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Receptor clustering affects signal transduction at the membrane level in the reaction-limited regime.

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Academic year: 2021

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Figure

FIG. 1. A. Dose-response curves obtained in simulation for n=1 (no cluster, open squares), n=5 (clusters of 5 receptors, open triangles) and n=10 (open circles), all simulation pa-rameters remaining equal (p +h = 0.1, p -h = 10 −4 )
FIG. 3. A. Empirical densities of times between consecutive activation events of the same G molecule, using the same set of parameters p +c = p -c = 0.01, p +h = 0.1, p -h = 10 −4 , for various cluster sizes n
FIG. 4. A. Fraction of activated G at equilibrium h ⋆ for ρ = 1 (squares) and ρ = 0.25 (triangles) versus various clus-ter sizes and for different diffusion coefficients D – transac-tivation is disabled (open symbols) or enabled (closed sym-bols)

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