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Submitted on 21 Dec 2011
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Epicardial fat volume is associated with coronary
endothelium-dependent vasomotor response in healthy
subjects
Benedicte Gaborit, Pierre Moro, Antonin Flavian, Frank Kober, Alexis
Jacquier, Jacques Quilici, Thomas Cuisset, Umberto Simeoni, Patrick J
Cozzone, Monique Bernard, et al.
To cite this version:
Benedicte Gaborit, Pierre Moro, Antonin Flavian, Frank Kober, Alexis Jacquier, et al.. Epicardial fat
volume is associated with coronary endothelium-dependent vasomotor response in healthy subjects.
Journal of Cardiovascular Magnetic Resonance, BioMed Central, 2011, 13 (Suppl 1), pp.P71.
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P O S T E R P R E S E N T A T I O N
Open Access
Epicardial fat volume is associated with coronary
endothelium-dependent vasomotor response in
healthy subjects
Bénédicte Gaborit
1*, Pierre Julien Moro
2, Antonin Flavian
3, Frank Kober
3, Alexis Jacquier
3, Jacques Quilici
4,
Thomas Cuisset
5, Umberto Simeoni
6, Patrick Cozzone
3, Monique Bernard
3, Anne Dutour
1From 2011 SCMR/Euro CMR Joint Scientific Sessions
Nice, France. 3-6 February 2011
Introduction
Epicardial fat (Efat) is an active ectopic fat depot, directly surrounding coronary arteries, and secreting high level of inflammatory adipokines; its development has been asso-ciated with coronary atherosclerosis. We investigated the relationship between Efatand endothelium dependent vasoreactivity of the coronary microcirculation.
Methods
Myocardial blood flow (MBF) was determined by mea-suring coronary sinus flow with velocity-encoded cine magnetic resonance imaging at 3 teslas. We measured MBF at baseline and in response to sympathetic stimu-lation by cold pressor testing (CPT) in 17 healthy volun-teers with normal left ventricular function (age 24 ±6 years, BMI=21.1±2.6kg/m2). Efatvolume was volume-trically assessed by manual delineation on short-axis views. CPT was applied by immersing one foot in ice water for 4 minutes.
Results
A significant increase in MBF was observed: 1.18±0.58 vs 0.84±0.47mL.min-1.g-1, CPT vs rest, p=0.002. Mean rela-tive MBF increase (ΔMBF) was 50±47%. Mean Efatvolume was 82±31mL and varied from 43 to 131 mL; mean LV mass and Left ventricular ejection fraction were 104±31g and 64±5%, respectively. CPT significantly increased heart rate (HR) by 28±13%, systolic blood pressure (BP) by 17±13%, diastolic BP by 23±19% and rate-pressure
product by 52±25%, p<0.01, indicating an increase in myo-cardial work load. The increase in HR, reflecting sympa-thetic stimulation, was not influenced by sex, age or Efat volume. CPT induced a decrease in coronary vascular resistance (150±93 vs 114±44 mmHg.mL-1.min.g) by trend (p=0.08). Interestingly, we found a significant nega-tive correlation between Efatvolume andΔMBF (r=-0.51, p=0.03), which remained significant after adjusting for age and sex.ΔMBF was not associated with waist circumfer-ence, BMI, CRP, lipid or glycemic parameters.
Conclusion
The increase in Efat is associated with a decrease in endothelium dependent vasoreactivity response, suggest-ing that Efatcould early influence endothelial function.
Author details 1
INSERM U626, Marseille, F-13385 France , Centre de Résonance Magnétique Biologique et Médicale (CRMBM), CNRS UMR 6612, Department of Endocrinology, Metabolic Diseases and Nutrition, CHU Nord, Marseille, France, Marseille, France.2Centre de Résonance Magnétique Biologique et Médicale, CNRS UMR N°6612,, Marseille, France.3Centre de Résonance Magnétique Biologique et Médicale (CRMBM), CNRS UMR 6612,, Marseille, France.4Department of Cardiology, CHU Timone, Marseille, France, Marseille, France.5INSERM U626, Marseille, F-13385 France , Department of Cardiology, CHU Timone, Marseille, France, Marseille, France.6Department of
Neonatalogy, Children and Parents Pole, CHU Timone, Marseille, France, Marseille, France.
Published: 2 February 2011
doi:10.1186/1532-429X-13-S1-P71
Cite this article as: Gaborit et al.: Epicardial fat volume is associated with coronary endothelium-dependent vasomotor response in healthy subjects. Journal of Cardiovascular Magnetic Resonance 2011 13(Suppl 1): P71.
1
INSERM U626, Marseille, F-13385 France , Centre de Résonance Magnétique Biologique et Médicale (CRMBM), CNRS UMR 6612, Department of Endocrinology, Metabolic Diseases and Nutrition, CHU Nord, Marseille, France, Marseille, France
Full list of author information is available at the end of the article
Gaborit et al. Journal of Cardiovascular Magnetic Resonance 2011, 13(Suppl 1):P71 http://jcmr-online.com/content/13/S1/P71
© 2011 Gaborit et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
