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HAL Id: tel-02387347

https://tel.archives-ouvertes.fr/tel-02387347

Submitted on 29 Nov 2019

HAL is a multi-disciplinary open access

archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.

L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

Le rôle des cellules myéloïdes et microARNs dans

l’arthrite juvénile

Nadege Nziza

To cite this version:

Nadege Nziza. Le rôle des cellules myéloïdes et microARNs dans l’arthrite juvénile. Médecine humaine et pathologie. Université Montpellier, 2019. Français. �NNT : 2019MONTT014�. �tel-02387347�

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! "! !

! !

THESE POUR OBTENIR LE GRADE DE DOCTEUR

DE L’UNIVERSITE DE MONTPELLIER

En Biologie-Santé

École doctorale Sciences Chimiques et Biologiques pour la Santé (CBS2)

Unité de recherche INSERM U1183

Présentée par Nadège NZIZA

Le 27 juin 2019

Sous la direction de Florence APPARAILLY et Eric JEZIORSKI Responsable scientifique Arthritis R&D : Yosra MESSAI

Devant le jury composé de

Eric SOLARY, PU-PH, INSERM Rozen LE PANSE, DR, CNRS Alexandre BELOT, PU-PH, CHU Florence APPARAILLY, DR, INSERM Eric JEZIORSKI, MCU-PH, INSERM Isabelle Duroux-Richard, IR, INSERM

Président Rapporteur Rapporteur Directrice de thèse Co-directeur de thèse Invitée !

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(25)

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(26)

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(27)

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(28)

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Figure

Fig. 1 Stratification of patients with JIA and SA and differences in monocyte and DC counts A)  Heatmap of log2 transformed cell counts in peripheral blood (red names) and synovial fluid (black  names) by multi-parametric flow cytometry

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