[Nuclear FoxO1 as a bridge beetwen metabolism and mitogenesis.]
Texte intégral
(2)
(3)
(4)
(5) !#"%$'& () *+
(6) ,, -,./0
(7) 1
(8) 23.456,72892%:6;# < + = >?A@B7C D)EFCGIHKJMLKN6HOHFC P@RQ SUT5C P%VW+WXQYB[Z\+Q P^]`_[Pa7QYB7H b+c+d+L9_fehgijc+LKeC k@RSmlon)D+Qp>nqD+Q k JrPQqL s5P+JutRQvBa7JmlonwDQUEFJxkqQ1y?Xz+\+JIC {[|PloJ}z?*SMJ~a7LCYW?+B7Cl?XJBQ D+QJM?*k \+JIHKJIQ LXzJmloC SCaloQ@B7L#sD+Q EKJMkqQ LX|#tRQ P@RQ#D+QT5C SM?*H W+B7?ha7QqLe{oc+vc+d+LEOJMk Q LAeB7C Pk Q XX6!v+ !¡-j¢[£/:¢7¤¥ ¤¦§6!¨ª©¬«* ¢o 0 !*/® ¯° Y ± + ²o¤¥ 6³«´¢[0«µ ¶O·Y¸¡¹hº+»¼ ½I¾xº+»h¸6¼ º+»h¸0·v¿0À Á · ¸6Â+Ã^»ÁYÄ9Å+½Iº+Â+·#Æ Ç0ÈÊÉ¥ºjÄKÄO·0Ë7Ì !Cz*S}@zCYBflD+QaOz+B7?AlonYJMP+Q¡a9k ?+P*al[JÊl~@+lJutXQaÍD+QÎSICÎt?*JuQwD+Qwa7JMZ*PCÏSIJ~a:Cl[Ju?XPD+QwSÐxJMPhaf@RSxJMPQ°a7?+Pl k ?+P*aÑQYBftRn QaC@ kq?@BaD+Q`SÐInYt?*Sm@+loJM?+PhÒ/\+QvÓ9ÔÕÖYר+Ù0ÙÚ+ÕRÛ+ÜrÝMÞÝrß5Ö àxÖ:áhÕ+×+ßvL S~Ð~C kloJ}tCloJM?+PD+QFk QlIloQt?+JMQ Qal)JMP+JmloJxnqQ8zCYBâSICãSIJICÏJ~aÑ?XPäC@äB7n kqQYzAloQ@Bªå5|e{æçDhÐ}@hPèSxJMZC P+Dça7JxHFJxSIC J}B:QêéëSÐ~JMPhaf@RSxJMPQAÒÎ!C z+\+?ha[z+\?XB[ìSxC0l[JM?+P9D@^BÑn k QYzAloQ@B!JrPD@hJÊloQzCYB6k QSrJMZC P+D^C klJ}tXQ|íN{YvLh?+Bl\?XSM?+ZA@RQ D+QSuC`a7?A@a7{@P+JÊl7n k CloCvSuì¡loJIî@RQ#D+QSICz\+?ha[z+\+C0l[JMDAìSxJMP?-a7Jmlo?SM{[ï+{fðJMP+CAa7Q LD+?APlSIQz+B7JMP+k JMzCÏSRQ ñfñoQ kloQ0@BòQaflSMCðJMPCa7Qå ó5{Y ôrõ öv÷Yøùxú Öxû6ÖY×+ÞÖv×RÜ ø Ýr×+Õ+ßÖëü¡ýÒU6QlIloQ'D+QYB[P+JIþYBÑQ'C kYlJ}tQ'C SM?+BaÿSxQ¡aðJrPCAaÑQaª|#ó # Ql|ó ò{fæL \+?HO?*SM?+ZA@RQa D+Q¡a ð*JMPCaÑQa |#ðAl Ió# \@RHFC JrPQAaÑLÎC JMPha7J°î@RQ'SICâðJMPCaÑQ8yíó5{Y ô Ö Ù ù Õ+×+Þ. à
(9) Ø
(10) ØAÙÜrÝ
(11) Ø+ÝrÞ ù ÝM×+Þ
(12) Ý~ÛAàIÖ ø Ýr×+Õ+ßÖªü¡ý0Ò6Qað+JMPCaÑQa¬ñ?+B7HOQ Pl9@P k ?XH5z*SIQ QH @hSÊl[JMHFnYB7JIî@RQ LOî@hJ k ?+PlBoXSuQwSMQwP+J}tRQ C@ÿD+Q¬z+\+?ha[z\+?+BÑìSIClJM?+PD+QåO|e¥{Yv+La7Q@RS\?*HO?*Su?XZA@RQ k ?XPjP@ÿD+Q¡a9ñC kloQ@B:a9D+Q lB7CYPa7kYB7J}zAloJM?+Ppe?+B[ð+\Q C DhÒ#6\+Q ÓSIQP+n HFClo?*D+QqLå |e{YvÿQafl^SuC1z+B7JrPk JrzC SIQk J}WhSIQD+QSxC1tX?*JMQD*Q a7J}ZPC SrJ~a:CloJM?+PD+QKSÐxJMPha@hSIJrPQjÒ*N/P^B7nYz?+P*aÑQKC@ SMJMZCÏPDD+Qå5|#e{fæL¥å5|e{YvQal6z+\+?ha[z+\?XB[ìSxnOzCYB#SMQAa ðJrPCAa7Qaò|#ó wQl!yíó5{vaf@BlBo?+Jxa B7nAa7JMD@aòk ?+Pha7QYBtRna!k Q#î@hJJMPD@hJÊl/a7?+POQ k S}@a7JM?XPD@^P+?XìC@ÍQlòa7?+P JMPC kloJ}tCloJM?+P Ò åOCvPha^k QlÍ?AB[ZCYP+J~a7HFQ°HO?*D+þ SIQ LSÐxJMPC k0l[J}tC0l[JM?+P D+QÎÞÕ ù ?@ D+QÎÕ¡áÖ ù ü aÑQlB7C D@JÊlKzCvBK@P C k kvB7?XJ~a:a7Q HFQÏP¡l^D+Q°SMCD@B7n QD+Q tJIQ L Q0l9SÐxJMPC kloJ}tCloJI?XPÿk ?+P+k ?+HOJmloC PloQD+Q Þ+Õ ù ü af@B k Qa^ñ?+P+D*a ZnYPnl[Juî@RQa^af@z+z+B7JMHFQwSIQÎz\+n P+?Al~ìjzQwD+QwSM?+PAZnYtJmlo n xæ :Ò !QaFZþYPQaFB7nYZA@RSMnAaKzCvB`å5|e{vvQlFî@J B7QYPD+Q Plk ?+H zAloQ#D@Fz+\+nYP?l~ìjzQ#D+Q#SM?XPjZhnYtJmlonaÑ?XP¡lJrHFz*SMJIî@RnaòD+C PhaòSMCB7n¡a7JaloC P+k Q#C@^alB7Qaa ? +ìD+C PloL SIC BÑnYzCYB7CloJM?+P3D+Qa D+?*HOHKCvZQa éâSÐx|åE QlSMQ¡a D+n ñQ P*a:Qa JxHKH @RP+JmloC J}B7QA a ~ ï Ò96QYzQvP+D+C PloLUSIC SM?k C SxJ~a:ClJM?+PP@Rk SInC J}BÑQkq?XPhal[Jml~@jlJ}tQèD+QãåO|e¥{Yv B7na@hSÊloCYPl D+Q SxCèH@+loClJM?+PD+Qa a7JmloQa3D+Q z+\+?ha[z+\?XB[ìSxC0l[JM?+POzCYB óªPQ`af@Rññ[Jml zCAa!éB7Qvz+B7?*D@JBQSxQ#z\+n P+?Al~ìjzQDQSM?*PjZnYtJmlon Lhk Qî@RJ a@Z+ZþYB7Q î@RQwDhÐIC@+lB7Q¡a9HO?DXJMñ[JIk CloJM?+P*aFz?-alo{ lBÑC D@RklJu?XP+PQÏSISIQa D+Qå5|e{vvQl ?A@ÿD+QaFñoC kloQ@BaÍC k kqQa0a7?*JB7Qa a7?+PlPn k Qa:a7C JMB7QAa z?@BQ +zSMJIî@RQYBSIQz+\nÏP?l~ìjzQ#D+QAa H @+loCYP¡l7aòD+QÞ+Õ ù Ò.
(13)
(14) !#"%$'&()*,+-.0/ 1 )- 32$* ""41'5+-)- 06
(15) -"%7 98:%7 ;1:< >= ?0@ ABC DE5+- !0 FG< +- < G< GIH- J-KI+-L'M5N OQPSRUTVI"/#WXFG-Y.1'< .Z [!\^]_ 5+ D$`a06
(16) -".7 98-.7 1 b< dcfeKgh!$-+ + FYi+* !0
(17) 5+-/ 1K j^+-Y< 1'K)-8- D< Kfk$ < l= ?0@ A7B [nm ]o_ OE p
(18) F%$- qr +-1 sitl$*h)-u1K& j#< vw2$*CFY+- 2$*%xC;1'" yz.7 1 $*"F <'X{G|`TV m %v;l +-1 'l+ 14"}0 7 ;"Y2$* xi 0$s~l<-+- < v<
(19) 5H- -#5+-L'M [ ]z_ {p Js FaF5 !#"Y%$!0 f1K& j-< %%$ &)-v+-.0/ 1 )- a2$* a+- 07 " +-%$+ /-#1 j^+s < G1:^)-8- DG"/-WpG %1'< 4' a FKwtG 6 "0 1 "1 .1' G< >5{I|`TV m .a+-L'M _ /-WYFf
(20) Kf< 1:n6;k1'aFU8:1' F< l06
(21) s!$*
(22) -%< k06I|`TVUNJ . FJ-A
(23) w I.^G;i ?- JK ZfK! J+-
(24) 2$< sIF<-% 7 ' <'Fl1'^)-8- D [ M^a ] %v;#f/ 1-1'1 )K$* < k{I|`TV m No1#$T7"F. ¡<-i"%.$- i< r0 -z" 9+K7 ;1:¢|Q1: 7H /#< >|`1K&- GZ£1: )K$*F¤<'
(25) ¥#)-% 98-I+- w".
(26) >8-1 [ V¦ ]z_§ E)- Kw" 9¨-F#d< w0"%%$- `|`1#&: ©1 `+ 1K$- a01 ".7 1 sw< + 1)- <$ª!n k1#& j:< v< £ +- F< 1:¤)-th06
(27) {¥u«¬1#$< h"1 5¨*%
(28) 0 r)- +-%0/#1:)- # [ V V ] Y01 "% 1 '®< 1:¯n6 %
(29) $*% 1 ° ±t©!6F²)-ª+- ! " J+- D%$°8- F
(30) F
(31) . _ § 6Fsk¨*F³< ³"K´< 1 K0$-) )- ®2$*³ 6
(32)
(33) +-
(34) F"% 1 µ< ´"%%$- |`1#&: %®< ³%$- . / 1-1'1 )K$*w< swG1 K)*8- DG!E"1:- 78:G%$¤"1K$ w< I06F8-1'D$ 1 _ X¶ ·`¸:¹}º:»v¼#½l¶p¾a¼-¿qÀvº-·xÁº ¹XÂw»ÄÃ>Ãv¼ º-½½Å¾Qƹ.»vÇ©¾x¼ ·È7º-É ÊËQÌ Í*Î ËQÏ4Ð
(35) Ñ
(36) Î ËbÒ©ÑFËÓ Ô ÕÌËÓ Ö ËÐ
(37) ÌG×³Ó ÌIØ}Ù ÚGÛ¥ÜÞÝ /-WXFKwY KÄ%E"/ WU!69k1'Y4'Fk1#$T0
(38)
(39) FI|`1K&Yßk áà"1'5+KIâ5¨# ã |`1K&- iVX1K$Y|RpXäáN v: ? =å Kæ5 ç 5è ?*é= æwê ? Kæ ?-Z'|`1#&: XL p1K$Y|RXpä § V'|`1#&: ¥â 1K$Y{I|ë³%|`1K&- m < 1:x06
(40) &#+ . 1'k!` 00 G.$£7j*! G- !8:%$'&:'.$l0/Kj-5$Ä%E%$ & s _ § U7".%$- G|`1K&- iVÄ|Q1#&: XL%I|`1K&- GâS1 ¥%i J 0 Fp ;< 7 0 F#U"/ Wr06
(41) /#1'£"1-l %f J+-
(42) F2$*U< 'p< KI0 '1-"% 1 sG %0 1K$ 8-¥< -p< KG / ¨-< 1-kj#1s "1'Kp98*1' K 1K$< 'u<-GF%$"Y Fplj:;1:ìF<-p )K$* _ %
(43) Y +'F F"% 1:< KGk¨- G|`1: H / << su"K "-"4 u%v%$- f í l+ 1-T7+#1:+010 2$*%v08-1
(44) vFY2$*
(45) " ""
(46) 9$sF 9 zY%$- uY0 Df%F0 7 9¨K$* $-5 í G< X0$-+ + ..$- w< $-%$- [ V.-aVL ]_ § i"+-" Di< Y|`1K&- iV%pp/ 1-1:;1:)K$*¥tC XFp"4F9$sFKp01'
(47) F"%$*
(48) ¥1#$® "9$sFKI1#$*"/#KvY4<$sF
(49) 9 z< KvYY F7 ft506 %Ä2$- K"Ä!w F5t5F5<$- 45<'G8-
(50) U<' ""
(51) 9$*
(52) K _#§ 6
(53) -"% 98-% 1 i< X|`1K&- pLi"/-W
(54) Y1#$- 0 G¥0 4<$s Dw+- q$- 5 s7$s07 z "U1#8:
(55) - + % $- rJ Fhtr06 0 4 -"1 0 í h< '
(56) h"j*"h"
(57) 9$*
(58) 9 zr< Kk"9$sFK01'F
(59) F"%$*
(60) 9 z _
(61) î
(62) Y F ï ð06 -"% 98-% 1 " 9¨-F°%´+-1s!T %µ< ,|`1K&- iVhL%´â< -©Fñ !$ / %1 + 1KìF% 2$*r< ¯1K$-
(63) K0U1'" htC$* b+ 1 7 %7 ;1:S -"1 0 í < #k"
(64) 9$*
(65) K1K$*"/- / %1 + 1KìF% 2$*Kw%Et>06F+K$* yz`+ k% $- G< G"G"1:U+- !0 E"J9$*F _.
(66) 5 F 5 . 6 < ' !0 %0 1 b<s6 )-0 1K& j-<-vt5"4#G1#$- yf!$-+ +
(67) "X+-/ #1# j^+-"52$* q0$-) )- 52$5FX+ 1-<$*"%0 1 i"" !$*5< X <: F".$'&bF ;¨- I F5tl06
(68) -".7 98-.7 1 < w5¨- x|`1K&- ©08-1
(69) G06 0 4G< 'wG"j-"Fp< w"9$sFK1K$*"/## [ V.â ]_ § ´0"%%$- h|`1K&- +s.$'8:%&: " SF$- ®!%¯0 '" o ï+K7 1 1' Dî©
(70) F < 9 "%Gti06
(71) {Iu«Y1' ~G < +-#< u<s6;$*-C F 1'h< 9 "%iti06
(72) {Iu« h%f " !$ +- f<s6F%$ 0 v0".%$- f< X '" o +K0 1 _ -f"Kf< %$ &"f< ! )K$- Ka;v+-1:+K$*% 1 'f< 5)- K " 9¨-
(73) Kk2$s G1 p )K$s;i1 U<
(74) ! "% _a§ £ )K$*F0 1:+- F5¨- Kp|`1#&: < £)- KU+ 1'T +-1 +y10 2$*pK!u< +- < i< Y.$- X F y1'h< 9 ".itY!6F{IG« _a u)- #Kp"1-< f+- u%&-+'F +-1K$- i¯+ 1K G
(75) 1K$³F F )-#<ª<$³ "4+K%$- l|Q# [ V V ]_ 48: "/-X Y5¨*F¢2$*S "+-4" ~Y< G5¨- I|Q1#&: t + G06
(76) & + #z 1 r< )- Ku2$s x8-1 7 f 6n0 < 'GF "j#"Fb"9$*
(77) Ä"1'£i)- -b< £b"j-"J -YrV4>1: Du < +* < b<s6;$-#£
(78) F 1 <: ".£t 06
(79) {GG« _© % b"+-4" ~£0p)-
(80) ¥1#¨* !8:b48:"Y$s-£01 b< C|`1K&- iVi"1 s!0 D $ 0 98: $*"F %bp$ < shF< 1 -<
(81) F y1: t 6F{¥u« [ V \^]_p 4" 5+-%$ h}6
(82) & +-
(83) F2$* +- 06
(84) ".0 1:k< u|`1K&- iVf8*">$sk%$ 0 I0"%%$- w< 0 %-z" 9+K 1:F
(85) GtG06
(86) {GG« _ «1K|`1#&: CV %v/#1'1'1 )K$*Ä+-1z < x$-ik1# § & & §x§ s+- 7% w%$- v 4"%7 ;1:¤48:"5F#Ä "+K%$- $*"F Kw%$ &/ 1 71 - [ V m ]_ i69$*S+-1' k< 8^$*r+'/Kj* 1'1 )' F2$*f2$*y+-.$'8:T %n r
(87) i J)- .$'&
(88) +-
(89) F2$*K< -YF 1-<$sF% 1 < XFkF F 1:¤tX06
(90) {¥u«µ< K5¨- q|Q1#&: § G+ Y F v DX+-/ 1s7+ /#1: 7j FG+- xOa R 0x$-Y ;<$h -l D $*5< -v
(91) U< 1: -5< 5J F z1:¤tX06
(92) {Iu«î< X|`1K&- No o #X \^m < ¥|`1K&- £V "/#W!6F/ 1'¢1K $. \^m Z _§ S+ / 1s7+ /#1: 7j#
(93) .7 1 ±< " D´<: K$*¢F¢
(94) F 1 ©< ¯|`1K&- %$-& < r +-1 'r)- F2$*htð06
(95) s7$* J-hNJz .
(96)
(97) èf9c }
(98) f
(99) æ 1K$±2$*#"!ä Z _ 6
(100) ¨#"°< K "1 $ª 1< sªF,+ 1:1K%$- ª< )- %## +-1 +K010 2$* [ V ] + / 1s7+ /#1: 7j#
(101) .7 1 'u2$* q08-1
(102) zv;%$- G&-"9$ 1'#x< G01 7Ku< k|`1K&- °+-/ 1s7+ / 1 7j FKu< -X1' < 1 J-U< X
(103) F 1't506
(104) {IG«µ+-1K$- 7 x F< Ä< 'vFX#1:j-%$ _ '< v"41:#<: D 1'-Ä1:+K0
(105) K F¥ ;1'"F y% 1:"j11: F2$*p< ¥|`1K&- iVG J#<$s ~¥+- Ä!6F Js7$*
(106) -5 ~w< X06F1: <K X< m ¦ [ VM ]_ +-D$X UK!¤<K r2$*S06
(107) 4"%7 98:%7 ;1:ª< ¯8-1- b< ¢70 i+-%$^¤%8-1 9 Y$*ª!%¤< 1: -b!$- iF 1-" yz.0 1:k< u|`1K&- ª 1
(108) E J#<$s ~I+- qn6
(109)
(110) -!$*
(111) - _ 5+ "G"1 .1' G<s6
(112) s!$*
(113) -G% < 5 J)- .$'&¤< l00 :|`1K&- ³0x 1-" zX< sFX-1Kj#%$bJ) lG+'/#1+ / 1 7j F% 1: -<$s DG+- OR [ V G-¦ ]_ < #C0%b<$°00 zb1#& j#<-K£0$- i06
(114) ".7 98- DS< ¯|`1K&- 0i< ¯ <$s ï F 0 -" 9+K 1 < I)- ##d+-1:+010 2$*Kw.x<s6F%$-) E"
(115) G< I)- Kw< I 0 "G.$£00 z [ xV ]_. L.
(116) #Y& +- F".0 1:< "Kv 0$sD.v+-1#$- 7 D % 2$*506
(117) ".0 1:i <$s ~l< 5|`1K&- iV8-" FK©z2$* "4#!ä N"1:-s!$wn{ Z < )* #±+-1 +K010 2$*±%$-)' Dª. <
(118) 7+-1 9¨s F
(119) D+-1#$- f )K$-F G06
(120) &#+ . 1'< l)- ##u2K$s E"1:7 ; #f< su
(121) .$- I )- 1 £+ 1'1K0 7 " $-%$ 0 Yv< 5 +-1 'z+ +-Fk N7"1 ss0$w d{ Z _* 1K7 vK!Ä 1K + < 'fFk+ 1'1K%$ f<$)- < lFi!$-+- 1K& j*< <: X$ [ ] `KWj-Y l+-
(122) F2$*<-' Fh< %1#&- 0 F".0 1:´< K 4<: F"%$-&J 9¨- K _ ´""1 <S%8:"h".
(123) r/Kj^+-1#0/# f< 0$s~% " !$-) )- 2$*á06 07 ' ~©< |Q1#&: +-1K$- h06
(124) FY£ ~h1' s´z- 9¨sF©tª06 %%< + / 1s7+ /#1: 7j#
(125) .7 1 Y0$- qX -I \^m 2$*I+-1K$ xn6
(126) FY`!ä [ -L ]_ X$0 DU< ðr"+-" Dtk1'<$*F
(127) r F y1'Str06
(128) {Iu«YvF£ F<$ª o -£ \^m +-.$ }0 "1 ' F< "1' $s o 7 !$-+K%$- 1'4"%$sn 9 < . 7 - ;1' 1: %% < + / 1s7+ /#1: 7j#
(129) .7 1 2$JFNZ1K$T!+-1 +K$-% 1 NoZw< ¥)- Kw" 9¨*
(130) Kx|`1K&- ³".0 ;8*G1K$ + _K %E%. < 5+ / 1s7+-/ 1 !j F% 1 i+s.$ %n 0 J
(131) " F
(132) F + 1-<$- D+- Ii!$-¨s! D $ 0 1 b< lFi -5 \^m +- !X<s69$s#X01 op< X|`1#&:1dVu"1 '! D $^0 ;8:Yw$*"F J 5N7X$ `|`1K&- iVT{Ik{GZ _ pk$ 1K$Ä5 s s+s o v< p1'0 2$*p< 'vFX01' F'|E1K&- iVX Dw"+-¨-FX<6F"% ;8: FXH- -z¥+-L'M -< +- < Yu<s69$s-i
(133) F 1 <: 9 ".itC06
(134) {Iu« [ â ]_ 7Ä!u1 G+-1s 9¨sFi2$E6;$* Y+* !0 ;£< K 01'#"%7 ;1:-p< £!$-+ + .%$- p< l $-.$- p< pY5¨- G|`1K&- 1' ~I FitiF%$- p"+-" Diti4"%7 98: XF H- J#Ki+-L'M^"
(135) FT7" v.¥"1:- <- b"1'¤$*¢0$-+ + z%$- U< ¤ $*%$- #1#l¥< 'U 01' F [ \ T! ]_ 5 F aFl%5 +'F F2$*< -IF5 + . 1 b< l06 & + . 1' < GG"j-" J->V [ sM ]_ ¶X·`¸:¹}º:»v¼¤ÁºC¹¼ ·aÆÄ½¸¼^ÅÃq¹zžQÆ ¶X¾
(136) bº ¹GÇ ¹·v¾sÈ7ŽǪº£À-÷a¹Å»vº fÌGÏÌ9ÍiÓxÙDÎ }Ï Ì .Ð .ÌGÓ ÌGØ}ÙDÖ Ó ÖÕÐ
(137) Ö ÐFÑ
(138) Î Ë"!iÔ4Ð
(139) Ö#-Î Ø
(140) Ñ%$'&ÌIÖ'&bÏÎ'&()vÓ'&*KÌ+ËÌ Ý § 6
(141) 4<'+K.0 1:<$b%%¨:1' YU"
(142) 9$sF 9 zp%$h!% $^x$ 0 7 D0 1 `< X06
(143) 1 7)- z¥ +-1X ) #< ¥+- !0 Fk0$- < Ä" YKÄ/$*1: %$'&:' j*w 1Kx+- G)'9$*")-1 %x06
(144) s0$sF J- _ § 501' 1K$*¥$-Y í:U"0 < 'vF5 F¤< 5!6F/ 1'410 X)-9$*" F< F2$* _ {I$"1#$- zv<$p- ,* 4
(145) +- %w5
(146) ¤< kFX)-Jj:"Y FX) ²4"5t5F ç ê ç . ê .U+K$s vt5FX+ 1-<$*"%0 1 i< p)'9$*"1s =-i
(147) Ny .4ç
(148) ç 0 /}Z5.pt£06F1:& j-< % 1 < #U" < Kp) _ h+'/##C+ #<: FF06 !79$-&®<' $ 0 J®%h;ñ4" % 1 °<s6
(149) s7$* J-±2$s b 0$sDª / ;¨*©F©#1:)-D$*"1 )-# #á/-+-.7 2$*4 48:1: yX06;$
(150) z%0 1 %w5!1-"H-)-p< ¥) ~$"1s51K$01 7p< ¥)-9j-"1 )- pN ç ê ç . ç 0 /.ZÄ1K$ <s6F"
(151) < Kx) wN!F c ç 0 /}Zwa+- 7%E<K 98- zzx 4"%7 F1 'w ¨-1' F2$*Kw"1 5+-
(152) &*2 143576'8:9;=<> _. â.
(153) 6F+ $- 0 %8- z+ +-1 y F 7% < ; !$- &#+ . 1' <s69$s- 01: i "1 '00 D $ 0 98-´$*"F ,< ³|`1#&: CV N |`1#&: CVT7{p{X{GZ< sF°01' °< µ1K$- 7 r" 7".%$- "1 1 <K1 K# D®!6F'z5¨-FX<-q8:1' Ä%%¨-1-J F2$*Kw/ +-.7 2$*KÄ! ¤< ¥+- % n ¥FXk 7 F<' FX)-Jj-" Fl< s< >8:
(154) .$- v 1
(155) K%$h"41#$- <$5- ,s- [ - ]_ |`1K&- iVX8-1 7 5 1KF 41:)-D$*"1 )-- l s `2$*5
(156) U".%¨-1' 5< Kv" F< Kv -#2$s `+ + 1#8- 1' #Ä"% G8-1 % .6F1 + +-1XtX;¥)-Jj:"1'9jszp%wtpX
(157) +-1 )- z _ {I$b"41#$- Ä< p"%F¥+ /#s Fa5¨sFp2$*¥|`1K&- iVG%wF H- J#Kl+-L'M&- "f< sGFY01' FY<-G01'#"%7 ;1:-X¤%%¨:1: F2$*KG)-Fv < 1 < I+K$* 2$* <s6F%$ 0 v .8-%$-&h1 1:0 Y2$*+-L'Mb048:1: yYFY-1:) ~$*"1:)-- %f J / 9¨*YFY
(158) +-1 )- K [ L ¦ LaV ]_. 35%6'8 9 ;=<. 5 ; 55. 5 8 ; ; 9. 8 8 95 5
(159) ; .
(160)
(161) ! "#$&% ' (. \.
(162) fÎÌËfÕ Ö.ÌÕ}Ö ËQÓ ÑFÖ Ø
(163) ÌÕ}ÔÏÎ ÏÌ&Ë . ØFÌIÑ
(164) Ë( &QØÑFËQÎ
(165) .ÌË(.Ñ #-Ñ
(166) ØFÑ .Ö ËÐ § 6
(167) s7$s -¯&: "SK"% 1 sY/$s1 F+* i¯ F 1:t£$s´ "+K%$- Y5¨ z 9 z +-1 y$- S"% 98- Dð0jK 1 SH- J-z _§ S+-/ 1s7+ /-1 !j F%0 1 ³!$- b F<$h -Kb< Ki+ 1K K < +K0 7 "4#w!ä sÄNJ }
(168) JUèI4
(169) c JK -éK 9 ? }Z08-1 o F Dw06 .%w<s6 s!$*J #1'T! ! "p2$* K!
(170) +-
(171) F2$*< 'f
(172) 5+-/Kjs 1 +-%0/#1'1 )' <$<: F¨- .l< XFj +-5 [ L L ]_ b%8-E< #v+ 1 Kv!ä saK !% %%¨:1'
(173) 2$* < !6F Js7$*
(174) - +-
(175) F2#$* 6 4"%0 98*%0 1 42$*7 ;FF < F + / 1s7+ /-.0 <#j-F 1Q D1 T7L T0H' - NyO`LRpZ % < + 1 K H' K < +- <- < + / 1s7+ /#1' 1s D <':OpRbVG%`OQpRp _§ 6
(176) ;<'0 ~X< XFGH' #IO5Rpi0x !G1 K)K5+sÄ;$ 98* %¤< ¯ 1 X¨# %$`iH- -Kb1 ¤%S!$*""4 98* J-" o J-4# [ LKâ ] !$`2$`6 tS06
(177) F< 7 0 F".0 1' "4ª<$ "1'5+-F4&:© w1: "°"1 á +-1:-¨-Fª<'ª"% ª".0 ;8- ~ [ L \^]_¥§ ®"1'U+'F&-K w1: "'V.r w1 "µ1 "1 '00 D $*h +-"% 98-ir+- ¯ 6FK1-" F%0 1 < áFH' -Kª q Gä N æ ? æXæ ?-
(178) ? K? ç @ðèv?c? æwê J-Zkt;+ 1 -äu+Ky1: k1#$trr+ 1 -£äG F"%y1: [ L m ]_a§ H- J#KYO5RbV%OpRpá+ /#1+ / 1 !j F¤¢ o -
(179) 0/^ 1 K -¯H- J#KðOR uG +-"%0 98-¤ +-1s7 D 1 qL ¦'MU% :â L _ i6F+ < " 0 .8-%$-&- "4# +-/ 1s7+-/ 1 !j n%0 1 ' < O`R +-1K$- 7
(180) %0 -< +- < b%¤ª< % - £; +-"
(181) 7 F" DS< !$-¨s!0 % _§ ¯+ / 1s7+-/ 1 !j F% 1 ª<-ðOaR +-1s7 D 1 qL ¦'Mª D +-1:-¨-FS< F¯+-D$-+- !¤< b07.£k%%¨-1-J F2$*Kb< S06
(182) s!$*
(183) -p< 1: 06
(184) /' 9¨* D 1'ª< ¢FS 1 )-D$*"1 )-- 4X%¤! J5$*F%0 1'ª< ´
(185) ¢7j#/ KS< S)-Jj-"41:)- #S%¤< F
(186) +-1 )- K _ OR +'/#1+ / 1 7j Fª5+-1 ~7 1 L ¦'MUK0 G06
(187) -"% 98-% 1 < ¥FG :RUT7LN ê ç .ê 9 ? . pJ ?-.beKZU%G;C+-/ 1s7+ /#1: 7j F%0 ;1:< Y|`1#&* iVi!$- pF J-Y \^m´[ L ]_ 8- "/ 4q + / 1s7+ /#1: 7j#
(188) .7 1 S< £O`R ¯+-1s D 1:â L Dp z+-1:-¨-Fð< rFr+'/#1+ / 1 7j F% 1:®<s6 %$ 0 !$ ¨00 %E<K1 `>0/^ 1 J#I â< >|`1#&: CVf2$* +- 4E1 %&-"9$ 1'U$"F 9 z _ «Y1s %8-%$-&i$ JF w$-r5$ Ä$*"F < l|`1K&* CV5 FYvl+-/ 1s7+ /#1: 7j#
(189) .7 1 b< lF o #¢ \^m N!|`1K&- iVT!{I{GZ¯1:b³8-%$- <6;$*© í ¢ s0$sF J#1'Ts 9¨s FJ zC< |`1K&- iVS< s 06
(190) /-+-%1-"%j [ â ]_ k'w< Kw".$sD $- x+ Y Kw<6
(191) /-+-%y1'".jw< I %K|`1K&- iV>+-/ 1s7+ /#1: 7j#
(192) X0$- F o #k \^m "%0 98* ~xOQ R %Ä78-1 7 DÄ Js x06F"40 ;1:¤< l06
(193) s7$s - _ 5
(194) l z 1K$µ8:1:- 1#¨* 78-$s- .$-)'%0 ;1:(<Q6F& + z ;1' <6J0ä -TV.3T! +-1 ' t¡F !$- %& + Kz 1'S< £|`1K&- iVT!{G{ _w +- < 06
(195) 4"%7 98:%7 ;1:®< COaR Þ J-<$* D£+- X|`1K&- iVi+- ! < s< v"F;$*Fv/ +-%7 ;2$*#vp$- o -Kv K8-
(196) F< Ä+s1K$- q;X)- >7è A7B _- " J#<: F2$*5< 1 "U2$*kF " G+- F2$|Q1#&: CVu"% ;8:¥OaR ±6
(197) F+' 2$*G+-Ä!6n%$-)'.0 1:<6
(198) &#+ K 1'<6J0ä -T 2$s w!f <$* DY+- p
(199) £0$- & + 1'< l|`1#&* iV _ i F i"1 "1-l ~itY06
(200) ".7 98-.7 1 h< OR uq 1K$p1K¨s 8:1:-U)-
(201) v$- b%$-)-%0 1 h< £FY+-/ 1s7+ / 1 7j F% 1 ¯!$- p< 98* p F<$ o #X<6J0ä -TV*< k1:0 d J- 2$X". ¥+ /#1+ /-1: !j#F%0 1 £!$- v o -X#5< 1 G+-v
(202) $Ctu$* 0 "±tá06 s!$*
(203) -ª<''®"ª"1 %&^ª4&#+-
(204) _G§ ³!$- %&#+ K 1- <'|`1#&: CVT7{I{ m.
(205) 0 y#074"%7 98:±$- %$-)-Y%0 1 <s6F"%0 98* D< H' -#3 l+-
(206) F2$*K3< s3"%F + / 1s7+ /#1: 7j#
(207) .7 1 ª!$- £ -¥;#P´{IOaR¡N ç G
(208) ? = .- J p ? .Z ävRbV) %F. {IOaR N *; ¥
(209) ? = }- pJ ? .4Z 7«R %+-L'M^C'S1-< J
(210) "%0 ;1:3< áF%$- ;8*%$ <s6F4&#+ . 1 _ § "4 z +- F2$|`1K&- iVT!{G{ "% ;8: Oa R 5¨-F
(211) +-
(212) F2$* $* %$-)-%0 ;1: < ª
(213) ª01: Y.0 1: .h< 06
(214) 4"%7 98- Dª<K$µ"41:5+-F&-á q1 " _ i69$- +- !X|`1K&- iV %$-)-£06 &#+ ;1'S< £F£+ 1 -¤äu
(215) ".1: U2$- f0 b< 'U
(216) "1:s00 D $ 0 1 S< b"£"1-5+'F&- _ ¤6
(217) %$ 0 £+- q06
(218) ".7 98-.7 1 S< b+-L'Mh+- X|`1K&- iVT7{I{8-1 7 r06
(219) Kz1-" ;%7 ;1:®0 £FU+ 1 - w1: %xäf "%1 v}Ä<^1:#"5501: % 1 i<$"1-5+'F&-5 w1 "b2$* s+'/#1+ / 1 7j F¥OaR 3!$- vY o - â L 143576'8 9 ; ''> _ ª%8-U< q1 "-G 6F".0 ;8- ~¢< ðOR <: 9 )-S"1 0 ¯ð0/K 41: -¯ â±< |`1K&- iV#< 1:)- i0G ' Ä"" !$*4q"i2$- w48:1: y1:%&-"9$ 1'h$*"F [ â ]_ f<K1 K- 2$*¥O`R 0w 7+-1 '¨-
(220) <
(221) p+'9$-+- !Ä< f0%f< 5!6F Js7$* -|`1K&- iV5$*"F Y5¨*
(222) < 1 " 8-1 7 ªKª4"%0 1 sh<: ï "%.S+- n6
(223)
(224) <
(225) 9 z°< ° H' -,+-L'M _ { #1#n "1 K# .-"4
(226) i )K$*F% 1:<$"1-5+'F&-r w1 "¯+- X|`1K&- iVi%u+- 5FCH- -Kr< ð00 zX+-L'M 6F48: D y®% + +#1: ªt"r1K$- [ â ]_ ª%$ 0 á $*< + +#1: b;#07.< á !$- %& + Kz 1'" ;¨-Fi< C|`1K&- iVT!{I{Þ%$´ 98*%$®/-+-%0 2$*b"/ WrFr1K$- 7 GJ
(227)
(228) "41: 7 ï o 2$*X06F"% ;8:% 1:< IOaR ± -<$s ~¥+- x|`1K&- iVGK!E <-+- <-p< kX F 1:¤tX06
(229) {IG«s%d2$*XK FY.$'&ª0 -7)- F2$*Kr1 $- s 9¨- F
(230) D´"" !$*´t¢ 6
(231) s7$* J- _ yb+ b±07%$- <$*".0 1:¤< Kq%$ &C" ".$sF< X)'9$*"1s4Q<s6F Js0$sF s5.Ä< ¥0 7 9)-9j-" < KvY+-/-k+ < FF5+- + +-1K E%$ & $'&l"1:0 7í [ L'M ]_ . . . . . . hº-½ .¾sÆÄ¸'¹Å¾QÆÄ½lÁĺ£¶p¾
(232) r¼#º:È· 2'º-½Ã·d¼È7·¿qÅ7ÆÄ·a½ºbà < 7 - D7 98*x$--ð < £< 1 -k.1-" KUt#1G0 .8-%$-&0$-) )- ¥2$*£" ! J# + 1 +K 7 ;%¤%
(233) 0 7 9¨^$*Ktð|`1#&: CV%K/ 1'1-1:)K$*< s< 98* #K+- "K+-1#$- %0 h +- !0 ;C Fptri"+-" Diti".7 98- G+-L'M _ 7v.6F)- Jf 1u< i 6
(234)
(235) +-
(236) F"% 1 h< G|`".%$- |`1 7H / 4<¢< -YFr+ / 1K j^+-h< ð1 K)*8- DI< ' ¯!$-+ + 1'¯ $-k1: h1K$ª "1 h< ' )K$*% 1 S<$%%¨-1-J r%$ "1K$- <$- ,* %U¯+-/ K£+ < FF _ u
(237) ®2$*06 4"%7 98- D<' |`1K&- iVI $ x D FE"1 ' F< X"41:X)-1:^ !G< G"
(238) FG< X06
(239) s0$sF J-4'
(240) zG< )-)-G<-¥F
(241) ~ $- ¢b< S 1sY0 .8-%$ &
(242) ´ 1K0 1:±2$*´< 'h¢01- X|`1K&- iV¯+ / 1s7+-/ 1 7j F´%i$*"F 9 z 1K$* D< 'f"%1 7)- X$-i í Fl s!$*
(243) #1'To' 9¨s F
(244) 0 J#< +- < Y<s69$s#l F 1 b<: ï 4"% tG 6
(245) {Ip« _ Y "I0 %8-%$-&% u48- F< -"i" ! J#K5" 9 "1:s0 "4#¥< spFK2$*
(246) FGO`R +-1K$- ! D %0 ,7+-4" 7 F2$*+ /#1+ / 1 j#F,1' ~¢0$- qL ¦'Mµ1: D´0$- :â L _ k%$ &° j^+-K´< .
(247) . . . .
(248) + / 1s7+ /-.<: 07 ".h" 9¨sF"4< %$-&µ Dh<-¢+ /#1+'/#1: 7j F%0 ;1: _¥§ ¢+-/ 1s7+-/ % OO`'{ < + /#1+'/#1: !j#F Df7+-"
(249) 0 F2$xOR °0$- I1 i ;<$hL ¦'M%Ä5+-/ 1s7+ / .¥O § OO®" 9¨sF D Fl K F<$hâ L _ kY F Y J Kx06
(250) & + . F1:< YFl+-/ 1s7+ /-%kO § OQOªz Dv <$* D < s´"4 ! ´
(251) )- ´"4F9$sF " " %$` [ L ]_ k'´"4# "1:#<: ~7 1-'´1 µOQ R D + 0
(252) FYI+-/ 1s7+ /#1: 7j#
(253) 4£r+-1s D 1:hâ L a|`1K&- iV£ Dp&-"9$®<$´ 1:j#%$®%u -"+-¨- <s6F4&: " 1 "%0 98- DG< X0$-+ + ..$- w< > $-%$- _ "1 "D$` 1'#¥i74"%%$- |`1K&- %&- "<s6F J+-1: Y01 ".0 1:s¤Y.%¨-1
(254) 2$¤% 7 T $-1: ;#´ <-+- < YS<s69$- ³
(255) F 1' <K J "%³t³ 6
(256) {GG« _Y 0 s´7+-4"%´< ³"K 01'#"%7 ;1:-G ". ~ fF%$- I+ /#1+'/#1: 0j F% 1:< sGFY< 1'k -l|`1 7H /#<r s w2$*YFYH' -z +-L'M _§ 6
(257) ;<'0 7 F".7 1 + " zX< 1-<: 7 F"%0 1 sÄ%x+- ! 9 Fl+-
(258) F2$*Ä< sFÄ01' ".7 1 'Ä< K "%%$- p|`1K&* K!G$-´< 0 Gz%$- k" Y 1-""%$-+-G$--£+-1s D 1 !0 %) 2$*htFh" 1 h< 1-k¨# %$#`8-1' Kw< X ï)'- z%7 ;1:-w"
(259) 9$*
(260) 9 z _. 3576'8 9;. V_. 3. ' . <. ;
(261)
(262) 57;# ; ) 5%6 5 5
(263) ; 8 5 9 ; .
(264) . u%$*Y ! ä _ f_ -"/ 07 D0W^ < P _ 0"H- > = J- . ç ?-
(265) ç J ?- K ?*é=- b
(266) ç ? b ;. i J . ïc '}r? =´ ç
(267) ê < 1-" 7 1--¦ ¦ ms_ < N! Zã+ _ VaV.T!-¦K _ RUKj#1' G_ _` / ^)- u _ X-"/ x{ _ ä>$*<K- q <£ä _ q%¨^0 F^)-
(268) ç ? æ ? ; ?
(269) 4
(270) 9
(271) I? v ç ?
(272) = ê cv «% $ 4dV L _ % N m â \ â Zã+ _ â m V}T!â _ 1'! _ X _ P X _ > $- "/ _ { _ P "
(273) _ p$- #<©{ _
(274)
(275) - pA? v. J?-^èI ç ? JKv @! A"A =-J? =G ç
(276) ê -¦ ¦ ms_ <'# N \ Z%ã+ _ V¦ L TV¦ \ L _ § J#'R _ _ 7 #K« _§ 9¨- -s#< G_ RUKj 1- èf ç J? @ 9 ?- Kz ?*é=- Jf
(277) ç ? ç
(278) ê c }- $ A"ié ê .
(279) %
(280) A? = ç æ
(281) J-5} ç ?-
(282) ç «%X#%Q-¦ ¦aV _ '& N! Zã+ _ VL KT!â \-_ p Q _ { _ _ P _('
(283) F$*8: _ u )K$* Q _ _ RU
(284) G_ _. ! _ _ ;< k1'1-< x _ äv$ 8 HK$* f#<®| _ P _ {I$`!$-¨-x ç AFq
(285) = F ç ? i= ?0@ A7B ? ièf. ? GJ ) ?- J?- ? 9-ç " F " -¦ ¦ L _ % N \^m Zã+ _ VKxVT _ . _ L_ â_. . . . . \-_. . . . . M.
(286) ms_. x 71-F u_ ä _ _ ³_Ä . /$* '_ äu KH-4 _ _x§ q| _ P _ {I$!$-¨*I <¯ _ _ RU :cfeKg èf ç J? !c z. @ æpæ K- èfïc . -? = 9 éK J ç
(287) ê J F ç ? O § 1 Yp .K-¦ ¦ ms_ '-NV VZ _ RU1 < 1-EP _ _ _ /
(288) aO _ _ y0#ER _ P %!$*1y1'w <i« _ z7/ cfeKg . ç ?- ; ? =-- c? 9 ? ê c?
(289) c?
(290) 9 KJ= ?
(291) ; .A æ =-? = ; ? . ? @ A" J ?- K ?*é=- JF ç ? i- 4
(292) P´4"/- ii1 {G)- J ) #<Uk8-1 +' -¦ ¦ \ _ <' N m T Zã+ _m â -T m â '_ RU+ +-F §f_ ¥_ k£P´)-/-5|`
(293) / 1- Y_a§ u1#$*"v#<®P _ 1'ïWK¨- 7)- ç ç ç -
(294) Ä? = 9 I Kæ ? J-9. cv
(295) I? ^J P´4< -" -N Ox 7 7Z -¦ ¦ ms_ ' '-N7LZ%ã+ _ \ KT m'\-_ äv$FF _ _ < G_ ä _ RU/ > = J- ç J? @Y? ç J ç «%xäu%8iP´1'
(296) G ;1'F -¦ ¦ s_ & N7Zã+ _^m MV.T m aV _ ' k F< §f_ O _ >P _ | _ U1'H G#<P _ O _. l F< ¯ £? = @ v F FJ ç æ ? -J æ @ v ³; ? . ? ? = ; ? } c ?- ç J? u 1-"/ . -¦ ¦Kâ _ %& NyOs Zã+ _ - TL ¦ _ G ï 7H-KH-+-¤R _ ¤_ <ñO _ _ 1 !
(297) 9 ? -. c h@K?- K ´? ç J? JK @ æpæ K- -Kæ ? }J sæU
(298) 4
(299) J =-
(300) @ K w7l$-#1' -¦ ¦ L _ <(<4N!â Zã+ _ V m #L T7 _ f !$- .:{ _ æ cv
(301) . F @
(302) ±; ? } c @K?- JK P´< -" -NyOE
(303) 7Z:-¦ ¦Kâ _ ' NV¦KZã+ _ M \^m T7 _ G f_ §f_ #<ñ{ _ I 0$- % ; ? . c r@K?- K S? i9 á @K?-±éK 9 ç
(304) ê ? = æ5K .7c c . G "41:)--4:-¦ ¦ \-_ '# N \ ¦KZ%ã+ _ âxV¦ T! \#_ w10/K1K8-4 _ aä _ RU1'
(305) +- _ _ p$s79j# _ _s§ d _ _` !0 JF1'#E _ G_` $sF G_ O _ P´".1 _ § W1-TyRU
(306) F _ ä _
(307) F
(308) i G_ - _ { _ {G 7i00 71 K)- f_ OE)K$* ä _ { _ k+- / 1->#<ð _ _ p JF
(309) F
(310) #< v
(311) ?- =-? JK @rå æ ? c
(312)
(313) * æ
(314) ^èI}J ? - .ê . ç
(315) KJ= ?
(316) *9 z F -¦ ¦ s_ <'& N!^Zã+ _ LK \ T7L L _ äuYkj- _ « _ «H-5$- I _ --F §f_ u 7)- 1 G < _ ä _ -
(317) %
(318) æ ? -J æ @ ç - ç ? ³? = æUK .7c c .} 3é ê 9 ; ? '} c b@K?- JK våXè "
(319) ;:-¦ ¦K _ '-NV.Zã+ _ MV}T7aV _ k1 kFO _ _~ G_ >
(320) y1 _ {p< ª < P _ _®§ #
(321) ç * @°cv } KJ Kæ c . F @ ? JK A!?-
(322) ? =
(323) c KGç ? æpæ ?h? = v C} ç ?-FJ ç c? ;# ? ê G 1- / -¦ ¦ L _ '& N!â m Zã+ _ â \ âsM \ T7aV _ I$*1' _ w _ äu 4 _` ;"/Kj:dë _ aO _a 1:/# w-< _ 7 - 9c -K ê J? @ . J-pB ("é ê c .- Y ? . ) =- 7c 9 ? -?-
(324) ? bé ê >åpè? = æ =-J? G9@F@ @iJ }
(325) J }
(326) J-A
(327) J çs}I9 @K?- JK AéKJ =-J ç c .- J-A qc }Kæ5- ?-
(328) ê®; . çs ? }
(329) =J }
(330) 9c }I - u 1' / ixV _ '# N! âKZ%ã+ _ V VMâ T7K _ _~ G_ w« _ f/ % "/ 7jKj: §f_ _ k _ { _ k#1#8: I < P _ P _ äu"/ F d }
(331) J J néK @ ; ? } c £ æ J? =é êS9 @ K ? =fc .- 4J v iJG -
(332) ê =- J - F? ^
(333) K} #< 1'" J#1'1 )Kj#:-¦ ¦ L _ <## NV.KZ%ã+ _K\^m V \ T! _ 'P _ { _ _ W^ s{ _ P _ < ' o FKT ' Ds _ - 1-1s « _ _ < ¥äv$* D _ §f_ u1 #< _ P _ v$- 7)- o ^)-
(334) 9 ? -. c ±@K?- 9K ?-
(335) ? ¬é ê ^J= ?
(336) î 9 . æ =-J? =¤é ê; I æ ?-
(337) ? .èv?- ? = 5¨*1 }:-¦ ¦Kâ _ ' %-N0 âKZã+ _ âsM^¦K#TV. _ | "Ks _ §f_ ' 7 ` <Y _ {p""
(338) F F p
(339) ? U; ?c cvJ ç @ ; -@ K ? = 9 ? } c @K?- K5v
(340) J? % A!=-Fcv =- =-?- ê ? c .KæU- b !c z. @ ç
(341) ç - F ç - G 1' / -¦ ¦ \-_ '& N0xV.Zã+ _ -¦ \ M^ T \-_ X #H-1#$*KP _ u_ < §f_ OE !0 7 ;<K)- G ?- ¤éK 9 4
(342) ? = 7è ( ` c cvJ ç ; pé?-? - J^ ? = }
(343)
(344) ?- x #<'
(345) G ;1'F:-¦ ¦Kâ _ <# NoMZ%ã+ _ â-¦'MTV. _ |s$- !$-j- _ _ «H-W ks _ «H- 1- <« _ P1 7 K=- @ F? @ 9 X=- @
(346) @ ?- =-J ; éK Gc?
(347) @ æ è IX? = .-.KkéK
(348) =-J ç . -4*@ Kpæ5 K} A " -KæU ç u 1'"/ }:-¦ ¦ ¦ _ %# N
(349) Os`KZã+ _Km - TLâ _ . s_. . . M_ _ V¦ _ V V _ V. _ VL _ V.â _. . . . . . . . V \-_ V ms_. . . . V s_ VM _ V _ -¦ _ xV _. _. . . . . . . . . . . .
(350) -L _. qR _ §f_ _ _ K$- G_ _ p$*K)- _ _ K)-qP _~ G_ X$-^)-> < G_ _ 1- qFê ?- 9 @ ; æ ? e?-A ) % :æ cv
(351) . ç ç ; ï@ @ @bc A ; ? .? ?- æ5 =- @
(352) ? «5$*" F"¥{p" F<'aäuK -¦ ¦ s_ % N!-¦Zã+ _Km 'Mâ#T7Kâ _ « P _ b« _ X.$K0 G_r / .$az< h{ _ P _' 98- < 4 _ {p""
(353) F ¯#< u_' I¨ ¨- 7)-/ # X 4
(354) ? ©v ? = ) 9 J ? = çs ? p ê ç ?-
(355) J ç ? ;# ? ê JpåYFc? J ê` < 1-" J#1:;1:) j#:-¦ ¦ s_ <#& N \ Z%ã+ _ â. â T! â-LKâ _ k _ <¢O _ #$-# 5c? 9^ ? ê © æ5K .c c .}
(356) J? } 5cfeKg x <'b G ;1'"/- F" -" F " -¦ ¦ s_ % '-NoMZã+ _ L m â T7L V _ 7j#1'< >R _ _ -H- IP _ k1: Jk1#1- _ x1#j# _ HK$7/ ->P _ -H-H' 9¨* 4 _ wH-/ _ |s$4 F1K1 P _ U1: _ ä _ <'a <« _ j#/ F:
(357)
(358) æ a @ ; xcfeKg æ Jç -A!?-
(359) ? =vc .- 4Ji ? 5?-.? =-5 Fc?
(360)
(361) F J? ? J Kæ ? #" s-¦ ¦ L _ NV. Zã+ _ L ¦aV T! ms_ x/
(362) !¨-"/ Iä _ _ _ -"/$sïW¥| _ 7H- X{ _ ' 1- 9)K _ P´ F%0W# p _ U k _~ G_ 8:1' RU
(363) !T äG.0W1 Usä _ _ F P _ { _ P´)-$1:# _ O$*"" 1-Q{ _ | _ O`0
(364) 0 O _ K¨- )- #<ðP _ äG !1k K? ç =S=- 7c @
(365) c? Fq@ ? ?KJ´0c } ´?- .¤ æ c?- = æ J - = J?-*@ K- X=- ? }=±
(366) @ ¯ïc? ª? = æ5K¤çs.^G; J æ X$* P´1' p % -¦ ¦ \-_ <# N! â Zã+ _ L'M \^ T m â _ § 8-1' ; _ « _ p _§ {p
(367) F -X{ _ f !$* %Iä _ P$sF p < _ OE1#$-j-.)K$- 'ê FJ !c z. ,zSèI ç J? = }
(368) ê é ê ; rc KB % c ? = p ç ?
(369) ê é ê 9 ê _ I ;1' _^ / _ xV ms_ ' (<N7LKâ Zã+ _ -¦ m ¦'MT!-¦ m V ms_ cfeKg %
(370) å p ? ;# ? Ä/ K)- ³_ _ OE0 J; _K / .$s/- _ I$-1- _ ä _ O`1 kF _§ :{ _ R51KKä _ P´.0 9H- ë _ ë5 41''ä _ | ^HQR _ { _ F< K F"/ 'P _ O _ '7#*ä _ 'Y_ |` ' _ _ K01 9W'O _ 1 _ _ RU1-1'¯P _ P®1:0l j# < _ _ ok# v ç ? æ cv
(371) æ ?*é F
(372) c? ;# ? ê J 9 °
(373)
(374) 9@ @ ç
(375) - ç - ç ê ê`
(376) h? =
(377) c ç -
(378) ç - !c .. G 1' / -¦ ¦ ms_ '&(<NV \ Zã+ _ V¦aV¦ \ T.V s_ 1- _ _ | _Ä 1'J s _~ G_ u"H- _ äG1K¨- < 1K$ &- G_ _d§ $-+-1- _ Y_ ëX ;1:^)->R _ _ k FF §f_ |`1- J )-p < _I 1' sscfeKg Jç -A0?-
(379) ? =bc }- áJ ? .cvJ? ê ð? æ J? K
(380) êi. FGJ
(381) c?
(382) ç
(383) - ç -}J u 1' /#:-¦ ¦ \-_ '& N \ Zã+ _ â LaV.T s_ ë5 1 K)- _ _ | _ 1
(384) s _ {p u_'§ $-+-1' z _ Q _ T _'§ ~$*Q _'§ 9$* _ äu1#¨- F< 1K$ &- _'§ 9$* #< _ 1-qcfeKg Jç -A0?-
(385) ? = .- 4J p9 ? . vJ? ê ´? ³ néK JKFê è
(386) ±J å
(387) c? Fq c ç -}J _ f 1' _^ /# _ :-¦ ¦ s_ '&'-N Z%ã+ _ â- '\ T!â-'M _ OE1 0 "4 G_ Eä _ J#q < _ p 9 < sè
Documents relatifs
To test whether the vesicular pool of Atat1 promotes the acetyl- ation of -tubulin in MTs, we isolated subcellular fractions from newborn mouse cortices and then assessed
Néanmoins, la dualité des acides (Lewis et Bronsted) est un système dispendieux, dont le recyclage est une opération complexe et par conséquent difficilement applicable à
Cette mutation familiale du gène MME est une substitution d’une base guanine par une base adenine sur le chromosome 3q25.2, ce qui induit un remplacement d’un acide aminé cystéine
En ouvrant cette page avec Netscape composer, vous verrez que le cadre prévu pour accueillir le panoramique a une taille déterminée, choisie par les concepteurs des hyperpaysages
Chaque séance durera deux heures, mais dans la seconde, seule la première heure sera consacrée à l'expérimentation décrite ici ; durant la seconde, les élèves travailleront sur
A time-varying respiratory elastance model is developed with a negative elastic component (E demand ), to describe the driving pressure generated during a patient initiated
The aim of this study was to assess, in three experimental fields representative of the various topoclimatological zones of Luxembourg, the impact of timing of fungicide
Attention to a relation ontology [...] refocuses security discourses to better reflect and appreciate three forms of interconnection that are not sufficiently attended to