Гомо - і гетероадгезивна активність аутосимбіонтних штамів Aerococcus Viridans

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(1)�� - � �� Aerococcus Viridans D.A. Stepansky, G.N. Kremenchutsky, I.P. Koshevaya, Ye.A. Velychko. To cite this version: D.A. Stepansky, G.N. Kremenchutsky, I.P. Koshevaya, Ye.A. Velychko. �� - � �� Aerococcus Viridans. Medical perspectives (Medicni Perspektivi), SE ”Dnipropetrovsk medical academy of Health Ministry of Ukraine”, 2016, 21 (4), pp.67-71. �hal-01450865�. HAL Id: hal-01450865 https://hal.archives-ouvertes.fr/hal-01450865 Submitted on 31 Jan 2017. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

(2) ɍȾɄ. Ⱦ.Ɉ. Cɬɟɩɚɧɫɶɤɢɣ, Ƚ.Ɇ. Ʉɪɟɦɟɧɱɭɰɶɤɢɣ, ȱ.ɉ. Ʉɨɲɨɜɚ, Ɉ.Ɉ. ȼɟɥɢɱɤɨ. ȽɈɆɈȱȽȿɌȿɊɈȺȾȽȿɁɂȼɇȺȺɄɌɂȼɇȱɋɌɖ ȺɍɌɈɋɂɆȻȱɈɇɌɇɂɏɒɌȺɆȱȼ $(52&2&&869,5,'$16. ȾɁ «Ⱦɧɿɩɪɨɩɟɬɪɨɜɫɶɤɚ ɦɟɞɢɱɧɚ ɚɤɚɞɟɦɿɹ ɆɈɁ ɍɤɪɚʀɧɢ» ɤɚɮɟɞɪɚ ɦɿɤɪɨɛɿɨɥɨɝɿʀ, ɜɿɪɭɫɨɥɨɝɿʀ, ɿɦɭɧɨɥɨɝɿʀ ɬɚ ɟɩɿɞɟɦɿɨɥɨɝɿʀ ɩɥ. ɋɨɛɨɪɧɚ, 4, Ⱦɧɿɩɪɨ, 49000, ɍɤɪɚʀɧɚ SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» Department of microbiology, virology, immunology and epidemiology Soborna Sq., 4, Dnipro, 49000, Ukraine e-mail: dstepanskiy@gmail.com Ʉɥɸɱɨɜɿɫɥɨɜɚ ɚɭɬɨɫɢɦɛɿɨɧɬɢ, Aerococcus viridans, ɚɞɝɟɡɿɹ .H\ZRUGV autosymbionts, Aerococcus viridans, adhesion Ɋɟɮɟɪɚɬ Ƚɨɦɨɢ ɝɟɬɟɪɨɚɞɝɟɡɢɜɧɚɹ ɚɤɬɢɜɧɨɫɬɶ ɚɭɬɨɫɢɦɛɢɨɧɬɧɵɯ ɲɬɚɦɦɨɜ $HURFRFFXV 9LULGDQV &ɬɟɩɚɧɫɤɢɣȾȺ ɄɪɟɦɟɧɱɭɰɤɢɣȽɇ Ʉɨɲɟɜɚɹɂɉ ȼɟɥɢɱɤɨȿȺ Ⱥɞɝɟɡɢɹ – ɜɚɠɧɟɣɲɢɣ ɷɬɚɩ ɜɡɚɢɦɨɞɟɣɫɬɜɢɹ ɦɢɤɪɨɨɪɝɚɧɢɡɦɨɜ ɫ ɦɚɤɪɨɨɪɝɚɧɢɡɦɨɦ, ɜɚɠɧɵɣ ɮɚɤɬɨɪ, ɫ ɩɨɦɨɳɶɸ ɤɨɬɨɪɨɝɨ ɦɢɤɪɨɮɥɨɪɚ ɤɨɥɨɧɢɡɢɪɭɟɬ ɪɚɡɥɢɱɧɵɟ ɛɢɨɬɨɩɵ ɦɚɤɪɨɨɪɝɚɧɢɡɦɚ, ɨɛɟɫɩɟɱɢɜɚɹ ɬɟɦ ɫɚɦɵɦ ɤɨɥɨɧɢɡɚɰɢɨɧɧɭɸ ɪɟɡɢɫɬɟɧɬɧɨɫɬɶ ɢ ɩɪɟɩɹɬɫɬɜɭɹ ɚɞɝɟɡɢɢ ɢ ɢɧɜɚɡɢɢ ɩɚɬɨɝɟɧɨɜ. ȼ ɪɚɛɨɬɟ ɩɪɟɞɫɬɚɜɥɟɧɵ ɞɚɧɧɵɟ ɚɞɝɟɡɢɜɧɵɯ ɫɜɨɣɫɬɜ ɚɭɬɨɫɢɦɛɢɨɧɬɨɜ Aerococcus viridans ɤɪɵɫ, ɦɵɲɟɣ ɢ ɱɟɥɨɜɟɤɚ. ɉɨɤɚɡɚɧɨ, ɱɬɨ ɚɭɬɨɫɢɦɛɢɨɧɬɵ Aerococcus viridans ɢɦɟɸɬ ɛɨɥɟɟ ɜɵɫɨɤɢɟ ɩɨɤɚɡɚɬɟɥɢ ɚɞɝɟɡɢɢ ɩɪɢ ɢɡɭɱɟɧɢɢ ɢɯ ɚɤɬɢɜɧɨɫɬɢ ɜ ɭɫɥɨɜɢɹɯ ɤɨɧɬɚɤɬɚ ɫ ɷɪɢɬɪɨɰɢɬɚɦɢ ɯɨɡɹɢɧɚ ɢ ɦɟɧɶɲɭɸ ɚɤɬɢɜɧɨɫɬɶ ɜ ɭɫɥɨɜɢɹɯ ɝɟɬɟɪɨɚɞɝɟɡɢɢ. ɋɪɟɞɢ ɩɨɤɚɡɚɬɟɥɟɣ ɝɨɦɨɚɞɝɟɡɢɢ ɫɚɦɵɣ ɜɵɫɨɤɢɣ ɂȺɆ (ɢɧɞɟɤɫ ɚɞɝɟɡɢɜɧɨɫɬɢ ɦɢɤɪɨɨɪɝɚɧɢɡɦɨɜ) ɛɵɥ ɭ ɚɭɬɨɫɢɦɛɢɨɧɬɨɜ ɱɟɥɨɜɟɤɚ – 5,78±0,04; ɭ ɤɪɵɫ – 4,49±0,06 ɢ ɭ ɦɵɲɟɣ – 4,29±0,04. Ɂɚ ɫɱɟɬ ɛɨɥɶɲɟɣ ɚɞɝɟɡɢɜɧɨɣ ɫɩɨɫɨɛɧɨɫɬɢ ɢɫɩɨɥɶɡɨɜɚɧɢɟ ɚɭɬɨɫɢɦɛɢɨɧɬɨɜ Aerococcus viridans ɬɟɨɪɟɬɢɱɟɫɤɢ ɦɨɠɟɬ ɛɵɬɶ ɨɛɨɫɧɨɜɚɧɧɵɦ ɞɥɹ ɤɨɪɪɟɤɰɢɢ ɞɢɫɛɢɨɬɢɱɟɫɤɢɯ ɫɨɫɬɨɹɧɢɣ ɱɟɥɨɜɟɤɚ ɢ ɠɢɜɨɬɧɵɯ, ɱɬɨ ɬɪɟɛɭɟɬ ɞɚɥɶɧɟɣɲɟɝɨ ɢɡɭɱɟɧɢɹ.. $EVWUDFW+RPRDQGKHWHURDGKHVLRQDFWLYLW\RIDXWRV\PELRQWVRI$HURFRFFXV9LULGDQVVWUDLQV6WHSDQVN\'$ .UHPHQFKXWVN\*1.RVKHYD\D,39HO\FKNR<H$Adhesion is the major stage of interaction of microorganisms with macroorganism, important factor with the help of which microflora colonizes different biotypes of macroorganism, thus providing colonization resistance, preventing adhesion and pathogenic invasion. In our study data about adhesive features of Aerococcus viridans autophytes of rats, mice and human are presented. Aerococcus viridans autosymbionts have higher performances of adhesion in the condition of heteroadhesion. Among performance of homoadhesion the highest microorganisms adhesive index (MAI) was in human autosymbionts – 5,78±0,04, in rats – 4,49±0,06 and mice – 4,29±0,04. On the account of greater adhesive features, using of autosymbionts of Aerococcus viridans theoretically can be justified for correction of disbiotic conditions of a human and animals, this requires further study.. ɉɪɨɛɿɨɬɢɱɧɿ ɩɪɟɩɚɪɚɬɢ ɧɚ ɨɫɧɨɜɿ ɦɿɤɪɨ ɨɪɝɚɧɿɡɦɿɜ ɪɨɞɭ $HURFRFFXV ɟɮɟɤɬɢɜɧɿ ɞɥɹ ɤɨ ɪɟɤɰɿʀ ɞɢɫɛɿɨɬɢɱɧɢɯ ɫɬɚɧɿɜ > @ Ⱥɧɬɚɝɨɧɿɡɦ ɳɨɞɨ ɲɢɪɨɤɨɝɨ ɤɨɥɚ ɩɚɬɨɝɟɧɧɢɯ ɿ ɭɦɨɜɧɨ ɩɚɬɨ ɝɟɧɧɢɯ ɦɿɤɪɨɨɪɝɚɧɿɡɦɿɜ ɚ ɬɚɤɨɠ ɫɚɦɨɫɬɿɣɧɚ ɟɥɿɦɿɧɚɰɿɹ ɡɿ ɲɥɭɧɤɨɜɨɤɢɲɤɨɜɨɝɨ ɬɪɚɤɬɭ ɫɬɢ ɦɭɥɸɸɱɢɣ ɜɩɥɢɜ ɧɚ ɬɪɚɜɥɟɧɧɹ ɩɪɨɬɢɚɥɟɪɝɟɧɧɚ ɚɧɬɢɬɨɤɫɢɱɧɚ ɫɚɧɭɸɱɚ ɿ ɡɚɝɚɥɶɧɨɡɦɿɰɧɸɸɱɚ ɞɿɹ ɧɚɨɪɝɚɧɿɡɦɡɪɨɛɢɥɢʀɯɨɫɨɛɥɢɜɨɩɟɪɫɩɟɤɬɢɜɧɢɦɢ ɩɪɢ ɫɬɜɨɪɟɧɧɿ ɩɪɨɛɿɨɬɢɱɧɢɯ ɩɪɟɩɚɪɚɬɿɜ >@ Ɉɫɨɛɥɢɜɟ ɡɧɚɱɟɧɧɹ ɧɚɥɟɠɢɬɶ ɜɢɜɱɟɧɧɸ ɚɞ ɝɟɡɢɜɧɢɯ ɜɥɚɫɬɢɜɨɫɬɟɣ ɩɪɨɛɿɨɬɢɱɧɢɯ ɲɬɚɦɿɜ >@ Ⱥɞɝɟɡɿɹ ɧɚɣɜɚɠɥɢɜɿɲɢɣ ɟɬɚɩ ɜɡɚɽɦɨɞɿʀ ɦɿɤɪɨ ɨɪɝɚɧɿɡɦɿɜ ɡ ɦɚɤɪɨɨɪɝɚɧɿɡɦɨɦ ɧɚɣɜɚɠɥɢɜɿɲɢɣ ɮɚɤɬɨɪ ɡɚ ɞɨɩɨɦɨɝɨɸ ɹɤɨɝɨ ɦɿɤɪɨɮɥɨɪɚ ɤɨɥɨ ɧɿɡɭɽ ɪɿɡɧɿ ɛɿɨɬɨɩɢ ɦɚɤɪɨɨɪɝɚɧɿɡɦɭ ɡɚɛɟɡɩɟ ɱɭɸɱɢɬɢɦɫɚɦɢɦɤɨɥɨɧɿɡɚɰɿɣɧɭɪɟɡɢɫɬɟɧɬɧɿɫɬɶɿ. 16/ Ɍɨɦ XXȱ / 4. ɩɟɪɟɲɤɨɞɠɚɸɱɢ ɚɞɝɟɡɿʀ ɬɚ ɿɧɜɚɡɿʀ ɩɚɬɨɝɟɧɿɜ ɍ ɪɨɛɨɬɿ5HVWD/HQDUW6HWDO>@ɛɭɥɨɩɨɤɚɡɚɧɨ ɳɨ ɠɢɜɿ ɲɬɚɦɢ ɩɪɨɛɿɨɬɢɤɿɜ ɚɞɝɟɡɭɸɬɶɫɹ ɞɨ ɟɩɿɬɟɥɿɸ ɿ ɬɢɦ ɫɚɦɢɦ ɭ ɤɿɧɰɟɜɨɦɭ ɩɿɞɫɭɦɤɭ ɫɩɪɢɹɸɬɶ ɩɿɞɜɢɳɟɧɧɸ ɪɟɡɢɫɬɟɧɬɧɨɫɬɿ ɟɩɿɬɟɥɿɸ ɩɨɫɢɥɸɸɱɢ ɣɨɝɨ ɛɚɪ ɽɪɧɿ ɮɭɧɤɰɿʀ ɿ ɡɚɯɢɫɬ ȼɿɞ ɚɞɝɟɡɢɜɧɢɯ ɜɥɚɫɬɢɜɨɫɬɟɣ ɦɿɤɪɨɨɪɝɚɧɿɡɦɿɜ ɛɚɝɚɬɨ ɜ ɱɨɦɭ ɡɚɥɟɠɢɬɶ ɫɤɥɚɞ ɫɬɚɛɿɥɶɧɿɫɬɶ ɿ ɡɚɯɢɫɧɿ ɜɥɚɫɬɢɜɨɫɬɿ ɛɿɨɩɥɿɜɤɢ ɤɢɲɟɱɧɢɤɭ ɹɤɚ ɫɬɜɨɪɸɽ ɟɤɨɥɨɝɿɱɧɢɣ ɛɚɪ ɽɪ ɞɥɹ ɩɚɬɨɝɟɧɿɜ > @ ȼɢɫɨɤɿ ɚɞɝɟɡɢɜɧɿɜɥɚɫɬɢɜɨɫɬɿɩɪɟɞɫɬɚɜɧɢɤɿɜɧɨɪɦɨɮɥɨɪɢ ɞɨɡɜɨɥɹɸɬɶ ɡɚɣɦɚɬɢ ʀɦ ɧɚɣɛɿɥɶɲ ɜɢɝɿɞɧɿ ɟɤɨɥɨɝɿɱɧɿ ɧɿɲɿ ɿ ɞɨɡɜɨɥɹɸɬɶ ɜɢɝɪɚɜɚɬɢ ɜ ɤɨɧɤɭ ɪɟɧɰɿʀɡɚɞɠɟɪɟɥɚɯɚɪɱɭɜɚɧɧɹ Ɂ ɿɧɲɨɝɨ ɛɨɤɭ ɹɜɢɳɟ ɚɞɝɟɡɿʀ ɜɢɡɧɚɱɚɽ ɩɚɬɨɝɟɧɧɿɫɬɶ ɦɿɤɪɨɨɪɝɚɧɿɡɦɿɜ ɍ ɦɨɦɟɧɬ ɡɞɿɣ ɫɧɟɧɧɹ ɦɿɤɪɨɨɪɝɚɧɿɡɦɨɦ ɚɞɝɟɡɿʀ ɡɚɩɭɫɤɚɽɬɶɫɹ. .

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(4) ɬɨɛɬɨɜɿɞɫɨɬɨɤɟɪɢɬɪɨɰɢɬɿɜɳɨɦɚɸɬɶɧɚ ɫɜɨʀɣɩɨɜɟɪɯɧɿɚɞɝɟɡɨɜɚɧɿɦɿɤɪɨɨɪɝɚɧɿɡɦɢɿɧɞɟɤɫ ɚɞɝɟɡɢɜɧɨɫɬɿ ɦɿɤɪɨɨɪɝɚɧɿɡɦɭ ȱȺɆ

(5) ɫɟɪɟɞɧɹ ɤɿɥɶɤɿɫɬɶ ɦɿɤɪɨɛɧɢɯ ɤɥɿɬɢɧ ɧɚ ɟɪɢɬɪɨɰɢɬɿ ɜɪɚ ɯɨɜɭɸɱɢ ɬɿɥɶɤɢ ɟɪɢɬɪɨɰɢɬɢ ɳɨ ɛɟɪɭɬɶ ɭɱɚɫɬɶ ɜ ɚɞɝɟɡɢɜɧɨɦɭɩɪɨɰɟɫɿȼɢɡɧɚɱɚɥɢȱȺɆɧɚɩɿɞɫɬɚɜɿ ɡɧɚɱɟɧɶ ɋɉȺ ɿ Ʉɍȿ ȱȺɆ ɋɉȺɄɍȿ

(6) ɯ >@ Ɇɿɤɪɨɨɪɝɚɧɿɡɦɢ ɜɜɚɠɚɥɢ ɧɟɚɞɝɟɡɢɜɧɢɦɢ ɩɪɢ ȱȺɆ ɧɢɡɶɤɨɚɞɝɟɡɢɜɧɢɦɢ ɜɿɞ ɞɨ ɫɟɪɟɞɧɶɨɚɞɝɟɡɢɜɧɢɦɢ ɜɿɞ ɞɨ ɜɢɫɨɤɨ ɚɞɝɟɡɢɜɧɢɦɢ ɩɪɢ ȱȺɆ! >@ Ɇɚɡɤɢ ɟɪɢ ɬɪɨɰɢɬɿɜ ɡ ɚɞɝɟɡɨɜɚɧɢɦɢ ɧɚ ɧɢɯ ɦɿɤɪɨɨɪɝɚ ɧɿɡɦɚɦɢ ɮɚɪɛɭɜɚɥɢ ɡɚ ɊɨɦɚɧɨɜɫɶɤɢɦȽɿɦɡɨɸ Ⱦɥɹ ɞɨɬɪɢɦɚɧɧɹ ɫɬɚɧɞɚɪɬɧɢɯ ɭɦɨɜ ɭ ɩɨɫɬɚɧɨɜɰɿ ɞɨɫɥɿɞɠɟɧɶ ɜɢɤɨɪɢɫɬɨɜɭɜɚɥɢ ɟɪɢɬɪɨɰɢɬɢ ɝɨɫɩɨ ɞɚɪɿɜ ɜɿɞɩɨɜɿɞɧɢɯ ɜɢɞɿɥɟɧɢɦ ɚɭɬɨɫɢɦɛɿɨɧɬɚɦ ȿɤɫɩɟɪɢɦɟɧɬɢɩɪɨɜɨɞɢɥɢɜɬɪɶɨɯɩɨɜɬɨɪɚɯȾɚɧɿ ɩɪɟɞɫɬɚɜɥɟɧɿ ɹɤ ɫɟɪɟɞɧɽ ɚɪɢɮɦɟɬɢɱɧɟ Ɇ

(7) ɫɬɚɧɞɚɪɬɧɚ ɩɨɯɢɛɤɚ ɫɟɪɟɞɧɶɨɝɨ P

(8) ɞɨ ɜɿɪɱɢɣ ɿɧɬɟɪɜɚɥ Ⱦȱ

(9) ɹɤ ɤɪɢɬɟɪɿɣ ɞɨɫɬɨ ɜɿɪɧɨɫɬɿ ɜɿɞɦɿɧɧɨɫɬɟɣ ɜɢɤɨɪɢɫɬɨɜɭɜɚɥɢ ɤɪɢɬɟɪɿɣ ɋɬɶɸɞɟɧɬɚɧɚɪɿɜɧɿɡɧɚɱɭɳɨɫɬɿ S

(10) . Ɉɛ ɽɤɬɚɦɢ ɞɨɫɥɿɞɠɟɧɧɹ ɛɭɥɢ ɩɪɨɛɿɨɬɢɱɧɿ ɫɢɦɛɿɨɧɬɧɿ ɲɬɚɦɢ ɚɟɪɨɤɨɤɿɜ ɳɨ ɜɯɨɞɹɬɶ ɞɨ ɫɤɥɚɞɭ ɧɨɪɦɨɮɥɨɪɢ ɥɸɞɢɧɢ ɿ ɬɜɚɪɢɧ ɬɚ ɽ ɩɟɪɫɩɟɤɬɢɜɧɢɦɢ ɞɥɹ ɪɨɡɪɨɛɤɢ ɚɭɬɨɩɪɨɛɿɨɬɢɤɨ ɬɟɪɚɩɿʀ ɜ ɥɿɤɭɜɚɧɧɿ ɿ ɩɪɨɮɿɥɚɤɬɢɰɿ ɞɢɫɛɿɨɡɿɜ ɲɥɭɧɤɨɜɨɤɢɲɤɨɜɨɝɨ ɬɪɚɤɬɭ ɬɜɚɪɢɧ ɿ ɥɸɞɢɧɢ Ⱦɥɹ ɨɰɿɧɤɢ ɦɨɧɨ ɿ ɝɟɬɟɪɨɚɞɝɟɡɿʀ ɚɟɪɨɤɨɤɿɜ ɜɢ ɤɨɪɢɫɬɨɜɭɜɚɥɢɚɭɬɨɫɢɦɛɿɨɧɬɧɿɲɬɚɦɢɜɢɞɿɥɟɧɿɡ ɤɚɥɭɦɢɲɟɣɳɭɪɿɜɿɥɸɞɢɧɢ>@ Ⱥɞɝɟɡɢɜɧɿ ɜɥɚɫɬɢɜɨɫɬɿ ɛɚɤɬɟɪɿɣ ɜɢɜɱɚɥɢ ɡ ɜɢɤɨɪɢɫɬɚɧɧɹɦɟɪɢɬɪɨɰɢɬɿɜɤɪɨɜɿɦɢɲɟɣɳɭɪɿɜɿ ɥɸɞɢɧɢ Ɉȱ ɝɪɭɩɢ ɳɨ ɧɟɫɭɬɶ ɧɚ ɫɜɨʀɣ ɩɨɜɟɪɯɧɿ ɝɥɿɤɨɮɟɪɢɧ ɪɟɱɨɜɢɧɭ ɿɞɟɧɬɢɱɧɭ ɝɥɿɤɨɤɚɥɿɤɫɭ ɟɩɿɬɟɥɿɚɥɶɧɢɯ ɤɥɿɬɢɧ >@ ȼɢɤɨɪɢɫɬɨɜɭɜɚɥɚɫɹ ɦɟ ɬɨɞɢɤɚ ɡɚɩɪɨɩɨɧɨɜɚɧɚ ȼȱ Ȼɪɿɥɥɿɫ ɿ ɫɩɿɜɚɜɬ >@ ȼɪɚɯɨɜɭɜɚɥɢɫɹ ɬɚɤɿ ɩɨɤɚɡɧɢɤɢ ɫɟɪɟɞɧɿɣ ɩɨ ɤɚɡɧɢɤ ɚɞɝɟɡɿʀ ɋɉȺ

(11) ɬɨɛɬɨ ɫɟɪɟɞɧɹ ɤɿɥɶɤɿɫɬɶ ɦɿɤɪɨɨɪɝɚɧɿɡɦɿɜ ɳɨ ɩɪɢɤɪɿɩɢɥɢɫɹ ɞɨ ɩɨɜɟɪɯɧɿ ɨɞɧɨɝɨ ɟɪɢɬɪɨɰɢɬɚ ɩɪɢ ɩɿɞɪɚɯɭɧɤɭ ɧɟ ɦɟɧɲɟ ɟɪɢɬɪɨɰɢɬɿɜɜɪɚɯɨɜɭɸɱɢɧɟɛɿɥɶɲɟɩ ɹɬɢɡɧɢɯɜ ɨɞɧɨɦɭɩɨɥɿɡɨɪɭɤɨɟɮɿɰɿɽɧɬɭɱɚɫɬɿɟɪɢɬɪɨɰɢɬɿɜ. Ȼɭɥɢ ɜɢɞɿɥɟɧɿ ɿɡɨɥɹɬɿɜ ɚɟɪɨɤɨɤɿɜ ɡ ɤɚɥɭ ɛɟɡɩɨɪɨɞɧɢɯ ɳɭɪɿɜ ɤ

(12) ɿɡɨɥɹɬɿɜ ɚɟɪɨɤɨɤɿɜ ɡ ɤɚɥɭɛɟɡɩɨɪɨɞɧɢɯɦɢɲɟɣ ɦ

(13) ɿɿɡɨɥɹɬɿɜɚɟɪɨ ɤɨɤɿɜɡɤɚɥɭɡɞɨɪɨɜɢɯɥɸɞɟɣ ɱ

(14) ɍɜɢɞɿɥɟɧɢɯ ɿɡɨɥɹɬɚɯ ɛɭɥɢ ɜɢɜɱɟɧɿ ɦɨɪɮɨɥɨɝɿɱɧɿ ɤɭɥɶ ɬɭɪɚɥɶɧɿ ɛɿɨɯɿɦɿɱɧɿ ɚɧɬɚɝɨɧɿɫɬɢɱɧɿ ɜɥɚɫɬɢɜɨɫɬɿ Ⱦɥɹ ɟɤɫɩɟɪɢɦɟɧɬɭ ɛɭɥɢ ɜɿɞɿɛɪɚɧɿ ɧɚɣɛɿɥɶɲ ɚɤɬɢɜɧɿ ɜ ɛɿɨɯɿɦɿɱɧɨɦɭ ɣ ɚɧɬɚɝɨɧɿɫɬɢɱɧɨɦɭ ɜɿɞ ɧɨɲɟɧɧɿɿɡɨɥɹɬɢ

(15) ɦ

(16) ɤ

(17) ɱ ɍ ɬɚɛɥɢɰɹɯ ʋ ɩɪɟɞɫɬɚɜɥɟɧɿ ɪɟɡɭɥɶɬɚɬɢ ɚɞɝɟɡɿʀ ɚɭɬɨɫɢɦɛɿɨɧɬɿɜ $HURFRFFXV YLULGDQV ɞɨ ɟɪɢɬɪɨɰɢɬɿɜɥɸɞɟɣɳɭɪɿɜɿɦɢɲɟɣ əɤ ɜɢɞɧɨ ɡ ɞɚɧɢɯ ɬɚɛɥɢɰɿ ɛɿɥɶɲ ɜɢɫɨɤɿ ɚɞɝɟɡɢɜɧɿɜɥɚɫɬɢɜɨɫɬɿɩɨɜɿɞɧɨɲɟɧɧɸɞɨɟɪɢɬɪɨ ɰɢɬɿɜ ɦɢɲɟɣ ɦɚɥɢ ɚɭɬɨɫɢɦɛɿɨɧɬɢ ɜɢɞɿɥɟɧɿ ɡ ɨɪɝɚɧɿɡɦɭ ɦɢɲɟɣ ɿɡɨɥɹɬ ɦ

(18) Ɂɝɿɞɧɨ ɡ ɤɥɚ ɫɢɮɿɤɚɰɿɽɸ Ȼɪɿɥɥɿɫ >@ ɩɨ ɜɿɞɧɨɲɟɧɧɸ ɞɨ ɟɪɢ ɬɪɨɰɢɬɿɜ ɦɢɲɟɣ ɿɡɨɥɹɬɢ $HURFRFFXV YLULGDQV ɱɿɤɽɫɟɪɟɞɧɶɨɚɞɝɟɡɢɜɧɢɦɢɚɿɡɨɥɹɬ ɦ±ɜɢɫɨɤɨɚɞɝɟɡɢɜɧɢɦ ɪ

(19) . ɤɚɫɤɚɞ ɿɦɭɧɨɥɨɝɿɱɧɨɨɩɨɫɟɪɟɞɤɨɜɚɧɢɯ ɪɟɚɤɰɿɣ ɹɤɿɜɢɡɧɚɱɚɸɬɶɫɩɟɰɢɮɿɤɭɿɧɮɟɤɰɿɣɧɨɝɨɩɪɨɰɟɫɭ Ⱥɞɝɟɡɿɹ ɹɜɢɳɟ ɫɩɟɰɢɮɿɱɧɟ ɿ ɨɛɨɜ ɹɡɤɨɜɨɸ ɭɦɨɜɨɸ ɞɥɹ ɭɫɩɿɲɧɨɝɨ ɡɚɜɟɪɲɟɧɧɹ ɰɶɨɝɨ ɩɪɨ ɰɟɫɭ ɽ ɤɨɦɩɥɟɦɟɧɬɚɪɧɿɫɬɶ ɮɚɤɬɨɪɿɜ ɤɨɥɨɧɿɡɚɰɿʀ ɦɿɤɪɨɨɪɝɚɧɿɡɦɭ ɚɞɝɟɡɢɧɢ Ʌɉɋ ɫɩɟɰɿɚɥɿɡɨɜɚɧɿ ɛɿɥɤɢ ɬɨɳɨ

(20) ɬɚ ɫɩɟɰɢɮɿɱɧɢɯ ɪɟɰɟɩɬɨɪɿɜ ɤɥɿɬɢɧ ɦɿɲɟɧɟɣ ɦɚɤɪɨɨɪɝɚɧɿɡɦɭ >@ Ⱦɨɤɥɿɧɿɱɧɟ ɜɢ ɜɱɟɧɧɹ ɜɥɚɫɬɢɜɨɫɬɟɣ ɚɭɬɨɫɢɦɛɿɨɧɬɿɜ ɚɟɪɨɤɨɤɿɜ ɩɨɤɚɡɚɥɨ ʀɯ ɜɢɫɨɤɭ ɚɧɬɚɝɨɧɿɫɬɢɱɧɭ ɚɤɬɢɜɧɿɫɬɶ ɚɬɨɤɫɢɱɧɿɫɬɶ ɿ ɧɟɲɤɿɞɥɢɜɿɫɬɶ ɩɪɢ ɜɜɟɞɟɧɧɿ ɦɿɤɪɨɛɧɨʀ ɫɭɫɩɟɧɡɿʀ ɛɿɥɢɦ ɦɢɲɚɦ >@ ɉɪɨɬɟ ɜ ɫɭɱɚɫɧɿɣ ɥɿɬɟɪɚɬɭɪɿ ɛɪɚɤɭɽ ɪɨɛɿɬ ɩɪɢɫɜɹɱɟɧɢɯ ɜɢɜɱɟɧɧɸ ɚɞɝɟɡɿʀ ɚɟɪɨɤɨɤɿɜ ɨɫɨɛɥɢɜɨ ɚɭɬɨɫɢɦ ɛɿɨɧɬɿɜɞɨɤɥɿɬɢɧɦɚɤɪɨɨɪɝɚɧɿɡɦɭ Ɇɟɬɚɪɨɛɨɬɢ±ɨɰɿɧɢɬɢɝɨɦɨɿɝɟɬɟɪɨɚɞɝɟɡɢɜ ɧɭ ɚɤɬɢɜɧɿɫɬɶ ɚɭɬɨɫɢɦɛɿɨɧɬɧɢɯ ɲɬɚɦɿɜ $HURFRFFXV YLULGDQV ɩɟɪɫɩɟɤɬɢɜɧɢɯ ɞɥɹ ɫɬɜɨɪɟɧ ɧɹ ɧɨɜɢɯ ɩɪɨɛɿɨɬɢɱɧɢɯ ɩɪɟɩɚɪɚɬɿɜ ɬɚ ɦɿɤɪɨ ɛɿɨɥɨɝɿɱɧɨɝɨ ɨɛʉɪɭɧɬɭɜɚɧɧɹ ɚɭɬɨɩɪɨɛɿɨɬɢɤɨ ɬɟɪɚɩɿʀɿɩɪɨɮɿɥɚɤɬɢɤɢ. ɊȿɁɍɅɖɌȺɌɂɌȺȲɏɈȻȽɈȼɈɊȿɇɇə. . Ɍɚɛɥɢɰɹ 1. ɉɨɤɚɡɧɢɤɢɚɞɝɟɡɿʀɚɭɬɨɫɢɦɛɿɨɧɬɧɢɯɲɬɚɦɿɜ$HURFRFFXVYLULGDQV ɞɨɟɪɢɬɪɨɰɢɬɿɜɦɢɲɿ ɆP

(21) ȼɢɞɢ ɚɭɬɨɫɢɦɛɿɨɧɬɿɜ ɿɡɨɥɹɬ

(22) . Ʉɿɥɶɤɿɫɬɶ ɟɪɢɬɪɨɰɢɬɿɜ. ɋɉȺ. Ʉɍȯ. ȱȺɆ. Ʌɸɞɢɧɢ ɱ

(23) . . . . . ɓɭɪɿɜ ɤ

(24) . . . . . Ɇɢɲɟɣ ɦ

(25) . . . . . ɉ ɪ ɢ ɦ ɿ ɬ ɤ ɚ ±Sɩɨɪɿɜɧɹɧɨɡɿɡɨɥɹɬɚɦɢɦɢɲɟɣ. . ɆȿȾɂɑɇȱ ɉȿɊɋɉȿɄɌɂȼɂ.

(26) ɮɿɤɚɰɿɽɸ Ȼɪɿɥɥɿɫ >@ ɩɨ ɜɿɞɧɨɲɟɧɧɸ ɞɨ ɟɪɢɬɪɨ ɰɢɬɿɜ ɳɭɪɿɜ ɿɡɨɥɹɬɢ $HURFRFFXV YLULGDQV ɱ ɿ ɦɽɫɟɪɟɞɧɶɨɚɞɝɟɡɢɜɧɢɦɢɚɿɡɨɥɹɬɤ± ɜɢɫɨɤɨɚɞɝɟɡɢɜɧɢɦ ɪ

(27) . əɤ ɜɢɞɧɨ ɡ ɞɚɧɢɯ ɬɚɛɥɢɰɿ ɛɿɥɶɲ ɡɧɚɱɧɿ ɚɞɝɟɡɢɜɧɿɜɥɚɫɬɢɜɨɫɬɿɩɨɜɿɞɧɨɲɟɧɧɸɞɨɟɪɢɬɪɨ ɰɢɬɿɜ ɳɭɪɿɜ ɦɚɥɢ ɚɭɬɨɫɢɦɛɿɨɧɬɢ ɜɢɞɿɥɟɧɿ ɡ ɨɪɝɚɧɿɡɦɭ ɳɭɪɿɜ ɿɡɨɥɹɬ ɤ

(28) Ɂɝɿɞɧɨ ɡ ɤɥɚɫɢ . Ɍɚɛɥɢɰɹ 2. ɉɨɤɚɡɧɢɤɢɚɞɝɟɡɿʀɚɭɬɨɫɢɦɛɿɨɧɬɧɢɯɲɬɚɦɿɜ$HURFRFFXVYLULGDQV ɞɨɟɪɢɬɪɨɰɢɬɿɜɳɭɪɿɜ ɆP

(29) ȼɢɞɢ ɚɭɬɨɫɢɦɛɿɨɧɬɿɜ. Ʉɿɥɶɤɿɫɬɶ ɟɪɢɬɪɨɰɢɬɿɜ. ɋɉȺ. Ʉɍȯ. ȱȺɆ. Ʌɸɞɢɧɢ ɱ

(30) . . . . . ɓɭɪɿɜ ɤ

(31) . . . . . Ɇɢɲɟɣ ɦ

(32) . . . . . ɉ ɪ ɢ ɦ ɿ ɬ ɤ ɚ ±Sɩɨɪɿɜɧɹɧɨɡɿɡɨɥɹɬɚɦɢɳɭɪɿɜ . ɤɿɦɽɫɟɪɟɞɧɶɨɚɞɝɟɡɢɜɧɢɦɢɚɿɡɨɥɹɬ ɱ±ɜɢɫɨɤɨɚɞɝɟɡɢɜɧɢɦ ɪ

(33) ɇɚ ɪɢɫɭɧɤɚɯ ɡɨɛɪɚɠɟɧɚ ɡɚɥɟɠɧɿɫɬɶ ɪɿɜɧɹ ɚɞɝɟɡɢɜɧɨɫɬɿ ɚɭɬɨɫɢɦɛɿɨɧɬɿɜ ɡɚɥɟɠɧɨ ɜɿɞ ɩɨ ɯɨɞɠɟɧɧɹɚɟɪɨɤɨɤɿɜɿɜɢɞɭɟɪɢɬɪɨɰɢɬɿɜ. əɤ ɜɢɞɧɨ ɡ ɞɚɧɢɯ ɬɚɛɥɢɰɿ ɛɿɥɶɲ ɜɢɫɨɤɿ ɚɞ ɝɟɡɢɜɧɿ ɜɥɚɫɬɢɜɨɫɬɿ ɩɨ ɜɿɞɧɨɲɟɧɧɸ ɞɨ ɟɪɢ ɬɪɨɰɢɬɿɜɥɸɞɢɧɢɦɚɥɢɚɭɬɨɫɢɦɛɿɨɧɬɢɜɢɞɿɥɟɧɿɡ ɨɪɝɚɧɿɡɦɭ ɥɸɞɢɧɢ ɿɡɨɥɹɬ ɱ

(34) Ɂɝɿɞɧɨ ɡ ɤɥɚ ɫɢɮɿɤɚɰɿɽɸ Ȼɪɿɥɥɿɫ >@ ɩɨ ɜɿɞɧɨɲɟɧɧɸ ɞɨ ɟɪɢ ɬɪɨɰɢɬɿɜ ɳɭɪɿɜ ɿɡɨɥɹɬɢ $HURFRFFXV YLULGDQV . Ɍɚɛɥɢɰɹ 3. ɉɨɤɚɡɧɢɤɢɚɞɝɟɡɿʀɚɭɬɨɫɢɦɛɿɨɧɬɧɢɯɲɬɚɦɿɜ$HURFRFFXVYLULGDQV ɞɨɟɪɢɬɪɨɰɢɬɿɜɥɸɞɢɧɢ ɆP

(35) ȼɢɞɢ ɚɭɬɨɫɢɦɛɿɨɧɬɿɜ. Ʉɿɥɶɤɿɫɬɶ ɟɪɢɬɪɨɰɢɬɿɜ. ɋɉȺ. Ʉɍȯ. ȱȺɆ. Ʌɸɞɢɧɢ ɱ

(36) . . . . . ɓɭɪɿɜ ɤ

(37) . . . . . Ɇɢɲɿ ɦ

(38) . . . . . ɉ ɪ ɢ ɦ ɿ ɬ ɤ ɚ ±Sɩɨɪɿɜɧɹɧɨɡɿɡɨɥɹɬɚɦɢɥɸɞɢɧɢ±Sɩɨɪɿɜɧɹɧɨɡɿɡɨɥɹɬɚɦɢɳɭɪɿɜ . ɁɪɢɫɭɧɤɭɜɢɞɧɨɳɨȱȺɆɚɟɪɨɤɨɤɿɜɥɸɞɢɧɢ ɧɚɣɜɢɳɢɣ ɞɨ ɟɪɢɬɪɨɰɢɬɿɜ ɥɸɞɢɧɢ ɬɚ ɫɬɚɧɨɜɢɬɶ ɚ ɞɨ ɟɪɢɬɪɨɰɢɬɿɜ ɳɭɪɿɜ ɬɚ ɦɢɲɟɣ. ɡɧɚɱɧɨ ɦɟɧɲɢɣ ɬɚ ɩɪɚɤɬɢɱɧɨ ɨɞɧɚɤɨɜɢɣ ɬɚɜɿɞɩɨɜɿɞɧɨS!

(39) . . . ȱȺɆ. . . . ȱȺɆɚɟɪɨɤɨɤɿɜɥɸɞɢɧɢɞɨ ɟɪɢɬɪɨɰɢɬɿɜɦɢɲɿ. ȱȺɆɚɟɪɨɤɨɤɿɜɥɸɞɢɧɢɞɨ ɟɪɢɬɪɨɰɢɬɿɜɳɭɪɿɜ. ȱȺɆɚɟɪɨɤɨɤɿɜɥɸɞɢɧɢɞɨ ɟɪɢɬɪɨɰɢɬɿɜɥɸɞɢɧɢ. Ɋɢɫɋɟɪɟɞɧɿɩɨɤɚɡɧɢɤɢ ɆȾȱ

(40) ȱȺɆɚɟɪɨɤɨɤɿɜɥɸɞɢɧɢɡɚɥɟɠɧɨɜɿɞɜɢɞɭɟɪɢɬɪɨɰɢɬɿɜ. 16/ Ɍɨɦ XXȱ / 4. .

(41) ɄɅȱɇȱɑɇȺ ɆȿȾɂɐɂɇȺ Ɂ ɪɢɫɭɧɤɭ ɜɢɞɧɨ ɳɨ ȱȺɆ ɚɟɪɨɤɨɤɿɜ ɳɭɪɿɜ ɧɚɣɜɢɳɢɣ ɞɨ ɟɪɢɬɪɨɰɢɬɿɜ ɳɭɪɿɜ

(42) ɿ ɞɨɫɬɨɜɿɪɧɨ ɩɟɪɟɜɢɳɭɽ ȱȺɆ ɞɨ ɟɪɢɬɪɨɰɢɬɿɜ ɥɸɞɢɧɢ

(43) ɭ ɪɚɡɭ S

(44) ɦɢɲɟɣ.

(45) ±ɭɪɚɡɢ S

(46) Ɋɿɡɧɢɰɹɦɿɠɩɨ ɤɚɡɧɢɤɚɦɢȱȺɆɞɨɟɪɢɬɪɨɰɢɬɿɜɥɸɞɢɧɢɿɦɢɲɟɣ ɬɚɤɨɠɞɨɫɬɨɜɿɪɧɚɡS. . ȱȺɆ. . . ȱȺɆɚɟɪɨɤɨɤɿɜɳɭɪɿɜɞɨ ɟɪɢɬɪɨɰɢɬɿɜɦɢɲɿ. ȱȺɆɚɟɪɨɤɨɤɿɜɳɭɪɿɜɞɨ ɟɪɢɬɪɨɰɢɬɿɜɳɭɪɿɜ. ȱȺɆɚɟɪɨɤɨɤɿɜɳɭɪɿɜɞɨ ɟɪɢɬɪɨɰɢɬɿɜɥɸɞɢɧɢ. Ɋɢɫɋɟɪɟɞɧɿɩɨɤɚɡɧɢɤɢ ɆȾȱ

(47) ȱȺɆɚɟɪɨɤɨɤɿɜɳɭɪɿɜɡɚɥɟɠɧɨɜɿɞɜɢɞɭɟɪɢɬɪɨɰɢɬɿɜ. ɉɨɤɚɡɧɢɤ ȱȺɆ ɚɟɪɨɤɨɤɿɜ ɦɢɲɟɣ ɞɨ ɟɪɢɬɪɨ ɰɢɬɿɜ ɦɢɲɟɣ

(48) ɩɪɟɞɫɬɚɜɥɟɧɢɣ ɧɚ ɪɢ ɫɭɧɤɭ ɞɨɫɬɨɜɿɪɧɨ ɩɟɪɟɜɢɳɭɽ ɜɿɞɩɨɜɿɞɧɿ ɩɨ ɤɚɡɧɢɤɢ ɞɨ ɟɪɢɬɪɨɰɢɬɿɜ ɥɸɞɢɧɢ

(49) ɜ ɪɚɡɢɳɭɪɿɜ

(50) ±ɜɪɚɡɢ S

(51) . Ɍɚɤɢɦ ɱɢɧɨɦ ɫɟɪɟɞ ɩɨɤɚɡɧɢɤɿɜ ɝɨɦɨɚɞɝɟɡɿʀ ɧɚɣɛɿɥɶɲɢɦɛɭɜȱȺɆɜɚɭɬɨɫɢɦɛɿɨɧɬɿɜɥɸɞɢɧɢ± ɭɳɭɪɿɜ± S

(52) ɬɚɭɦɢ ɲɟɣ± SɿSɩɨɪɿɜɧɹɧɨɡɩɨ ɩɟɪɟɞɧɿɦɢɩɨɤɚɡɧɢɤɚɦɢ

(53) . . . . ȱȺɆ. . . ȱȺɆɚɟɪɨɤɨɤɿɜɦɢɲɿɞɨ ɟɪɢɬɪɨɰɢɬɿɜɦɢɲɿ. ȱȺɆɚɟɪɨɤɨɤɿɜɦɢɲɿɞɨ ɟɪɢɬɪɨɰɢɬɿɜɳɭɪɿɜ. ȱȺɆɚɟɪɨɤɨɤɿɜɦɢɲɿɞɨ ɟɪɢɬɪɨɰɢɬɿɜɥɸɞɢɧɢ. Ɋɢɫɋɟɪɟɞɧɿɩɨɤɚɡɧɢɤɢ ɆȾȱ

(54) ȱȺɆɚɟɪɨɤɨɤɿɜɦɢɲɟɣɡɚɥɟɠɧɨɜɿɞɜɢɞɭɟɪɢɬɪɨɰɢɬɿɜ. ȼɂɋɇɈȼɄɂ. ɉɨɤɚɡɚɧɨ ɳɨ $HURFRFFXV YLULGDQV ɽ ɤɨɦɩɨ ɧɟɧɬɨɦ ɧɨɪɦɚɥɶɧɨʀ ɦɿɤɪɨɮɥɨɪɢ ɤɢɲɤɿɜɧɢɤɚ ɥɸɞɢɧɢɬɚɬɜɚɪɢɧ ȼɢɜɱɚɸɱɢ ɚɞɝɟɡɢɜɧɭ ɚɤɬɢɜɧɿɫɬɶ ɚɭɬɨɫɢɦ ɛɿɨɧɬɧɢɯɲɬɚɦɿɜɚɟɪɨɤɨɤɿɜɩɨɤɚɡɚɧɨɳɨɜɨɧɚ. . ɪɿɡɧɚɿɡɚɥɟɠɢɬɶɜɿɞɩɨɯɨɞɠɟɧɧɹɦɿɤɪɨɨɪɝɚɧɿɡɦɭɿ ɜɢɞɭ ɝɨɫɩɨɞɚɪɹ ɟɪɢɬɪɨɰɢɬɿɜ Ⱥɭɬɨɫɢɦɛɿɨɧɬɢ $HURFRFFXV YLULGDQV ɦɚɸɬɶ ɛɿɥɶɲ ɜɢɫɨɤɿ ɩɨ ɤɚɡɧɢɤɢ ɚɞɝɟɡɿʀ ɩɪɢ ɜɢɜɱɟɧɧɿ ʀɯ ɚɤɬɢɜɧɨɫɬɿ ɜ ɭɦɨɜɚɯ ɤɨɧɬɚɤɬɭ ɡ ɟɪɢɬɪɨɰɢɬɚɦɢ ɝɨɫɩɨɞɚɪɹ ɿ ɦɟɧɲɭɚɤɬɢɜɧɿɫɬɶɜɭɦɨɜɚɯɝɟɬɟɪɨɚɞɝɟɡɿʀ. ɆȿȾɂɑɇȱ ɉȿɊɋɉȿɄɌɂȼɂ.

(55) Ɂɚ ɪɚɯɭɧɨɤ ɛɿɥɶɲɨʀ ɚɞɝɟɡɢɜɧɨʀ ɡɞɚɬɧɨɫɬɿ ɜɢɤɨɪɢɫɬɚɧɧɹɚɭɬɨɫɢɦɛɿɨɧɬɿɜ$HURFRFFXVYLULGDQV ɬɟɨɪɟɬɢɱɧɨ ɦɨɠɟ ɛɭɬɢ ɨɛʉɪɭɧɬɨɜɚɧɢɦ ɞɥɹ. ɤɨɪɟɤɰɿʀɞɢɫɛɿɨɬɢɱɧɢɯɫɬɚɧɿɜɥɸɞɢɧɢɿɬɜɚɪɢɧɬɚ ɩɨɬɪɟɛɭɽɩɨɞɚɥɶɲɨɝɨɜɢɜɱɟɧɧɹ. ɋɉɂɋɈɄɅȱɌȿɊȺɌɍɊɂ ȻɚɪɚɧɨɜɫɤɢɣȺɘȾɢɫɛɚɤɬɟɪɢɨɡɤɢɲɟɱɧɢɤɚ± ɟ ɢɡɞ ȺɘȻɚɪɚɧɨɜɫɤɢɣ ɗȺɄɨɧɞɪɚɲɢɧɚ ± ɋɉɛɉɢɬɟɪ±ɫ ɄɪɟɦɟɧɱɭɰɤɢɣȽɇ Ȼɢɨɥɨɝɢɱɟɫɤɢɟ ɨɫɨɛɟɧ ɧɨɫɬɢ Ⱥɛɚɤɬɟɪɢɧɚ ȽɇɄɪɟɦɟɧɱɭɰɤɢɣ Ɇɟɞɢɱɧɿ ɩɟɪɫɩɟɤɬɢɜɢɌʋɋ ɄɪɟɦɟɧɱɭɰɤɢɣȽɇɊɨɥɶɦɢɤɪɨɷɤɨɥɨɝɢɢɨɪɝɚ ɧɢɡɦɚɱɟɥɨɜɟɤɚɢɩɪɢɧɰɢɩɵɟɺɤɨɪɪɟɤɰɢɢȽɇɄɪɟ ɦɟɧɱɭɰɤɢɣ ɋȺ Ɋɵɠɟɧɤɨ ɋɂ ȼɚɥɶɱɭɤ ± Ⱦɧɟɩɪɨ ɩɟɬɪɨɜɫɤɉɨɪɨɝɢ±ɫ Ɇɟɬɨɞɢ ɜɢɞɿɥɟɧɧɹ ɬɚ ɿɞɟɧɬɢɮɿɤɚɰɿʀ ɝɪɚɦɩɨ ɡɢɬɢɜɧɢɯ ɤɚɬɚɥɚɡɨɧɟɝɚɬɢɜɧɢɯ ɤɨɤɿɜ ɦɟɬɨɞ ɪɟɤɨɦɟɧ ɞɚɰɿʀ ȽɇɄɪɟɦɟɧɱɭɰɤɢɣ ɅȽɘɪɝɟɥɶ Ɉȼɒɚɪɭɧ ȾɈɋɬɟɩɚɧɫɶɤɢɣ>ɬɚɿɧ@±Ʉɢɟɜ±ɫ Ɇɟɬɨɞɢɤɚɢɡɭɱɟɧɢɹɚɞɝɟɡɢɜɧɨɝɨɩɪɨɰɟɫɫɚɦɢɤ ɪɨɨɪɝɚɧɢɡɦɨɜ ȼɂȻɪɢɥɢɫ ɌȺȻɪɢɥɟɧɟ ɏɉɅɟɧ ɰɧɟɪ ȺȺ Ʌɟɧɰɧɟɪ Ʌɚɛ ɞɟɥɨ ± ± ʋ ± ɋ ɉɪɨɛɢɨɬɢɤɢ ɫɪɚɜɧɢɬɟɥɶɧɚɹ ɯɚɪɚɤɬɟɪɢɫɬɢɤɚ ɦɨɧɨ ɢ ɩɨɥɢɤɨɦɩɨɧɟɧɬɧɵɯ ɩɪɟɩɚɪɚɬɨɜ ȼȺɇɟɫ. ɱɢɫɥɹɟɜəȼȾɨɥɝɢɯȿȼɈɪɥɨɜɚɄȺɅɵɫɤɨ>ɢɞɪ@ ɋɢɛɢɪɦɟɞɠɭɪɧɚɥ±±Ɍʋɜɵɩ± ɋ ɋɬɟɩɚɧɫɶɤɢɣ ȾɈ Ⱦɨɤɥɿɧɿɱɧɟ ɜɢɜɱɟɧɧɹ ɜɥɚɫ ɬɢɜɨɫɬɟɣ ɚɭɬɨɫɢɦɛɿɨɧɬɿɜ ɥɸɞɢɧɢ $YLULGDQV ȾɈɋɬɟɩɚɧɫɶɤɢɣ ȽɇɄɪɟɦɟɧɱɭɰɶɤɢɣ ȱɉɄɨɲɨɜɚ Ɇɟɞɢɱɧɿ ɩɟɪɫɩɟɤɬɢɜɢ ± ± Ɍ;;, ʋ ± ɋ *LEVRQ *5 'LHWDU\ PRGXODWLRQ RI WKH KXPDQ FRORQLFPLFURELRWDLQWURGXFLQJWKHFRQFHSWRISUHELRWLFV *5*LEVRQ 0%5REHUIURLG * 1XWU ± ± 9RO±3 *XQWXQHQ ɆɄ $GKHUHQFH RI SURELRWLF EDFWHULD WR KXPDQ LQWHVWLQDO PXFXVLQ KHDOWK\ LQIDQWV DQG GXULQJ URWDYLUXV LQIHFWLRQ ɆɄ*XQWXQHQ 39.LUMDYDLQHQ Ⱥɋ2XZHKDQG&OLQ'LDJQ/DE,PPXQRO±± 9RO1±3 +RUL . %DFWHULDO DGKHVLRQ )URP PHFKDQLVP WR FRQWURO .+RUL 60DWVXPRWR %LRFKHPLFDO (QJL QHHULQJ-±±9RO±3. 5()(5(1&(6 %DUDQRYVNL\ $<X .RQGUDVKLQD ($ >,QWHVWLQDO G\VELRVLV@3LWHUHL]G5XVVLDQ .UHPHQFKXWVNL\ *1 >%LRORJLFDO IHDWXUHV RI $ EDFWHULQ@0HGLFQɿSHUVSHNWLYL

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