Enhanced bactericidal activity of brucite through partial copper substitution

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Enhanced bactericidal activity of brucite through partial

copper substitution

Batiste Clavier, Téo Baptiste, Florian Massuyeau, Alain Jouanneaux,

Amandine Guiet, Fabien Boucher, Vincent Fernandez, Christine Roques,

Gwenaël Corbel

To cite this version:

Batiste Clavier, Téo Baptiste, Florian Massuyeau, Alain Jouanneaux, Amandine Guiet, et al..

En-hanced bactericidal activity of brucite through partial copper substitution. Journal of materials

chem-istry B, Royal Society of Chemchem-istry, 2020, 8 (1), pp.100-113. �10.1039/c9tb01927h�. �hal-02428758�

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spectrometric (MS) evolved gas analyses. The presence in a very low amount of water molecules in the galleries induces disorder in the stacking of layers of edge-sharing octahedra along the c-axis. The dehydration of the hydroxides taking place below 225 °C preserves the brucite-type structure of the samples while suppressing the stacking disorder. Copper substitution greatly enhances the bactericidal activity of nanometer-sized platelets of brucite against two bacteria frequently involved in healthcare-associated-infections. 10 mol% of cupric ions in Mg(OH)2 (a copper loading of 0.102 mg.mL-1 _{in the suspension) were sufficient}

to induce, after 3 h in contact, 100% and 99.3% reductions in viability of Gram-negative E. coli and Gram-positive S. aureus, respectively (reductions as low as 23% and 48% are reported for the parent compound Mg(OH)2 in the same conditions). A good

compromise between fast bactericidal kinetics and a high reduction in viability is reached by the 15 mol% copper-substituted Mg(OH)2 hydroxide. Its use gives the opportunity to five-fold reduce the copper loading of the bactericidal agent while being at

least equally or even more efficient compared to the conventional CuO (a Cu loading of 0.799 mg.mL-1_{and 0.154 mg.mL}-1_{in the}

suspension of CuO and 15 mol% copper substituted Mg(OH)2 particles, respectively).

1 _{Institut des Molécules et Matériaux du Mans (IMMM), UMR-6283 CNRS, Le}

Mans Université, Avenue Olivier Messiaen, 72085 Le Mans Cedex 9, France. * E-mail: gwenael.corbel@univ-lemans.fr ; Fax: +33 (0)2 43 83 35 06 ; Tel: +33 (0)2 43 83 26 48 ; ORCID : 0000-0003-2605-7702

2 _{Institut des Matériaux Jean Rouxel (IMN), UMR-6502 CNRS, Université de}

Nantes, 2 rue de la Houssinière, BP32229, 44322 Nantes cedex 3, France

3 _{Institut Universitaire de Technologie du Mans, Le Mans Université, Avenue}

Olivier Messiaen, 72085 Le Mans Cedex 9, France

4 _{Laboratoire de Génie Chimique, UMR-5503 CNRS, Faculté de Pharmacie,}

Université Paul Sabatier - Toulouse III, 35, chemin des maraîchers, 31062 Toulouse Cedex 4, France

____________________________________________________________ Electronic supplementary information (ESI) available: 1-Experimental. 2-Origin of the lattice expansion when dehydrating samples. 3-Chemical state of surface particles probed by X-ray Photoelectron Spectroscopy (XPS).

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2-Results and discussion

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