Patterns of anemia during malaria

HAL Id: hal-01224282

https://hal.sorbonne-universite.fr/hal-01224282

Submitted on 4 Nov 2015

HAL is a multi-disciplinary open access

archive for the deposit and dissemination of

sci-entific research documents, whether they are

pub-lished or not. The documents may come from

teaching and research institutions in France or

abroad, or from public or private research centers.

L’archive ouverte pluridisciplinaire HAL, est

destinée au dépôt et à la diffusion de documents

scientifiques de niveau recherche, publiés ou non,

émanant des établissements d’enseignement et de

recherche français ou étrangers, des laboratoires

publics ou privés.

Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives| 4.0

International License

Patterns of anemia during malaria

Stéphane Jauréguiberry, Papa Alioune Ndour, Marc Thellier, Eric Caumes,

Pierre Buffet

To cite this version:

Stéphane Jauréguiberry, Papa Alioune Ndour, Marc Thellier, Eric Caumes, Pierre Buffet. Patterns

of anemia during malaria. International Journal of Infectious Diseases, Elsevier, 2015, 33, pp.89-89.

�10.1016/j.ijid.2014.12.048�. �hal-01224282�

Letter

to

the

editor

Patternsofanemiaduringmalaria DearEditor,

We readwithinterest thearticle byRehman etal. on post-artesunate hemolysis (PADH).1 Hemolysis is indeed commonly associatedwiththeclassofartemisinindrugswhenusedforthe treatment of severe malaria. Their review confirmed the high incidenceofthis adverseeventrelatedtothemodeofactionof artemisinins and the physiological role of the spleen.2 _{As the} authors wisely pointed out, delayed hemolysis should not jeopardizethedeploymentofartesunateasthefirst-linetreatment ofseveremalariaworldwide.WhilePADHisindeedrarely(ifever) fatal, artesunatesignificantly reducesmortality ascompared to quinine,markedlysoinpatientswithparasitemiagreaterthan10% onadmission.3Importantly,PADHhasbeenfurthercharacterized byapathophysiologicalstudyintravelerstreatedwithartesunate forseveremalaria.4_{Earlypeakconcentrationsofcirculating} once-infectederythrocytesarepredictivefortheoccurrenceofPADH andmaythereforeserveasafuturecandidatemarkerforPADH. Rehmanetal.referredtodifferentanemiapatternsintheiranalysis of published reports. This definition was based on initial descriptions by Zoller et al.5 _{and on a more refined definition} proposed in a closed meeting organized by the Medicine for MalariaVenture(MMV)inMarch2013inVienna (http://www. mmv.org/sites/default/files/uploads/docs/events/2013/ InjectableArtesunateExpertGroupMeeting.pdf)6 _{and later} pub-lishedintheabovementionedpathophysiologicalpaper.4_Whereas initialreportswereacknowledgedinthearticlebyRehmanetal., theoptimizednosologicalclassificationwasnotreferencedinthe manuscript.Thisomissionis likely duetothedisclosurein the MMVreport(whichbecamepubliclyavailablein2013)ofthethen unpublished, optimized case definition proposed by ourgroup, withoutprecisereferencingofthesourceofthatparticularsetof information. Sharing unpublished results or concepts during subject-specific meetings, like the one efficiently organized by MMVinVienna,isimportantasitallowsthemalariacommunityto adaptrapidlyandefficientlytonewproblemswithapublichealth impact.Whenreportsofsuchmeetingscarefullyacknowledgeall respectivecontributions,thisultimatelycontributesto maintain-ingrichexchangesbetweenattendees.

References

1.RehmanK,LotschF,KremsnerPG,RamharterM.Haemolysisassociatedwiththe treatment of malariawith artemisinin derivatives:a systematic review of currentevidence.Internationaljournalofinfectiousdiseases:IJID:official publica-tionoftheInternationalSocietyforInfectiousDiseases2014;29C:268–73.

2.BuffetPA,SafeukuiI,DeplaineG,BrousseV,PrendkiV,ThellierM,etal.The pathogenesis of Plasmodium falciparummalariain humans: insights from splenicphysiology.Blood2011;117:381–92.

3.DondorpA,NostenF,StepniewskaK,DayN,WhiteN.Artesunateversusquinine fortreatmentofseverefalciparummalaria:arandomisedtrial.Lancet2005;366: 717–25.

4.Jaureguiberry S, NdourPA,RousselC, AderF, SafeukuiI, NguyenM,etal. Postartesunatedelayedhemolysisisapredictableeventrelatedtothelifesaving effectofartemisinins.Blood2014;124:167–75.

5.Zoller T,JunghanssT,KapaunA,GjorupI,RichterJ,Hugo-PerssonM,etal. Intravenousartesunateforseveremalariaintravelers,Europe.EmergInfectDis 2011;17:771–7.

6.MMV.ExpertsGroupMeetingondelayedanaemiafollowingtreatmentwith injectable artesunate,WienAustria.http://www.mmv.org/sites/default/files/ uploads/docs/events/2013/InjectableArtesunateExpertGroupMeeting.pdf;2013.

Ste´phaneJaure´guiberrya,b,c,* PapaAliouneNdourb MarcThellierb,c,d EricCaumesa PierreBuffetb,c,d

a_{AP-HP,HoˆpitalPitie´-Salpeˆtrie`re,Servicedesmaladiesinfectieuseset}

me´decinetropicale,Paris,F-75013,France

b_{Centred’ImmunologieetdesMaladiesInfectieusesdeParis,}

CIMI-PARIS,U1135INSERM/UPMCUniversite´ ParisVI,ParisF-75005, France

c

CentreNationaldeRe´fe´renceduPaludisme-sitePitie´ Salpetrie`re, Paris,F-75013,France

d_{AP-HP,HoˆpitalPitie´-Salpeˆtrie`re,Servicedeparasitologie-mycologie,}

Paris,F-75013,France

*Correspondingauthor. E-mailaddress:[email protected] (S.Jaure´guiberry).

Received19December2014 Accepted25December2014

InternationalJournalofInfectiousDiseases33(2015)89

ContentslistsavailableatScienceDirect

International

Journal

of

Infectious

Diseases

j o urn a l hom e pa ge : ww w. e l s e v i e r. c om/ l o ca t e / i j i d

http://dx.doi.org/10.1016/j.ijid.2014.12.048

1201-9712/ß2015TheAuthors.PublishedbyElsevierLtdonbehalfofInternationalSocietyforInfectiousDiseases.ThisisanopenaccessarticleundertheCCBY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).