Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.

Texte intégral

(1)Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer’s disease. Jean-Charles Lambert, Benjamin Grenier-Boley, Denise Harold, Diana Zelenika, Vincent Chouraki, Y. Kamatani, K. Sleegers, M. A. Ikram, M. Hiltunen, C. Reitz, et al.. To cite this version: Jean-Charles Lambert, Benjamin Grenier-Boley, Denise Harold, Diana Zelenika, Vincent Chouraki, et al.. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer’s disease.. Molecular Psychiatry, Nature Publishing Group, 2012, 18, pp.521-521. �10.1038/mp.2012.75�. �hal-00778632�. HAL Id: hal-00778632 https://hal.archives-ouvertes.fr/hal-00778632 Submitted on 25 Jan 2013. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

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(22) Figure 1. Haplotype frequency Controls Cases. OR. CI, 95% −6. Stage 1. EADI1. 0.025 0.041. 1.80 [1.40 , 2.31]. P = 4.2x10. Stage 2. GERAD1 0.028 0.037. 1.71 [1.23 , 2.37]. P = 7.4x10. Stage 3. Whole. 1.55 [1.19 , 2.00]. P = 9.2x10−4. 0.023 0.032. Belgium. 0.033. 0.037. 1.44 [0.79 , 2.64]. Finland. 0.013. 0.024. 1.83 [0.83 , 4.01]. Germany. 0.023. 0.034. 1.48 [0.82 , 2.67]. Italy. 0.023. 0.031. 1.43 [0.85 , 2.42]. Spain. 0.023. 0.035. 1.66 [1.02 , 2.71]. −3. Combined 1.68 [1.43 , 1.96]. Fixed effect model 0.5. 1. 1.5. 2. 2.5. OR. 3. 3.5. 4. P = 1.1x10−10.

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(24) Figure 3 100. 8. 80. ●. − log10(p−value). ● ●. 60 ● ●. 4. ● ● ● ● ●. 2. 0. ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ●● ● ● ● ●●● ● ●● ●● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●● ●● ● ● ● ● ● ●● ● ● ● ●●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●●● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● ● ● ● ●●● ●● ● ●● ● ● ●● ● ● ● ●● ● ●● ● ●● ● ● ●● ●●●●● ● ● ● ● ● ● ● ●●● ●● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ●●● ● ● ● ●● ●● ● ●● ● ● ●● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ●● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●● ● ● ●●●●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ●●● ● ● ● ●● ● ●● ● ● ● ● ● ●● ● ● ● ● ●●● ● ● ●● ●● ● ●● ●● ● ● ● ● ●●●●● ●● ● ● ● ●●● ● ●● ●● ● ● ● ● ● ● ●●● ● ● ● ●●● ●● ● ● ●● ● ● ●● ●● ●● ● ● ●● ● ●● ● ●●●● ●● ● ● ●● ● ● ● ●● ●● ● ●●● ●● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ●● ● ● ● ● ● ● ●●●● ●● ● ● ● ●●● ● ● ● ●●● ●● ● ● ● ● ● ●● ● ●● ●● ● ● ● ●● ● ●● ●● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ●● ●● ●●● ● ● ●● ●● ●● ● ● ●● ● ● ● ●● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●●●● ● ● ● ● ●● ●● ● ● ●● ●●● ● ●● ● ●●● ● ● ● ● ●● ●●●● ● ● ● ● ● ●● ● ● ● ● ● ● ● ●● ●●●● ● ●● ●● ● ● ●● ● ● ● ● ●● ●. PRPF18 FRMD4A. 13.7. 13.8. 13.9. 14. 14.1. position on chr10 (Mb). 14.2. 14.3. 14.4. 40. 20. 0. recombination rate (cM/Mb). ● ● ● ● ●. 6.

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