Combined liver‐kidney transplantation for primary hyperoxaluria type 1

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(1)Nephrol Dial Transplant (2001) 16: 2113. 2113. Combined liver-kidney transplantation for primary hyperoxaluria type 1 Sir, We read with great interest the paper by Ellis et al. w1x, reporting their experience with six children undergoing combined liver-kidney transplantation for primary hyperoxaluria type 1 (PH1). Although the median time on dialysis was only 1 year and 4 months (range between 0 to 2 years and 2 months) outcome was unsatisfactory with two deaths and recurrence of oxalate deposits in all kidney grafts leading to organ loss in one child. This is in contrast to data from the European Oxalosis Registry w2x, where patient and graft survival in patients with PH1 after combined liver-kidney transplantation was superior in those less than 2 years of end-stage renal disease (ESRD). The report by Ellis et al. strongly suggests that young children, and especially infants with ESRD due to PH1, may do far worse. We fully support the authors’ conclusion, namely that avoiding ESRD by pre-emptive liver transplantation, is a potentially promising therapeutic strategy. Although the timing of this transplantation procedure remains controversial, our own short- w3x and long-term follow up w4x data of four children with PH1 after pre-emptive liver transplantation are encouraging. Patient survival is 100% after a median of 4.5 years at present and renal function could be preserved in all and even improved in one patient, where nephrocalcinosis completely disappeared. In one girl, who received the liver transplant at the age of 9.8 years at a glomerular filtration rate (calculated according to the Schwartz formula) of 27 mluminu1.73 m2, creatinine clearance has remained stable at 25 mluminu1.73 m2 for more than 6 years. Importantly, however, systemic oxalate production has also been stopped in this patient, so that in a future renal transplant, recurrence of oxalate disposal will not occur, thus improving long-term prognosis. On the other hand, this example clearly shows that pre-emptive liver transplantation should not be delayed for too long in a patient with declining renal function due to PH1, since function may not recover completely. If ESRD has been reached, and this is in accordance with the conclusion of Ellis et al., early combined or sequential liver-kidney grafting is to be advocated before oxalate disposal (mainly in the bone) occurs. Improvements with splitting techniques w5x have resulted in the possibility of living related liver transplantation not only in children but also adolescents and even in adults, so that planning of pre-emptive or combined liver transplantation for PH1 becomes easier, minimizing the potential risks of oxalate deposition during ESRD. 1 University Children’s Hospital Zurich Switzerland 2 University Children’s Hospital Hamburg Germany. M. J. Kemper1 M. Burdelski2 D. E. Mu¨ller-Wiefel2. 1. Ellis SR, Hulton SA, McKiernan PJ, de Ville Goyet J, Kelly DE. Combined liver-kidney transplantation for primary hyperoxaluria type 1 in young children. Nephrol Dial Transplant 2001; 16: 348–354 2. Jamieson NV. Oxalosis registry report 1987–1999. Nephrol Dial Transplant 1999; 14: 2788 3. Kemper MJ, Nolkemper D, Rogiers X, et al. Preemptive liver transplantation in primary hyperoxaluria type 1: timing and preliminary results. J Nephrol 1998; 11: 46–48.

(2) 2114 4. Nolkemper D, Kemper MJ, Burdelski M, et al. Long term results of preemptive liver transplantation in primary hyperoxaluria type 1. Pediatr Transplantation 2000; 4: 177–181 5. Rogiers X, Topp S, Broering DC. Split liver transplantation: in situ or ex situ. Curr Opin Organ Transplant 2000; 5: 64–68. Nephrol Dial Transplant (2001) 16: 2114.

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