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Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis

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Academic year: 2021

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Figure

Fig 1. L donovani infection is associated with increased glutamine metabolism. (A) Heatmap of gene expression pattern of glutamine genes in uninfected or L.
Fig 2. GLS inhibition increases susceptibility of L. donovani infection. (A) Spleen cells from 30 days infected mice were isolated and subjected to an in vitro stimulation with SLA (10 μg/ml) + IL-2 (20 ng/ml)
Fig 3. Impairment of T cell L. donovani specific response associates with the increased susceptibility to infection upon GLS inhibition
Fig 4. L-glutamine supplementation to anti-Leishmania miltefosine treatment improves CD8 T cell inflammatory response
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