The STATus of STAT3 in Lung Cell Senescence?

HAL Id: hal-02323493

https://hal.archives-ouvertes.fr/hal-02323493

Submitted on 17 Nov 2020

HAL is a multi-disciplinary open access

archive for the deposit and dissemination of

sci-entific research documents, whether they are

pub-lished or not. The documents may come from

teaching and research institutions in France or

abroad, or from public or private research centers.

L’archive ouverte pluridisciplinaire HAL, est

destinée au dépôt et à la diffusion de documents

scientifiques de niveau recherche, publiés ou non,

émanant des établissements d’enseignement et de

recherche français ou étrangers, des laboratoires

publics ou privés.

The STATus of STAT3 in Lung Cell Senescence?

Serge Adnot, Larissa Lipskaia, David Bernard

To cite this version:

Serge Adnot, Larissa Lipskaia, David Bernard. The STATus of STAT3 in Lung Cell Senescence?.

American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2019, 61

(1), pp.5-6. �10.1165/rcmb.2019-0013ED�. �hal-02323493�

0123452678

99 99 9





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`OBPB/!0+.11'!* (3 '*%()" " !*5,*%!0 '0)!'!$ ##.(),/#(!! %(,,5 % '/!* &!*&%$'#$('*,,$%)'!)*%(.(!,(6<a;?B0. 

-%*+%!*5'!)2!"5.+)"2 )!.*1'.!*-)%(3  *+!01'!* (3%"0* ,*%(?OBPB>)(#!%!'.!*/#(,)' ! %(' )/!)*%1'!* !0!'%'*$/#+)!0,$#!)/#'.!*-)%( %" *+!01'!* '/!* (3($'0(!0/<>a`@bF '/!* 3 2('$# %"*!0#)# *+!01'!* 3/#!#!&" )2" *+!0 1'!* 3%"c/ *!)%='*$/#" '/!* #)%"(6<a3<<;? O#'!)2^P_'!)2!)*%5.")11 %! '/!* (/ *"$'( ")11 %!ZL[Z[I11'!(?7*%(Y$%!#.3! !)%(/')4' '/!* $/(! , *1!0/!0+.6^P_* OBPB;,.02 ")11 %!11'!(3%*!5#.*%!0(%('%'/ * ,?B0 ,'0%)(,($/(! , *1OBPB>'!)2!)*%,$(!!0 1* 5 )%2(!)!")%")11 %!#$%&'##!./()%45 *!)'#$%!)(($( 1 *, 0$,%/!)%!(%"/ ),%!#%),#(? !%()2^P_`OBPB/!0+.(!$")()%)%02 ",*%(! !"!0!!0)(/!0+./#.(,d* *#)% $#!)% '.!*-)%/ *"$'!)*%(/ !*1!0(%('%'&((*')!" (' !* ./0%*!./6OPO9;?9 2)*$((!$")((!5#)(0"!0! ^P_'!)2!)*%,")!(!0OPO9)%")/*('##("$ )%)% 6<S;?^P_<`S)%0)5)!* ( "$'")%A,,!)*%%"##2)!" 1 )#!.)%",)'6<S;?e%!)#%*+3!0( '01* ,%(*1 5#*'-)%!0^P_`OBPB/!0+.0(1*'$("*%^P_5'$( (#'!)2%"%*%(#'!)2^P_<`S)%0)5)!* ( 2)#5#%" $("'#)%)'##.6<a;?R 3E! (%"'*##$((0*+!0! ! !)%OBPB>3)%"")!)*%!*)%0)5)!)%' !)%OPO9 '*,/*%%!(3/ *!'!")%(!'##(%('%'6F;?B !)% ^P_<`S* OBPB>,.!0 1* / *"$'")11 %!11'!(? O$//* !1* !0)(/*(()5)#)!.'*,(1 *, !05)#)!.*1OBPB!* 5'!)2!"%*!*%#.5.^P_5$!#(*5.!0,)!*%&'!)2!" / *!)%-)%(/!0+.6<a;?f* *2 3/ 2)*$((!$". (0*+"!0!! %(1* ,)% *+!01'!* &T(!),$#!)*%*1 #$%45 *5#(!( ($#!")%OfP:S`OfP:>&"/%"%! /0*(/0* .#!)*%*1OBPB>6<>;?Q$ !0 ($//* !1* ") '!#. ! !)%OBPB>'%#(*51*$%")%!0!(!$".3+0)'0(0*+" !0!!0(,##&,*#'$#OBPB>)%0)5)!* 7&<VV&]"' (" /$#,*% .45 *()()%!0,*$(5#*,.')%,*"#6<>;? f* *2 3OBPB>0(5%(0*+%!*'*%! )5$!!*/$#,*% . 45 *()(!0 *$0/)!0#)#)%d$ .%"45 *5#(!=,.*45 *5#(! ")11 %!)!)*%3(+##(!*/)!0#)#'##")11 %!)!)*% 6<>3<C;? P%*!0 )(($ )("5.!0(4%")%()(+0!0 OBPB> '!)2!)*%)( #2%!*%#.!*!0#$%&'##(%('%'/ * , )%2*#2")%!0/!0*%()(*1@9Q* #(*/#.( *#)%*!0 #$% ")(((($'0(789:%",/0.(,?P'$(# #!)*%(0)/ 5!+%'##(%('%'%"!0#$%,%)1(!!)*%(*1#$%45 *()( * 789:0(5%4 ,#.(!5#)(0"5. /* !(!0!)%")2)"$#( ' .)%!#*, (BgB%,$!!)*%"2#*/)!0 #$% 45 *()(* #$%,/0.(,3* 5*!06<D3<F;?R*+2 3!0 (*%( $%" #.)%!0")11 %'(,*%!0(")((/0%*!./(  $%-%*+%?B0.,. #!!*!0'##!./()%2*#2"3")11 %'(

hijklmnjopqjkrsqtlooqkkltuujknmjvwnquwtuqmniqnqmxkryniqzmqlnj{qzrxxrtk|nnmjvwnjrt}rt~zrxxqmojlp}rqmj{lnj{qk€joqtkq‚ƒ „inns…††omqlnj{qorxxrtk‚rm‡†pjoqtkqk†vˆ~to~tu†‚ƒ†‰‚Šrmorxxqmojlpwkl‡qltumqsmjtnkspqlkqortnlonjltq‹qmt„u‡qmtŒnirmlojo‚rm‡‰‚

0123445631362312378986 986732029432486313623123 321066789936732024179490361012836301 678309643916830141689 70316 0 ! 49068943619013603"#$%&983938 7200916'3318379830119174918 358343063636"#(% 6 0310209196386014017601943 012344563136231237898601) *1 !0683141333 9'338138619631362312344629180'39363 06363619'3383139432488369883833 387036+

,-./012345604-17489:8;8<=8>=:?<@A@A:@:B@CD@A<E89@<F=:8@ ???G8@EHCI9J8=EGC9KG

LMNOMPQRSTUVWXWUYZWXW [\N]^^\[]_^`\]\UYZWXW abcdef ghii jklmnmopqrkstum

vlmwsknmxmtnymz{|}o~p~om€dwp~ksno~t}r~tuno~ttmppm} v‚g€ƒ„…†q‚‡~wonsp‚mtkof~ty~k jklmnmopqrkstum \RQ gtoˆmk}onlmzsko}€d}njklmnmop jklmnmopqrkstum X\‰]QŠMNR\NQUYZWXW

gfeabcdef g‹ŒiŽjbeci gtoˆmk}onlmym‘|~t’jmtnkm‘lm~t†lmksky ‘|~tqrkstum

“7”717•574

–WP—QMN˜™UšZMR˜˜U[\R›\^TMN[UX\RSœœLULLšUšSO\R˜XUmnspW LZSNTTM—SžMNM^\NM\N]^`œ\›TSNœSN]Q]S_\TZ]›_—žSR\NŸ ¡NS^]^W zk~ubsnpƒusycuogcƒ¢££¤¥–£¦§–¨£¦–©–¨£¦ªW

¢WPQRSTLUPž^M——Mž «UŠSŸMN[UV\N›S^¬UL\`MNVU­S^^\]R]PU mnspW®M—SžMNMQŸ^œR›T]SR\RQ›M——^MRM^›MR›M]R›ZNSR]›—RO Q]^M\^M^§TZMN\_MT]›_STMRT]\—Wz{skxsu~p„{mk¢£–¦¥–¦¨§ –¢¦©–¨¯W ¨W™ž\NVULMMOMN°U«S^±]R›`M—²WLMRM^›MR›M³\^^S›]\TMQ ^M›NMTSNŸ_ZMRSTŸ_M\RQ]T^_S^^]¡—MNS—M]R›ZNSR]›S¡^TN›T]‰M _—žSR\NŸQ]^M\^MWƒx ´em}wokjmppf~p†o~p¢£–¯¥¦–§¨¢¨© ¨¨¨W

¯WL›Z\œMNV˜U°Z]TM®PUµ]¶]ž\™U­\\`P˜U[]ONM^T]·UPT`]R^SR¬˜U mnspWšM———\N^MRM^›MR›MžMQ]\TM^ ¡NST]›_—žSR\NŸQ]^M\^MW bsnj~xx¸t¢£–¹¥¤§–¯¦¨¢W

¦W­S^^\]R]PUŠNM\VU™M¡M™UP¡]QLUV\N›S^¬U[]_^`\]\[UmnspWž®º² _\TZ±\Ÿ\›T]‰\T]SRQN]‰M^—RO›M——^MRM^›MR›M\RQMž_ZŸ^Mž\W´ja at}o{n¢£–¤¥¨§_]]§»¨¢£¨W

ªW°\TMN^X°UŠ—S`—\RQ™¬šUY\TZ]R\Ÿ\`MYLU°M][UL›Z—]O\VU˜\œœ\N˜U mnspWL®P®¨NMO—\TM^TZMSR^MTSœS¼]Q\RT³]RQ›MQ^MRM^›MR›M]R —RO ¡NS¡—\^T^Wƒx ´em}wokjmppf~p†o~p¢£–»¥ª–§ª–©¹¨W ¹WYM›Z`S‰^`ŸX«UYN½M—MšVU°SRO˜U­SO\¡S\ž šVUV›PR—TŸ²˜U

[\NMRT·˜UmnspWL®P®¨³žMQ]\TMQ^]OR\—]ROQŸ^NMO—\TM^—RO  ¡NS¡—\^T³žŸS ¡NS¡—\^T\›T]‰\T]SR\RQQ]œœMNMRT]\T]SR]R¾µY¿µYÀWƒx´ zsn{~p¢£–¢¥–¤£§–¨»¤©–¯–¢W

¤WLS¡STT\VšU[]S°ULTÁS›`MNLU®\—±\NXUºMZ—MNVU²__MNT®UmnspW YMNS¼]NMQS¼]R³¢\RQL®P®¨œSNž\NMQS¼NM—\ŸœSN­¢º¢^]OR\—]ROWbsn j{mx †o~p¢£–¦¥––§ª¯©¹£W

»WÂP—‰\NMÃXUšÂ\NQMRM^ÄULM——\NÂM^˜UŠMRSVUšSNMŸšU­\Rž\RTZ«LU mnspWµYÀ—RO ¡NS¡—\^T^Z\‰M\^MRM^›MRT_ZMRSTŸ_MWƒx ´z{|}o~p ‘¸tjmppf~pz{|}o~p¢£–¹¥¨–¨§[––ª¯©[––¹¨W

–£WºÅLZM\˜˜UL›Z±\NTÃXVU«]——\N]RSP«U·\Q]R\VUV›µRRM^µŠU[\NMR›M PW®ZM˜P™³L®P®_\TZ±\Ÿ§]ž_\›TSRZž\RQ]^M\^M\RQTZMN\_MT]› ]RTMN‰MRT]SRWƒtt¸emˆfmy¢£–¦¥ªª§¨––©¨¢¤W

––W­M]RN]›ZYšUŠMZNž\RRµU­\\RLU­MNž\RR^­VUVÁ——MN³ÄM±MR·U L›Z\_MNÀWYN]R›]_—M^Sœ]RTMN—M`]RƵ[dzª³TŸ_M›ŸTS`]RM^]OR\——]RO\RQ ]T^NMO—\T]SRW†o~u{mx ´¢££¨¥¨¹¯§–©¢£W

–¢WȝVU®›Z`SR]\®UX]RO­UºONSQR]`VU[¡¡MN^¬²UY]NT^`Z\—\‰\®U mnspW˜P™]RZ]¡]T]SR\——M‰]\TM^TZM›M———\N^MRM^›MR›M³\^^S›]\TMQ ^M›NMTSNŸ_ZMRSTŸ_M\RQœN\]—TŸ]RS—Q\OMWzk~ubsnpƒusycuogcƒ ¢£–¦¥––¢§¬ª¨£–©¬ª¨–£W

–¨WYMQNSÃ\VU[M®®U[M±]^™U™\NžSTŸ³É]RT\R\­U®SLU·MSNOMP®U mnspWL®P®³¨›SRTN]¡TM^TS_—žSR\NŸ ¡NS^]^TZNSOZM_]TZM—]\— ]R¶NŸ\RQ ¡NS¡—\^T³žŸS ¡NS¡—\^TQ]œœMNMRT]\T]SRWrƒcd†´¢£–ª¥¨£§ –¢»©–¯£W

–¯W[\NM^OS]T]¾UÄ]`S—]›VÊU²\SšUŠN\QŸ˜[U²]›Z\NQ^SR²«UŠ\T›ZMR¬˜U mnspW[ROM_]TZM—]\—T]__NSOMR]TSN^]RTMON\TMO—›S›SNT]›S]Q³\RQ L®P®¨³žMQ]\TMQ^]OR\—^TS›SRTNS—_NSOMRŸœ\TMWvmˆmp~wxmtn¢£–ª¥ –¯¨§¨ª¤ª©¨ª»»W

–¦WP—QMN˜™U·SÄU™Mž¡SÀUY\NNŸ¬VUPRQMN^SRš˜U·SNOŸPµUmnspW ®M—SžMNM—MROTZ]^\QMTMNž]R\RTSœMž_ZŸ^Mž\^^›M_T]¡]—]TŸWƒx´ em}wokjkonjskmfmy¢£––¥–¤¯§»£¯©»–¢W

–ªWLT\R—MŸL¬UšZMR˜˜UYSQ—M‰^`Ÿ˜XUP—QMN˜™U­\R^M—ÄÄUV\TZ]\^²PU mnspW®M—SžMN\^MžT\T]SR^]R^žS`MN^±]TZ^M‰MNMMž_ZŸ^Mž\W´ jpotatˆm}n¢£–¦¥–¢¦§¦ª¨©¦¹£W

–¹WËM±³ŠSSTZ[UŠ]NNM——VPU[\VLUŠ\`MN™U˜SRM^«U™]—TŸµUmnspW˜P™³ L®P®_\TZ±\Ÿ\›T]‰\T]SR]RšºYXWd¸kem}wok´¢£–¦¥¯ª§¤¯¨©¤¯¦W

ÌÍÎ

ÏГÎ

,ÑÒ