Titre:
Title :
Identifying biomarkers of Wharton's Jelly mesenchymal stromal cells using a dynamic metabolic model: the cell passage effect:
Suppléments Auteurs:
Authors : Benoît Laflaquière, Gabrielle Leclercq, Chandarong Choey, Jingkui Chen, Sabine Peres, Caryn Ito et Mario Jolicoeur
Date: 2018
Type: Article de revue / Journal article
Référence:
Citation :
Laflaquière, B., Leclercq, G., Choey, C., Chen, J., Peres, S., Ito, C. & Jolicoeur, M.
(2018). Identifying biomarkers of Wharton's Jelly mesenchymal stromal cells using a dynamic metabolic model: the cell passage effect. Metabolites, 8(1).
doi:10.3390/metabo8010018
Document en libre accès dans PolyPublie
Open Access document in PolyPublie
URL de PolyPublie:
PolyPublie URL:
https://publications.polymtl.ca/3564/
Version: Matériel supplémentaire / Supplementary material Révisé par les pairs / Refereed
Conditions d’utilisation:
Terms of Use
: CC BY
Document publié chez l’éditeur officiel Document issued by the official publisher
Titre de la revue:
Journal Title:
Metabolites (vol. 8, no 1) Maison d’édition:
Publisher:
MDPI URL officiel:
Official URL:
https://doi.org/10.3390/metabo8010018 Mention légale:
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Metabolites 2017, 7, x FOR PEER REVIEW 2 of 30
Table S1. Reaction equations (continued)
Reaction
number Reaction
name Reaction
18 G6PDH G6P + 2 NADP => R5P + 2 NADPH
19 GLDH GLU + NAD = AKG + NADH + NH4
20 GLN GLN = NH4 + GLU
21 GLNt EGLN + ATP => GLN + ADP
22 GLUt GLU + ADP => EGLU + ATP
23 GLYt EGLY + ATP => GLY + ADP
24 growth
0.06 EALA + 0.04 EARG + 0.03 EASN + 0.04 EASP + 0.02 ECYS + 0.03 EGLN + 0.04 EGLU + 0.06 EGLY + 0.02 EHIS + 0.03 EILE + 0.06 ELEU + 0.06 ELYS + 0.01 EMET + 0.02 EPHE + 0.03 EPRO + 0.05 ESER + 0.04 ETHR + 0.005 ETRP + 0.02 ETYR + 0.04 EVAL +
3.78 ATP + 0.03 G6P + 0.03 R5P + 0.09 CIT => X + 3.78 ADP
25 HISARGTA EHIS + EARG + AKG => 4 GLU + NH4
26 HK EGLC + ATP => G6P + ADP
27 IDO ETRP => KYN
28 iNOS ARG + NADP => CTR + NADPH + NO
29 KOT KYN + AKG => KYT + GLU
30 LDH PYR + NADH => ELAC + NAD
31 leak 2 NADH => 2 NAD
32 ME MAL + NAD => PYR + NADH
33 MLD MAL + NAD => OXA + NADH
34 NADPHox NADPH => NADP
35 NAT 2 R5P + 2 ATP + GLN => NAD + AMP + GLU
36 NHG NAD + ATP => NADP + ADP
37 OCT ORN => CTR
38 PC PYR + ATP => OXA + ADP
Metabolites 2017, 7, x FOR PEER REVIEW 3 of 30
Table S1. Reaction equations (continued)
Reaction
number Reaction
name Reaction
39 PYR + NAD => ACCOA + NADH
40 PFK F6P + ATP => 2 GAP + ADP
41 PGI G6P = F6P
42 PGK GAP + ADP + NAD => PEP + ATP + NADH
43 PK PEP + ADP => PYR + ATP
44 PPRibP R5P + 2 GLN + ASP + GLY + 5 ATP => 2 GLU + FUM + 4 ADP + 2 AMP
45 resp 2 NADH + 4 ADP => 2 NAD + 4 ATP
46 SCOAS SCOA + ADP => ATP + SUC
47 SDH SUC + 0.66 NAD + ADP => FUM + 0.66 NADH + ATP
48 SDHH ESER => PYR + NH4
49 TK 3 R5P => 2 F6P + GAP
Metabolites 2017, 7, x FOR PEER REVIEW 4 of 30
Table S2. Successive steps for model calibration
Step
number Used
metabolite Determined
reactions Step
number Used
metabolite Determined reactions
1 X growth 24 ASN ASN
2 PCr CK 25 ASP ASTA
3 EGLC HK 26 ACCOA CS & PDH
4 ELAC LDH 27 CIT CITS
5 ETRP IDO 28 AKG AKGDH & GLD
6 KYN KOT 29 SCOA SCOAS
7 ELEU AAtoSUC 30 SUC SDH
8 EHIS HISARGTA 31 NH4 GLN
9 EGLY GLYt 32 FUM FUM
10 UREA ARG1 33 GLN NAT
11 NO iNOS 34 AMP AK
12 R5P PPRibP 35 G6P G6PDH & PGI
13 R5P NAT. 36 NADPH NADPHox
14 EARG ARGt 37 NADP NHG
15 EGLU GLUt 38 F6P PFK & TK
16 EGLN GLNt 39 GAP PGK
17 EALA ALATA 40 PEP PK
18 ESER SDHH 41 R5P EP
19 EASN ASNt 42 MAL ME & MLD
20 EASP ASPt 43 OXA PC
21 ORN OCT 44 ADP ATPase & resp
22 CTR ASS 45 NAD leak
23 AS·ARG ASL
Metabolites 2017, 7, x FOR PEER REVIEW 5 of 30
Figure S1. Experimental data and model simulation of cofactors and nucleotides concentrations·
(A) Nicotinamide adenine dinucleotide concentration; (B) Nicotinamide adenine dinucleotide H
concentration; (C) Nicotinamide adenine dinucleotide phosphate concentration; (D) Nicotinamide
adenine dinucleotide phosphate H concentration; (E) Adenosine triphosphate concentration; (F)
Adenosine diphosphate concentration; (G) Adenosine monophosphate concentration. are P4
cells experimental data, are P9 cells experimental· Data Average values are shown for both
passages (n=3). Blue line is P4 cells simulation, red line is P9 cells simulation.
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Metabolites 2017, 7, x FOR PEER REVIEW 6 of 30 Table S3. Parameter values for average simulation (continued)
Parameters Values Units
!
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-04mmol·10-6cells
!
,-'.&/EF18.79 x 10
-05mmol·10
-6cells
!
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Metabolites 2017, 7, x FOR PEER REVIEW 7 of 30 Table S4. MRM transition and retention time of each amino acid
Compound name IS Precursor ion Product ion frag CE polarity RT min
Cystine NO 241.3 241 76 0 pos 14.78
Homoarginine YES 189.2 144 92 12 pos 14.44
Tyrosine NO 182.2 136.1 66 8 pos 8.74
Homophenylalanine YES 180.2 134.1 75 8 pos 6.12
Arginine NO 175.2 70.1 95 24 pos 15.09
Phenylalanine NO 166.2 120.1 72 8 pos 6.92
Histidine NO 156.2 110.1 81 12 pos 16.84
Methionine-d3 YES 153.2 136.1 69 4 pos 8.22
Methionine NO 150.2 133 63 4 pos 8.18
Glutamic acid NO 148.1 84.1 72 16 pos 12.59
Lysine NO 147.2 84.1 66 12 pos 15.48
Glutamine NO 147.2 84.1 72 16 pos 11.3
Aspartic acid NO 134.1 74.1 61 12 pos 14.23
Asparagine NO 133.1 74 60 12 pos 11.87
Isoleucine NO 132.2 86.1 63 4 pos 7.431
Leucine NO 132.2 86.1 72 4 pos 7.431
Threonine NO 120.1 103.1 133 16 pos 6.94
Valine NO 118.2 72.1 55 8 pos 9
Proline NO 116.1 70.1 75 12 pos 9.6
Serine NO 106.1 60.1 60 8 pos 11.62
Alanine NO 90.1 44.1 42 8 pos 10.7
Glycine NO 76.1 30.1 39 4 pos 11.47
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ggvxh ¦±¬.@
=
goµ LH@M
go¾+58¿
¾+58¿ ³ FH
go§ª¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿³ FH
go ª´ LH@MJ
go¾+-8¿
¾+;8¿
¾+-8¿
¾+;8¿ ³ FH
goª/@
=
golimµ LH@M
golim¾+30¿
¾+30¿ ³ FH
golim¥¢¾6+-¿
¾6+-1¿
¾6+-¿
¾6+-1¿ ³ FH
golim¨0@
=
gpgwgµ LH@M
gpgwg¾04<¿
¾04<¿ ³ FH
gpgwg¢¦®¾8?9¿
¾8?9¿ ³ FH
gpgwgª±«´ LH@MJ+4+;+ ¾+30¿
¾+30¿ ³ FH
gpgwg¥¢¾ +4+¿
¾ +4+¿ ³ FH
gpgwg ¦1@
=
gulNµ LH@M
gulN¾+90¿
¾+90¿ ³ FH
gulN«¢#!"(8@8@*@@@@ @ 5@ !@ /,@
) &7@'*@ &@#'&! %@;! & '<@
) )
2@
=
gulµ LH@M
gul¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿³ FH
gul ª¾ +90¿
¾ +90¿ ³ FH
gul «¢3@
=
gvpµ LH@M
gvp¾+:¿
¾+:¿ ³ FH
gvp¬4@
=
gvrµ LH@M
gvr¾+:6¿
¾+:6¿ ³ FH
gvr¬¨´ LH@MJ
gvr¾+:8¿
¾+:8¿ ³ FH
gvr¬ª¾61$¿
¾61$¿ ³ FH
gvr¨£5@
=
gvrµ LH@M
gvr¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿ ³ FH
gvr ª¾ +:6¿
¾ +:6¿ ³ FH
gvr ¬-,@
=
gvtµ LH@M
gvt¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿ ³ FH
gvt ª¾ +:8¿
¾ +:8¿ ³ FH
gvt »--@
=
gvvµ LH@M
gvv¾+:8¿
¾+:8¿ ³ FH
gvv¬ª¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿³ FH
gvv ª¾,;9¿
¾,;9¿ ³ FH
gvv «#!"(8@8@*@@@@ @ -,@ !@ /,@
) &7@'*@ &@#'&! %@;! & '<@
) )
-.@
=
gvwgµ LH@M
gvwg¾+30¿
¾+30¿ ³ FH
gvwg¥¢¾+:8¿
¾+:8¿ ³ FH
gvwg¬ª´ LH@MJ
gvwg¾04<¿
¾04<¿ ³ FH
gvwg¢¦®¾7>+¿
¾7>+¿ ³ FH
gvwg©°-/@
=
gwtz |µ LH@M
gwtz |* ¾+;8¿
¾+;8¿ ³ FH
gwtz | ª-0@
=
hnwvµ LH@M
hnwv¾,2;¿
¾,2;¿ ³ FH
hnwv¤¾6+-¿
¾6+-1¿
¾6+-¿
¾6+-1¿³ FH
hnwv¨-1@
=
hoµ LH@M
ho¾+-8¿
¾+;8¿
¾+-8¿
¾+;8¿ ³ FH
hoª¾8,J¿
¾8,J¿ ³ FH
hoª²´ LH@MJ
ho¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿³ FH
ho ª¾,J¿
¾,J¿ ³ FH
ho²-2@
=
hvµ LH@M
hv¾+,,7+¿
¾+,,7+¿ ³ FH
hv©¾7>+¿
¾7>+¿ ³ FH
hv©°-3@
=
kxqµ LH@M
kxq¾/<5¿
¾/<5¿ ³ FH
kxq¡®§#!"(8@8@*@@@@ @ --@ !@ /,@
) &7@'*@ &@#'&! %@;! & '<@
) )
-4@
=
lOtimµ LH@M
lOtim¾0&8¿
¾0&8¿ ³ FH
lOtim¢ª¾6+-8¿
¾6+-81¿
¾6+-8¿
¾6+-81¿³ FH
lOtim¨ª-5@
=
lpimµ LH@M
lpim¾04<¿
¾04<¿ ³ FH
lpim¢¦®¾6+-¿
¾6+-1¿
¾6+-¿
¾6+-1¿³ FH
lpim¨´ LH@MJ
lpim¾+30¿
¾+30¿ ³ FH
lpim¥¢¾6+-1¿
¾6+-¿
¾6+-1¿
¾6+-¿ ³ FH
lpim¨£¾61$¿
¾61$¿ ³ FH
lpim¨£.,@
=
lprµ LH@M
lpr¾046¿
¾046¿ ³ FH
lpr¢¦¨´ LH@MJ046 ¾04<¿
¾04<¿ ³ FH
lpr¢¦®¾61$¿
¾61$¿ ³ FH
lpr¨£.-@
=
lprµ LH@M
lpr¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿³ FH
lpr ª¾ 046¿
¾ 046¿ ³ FH
lpr ¢¦¨..@
=
lpxµ LH@M
lpx*
¾+-8¿
¾+;8¿
¾+-8¿
¾+;8¿ ³ FH
lpxª* ¾04<¿
¾04<¿ ³ FH
lpx¢¦®#!"(8@8@*@@@@ @ -.@ !@ /,@
) &7@'*@ &@#'&! %@;! & '<@
) )
./@
=
lpyµ LH@M
lpy*
¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿³ FH
lpyª* ¾ 04?¿
¾ 04?¿ ³ FH
lpy ¢¦±.0@
=
}~µ LH@M
}~*
¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿ ³ FH
}~ª* ¾,2;¿
¾,2;¿ ³ FH
}~¤* ¾0&8¿
¾0&8¿ ³ FH
}~¢ª* ¾9%8¿
¾9%8¿ ³ FH
}~«ª* ¾ +90¿
¾ +90¿ ³ FH
}~ «¢* ¾ ;98¿
¾ ;98¿ ³ FH
}~ «ª* ¾ 04<¿
¾ 04<¿ ³ FH
}~ ¢¦®* ¾ 046¿
¾ 046¿ ³ FH
}~ ¢¦¨* ¾ +4+¿
¾ +4+¿ ³ FH
}~ ¦* ¾ : 9¿
¾ : 9¿ ³ FH
}~ ¬ «* ¾ +:6¿
¾ +:6¿ ³ FH
}~ ¬¨* ¾ +:8¿
¾ +:8¿ ³ FH
}~ ¬ª* ¾ 24 ¿
¾ 24 ¿ ³ FH
}~ ¤¦* ¾ =+4¿
¾ =+4¿ ³ FH
}~ ¯¦* ¾ ;19¿
¾ ;19¿ ³ FH
}~ £«* ¾ 4 <¿
¾ 4 <¿ ³ FH
}~ ¦ ®* ¾ ;?9¿
¾ ;?9¿ ³ FH
}~ ±«* ¾ ,?:¿
¾ ,?:¿ ³ FH
}~ ±¬* ¾ 4?:¿
¾ 4?:¿ ³ FH
}~ ¦±¬* ¾ 897¿
¾ 897¿ ³ FH
}~ ª«©* ¾ 5 ;¿
¾ 5 ;¿ ³ FH
}~ § * ¾ 81 ¿
¾ 81 ¿ ³ FH
}~ ª£* ¾ 12:¿
¾ 12:¿ ³ FH
}~ £¤¬* ¾ 04?¿
¾ 04?¿ ³ FH
}~ ¢¦±#!"(8@8@*@@@@ @ -/@ !@ /,@
) &7@'*@ &@#'&! %@;! & '<@
) )
.1@
=
mnvgulwgµ LH@M
mnvgulwg* ¾+30¿
¾+30¿ ³ FH
mnvgulwg¥¢* ¾ +90¿
¾ +90¿ ³ FH
mnvgulwg «¢* ¾ 12:¿
¾ 12:¿ ³ FH
mnvgulwg £¤¬.2@
=
moµ LH@M
mo*
¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿³ FH
mo ª*
¾ 04,¿ *¸ ! ³ ACK@
mo§ªª* ¾+58¿
¾+;8¿
@GID@
mo§ªª* F@
mo§ªª»
FH
mo ¢¦* ¸ ! ³
¾+58¿
¾+;8¿
F@
mo§ªª»³ ¾ 04,¿ *¸ ! ³
¾+58¿
¾+;8¿
@GID@
mo§ªª* F@
mo§ªª»
* FE
mo¢ªFE
mo¢ª³ ¾0&8¿
.3@
=
nisµ LH@M
nis* ¾ ;98¿
¾ ;98¿ ³ FH
nis ǻ.4@
=
rsvµ LH@M
rsv* ¾+90¿
¾+90¿ ³ FH
rsv«¢*
¾6+-8¿
¾6+-81¿
¾6+-8¿
¾6+-81¿³ FH
rsv¨ª#!"(8@8@*@@@@ @ -0@ !@ /,@
) &7@'*@ &@#'&! %@;! & '<@
) )
.5@
=
oswµ LH@M
osw* ¾+30¿
¾+30¿ ³ FH
osw¥¢* ¾3?6¿
¾3?6¿ ³ FH
osw¥±¨/,@
=
pimµ LH@M
pim*
¾6+-1¿
¾6+-¿
¾6+-1¿
¾6+-¿ ³ FH
pim¨£*
¾8?9¿ *¸ ! ³ ACK@
pim§ªª* ¾+58¿
¾+;8¿
@GID@
pim§ªª* F@
pim§ªª»
FH
pimª±«* ¸ ! ³
¾+58¿
¾+;8¿
F@
pim§ªª» ³ ¾8?9¿ *¸ ! ³
¾+58¿
¾+;8¿
@GID@
pim§ªª* F@
pim§ªª»
/-@
=
|zµ LH@M
|z* ¾6+-1¿
¾6+-1¿ ³ FH
|z¨£/.@
=
qjµ LH@M
qj* ¾5+4¿
¾5+4¿ ³ FH
qj§¦*
¾6+-¿
¾6+-1¿
¾6+-¿
¾6+-1¿³ FH
qj¨//@
=
qpiµ LH@M
qpi* ¾5+4¿
¾5+4¿ ³ FH
qpi§¦*
¾6+-¿
¾6+-1¿
¾6+-¿
¾6+-1¿³ FH
qpi¨#!"(8@8@*@@@@ @ -1@ !@ /,@
) &7@'*@ &@#'&! %@;! & '<@
) )
/0@
=
rgitmµ LH@M
rgitm* ¾6+-81¿
¾6+-81¿ ³ FH
rgitm¨ª£/1@
=
rgwµ LH@M
rgw*
¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿³ FH
rgw ª* ¾046¿
¾046¿ ³ FH
rgw¢¦¨* ¾9%8¿
¾9%8¿ ³ FH
rgwǻ/2@
=
rmlµ LH@M
rml*
¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿³ FH
rml ª*
¾6+-¿
¾6+-1¿
¾6+-¿
¾6+-1¿³ FH
rml¨/3@
=
shwµ LH@M
shw* ¾796¿
¾796¿ ³ FH
shw©«¨/4@
=
thµ LH@M
th*
¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿³ FH
th ª* ¾8?9¿
¾8?9¿ ³ FH
thª±«#!"(8@8@*@@@@ @ -2@ !@ /,@
) &7@'*@ &@#'&! %@;! & '<@
) )
/5@
=
timµ LH@M
tim*
¾6+-¿
¾6+-1¿
¾6+-¿
¾6+-1¿³ FH
tim¨* ¾8?9¿
¾8?9¿ ³ FH
timª±«0,@
=
tkoµ LH@M
tko*
¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿³ FH
tko ª*
¾/&8¿ *¸ ! ³ ACK@
tko§ªª* ¾+58¿
¾+;8¿
@GID@
tko§ªª* F@
tko§ªª»
FH
tko¡ª* ¸ ! ³
¾+58¿
¾+;8¿
F@
tko§ªª» ³ ¾/&8¿ *¸ ! ³
¾+58¿
¾+;8¿
@GID@
tko§ªª* F@
tko§ªª»
0-@
=
tlnµ LH@M
tln* ¾0&8¿
¾0&8¿ ³ FH
tln¢ª* FE
tlnª ªFE
tlnª ª³ ¾8 8¿ ´ LH@MJ
tln* ¾/&8¿
¾/&8¿ ³ FH
tln¡ª0.@
=
tloµ LH@M
tlo*
¾+-8¿
¾+;8¿
¾+-8¿
¾+;8¿ ³ FH
tloª* ¾0+8¿
¾0+8¿ ³ FH
tlo¢ª*
¾6+-¿
¾6+-1¿
¾6+-¿
¾6+-1¿³ FH
tlo¨#!"(8@8@*@@@@ @ -3@ !@ /,@
) &7@'*@ &@#'&! %@;! & '<@
) )
0/@
=
toµ LH@M
to*
¾+-8¿
¾+;8¿
¾+-8¿
¾+;8¿ ³ FH
toª*
¾8 8¿ * À! ³ ACK@
to¡ª*¾/&8¿
@GID@
to¡ª* F@
to¡ªÁ FH
toª ª* ·! ³ ¾/&8¿
F@
to¡ªº ³ ¾8 8¿ *·! ³ ¾/&8¿
@GID@
to¡ª* F@
to¡ªº
00@
=
ttu{tµ LH@M
ttu{t* ¾+:8¿
¾+:8¿ ³ FH
ttu{t»*
¾+;8¿
¾+-8¿
¾+;8¿
¾+-8¿³ FH
ttu{t ª* ¾046¿
¾046¿ ³ FH
ttu{t¢¦¨* ¾04?¿
¾04?¿ ³ FH
ttu{t¢¦±* ¾9%8¿
¾9%8¿ ³ FH
ttu{tǻ01@
=
| µ LH@M
| * ¾+-8¿
¾+-8¿ ³ FH
| ª* ¾6+-1¿
¾6+-1¿ ³ FH
| ¨£02@
=
vhsgvµ LH@M
vhsgv*
¾+-8¿
¾+;8¿
¾+-8¿
¾+;8¿ ³ FH
vhsgvª* ¾:,7+¿
¾:,7+¿ ³ FH
vhsgv©03@
=
vimµ LH@M
vim*
¾+-8¿
¾+;8¿
¾+-8¿
¾+;8¿ ³ FH
vimª*
¾6+-¿
¾6+-1¿
¾6+-¿
¾6+-1¿³ FH
vim¨* ¾:<,¿
¾:<,¿ ³ FH
vim¨#!"(8@8@*@@@@ @ -4@ !@ /,@
) &7@'*@ &@#'&! %@;! & '<@
) )
04@
=
vimmµ LH@M
vimm* ¾ : 9¿
¾ : 9¿ ³ FH
vimm ¬ «05@
=
woµ LH@M
wo* ¾9%8¿
¾9%8¿ ³ FH
woǻ)
#!"(8@8@*@@@@ @ -5@ !@ /,@
) '7@ %%@ %@! @&!&@! &$&! %@
)
) ))
-@ B¾+,,7+¿
BK µ ¼( * =
ggvxh½=
hv³ =
tim¶=
}~* ¾+,,7+¿¹
.@
B¾+-8¿
BK µ =
ggvxh³ ¼" *=
go½³ =
gul³ =
gvr³ =
gvt³ =
gwtz |=
ho³ =
lpr=
lpx³ =
lpy³ =
mo³ =
rml³ =
th³ =
tko=
tlo=
to³ ¼$ *=
ttu{t½ ¶$ *=
| ¹=
vhsgv=
vim¶=
}~* ¾+-8¿¹
³ ¶=
}~ª* =
}~¹
/@ B¾+30¿
BK µ ´¼' *=
ggvxh½´=
golim³ =
gpgwg´ =
gvwg³ =
hnwv³ =
lpim´ =
mnvgulwg´ =
osw´ ¶=
}~* ¾+30¿¹
0@ B¾+58¿
BK µ ´=
go³ =
gvv³ =
rgw³ ¼" * =
ttu{t½´¶=
}~*¾+58¿¹
1@ B¾+90¿
BK µ ´=
gulN³ =
gul³ =
gvp´=
rsv´ ¶=
}~*¾+90¿¹
2@ B¾+:¿
BK µ ´=
gvp³ =
gvv´ ¶=
}~* ¾+:¿¹
3@ B¾+:6¿
BK µ ´=
gvr³ =
gvr´ ¶=
}~* ¾+:6¿¹
#!"(8@8@*@@@@ @ .,@ !@ /,@
) '7@ %%@ %@! @&!&@! &$&! %@;! & '<@
)
) ))
4@ B¾+:8¿
BK µ =
gvr³ =
gvt´ =
gvv´=
gvwg´ =
ttu{t´¶=
}~*¾+:8¿¹
5@
B¾+;8¿
BK µ ´=
ggvxh´=
go´=
gul´=
gvr´ =
gvt´ =
gvv´=
gwtz |³ =
ho´ =
lpr³ =
lpx´=
lpy´ =
mo´ ¼" *=
rgw½´=
rml´ =
th´ =
tko³ =
tlo³ =
to´ ¼% *=
ttu{t½³ ¶$ *=
| ¹³ =
vhsgv³ =
vim´¶=
}~*¾+;8¿¹´¶=
}~ ª*=
}~¹
-,@ B¾,2;¿
BK µ ´=
hnwv³ =
hv´¶=
}~*¾,2;¿¹´ ¶=
}~¤*=
}~¹
--@ B¾/&8¿
BK µ ´=
tko³ =
tln³ ¼" * =
wo½´¶=
}~* ¾/&8¿¹
-.@ B¾/<5¿
BK µ =
gvp´ =
kxq³ =
ttu{t³ =
vim´ ¶=
}~* ¾/<5¿¹
-/@ B¾&¿
µ ´
SOZRT³
TV´
ZSU´ ¶
dc ea* ¾&¿¹´¶
dc ea *
dc ea¹
-0@ B¾0+8¿
BK µ ¼" * =
tko½´=
tlo³ =
wo´ ¶=
}~* ¾0+8¿¹
-1@ B¾046¿
BK µ ´=
lpr³ =
lpr´ =
rgw´ ¼" * =
ttu{t½´¶=
}~*¾046¿¹
#!"(8@8@*@@@@ @ .-@ !@ /,@
) '7@ %%@ %@! @&!&@! &$&! %@;! & '<@
)
) ))
-2@
B¾04<¿
BK µ ¼$ * =
ggvxh½´=
gpgwg³ =
gvwg´=
lpim³ =
lpr´ =
lpx³ ¼$ *=
mnvgulwg½³ =
osw³ =
rgw³ ¼" *=
ttu{t½
´¶=
}~*¾04<¿¹
-3@ B ¾04?¿
BK µ =
lpy´ =
ttu{t´ ¶=
}~* ¾04?¿¹
-4@ B¾5+4¿
BK µ =
ggvxh³ =
kxq´=
qj´ =
qpi´ ¶=
}~* ¾5+4¿¹
-5@
B¾6+-¿
BK µ ´¼) *=
ggvxh½´=
golim´=
hnwv´ =
lpim³ =
pim³ ¼" *=
|z½´=
qj´ =
qpi³ =
rgw´=
rml´ =
tim´=
tlo³ ¶" * =
| ¹´ ¼ && * =
vim½´¶=
}~* ¾6+-¿¹
.,@
B¾6+-1¿
BK µ ¼) *=
ggvxh½³ =
golim³ =
hnwv³ =
lpim´ =
pim´ ¼" *=
|z½³ =
qj³ =
qpi³ =
tim³ =
tlo´ ¶" * =
| ¹³ ¼ && * =
vim½´¶=
}~* ¾6+-1¿¹
.-@ B¾6+-8¿
BK µ ´¼" * =
ggvxh½´ ¼" *=
lOtim½´=
rsv³ =
rgitm³ =
rml´ ¶=
}~*¾6+-8¿¹
..@ B¾6+-81¿
BK µ ¼" *=
ggvxh½³ ¼" *=
lOtim½³ =
rsv´=
rgitm´¶=
}~*¾6+-81¿¹
./@ B¾7>+¿
BK µ =
gvwg´=
hv³ =
qpi³ =
th´ ¶=
}~* ¾7>+¿¹
#!"(8@8@*@@@@ @ ..@ !@ /,@
) '7@ %%@ %@! @&!&@! &$&! %@;! & '<@
)
) ))
.0@ B¾8,J¿
BK µ ´=
ho´¶=
}~*¾8,J¿¹
.1@ B¾8 8¿
BK µ =
tlo´=
to´ ¶=
}~* ¾8 8¿¹
.2@ B¾8?9¿
BK µ ´=
gpgwg´=
pim³ =
qj´=
th´ =
tim³ =
to³ =
vimm´¶=
}~*¾8?9¿¹
.3@ B¾9%8¿
BK µ =
lOtim´ ¼" * =
rgw½´=
ttu{t´ ¼ * =
wo½´¶=
}~* ¾9%8¿¹´ ¶=
}~ǻ* =
}~¹
.4@ B¾:,7+¿
BK µ =
golim´ =
vhsgv´¶=
}~*¾:,7+¿¹
.5@ B¾:<,¿
BK µ ¼ *=
ggvxh½³ =
vhsgv´=
vim´¶=
}~*¾:<,¿¹
/,@ B¾ +90¿
BK µ ¶´=
gul´=
mnvgulwg´ =
}~ «¢* =
}~¹* ¼¾>¿ * ! ½
/-@ B¾796¿
BK µ ¼=
gulN´=
shw½*¼¾>¿ * ! ½
/.@ B¾,;9¿
BK µ ¼´=
gvv³ =
rsv³ =
shw½*¼¾>¿ * ! ½
#!"(8@8@*@@@@ @ ./@ !@ /,@
) '7@ %%@ %@! @&!&@! &$&! %@;! & '<@
)
) ))
//@ B¾ 04,¿
BK µ ¼´=
mo½*¼¾>¿ * ! ½
/0@ B¾ 4+,¿
BK µ ¼=
pim½*¼¾>¿ * ! ½
/1@ B¾ ¿
µ ¶´
URY´
dc ea *
dc ea¹*¼¾¿ * ! ½
/2@ B¾¿
µ ¼
URY´
VY½*¼¾¿ * ! ½
/3@ B¾ ¿
µ ¼
VY½*¼¾¿ * ! ½
/4@ B¾ ¿
µ ¶
S ^e´
dc ea *
dc ea¹*¼¾¿ * ! ½
/5@ B¾ ¿
µ ¶´
S Xe´
dc ea *
dc ea¹* ¼¾¿ * ! ½
0,@ B¾ ¿
µ ¶
P P P´
dc ea*
dc ea¹* ¼¾¿ * ! ½
0-@ B¾ ¿
µ ¶´
\RTT´
dc ea*
dc ea¹* ¼¾¿ * ! ½
#!"(8@8@*@@@@ @ .0@ !@ /,@
) '7@ %%@ %@! @&!&@! &$&! %@;! & '<@
)
) ))
0.@ B¾ ¿
µ ¶´
P\Xe´
dc ea*
dc ea¹* ¼¾¿ * ! ½
0/@ B¾ ¿
µ ¶´
P\Ze´
dc ea*
dc ea¹*¼¾¿ * ! ½
00@ B¾ ¿
µ ¶´
PPec\^Q´
dc ea*
dc ea¹*¼¾¿ * ! ½
01@ B¾ ¿
µ ¶´
PPec\^Q´
dc ea*
dc ea¹* ¼¾¿ * ! ½
02@ B¾ ¿
µ ¶´
dc ea *
dc ea¹* ¼¾¿ * ! ½
03@ B¾ ¿
µ ¶´
PPec\^Q´
dc ea*
dc ea¹* ¼¾¿ * ! ½
04@ B¾ ¿
µ ¶´
PPec\^Q´
dc ea *
dc ea¹*¼¾¿ * ! ½
05@ B¾ ¿
µ ¶´
dc ea *
dc ea¹* ¼¾¿ * ! ½
1,@ B¾ ¿
µ ¶´
PPec\^Q´
dc ea *
dc ea¹*¼¾¿ * ! ½
#!"(8@8@*@@@@ @ .1@ !@ /,@
) '7@ %%@ %@! @&!&@! &$&! %@;! & '<@
