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Characterization and modeling of Ca2 + oscillations in mouse primary mesothelial cells

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Academic year: 2022

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time (min) time (sec) INF cCYT cytdep EREFF+LEA ERdep cER EFF Serca [InsP3] ri2 rimax µ time (min) observation

0 0 0.01 110 1.12991 1.63778 0.25788 260000 0 0.77 0.015 703.689 3.02063 2.18163 0 111.573

0.00167 0.1 0.01 110.878 1.18524 1.60826 0.17302 259609 0.00492 0.7937 0.015 703.689 3.02063 2.18163 0.05 111.814

0.00333 0.2 0.01 111.697 1.23762 1.58086 0.09324 259243 0.01886 0.81583 0.015 703.689 3.02063 2.18163 0.1 109.586

0.005 0.3 0.01 112.454 1.28647 1.55469 0.01822 258899 0.03171 0.83625 0.015 703.689 3.02063 2.18163 0.15 110.77

0.00667 0.4 0.01 113.15 1.33188 1.52955 -0.05233 258575 0.04356 0.85506 0.015 703.689 3.02063 2.18163 0.2 111.906

0.00833 0.5 0.01 113.791 1.37394 1.50531 -0.11864 258272 0.05445 0.87236 0.015 703.689 3.02063 2.18163 0.25 111.378

0.01 0.6 0.01 114.38 1.41277 1.48184 -0.18094 257987 0.06446 0.88825 0.015 703.689 3.02063 2.18163 0.3 110.862

0.01167 0.7 0.01 114.919 1.44849 1.45907 -0.23942 257720 0.07362 0.90281 0.015 703.689 3.02063 2.18163 0.35 112.216

0.01333 0.8 0.01 115.412 1.48123 1.43695 -0.29428 257470 0.082 0.91611 0.015 703.689 3.02063 2.18163 0.4 111.779

0.015 0.9 0.01 115.86 1.51113 1.41543 -0.3457 257235 0.08963 0.92823 0.015 703.689 3.02063 2.18163 0.45 112.224

0.01667 1 0.01 116.268 1.53832 1.39448 -0.39384 257016 0.09655 0.93923 0.015 703.689 3.02063 2.18163 0.5 112.211

0.01833 1.1 0.01 116.637 1.56294 1.37408 -0.43886 256811 0.10282 0.94919 0.015 703.689 3.02063 2.18163 0.55 110.916

0.02 1.2 0.01 116.969 1.58513 1.35422 -0.48091 256620 0.10847 0.95815 0.015 703.689 3.02063 2.18163 0.6 111.576

0.02167 1.3 0.01 117.266 1.60502 1.33488 -0.52014 256442 0.11353 0.96619 0.015 703.689 3.02063 2.18163 0.65 112.053

0.02333 1.4 0.01 117.531 1.62275 1.31607 -0.55667 256276 0.11803 0.97335 0.015 703.689 3.02063 2.18163 0.7 110.001

0.025 1.5 0.01 117.766 1.63843 1.29777 -0.59066 256122 0.12202 0.97969 0.015 703.689 3.02063 2.18163 0.75 111.449

0.02667 1.6 0.01 117.972 1.6522 1.27998 -0.62222 255978 0.12553 0.98525 0.015 703.689 3.02063 2.18163 0.8 109.503

0.02833 1.7 0.01 118.151 1.66417 1.26269 -0.65148 255846 0.12857 0.99009 0.015 703.689 3.02063 2.18163 0.85 112.488

0.03 1.8 0.01 118.305 1.67446 1.2459 -0.67856 255723 0.13119 0.99425 0.015 703.689 3.02063 2.18163 0.9 112.018

0.03167 1.9 0.01 118.436 1.68317 1.2296 -0.70357 255610 0.13341 0.99777 0.015 703.689 3.02063 2.18163 0.95 114.871

0.03333 2 0.01 118.544 1.6904 1.21379 -0.72661 255506 0.13525 1.0007 0.015 703.689 3.02063 2.18163 1 113.414

0.035 2.1 0.01 118.632 1.69627 1.19846 -0.74781 255410 0.13675 1.00307 0.015 703.689 3.02063 2.18163 1.05 115.525

0.03667 2.2 0.01 118.701 1.70084 1.1836 -0.76725 255322 0.13791 1.00492 0.015 703.689 3.02063 2.18163 1.1 242.28

0.03833 2.3 0.01 118.752 1.70423 1.1692 -0.78503 255241 0.13878 1.00629 0.015 703.689 3.02063 2.18163 1.15 241.995

0.04 2.4 0.01 118.786 1.70651 1.15526 -0.80125 255168 0.13936 1.00721 0.015 703.689 3.02063 2.18163 1.2 242.206

0.04167 2.5 0.01 118.804 1.70775 1.14176 -0.81599 255101 0.13967 1.00772 0.015 703.689 3.02063 2.18163 1.25 240.819

0.04333 2.6 0.01 118.809 1.70804 1.1287 -0.82934 255041 0.13975 1.00784 0.015 703.689 3.02063 2.18163 1.3 239.378

0.045 2.7 0.01 118.8 1.70745 1.11607 -0.84138 254987 0.1396 1.0076 0.015 703.689 3.02063 2.18163 1.35 236.789

0.04667 2.8 0.01 118.779 1.70604 1.10385 -0.85219 254938 0.13924 1.00703 0.015 703.689 3.02063 2.18163 1.4 232.81

0.04833 2.9 0.01 118.746 1.70388 1.09204 -0.86184 254894 0.13869 1.00615 0.015 703.689 3.02063 2.18163 1.45 220.182

0.05 3 0.01 118.704 1.70103 1.08062 -0.8704 254856 0.13796 1.005 0.015 703.689 3.02063 2.18163 1.5 181.773

0.05167 3.1 0.01 118.651 1.69754 1.06959 -0.87794 254822 0.13707 1.00358 0.015 703.689 3.02063 2.18163 1.55 146.213

0.05333 3.2 0.01 118.59 1.69346 1.05894 -0.88452 254792 0.13603 1.00193 0.015 703.689 3.02063 2.18163 1.6 128.403

0.055 3.3 0.01 118.521 1.68886 1.04865 -0.89021 254766 0.13486 1.00007 0.015 703.689 3.02063 2.18163 1.65 119.244

0.05667 3.4 0.01 118.445 1.68377 1.03871 -0.89505 254744 0.13356 0.99801 0.015 703.689 3.02063 2.18163 1.7 114.299

0.05833 3.5 0.01 118.362 1.67823 1.02912 -0.89911 254726 0.13215 0.99577 0.015 703.689 3.02063 2.18163 1.75 112.579

0.06 3.6 0.01 118.273 1.6723 1.01987 -0.90244 254711 0.13064 0.99338 0.015 703.689 3.02063 2.18163 1.8 114.222

0.06167 3.7 0.01 118.179 1.66602 1.01094 -0.90508 254699 0.12904 0.99083 0.015 703.689 3.02063 2.18163 1.85 113.699

0.06333 3.8 0.01 118.08 1.65941 1.00232 -0.90709 254690 0.12736 0.98816 0.015 703.689 3.02063 2.18163 1.9 112.514

0.065 3.9 0.01 117.977 1.65251 0.99401 -0.9085 254684 0.12561 0.98538 0.015 703.689 3.02063 2.18163 1.95 115.533

0.06667 4 0.01 117.87 1.64537 0.98601 -0.90936 254680 0.12379 0.98249 0.015 703.689 3.02063 2.18163 2 118.118

0.06833 4.1 0.01 117.76 1.638 0.97829 -0.90971 254678 0.12191 0.97951 0.015 703.689 3.02063 2.18163 2.05 129.97

0.07 4.2 0.01 117.646 1.63043 0.97085 -0.90959 254679 0.11999 0.97646 0.015 703.689 3.02063 2.18163 2.1 211.503

0.07167 4.3 0.01 117.531 1.62271 0.96368 -0.90903 254681 0.11803 0.97333 0.015 703.689 3.02063 2.18163 2.15 231.994

0.07333 4.4 0.01 117.413 1.61484 0.95678 -0.90807 254686 0.11602 0.97016 0.015 703.689 3.02063 2.18163 2.2 229.03

0.075 4.5 0.01 117.294 1.60686 0.95013 -0.90673 254692 0.11399 0.96693 0.015 703.689 3.02063 2.18163 2.25 198.51

0.07667 4.6 0.01 117.173 1.59878 0.94373 -0.90506 254699 0.11194 0.96367 0.015 703.689 3.02063 2.18163 2.3 149.526

0.07833 4.7 0.01 117.051 1.59064 0.93757 -0.90307 254708 0.10987 0.96038 0.015 703.689 3.02063 2.18163 2.35 121.221

0.08 4.8 0.01 116.928 1.58244 0.93165 -0.90079 254719 0.10778 0.95707 0.015 703.689 3.02063 2.18163 2.4 109.373

0.08167 4.9 0.01 116.805 1.5742 0.92595 -0.89826 254730 0.10569 0.95374 0.015 703.689 3.02063 2.18163 2.45 104.961

0.08333 5 0.01 116.682 1.56595 0.92047 -0.89548 254742 0.10359 0.95041 0.015 703.689 3.02063 2.18163 2.5 101.816

0.085 5.1 0.01 116.558 1.5577 0.9152 -0.8925 254756 0.10149 0.94707 0.015 703.689 3.02063 2.18163 2.55 102.489

0.08667 5.2 0.01 116.435 1.54946 0.91014 -0.88932 254770 0.09939 0.94374 0.015 703.689 3.02063 2.18163 2.6 102.451

0.08833 5.3 0.01 116.312 1.54125 0.90528 -0.88597 254785 0.0973 0.94042 0.015 703.689 3.02063 2.18163 2.65 101.282

0.09 5.4 0.01 116.189 1.53308 0.90061 -0.88247 254801 0.09522 0.93711 0.015 703.689 3.02063 2.18163 2.7 102.25

0.09167 5.5 0.01 116.068 1.52496 0.89613 -0.87883 254818 0.09315 0.93383 0.015 703.689 3.02063 2.18163 2.75 102.47

0.09333 5.6 0.01 115.947 1.5169 0.89183 -0.87507 254835 0.0911 0.93057 0.015 703.689 3.02063 2.18163 2.8 102.785

0.095 5.7 0.01 115.827 1.50891 0.8877 -0.87121 254852 0.08906 0.92733 0.015 703.689 3.02063 2.18163 2.85 101.645

0.09667 5.8 0.01 115.708 1.501 0.88374 -0.86726 254870 0.08704 0.92413 0.015 703.689 3.02063 2.18163 2.9 101.037

0.09833 5.9 0.01 115.591 1.49317 0.87994 -0.86323 254888 0.08505 0.92095 0.015 703.689 3.02063 2.18163 2.95 103.027

0.1 6 0.01 115.475 1.48545 0.8763 -0.85914 254906 0.08307 0.91782 0.015 703.689 3.02063 2.18163 3 103.441

0.10167 6.1 0.01 115.36 1.47782 0.87282 -0.855 254925 0.08112 0.91473 0.015 703.689 3.02063 2.18163 3.05 99.9534

0.10333 6.2 0.01 115.247 1.4703 0.86948 -0.85083 254944 0.0792 0.91168 0.015 703.689 3.02063 2.18163 3.1 98.3931

0.105 6.3 0.01 115.136 1.4629 0.86628 -0.84662 254963 0.07731 0.90867 0.015 703.689 3.02063 2.18163 3.15 103.142

0.10667 6.4 0.01 115.026 1.45561 0.86321 -0.8424 254982 0.07544 0.90571 0.015 703.689 3.02063 2.18163 3.2 110.944

0.10833 6.5 0.01 114.918 1.44845 0.86028 -0.83816 255001 0.07361 0.90279 0.015 703.689 3.02063 2.18163 3.25 232.777

0.11 6.6 0.01 114.812 1.44141 0.85748 -0.83393 255020 0.07181 0.89993 0.015 703.689 3.02063 2.18163 3.3 232.089

0.11167 6.7 0.01 114.708 1.43449 0.85479 -0.8297 255039 0.07003 0.89711 0.015 703.689 3.02063 2.18163 3.35 222.378

0.11333 6.8 0.01 114.605 1.42771 0.85223 -0.82549 255059 0.06829 0.89435 0.015 703.689 3.02063 2.18163 3.4 166.971

0.115 6.9 0.01 114.505 1.42106 0.84977 -0.82129 255077 0.06659 0.89164 0.015 703.689 3.02063 2.18163 3.45 114.728

0.11667 7 0.01 114.407 1.41455 0.84743 -0.81712 255096 0.06491 0.88898 0.015 703.689 3.02063 2.18163 3.5 106.838

0.11833 7.1 0.01 114.31 1.40817 0.84519 -0.81298 255115 0.06327 0.88637 0.015 703.689 3.02063 2.18163 3.55 102.729

0.12 7.2 0.01 114.216 1.40193 0.84305 -0.80888 255134 0.06167 0.88382 0.015 703.689 3.02063 2.18163 3.6 99.9641

0.12167 7.3 0.01 114.123 1.39583 0.84101 -0.80482 255152 0.0601 0.88133 0.015 703.689 3.02063 2.18163 3.65 98.1084

0.12333 7.4 0.01 114.033 1.38986 0.83905 -0.80081 255170 0.05856 0.87889 0.015 703.689 3.02063 2.18163 3.7 100.192

0.125 7.5 0.01 113.944 1.38403 0.83719 -0.79684 255188 0.05706 0.8765 0.015 703.689 3.02063 2.18163 3.75 98.3827

0.12667 7.6 0.01 113.858 1.37834 0.83542 -0.79293 255206 0.05559 0.87417 0.015 703.689 3.02063 2.18163 3.8 96.6685

0.12833 7.7 0.01 113.774 1.37279 0.83372 -0.78907 255223 0.05415 0.87189 0.015 703.689 3.02063 2.18163 3.85 95.8775

0.13 7.8 0.01 113.691 1.36738 0.83211 -0.78527 255240 0.05275 0.86967 0.015 703.689 3.02063 2.18163 3.9 99.2985

0.13167 7.9 0.01 113.611 1.3621 0.83056 -0.78153 255257 0.05139 0.8675 0.015 703.689 3.02063 2.18163 3.95 98.2906

0.13333 8 0.01 113.533 1.35695 0.8291 -0.77785 255274 0.05006 0.86538 0.015 703.689 3.02063 2.18163 4 99.7091

0.135 8.1 0.01 113.456 1.35194 0.8277 -0.77424 255290 0.04876 0.86332 0.015 703.689 3.02063 2.18163 4.05 100.021

0.13667 8.2 0.01 113.382 1.34706 0.82636 -0.7707 255306 0.04749 0.86132 0.015 703.689 3.02063 2.18163 4.1 95.4396

0.13833 8.3 0.01 113.31 1.34231 0.82509 -0.76722 255322 0.04626 0.85936 0.015 703.689 3.02063 2.18163 4.15 99.2495

0.14 8.4 0.01 113.239 1.33769 0.82388 -0.76381 255337 0.04506 0.85745 0.015 703.689 3.02063 2.18163 4.2 98.9321

0.14167 8.5 0.01 113.17 1.3332 0.82273 -0.76047 255352 0.0439 0.8556 0.015 703.689 3.02063 2.18163 4.25 100.294

0.14333 8.6 0.01 113.104 1.32883 0.82163 -0.7572 255367 0.04276 0.8538 0.015 703.689 3.02063 2.18163 4.3 101.129

0.145 8.7 0.01 113.039 1.32458 0.82059 -0.754 255382 0.04166 0.85205 0.015 703.689 3.02063 2.18163 4.35 100.111

0.14667 8.8 0.01 112.976 1.32046 0.81959 -0.75087 255396 0.04059 0.85034 0.015 703.689 3.02063 2.18163 4.4 98.986

0.14833 8.9 0.01 112.914 1.31646 0.81865 -0.74781 255410 0.03954 0.84869 0.015 703.689 3.02063 2.18163 4.45 98.7942

0.15 9 0.01 112.855 1.31257 0.81775 -0.74482 255423 0.03853 0.84708 0.015 703.689 3.02063 2.18163 4.5 97.5102

0.15167 9.1 0.01 112.797 1.3088 0.81689 -0.7419 255436 0.03755 0.84551 0.015 703.689 3.02063 2.18163 4.55 99.0547

0.15333 9.2 0.01 112.741 1.30514 0.81608 -0.73906 255449 0.03659 0.844 0.015 703.689 3.02063 2.18163 4.6 101.216

0.155 9.3 0.01 112.686 1.30159 0.81531 -0.73628 255462 0.03566 0.84253 0.015 703.689 3.02063 2.18163 4.65 103.032

0.15667 9.4 0.01 112.633 1.29815 0.81457 -0.73358 255474 0.03477 0.8411 0.015 703.689 3.02063 2.18163 4.7 100.634

0.15833 9.5 0.01 112.582 1.29481 0.81388 -0.73094 255486 0.03389 0.83971 0.015 703.689 3.02063 2.18163 4.75 97.6471

0.16 9.6 0.01 112.532 1.29158 0.81321 -0.72837 255498 0.03305 0.83837 0.015 703.689 3.02063 2.18163 4.8 103.3

0.16167 9.7 0.01 112.484 1.28845 0.81258 -0.72587 255509 0.03223 0.83707 0.015 703.689 3.02063 2.18163 4.85 224.124

0.16333 9.8 0.01 112.437 1.28542 0.81199 -0.72343 255520 0.03143 0.83581 0.015 703.689 3.02063 2.18163 4.9 226.611

0.165 9.9 0.01 112.392 1.28248 0.81142 -0.72106 255531 0.03067 0.83459 0.015 703.689 3.02063 2.18163 4.95 199.733

0.16667 10 0.01 112.348 1.27964 0.81088 -0.71876 255541 0.02992 0.8334 0.015 703.689 3.02063 2.18163 5 158.367

0.16833 10.1 0.01 112.306 1.27689 0.81037 -0.71652 255551 0.0292 0.83226 0.015 703.689 3.02063 2.18163 5.05 120.003

0.17 10.2 0.01 112.265 1.27423 0.80988 -0.71434 255561 0.0285 0.83115 0.015 703.689 3.02063 2.18163 5.1 107.963

0.17167 10.3 0.01 112.225 1.27165 0.80942 -0.71223 255571 0.02782 0.83007 0.015 703.689 3.02063 2.18163 5.15 100.13

0.17333 10.4 0.01 112.186 1.26916 0.80898 -0.71018 255580 0.02717 0.82903 0.015 703.689 3.02063 2.18163 5.2 98.4767

0.175 10.5 0.01 112.149 1.26675 0.80857 -0.70818 255589 0.02654 0.82803 0.015 703.689 3.02063 2.18163 5.25 99.1013

0.17667 10.6 0.01 112.113 1.26443 0.80818 -0.70625 255598 0.02593 0.82706 0.015 703.689 3.02063 2.18163 5.3 97.4657

0.17833 10.7 0.01 112.078 1.26218 0.8078 -0.70437 255606 0.02533 0.82612 0.015 703.689 3.02063 2.18163 5.35 98.2708

0.18 10.8 0.01 112.045 1.26 0.80745 -0.70255 255614 0.02476 0.82521 0.015 703.689 3.02063 2.18163 5.4 99.2428

0.18167 10.9 0.01 112.012 1.2579 0.80712 -0.70079 255622 0.02421 0.82433 0.015 703.689 3.02063 2.18163 5.45 96.3029

0.18333 11 0.01 111.981 1.25587 0.8068 -0.69908 255630 0.02367 0.82348 0.015 703.689 3.02063 2.18163 5.5 97.1106

0.185 11.1 0.01 111.95 1.25392 0.8065 -0.69742 255638 0.02316 0.82266 0.015 703.689 3.02063 2.18163 5.55 96.0458

0.18667 11.2 0.01 111.921 1.25202 0.80621 -0.69581 255645 0.02266 0.82187 0.015 703.689 3.02063 2.18163 5.6 98.585

0.18833 11.3 0.01 111.893 1.2502 0.80594 -0.69426 255652 0.02218 0.82111 0.015 703.689 3.02063 2.18163 5.65 97.8204

0.19 11.4 0.01 111.866 1.24844 0.80569 -0.69275 255659 0.02171 0.82037 0.015 703.689 3.02063 2.18163 5.7 99.0656

0.19167 11.5 0.01 111.839 1.24674 0.80545 -0.69129 255665 0.02126 0.81966 0.015 703.689 3.02063 2.18163 5.75 99.3814

0.19333 11.6 0.01 111.814 1.2451 0.80522 -0.68988 255672 0.02083 0.81897 0.015 703.689 3.02063 2.18163 5.8 101.228

0.195 11.7 0.01 111.789 1.24351 0.805 -0.68851 255678 0.02041 0.8183 0.015 703.689 3.02063 2.18163 5.85 95.7788

0.19667 11.8 0.01 111.765 1.24199 0.8048 -0.68719 255684 0.02001 0.81766 0.015 703.689 3.02063 2.18163 5.9 100.597

0.19833 11.9 0.01 111.742 1.24052 0.8046 -0.68591 255690 0.01962 0.81705 0.015 703.689 3.02063 2.18163 5.95 98.7223

0.2 12 0.01 111.72 1.2391 0.80442 -0.68468 255695 0.01925 0.81645 0.015 703.689 3.02063 2.18163 6 98.7759

0.20167 12.1 0.01 111.699 1.23773 0.80425 -0.68348 255701 0.01889 0.81588 0.015 703.689 3.02063 2.18163 6.05 97.5793

0.20333 12.2 0.01 111.679 1.23641 0.80409 -0.68232 255706 0.01854 0.81532 0.015 703.689 3.02063 2.18163 6.1 97.3298

0.205 12.3 0.01 111.659 1.23514 0.80393 -0.68121 255711 0.0182 0.81479 0.015 703.689 3.02063 2.18163 6.15 100.89

0.20667 12.4 0.01 111.64 1.23392 0.80379 -0.68013 255716 0.01788 0.81427 0.015 703.689 3.02063 2.18163 6.2 101.305

0.20833 12.5 0.01 111.621 1.23274 0.80365 -0.67909 255721 0.01756 0.81378 0.015 703.689 3.02063 2.18163 6.25 100.311

0.21 12.6 0.01 111.604 1.2316 0.80352 -0.67808 255725 0.01726 0.8133 0.015 703.689 3.02063 2.18163 6.3 168.105

0.21167 12.7 0.01 111.587 1.23051 0.8034 -0.67711 255730 0.01697 0.81284 0.015 703.689 3.02063 2.18163 6.35 229.937

0.21333 12.8 0.01 111.57 1.22945 0.80328 -0.67617 255734 0.01669 0.8124 0.015 703.689 3.02063 2.18163 6.4 220.185

0.215 12.9 0.01 111.554 1.22844 0.80317 -0.67527 255738 0.01643 0.81197 0.015 703.689 3.02063 2.18163 6.45 189.36

0.21667 13 0.01 111.539 1.22746 0.80307 -0.67439 255742 0.01617 0.81156 0.015 703.689 3.02063 2.18163 6.5 140.624

0.21833 13.1 0.01 111.525 1.22652 0.80297 -0.67355 255746 0.01592 0.81116 0.015 703.689 3.02063 2.18163 6.55 118.318

0.22 13.2 0.01 111.51 1.22562 0.80288 -0.67273 255750 0.01568 0.81078 0.015 703.689 3.02063 2.18163 6.6 102.546

0.22167 13.3 0.01 111.497 1.22475 0.8028 -0.67195 255753 0.01545 0.81042 0.015 703.689 3.02063 2.18163 6.65 100.503

0.22333 13.4 0.01 111.484 1.22391 0.80272 -0.67119 255756 0.01523 0.81006 0.015 703.689 3.02063 2.18163 6.7 98.4587

0.225 13.5 0.01 111.471 1.2231 0.80264 -0.67046 255760 0.01501 0.80972 0.015 703.689 3.02063 2.18163 6.75 98.1806

0.22667 13.6 0.01 111.459 1.22233 0.80257 -0.66976 255763 0.01481 0.8094 0.015 703.689 3.02063 2.18163 6.8 98.7539

0.22833 13.7 0.01 111.448 1.22158 0.8025 -0.66908 255766 0.01461 0.80908 0.015 703.689 3.02063 2.18163 6.85 97.603

0.23 13.8 0.01 111.436 1.22087 0.80244 -0.66843 255769 0.01442 0.80878 0.015 703.689 3.02063 2.18163 6.9 96.6621

0.23167 13.9 0.01 111.426 1.22018 0.80238 -0.6678 255772 0.01423 0.80849 0.015 703.689 3.02063 2.18163 6.95 98.655

0.23333 14 0.01 111.415 1.21952 0.80232 -0.66719 255775 0.01406 0.80821 0.015 703.689 3.02063 2.18163 7 97.2961

0.235 14.1 0.01 111.405 1.21888 0.80227 -0.66661 255777 0.01389 0.80794 0.015 703.689 3.02063 2.18163 7.05 95.8216

0.23667 14.2 0.01 111.396 1.21827 0.80222 -0.66604 255780 0.01373 0.80768 0.015 703.689 3.02063 2.18163 7.1 98.1858

0.23833 14.3 0.01 111.387 1.21768 0.80218 -0.6655 255782 0.01357 0.80744 0.015 703.689 3.02063 2.18163 7.15002 97.8731

0.24 14.4 0.01 111.378 1.21711 0.80214 -0.66498 255785 0.01342 0.8072 0.015 703.689 3.02063 2.18163 7.20002 99.2209

0.24167 14.5 0.01 111.369 1.21657 0.8021 -0.66448 255787 0.01328 0.80697 0.015 703.689 3.02063 2.18163 7.25002 96.087

0.24333 14.6 0.01 111.361 1.21605 0.80206 -0.66399 255789 0.01314 0.80675 0.015 703.689 3.02063 2.18163 7.30002 100.626

0.245 14.7 0.01 111.353 1.21555 0.80202 -0.66353 255791 0.01301 0.80654 0.015 703.689 3.02063 2.18163 7.35002 97.0124

0.24667 14.8 0.01 111.346 1.21507 0.80199 -0.66308 255793 0.01288 0.80633 0.015 703.689 3.02063 2.18163 7.40002 101.713

0.24833 14.9 0.01 111.339 1.21461 0.80196 -0.66265 255795 0.01275 0.80614 0.015 703.689 3.02063 2.18163 7.45002 96.1493

0.25 15 0.01 111.332 1.21416 0.80193 -0.66223 255797 0.01264 0.80595 0.015 703.689 3.02063 2.18163 7.50002 97.3299

0.25167 15.1 0.01 111.325 1.21374 0.80191 -0.66183 255799 0.01252 0.80577 0.015 703.689 3.02063 2.18163 7.55002 103.024

0.25333 15.2 0.01 111.319 1.21333 0.80188 -0.66145 255801 0.01241 0.8056 0.015 703.689 3.02063 2.18163 7.60002 99.124

0.255 15.3 0.01 111.312 1.21294 0.80186 -0.66108 255802 0.01231 0.80543 0.015 703.689 3.02063 2.18163 7.65002 104.156

0.25667 15.4 0.01 111.307 1.21256 0.80184 -0.66072 255804 0.01221 0.80528 0.015 703.689 3.02063 2.18163 7.70002 101.102

0.25833 15.5 0.01 111.301 1.2122 0.80182 -0.66038 255805 0.01211 0.80512 0.015 703.689 3.02063 2.18163 7.75002 99.1911

0.26 15.6 0.01 111.295 1.21185 0.8018 -0.66005 255807 0.01202 0.80498 0.015 703.689 3.02063 2.18163 7.80002 99.8838

0.26167 15.7 0.01 111.29 1.21152 0.80178 -0.65974 255808 0.01193 0.80484 0.015 703.689 3.02063 2.18163 7.85002 102.907

0.26333 15.8 0.01 111.285 1.2112 0.80177 -0.65943 255810 0.01185 0.8047 0.015 703.689 3.02063 2.18163 7.90002 196.619

0.265 15.9 0.01 111.28 1.2109 0.80175 -0.65914 255811 0.01177 0.80457 0.015 703.689 3.02063 2.18163 7.95002 226.971

0.26667 16 0.01 111.276 1.2106 0.80174 -0.65886 255812 0.01169 0.80445 0.015 703.689 3.02063 2.18163 8.00002 209.594

0.26833 16.1 0.01 111.271 1.21032 0.80173 -0.65859 255814 0.01162 0.80433 0.015 703.689 3.02063 2.18163 8.05002 182.426

0.27 16.2 0.01 111.267 1.21005 0.80172 -0.65834 255815 0.01154 0.80422 0.015 703.689 3.02063 2.18163 8.10002 148.838

0.27167 16.3 0.01 111.263 1.20979 0.80171 -0.65809 255816 0.01147 0.80411 0.015 703.689 3.02063 2.18163 8.15002 123.651

0.27333 16.4 0.01 111.259 1.20955 0.8017 -0.65785 255817 0.01141 0.804 0.015 703.689 3.02063 2.18163 8.20002 108.166

0.275 16.5 0.01 111.256 1.20931 0.80169 -0.65762 255818 0.01135 0.8039 0.015 703.689 3.02063 2.18163 8.25002 98.8231

0.27667 16.6 0.01 111.252 1.20908 0.80168 -0.6574 255819 0.01129 0.80381 0.015 703.689 3.02063 2.18163 8.30002 98.7761

0.27833 16.7 0.01 111.249 1.20886 0.80168 -0.65719 255820 0.01123 0.80371 0.015 703.689 3.02063 2.18163 8.35002 100.308

0.28 16.8 0.01 111.245 1.20866 0.80167 -0.65699 255821 0.01117 0.80363 0.015 703.689 3.02063 2.18163 8.40002 96.7745

0.28167 16.9 0.01 111.242 1.20846 0.80166 -0.65679 255822 0.01112 0.80354 0.015 703.689 3.02063 2.18163 8.45002 98.6737

0.28333 17 0.01 111.239 1.20826 0.80166 -0.65661 255823 0.01107 0.80346 0.015 703.689 3.02063 2.18163 8.50002 99.021

0.285 17.1 0.01 111.236 1.20808 0.80165 -0.65643 255823 0.01102 0.80338 0.015 703.689 3.02063 2.18163 8.55002 100.579

0.28667 17.2 0.01 111.234 1.20791 0.80165 -0.65626 255824 0.01097 0.80331 0.015 703.689 3.02063 2.18163 8.60002 98.5024

0.28833 17.3 0.01 111.231 1.20774 0.80165 -0.65609 255825 0.01093 0.80324 0.015 703.689 3.02063 2.18163 8.65002 99.5992

0.29 17.4 0.01 111.229 1.20758 0.80164 -0.65593 255826 0.01088 0.80317 0.015 703.689 3.02063 2.18163 8.70002 100.03

0.29167 17.5 0.01 111.226 1.20742 0.80164 -0.65578 255826 0.01084 0.8031 0.015 703.689 3.02063 2.18163 8.75002 98.7076

0.29333 17.6 0.01 111.224 1.20728 0.80164 -0.65564 255827 0.0108 0.80304 0.015 703.689 3.02063 2.18163 8.80002 100.448

0.295 17.7 0.01 111.222 1.20714 0.80164 -0.6555 255828 0.01077 0.80298 0.015 703.689 3.02063 2.18163 8.85002 101.394

0.29667 17.8 0.01 111.219 1.207 0.80164 -0.65536 255828 0.01073 0.80293 0.015 703.689 3.02063 2.18163 8.90002 98.0253

0.29833 17.9 0.01 111.217 1.20687 0.80164 -0.65524 255829 0.0107 0.80287 0.015 703.689 3.02063 2.18163 8.95002 97.9353

0.3 18 0.01 111.216 1.20675 0.80164 -0.65511 255829 0.01066 0.80282 0.015 703.689 3.02063 2.18163 9.00002 100.611

0.30167 18.1 0.01 111.214 1.20663 0.80164 -0.655 255830 0.01063 0.80277 0.015 703.689 3.02063 2.18163 9.05002 101.037

0.30333 18.2 0.01 111.212 1.20652 0.80164 -0.65488 255830 0.0106 0.80272 0.015 703.689 3.02063 2.18163 9.10002 99.2788

0.305 18.3 0.01 111.21 1.20641 0.80164 -0.65477 255831 0.01057 0.80268 0.015 703.689 3.02063 2.18163 9.15002 102.226

0 50000 100000 150000 200000 250000 300000

125951777510331291154918072065232325812839309733553613387141294387464549035161541956775935619364516709696772257483774179998257 85158773

cER

cER 0

50 100 150 200 250 300

1221441661881110113211541176119812201242126412861308133013521374139614181440146214841506152815501572159416161638166016821704172617481770179218141836185818801

cCYT

0 50 100 150 200 250 300

-1 1 3 5 7 9 11 13 15

observation

0 0.1 0.2 0.3 0.4 0.5 0.6

1377753112915051881225726333009338537614137451348895265564160176393676971457521789782738649

INF

INF

0 0.2 0.4 0.6 0.81 1.2 1.4 1.6 1.8 2

139378511771569196123532745313735293921431347055097548958816273666570577449784182338625

[InsP3]

[InsP3]

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