• Aucun résultat trouvé

A new multi-directional fiber model for low angular resolution diffusion imaging


Academic year: 2021

Partager "A new multi-directional fiber model for low angular resolution diffusion imaging"


Texte intégral


HAL Id: inserm-00858206


Submitted on 4 Sep 2013

HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.

L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

A new multi-directional fiber model for low angular

resolution diffusion imaging

Aymeric Stamm, Patrick Pérez, Christian Barillot

To cite this version:

Aymeric Stamm, Patrick Pérez, Christian Barillot. A new multi-directional fiber model for low angular resolution diffusion imaging. International Society for Magnetic Resonance in Medicine, May 2012, Australia. pp.908. �inserm-00858206�



Intro (DW) seldo angul resol cross accur Theo the d that convo conce (cylin analy these Meth single 30, 4 samp estim Scann image Discu theor this m acqui clinic aniso provi part κ((κ+ Refer Wede MEDI Callag D. Tu 58, 49


oduction: Diff ) images acqu om exceed 10 lar resolution ution samplin s. To account f rately perform ory: In each v diffusion along account for t olution of a v entration (aro ndrical shape) ytically derive e parameters i hods: An eval e voxel. These 1, 64 and 200 ples were syn mated FOs in s ner with a 8-es repr8-esents ussion: This retically estim model allows ired over the cs, one could otropy (FA) a

ided with this of our model +1)2+2)-1/2 and rences: [1] Ba een et al., MR IA, 1-19, 2010 ghan, 1991 [6 uch, MRM 52 97-510, 2007 A new m 1Visages IN fusion MRI (dM uired from ng minutes acqu n diffusion (LA ngs (ng≥60 and

for that effect med from LARD

oxel, the EAP g some fiber o the diffusion a von Mises & F

ound µ) para ). Crossing fib d as a functio is then perform uation of the e data were ge 0. The resultin nthetized. For situations whe -ch head coil, a typical case s model en mated from on

for the retro past years. wonder whet and mean dif s model. For a l and by anal d MD = (1+κ/3 asser et al., Bi RM 54, 1377-0 [4] Tuch et a 6] Barmpoutis /6, 1358-72, [9] Basser et ulti-directiona Aym NSERM/INRIA U74 MRI) permits gradient dire uisition, with ARD) images b d nb≥1) [2,3,4 t, we propose D images obta is modeled a orientation (FO along directio Fisher pdf on ameter κ≥0, a bers are cons n of the param med by a least crossing angl enerated as in ng data sets w a given ng a

ere the real F TR/TE/τ = 1 e of LARD imag nables crossi nly 8 DW im ospective stud For a compl ther maps ak ffusivity (MD)

given FO, bas ogy with DTI 3) R2/(1+κ). iophys. J. 66/ -86, 2005 [3] al., MRM 48, 57 s et al., IPMI 2 2004 [8] Desc al., J. Magn. Re al fiber model

meric Stamm1, Patr

46, IRISA - UMR C to infer the en ctions and nb ng ≤ 30 and o by assuming a 4] have reveal a non-Gaussi ained in clinica s a mixture. E O) ±µ, ||µ||=1 ons µ and -µ the sphere o and a centere sequently cha meters of the m t squares fittin le resolution n [6] for differ were then corr and σ, the CA Os are colline 10000/64/22 ges with low s

Res sign low typi of 3 60° sho fibe pro esti ng fibers t ages. In parti dy of DW dat ete applicabil in to the frac ) maps [9] c sed on the Gau I, we propose 1, 259-67, 199 Descoteaux 77-82, 2002 [5 1, 338-49, 20 coteaux et al., eson. B-111, 2

l for low angu

rick Pérez2, and Ch

CNRS 6074, Renn

nsemble aver

b b-values. In

only one b-va a Gaussian dif ed a non-Gaus an parametric al context. Each probabili 1, and is in tur respectively. f radius R>0 ed 3D Gaussia aracterized by model and yie ng of the obse (CAR) of the rent configura rupted with in AR was comp ear. A healthy .1ms, b=800s spatial resolut sults: Figure o nal-to-noise ra w SNRs, increa ical clinical va 30° outperform for higher a ws an extrem ers (the height portional to mated despite to be icular, ta sets lity in ctional an be ussian e FA = 94 [2] et al., 5] P.T. 09 [7] MRM 209-19, 1996. ular resolution hristian Barillot1

es, France, 2Techn

rage propagato the context o alue. The EAP ffusion profile ssian diffusion c modeling of ity density fu rn modeled as . The diffusio (mean covere an pdf with y 8 parameter

elds the theor rved DW inte model was fi ations of the t ncreasing Rici puted as the 9 y adult male w s/mm2, ng=15

tion from whic on the left sho atios (SNR). E asing ng does

alues of SNR = ms the CAR ob angular resolu mity of the cor t of the cones 1/(κ+1)). Fi e the low angu

n diffusion ima nicolor, Rennes, F or (EAP) from of clinical brai P is then infer e [1]. In resea n profile in th f the EAP, the nction (pdf) i s a mixture of on pdf along d ed distance), covariance m rs. The Fouri retical DW inte nsities to the irst performe two FOs with ian noise and 95% confiden was scanned o 5 and 2x2x2m ch our model ows the CAR ach curve cor s not significa = 20dB and ng btained in Q-B ution (ng=81) rpus callosum s is proportion iber crossing ular and spati



m a set of diffu in imaging, dM rred from the arch context, h he white matt estimation of in the mixture f two equally direction µ is with mean d matrix D=R2 (I ier transform ensity [5]. The theoretical on d using synth b = 1500s/m , for each nois nce angle bet on a 3T Achiev mm3 voxels. T of the EAP wa of the model rresponds to a antly improve =30, the corre Ball Imaging [8]. Figure o m known to co nal to R² whil gs seem to al resolutions usion-weighte MRI sequence e resulting low higher angula er when fiber f which can b e characterize weighted pdf s given by th irection µ an 3+κµµ’)/(κ+1 of the EAP i e estimation o nes. hetic data on mm2 and ng=15 se level σ, 10 tween the tw va Philips MR This set of DW as estimated. for increasin a given ng. Fo e the CAR. Fo esponding CAR [7], i.e. aroun on the bottom ontain crossin le the radius i be accuratel s. d es w ar rs e es fs e d 1) is of a 5, 0 o RI W g or or R d m g s y


Documents relatifs

To test whether the vesicular pool of Atat1 promotes the acetyl- ation of -tubulin in MTs, we isolated subcellular fractions from newborn mouse cortices and then assessed

Néanmoins, la dualité des acides (Lewis et Bronsted) est un système dispendieux, dont le recyclage est une opération complexe et par conséquent difficilement applicable à

Cette mutation familiale du gène MME est une substitution d’une base guanine par une base adenine sur le chromosome 3q25.2, ce qui induit un remplacement d’un acide aminé cystéine

En ouvrant cette page avec Netscape composer, vous verrez que le cadre prévu pour accueillir le panoramique a une taille déterminée, choisie par les concepteurs des hyperpaysages

Chaque séance durera deux heures, mais dans la seconde, seule la première heure sera consacrée à l'expérimentation décrite ici ; durant la seconde, les élèves travailleront sur

A time-varying respiratory elastance model is developed with a negative elastic component (E demand ), to describe the driving pressure generated during a patient initiated

The aim of this study was to assess, in three experimental fields representative of the various topoclimatological zones of Luxembourg, the impact of timing of fungicide

Attention to a relation ontology [...] refocuses security discourses to better reflect and appreciate three forms of interconnection that are not sufficiently attended to