Supplementary Figs. 1–4. Supplementary Fig. S1. Heligmosomoides polygyrus Venom Allergen-like Protein-4
(HpVAL-4) crystallographic tetramer packing shows no appreciable interaction between monomers. Supplementary Fig.
S2. Superposition of the Heligmosomoides polygyrus Venom Allergen-like Protein-4 (HpVAL-4) monomers reveals
extensive structural similarity. Supplementary Fig. S3. The secondary structure alignment of Heligmosomoides
polygyrus Venom Allergen-like Protein-4 (HpVAL-4) with Ostertagia ostertagi activation-associated secreted protein-1
(OoASP-1) reveals conserved secondary structure motifs and variations in loop regions. Supplementary Fig. S4. The
secondary structure alignment of Necator americanus Ancylostoma secreted protein-1 (Na-ASP-1) reveals conserved
secondary structure motifs and variations in loop regions.
Chain A
2 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 EFGCDGTLEQNDTTREVFLRFHNDVRKFI ALGI YP NKVGVLGPAKNMYQLKWSCDLEEEAHESIYSCSYNPLLL HPQSYSKLLSVD LPDT GFCCPADLNQTDEARKIFLDFHNQVRRDI AGAS PLLNLAVQMRNVLGPAKNMYRMDWDCNLEAKAKAMIWPCT TPLPIDTS IPQNLAQWLLFQNSQEN 1 5 10 15 20 25 30 35 41 45 50 55 60 65 70 75 80 85 90 95 100 4g2u(A)
Chain A
92 95 100 105 110 115 120 125 130 135 140 145 150 155 160 165 170 175 180 185 DVVGATLEMWTEFMR I YGV NTKTNSYNPSFSQFANMAYSKNTKVGCSYKKCG GDTLVTCVYELGVKLPSHPQMWENGPTCVCVAYTDSICNDNNL EVLTQTPWSWVTASLRNLQPDTEANIYNWQIRPLSNIANWQNLKVGCAHKVCKFPTGTNMVVSCAYGGEV LQDNEVVWDKGPTCMCNAYPNSFC CNNL 101 105 110 115 120 125 130 135 140 145 150 155 160 165 170 175 180 185 190 195 4g2u(A)
Chain A
187 CEY CDT I AAATLRNQPC 199 205 210 4g2u(A) HpVAL-4 HpVAL-4 HpVAL-4 OoASP-1 OoASP-1 OoASP-1Supplementary Fig. S3.
Chain A
2 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95 EFGCDGTLEQNDTTREVFLRFHNDVRKFIALGIYPNKVGVLGPAKNMYQLKWSCDLEEEAHESIYSCS YNPLLLHPQSYSKLLS VDLP DTDVVGAT SFGCSNS G I TDSDRQAFLDFHNNARRRVAKGLEDSNSGKLNPAKNMYKLSWDCAMEQQLQDAIQSCPSGFAGIQGVAQNTMSWSSSGGYPDPSVKIEPT 24 30 35 40 45 50 55 60 65 70 75 80 85 90 95 100 105 110 115 120 3nt8(A)
Chain A
98 105 110 115 120 125 130 135 140 145 150 155 160 165 170 175 180 185 LEMWTEFMRI YGVNTKTNSYNP SFSQFANMAYSKNTKVGCSYKKCGGDTLVTCVYELGVKLPSHPQMWENGPTC VCVAYTDSICNDNNLCE LSGWWSGAKKNGVG PDNKYTGGGLFAFSNMVYSETTKLGCAYKVCGTKLAVSCIYNGVGYITNQP MWETGQACQTGADCSTYKNSGCED GLCTKGPD 123 130 135 140 145 150 155 160 165 170 175 180 185 190 195 200 205 210 215 3nt8(A)
Chain A
VPETNQQCPSNTGMTDSVRDTFLSVHNEFRSSVARGLEPDALGGNAPKAAKMLKMVYDCEVEASA I RHGNKCVYQHSHGEDRPGLGEN I YKTSVLKFDKN 220 225 230 235 240 245 250 255 260 265 270 275 280 285 290 295 300 305 310 315 3nt8(A) HpVAL-4 HpVAL-4 NaASP-1 NaASP-1 OoASP-1