HAL Id: inserm-00656238
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Vasopressin, ATP and catecholamines differentially
control potassium secretion in inner ear cell line.
Jérôme Nevoux, Marie Teixeira, Say Viengchareun, Claudine Cosson, Daniel
Butlen, Marc Lombes, Evelyne Ferrary
To cite this version:
Jérôme Nevoux, Marie Teixeira, Say Viengchareun, Claudine Cosson, Daniel Butlen, et al.. Vaso-pressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line.. FEBS Letters, Wiley, 2011, 585 (17), pp.2703-8. �10.1016/j.febslet.2011.07.025�. �inserm-00656238�
Figure 1
A
C
EC5v
Bas al dDA VP Cal cito nin hPTH Iso Iso+ Prop ra 2 PGE FSK 0 1000 2000 3000 4000***
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c A M P p ro d u c ti o n (f m o l/ 5 m in /µ g p ro te in s )KC3AC1
Bas al dDA VP dDA VP+O VTA dDA VP+d esG ly Calc itoni n hPTH Is o Iso+ Prop ra 2 PGE FSK 0 2000 4000 6000 8000 10000 12000 14000 16000***
***
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c A M P p ro d u c ti o n (f m o l/ 5 m in /µ g p ro te in s )EC5v
-9 -8 -7 -6 -5 0 100 200 300 400 500 600 700 800 900Ka
[Isoproterenol] (Log M) c A M P p ro d u c ti o n (f m o l/ 5 m in /µ g p ro te in s )B
KC3AC1
-11 -10 -9 -8 -7 -6 -5 0 2000 4000 6000 8000 10000 12000 14000 16000Ka
[dDAVP] (Log M)D
c A M P p ro d u c ti o n (f m o l/ 5 m in /µ g p ro te in s )Figure 2
EC5v
-9 -8 -7 -6 -5 -4 -3 0 2 4 6 8Ka
[ATP] (Log M)
[
3H
]I
n
s
P
s
p
ro
d
u
c
ti
o
n
(% t o ta l ra d io a c ti v it y i n c o rp o ra te d )KC3AC1
-10 -8 -6 -4 -2 0 1 2 3 4 5Ka
[ATP] (Log M)
EC5v
0 100 200 300 400 500 0 100 200 300 400AVP poVT ATP
KC3AC1
0 100 200 300 400 500 0 200 400 600poVT AVP ATP