Regulatory T cell plasticity: another layer of complexity in atherosclerosis

Following binding to CD4, tregalizumab induces a T-cell receptor (TCR) signaling pathway that is incomplete and unique when compared with OKT3 and other anti-CD4 antibodies, but that

9–13 In this review, we will try to give an overview of the functions of immune cells in the regulation of atherosclerosis with particular emphasis on regu- latory B cells

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Follicular regulatory T cells can be specific for the immunizing antigen and derive

More direct and convincing evidence for a role of adaptive immunity in atherosclerosis has been provided using experimental mouse models of atherosclerosis, especially Apolipoprotein

The impaired CD4 T cell response of TSSP-deficient mice to HEL correlated with significant alteration of the dominant TCR- chain repertoire expressed by HEL-specific CD4 T

The TME is in particular composed of immune cells including T cell subsets (follicular helper T cells [Tfh], regulatory T cells [Treg]), stromal cells, dendritic cells, and

We show here that hybridoma cells expressing a chimeric TCR-b chain (bIII) containing intracellular and transmembrane TCR-g amino acids, together with a wild-type TCR-a (awt)

The present study investigated the effect of combined RAPA/MR1 treatment on rat-to-mouse islet xenograft survival and analyzed the role of CD4 + CD25 + Foxp3 + T regulatory cells