HAL Id: hal-03036683
https://hal.archives-ouvertes.fr/hal-03036683
Preprint submitted on 2 Dec 2020
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D Aladin, Y Chu, R Robinson, V Viasnoff, N Borghi, J Thiery, Sylvie Dufour
To cite this version:
D Aladin, Y Chu, R Robinson, V Viasnoff, N Borghi, et al.. Extracellular domains of E-cadherin determine key mechanical phenotypes of an epithelium through cell- and non-cell-autonomous outside- in signalling. 2020. �hal-03036683�
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58 7L95*A 0X7-=" E2F 'JL)N)L)F7 58 425 QED'7F7 '9F 7O'L)'&&G 9FA3&'LF( 3O5* JF&&RJF&&
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)* L39* J5*L9)63LF L5 L2F )*LF9JF&&3&'9 '(2F7)5* F*F9AG '*( O95W5LF J5WO'JL)5*-H,-I"
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LF*7)5*7 (FOF*(F*L 5* L2F J'(2F9)* P1 (5W')*7 63L )*(FOF*(F*L 58 )*LF9JF&&3&'9 '(2F7)5*" E2F9F859F, J'(2F9)* P1 (5W')*7, 7OFJ)8)J'&&G PP1+R. '*( PP1:, '9F )*N5&NF( )* ' JF&&R'3L5*5W537 53L7)(FR)* 7)A*'&)*A L'9AFL)*A 425 QED'7F7 '*(
J59L)J'& LF*7)5*" !F7O)LF L2F J5WW5* )*N5&NFWF*L 58 PP1: )* J59L)J'& LF*7)5* '*(
FO)L2F&)'& )*LFA9)LG, L2F &'Jd 58 J599F&'L)5* 6FLcFF* L2F7F Lc5 O95OF9L)F7 '7 ' 83*JL)5*
58 PP1+R. O9FJ&3(F7 L2'L FO)L2F&)'& )*LFA9)LG FWF9AF7 895W 2)A2 JF&& J59L)J'& LF*7)5*"
K* J5*L9'7L, L2F L)773F 7L9FLJ2)*A '77'G 9FNF'&7 ' J599F&'L)5* 6FLcFF* &5c J59L)J'&
LF*7)5* '*( L)773F (3JL)&)LG, c2)J2 73OO59L7 ' W5(F& 6G c2)J2 L)773F (3JL)&)LG '9)7F7 895W JF&&R'3L5*5W537 &5c J59L)J'& LF*7)5*" %&5*A L2F 7'WF &)*F, JF&&7 F^O9F77)*A PR J'(7 J5WOFLF*L 59 )*J5WOFLF*L 859 gR()WF9)`'L)5* 725c L2F 7'WF (3JL)&F 6F2'N)59 '7 ' L)773F, 839L2F9 73OO59L)*A L2'L J59L)J'& LF*7)5* '*( (3JL)&)LGfO95N)(F( L2'L 7L'6&F JF&&RJF&& b3*JL)5*7 J'* 5JJ39f'9F 9FA3&'LF( )*(FOF*(F*L&G 58 J'(2F9)* !"#$%R65*(
9FA3&'L)5*, '*( '9F L2F9F859F JF&&R'3L5*5W537"
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J'(2F9)* P1 (5W')*7" ?FNF9L2F&F77, L2F F88FJL7 58 P1 (5W')*7 5* )*LF9JF&&3&'9 J5*L'JL 859W'L)5*, 0X7, J59L)J'& LF*7)5*, L)773F LF*7)&F 7L9F*AL2, '*( L)773F (3JL)&)LG '&&5c 37 L5 O95O57F L2F 85&&5c)*A W5(F&" X)97L, L2F 859W'L)5* 58 L2F JF&& &'GF9 (FN5)(
58 )*LF9JF&&3&'9 A'O7, 73OO59LF( 6G PP1:, ('WOF*7 7)*A&FRJF&& W)A9'L)5* 7OFF(, '*(
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'(2F7)5*" X)*'&&G, PP1+,- O95N)(F L)773F (3JL)&)LG, c2)J2 '&&5c7 JF&&7 L5 3*(F9A5 2)A2F9 7L9')*7 (39)*A J5&&FJL)NF W)A9'L)5*, '7 )8 JF&&7 3*b'WWF( 895W ' J59L)J'&R LF*7)5*F( 7L'LF.=, L2F9F6G '&&5c)*A FNF* A9F'LF9 J5&&FJL)NF W)A9'L)5* 7OFF(, SX)A" BT"
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