H .`U^Ec :=<5"@798:RFzg c ¶9MB1>J6?5*5$6J>V85!552D9<FG>?BHI85*B962798X7K<9FIK<EF >?:J5$6"¶ "+$ '$4( d99 "s¾i99w$ ³ .¶ !d¨k B5$6K kg;^GBG>>+:Z5?B9< ^kK>+>?:=<9B Q ¥¶ g 428K/6JL>?85*B9):=<68d>!5?8@/62:=B1<5+D9<FG>?BHU8;B162798;2B9>?8K>+H¶ ) "+$)"' %/'299, s¾y/9 ³ w /9¶ !9 `IK<9NCB<zTf ^Gc Ls8N=NZ8< !gl¶P4+<68d>!5?8@/62:=B1<5+D9<9FG>VBHI89¾GK;@K5?8X>?8dMB1>J6K<EFU>V8Ap:R8 B962798;N¤:e68>?KA6JL>?8¶
(31) :+ % ~d99, 9¾n9 99w9)¶ !/ ¨² 7EB1>!5VB1< ^ ¥KA±B|g °¶Gk B1HIHIB<68<9F9:=<:n6:J5 M9>?BG±N=8H¡5:=<z627E8q7EK<9FIK<9FÃ2B9>?8Kd>+H¡¶
(32) '$< "+ d9G .¾n ³ w+G.¶. </'. 2;0. !d¨F98 c:=HK ´0^ l:ZH'` /^ Q Nj±s8>$6yB6Z62:G^Gg85?<9:R@ |T¡¶P4+<P68>´5V8@A6:=B9<5+D9<FG>?B9HI89¾~g:RHKd:=<9 n: 627 K<9KA6B9HI:R@;@BH|MK>?:J5?B9<IB962798;F9:y526KN2B1>?8K>?H¡¶ ? &2;@ 2): /'29G .¾nG9w+9)P¶ !/ X>VB <98 ·^E`U8N=H¡5k Q ¶4<68>!5V8@A62:=B9<5+DE<FG>?B1HU8;B16278X2B9>?8K>?H¡¶ .¾ 9¶. <014) /&#$+©99. ! ³ Q 1± KF1:RK;^ETU8N=8HIBG6J68 ;^TU8N=8dM:=<8 Q ^XL:=NRNZ8HID;^Ec 8dM9>´:=<E@8 Q ^F98 B9<GB9N=+:R8>*k;¶ Q 2+8@/6+:=B9<5 Ma>?:=K>$62:R@ALsNRK¥:_>?8G5 M9>?BGpBrLsa85 MK> NC8 62>?KApK:=N¾¥6KA±N=8PKALF98;HIKNRKF1:R8XM9>?B9285/5?:=B<9<98NZNR8 u *T ³ v·¶.
(33) 9 4+<526+:n6JL961K!62:=B9<9KNMBGL> N=KX>?8@¥7E8>?@798;8/6)NCK|a@AL>?:n6a^9999.¾ ³ w+¶. HAL author manuscript. !d Q GM 68¥NG^KALsF98 k;¶ Q 28@A6:=B1<5 F98qN KM9MK>?8:RNN=B@BHB68AL>x8<|>?KdM9MBG>y6xKAp18@qN 8S8>V@¥:R@8;F L<E8 M9>?B128P5!5?:=B<s¶¥ <9@D1@¥NCB1MaF9:R8 aF9:R@Bw+k 79:j>2L>+:R@KNR8 u Njps5"8p:R8>VwyK5/5VB1<v?^ Q M9MK>?8:=N1c B@B9HIBE68/L>+^ ³ w+)/w Q d9^999¶. inserm-00222731, version 1.
(34) / ):=GL>?8¾~F9bH8p:J5?:C±sNR8 ~N :=<5M8@/62:=B1< @H F8 NZK}5$62D9N=B RF98>?KF1:RKNR8^062DM:RrLs8 F Ls<5+DE<FG>?BHI8 FGL @>?B9:Z5?8H8<6 u pGLs8;Kd<6a>?:=8AL>V8;FLMB9:j<98A6xFG>B1:e62v/¶ HAL author manuscript inserm-00222731, version 1.
(35)
Documents relatifs
To test whether the vesicular pool of Atat1 promotes the acetyl- ation of -tubulin in MTs, we isolated subcellular fractions from newborn mouse cortices and then assessed
Néanmoins, la dualité des acides (Lewis et Bronsted) est un système dispendieux, dont le recyclage est une opération complexe et par conséquent difficilement applicable à
Cette mutation familiale du gène MME est une substitution d’une base guanine par une base adenine sur le chromosome 3q25.2, ce qui induit un remplacement d’un acide aminé cystéine
En ouvrant cette page avec Netscape composer, vous verrez que le cadre prévu pour accueillir le panoramique a une taille déterminée, choisie par les concepteurs des hyperpaysages
Chaque séance durera deux heures, mais dans la seconde, seule la première heure sera consacrée à l'expérimentation décrite ici ; durant la seconde, les élèves travailleront sur
A time-varying respiratory elastance model is developed with a negative elastic component (E demand ), to describe the driving pressure generated during a patient initiated
The aim of this study was to assess, in three experimental fields representative of the various topoclimatological zones of Luxembourg, the impact of timing of fungicide
Attention to a relation ontology [...] refocuses security discourses to better reflect and appreciate three forms of interconnection that are not sufficiently attended to