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Heligmosomoides polygyrus venom allergen-like protein-4 (HpVAL-4) is a sterol binding protein

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Academic year: 2021

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Supplementary Figs. 1–4. Supplementary Fig. S1. Heligmosomoides polygyrus Venom Allergen-like Protein-4

(HpVAL-4) crystallographic tetramer packing shows no appreciable interaction between monomers. Supplementary Fig.

S2. Superposition of the Heligmosomoides polygyrus Venom Allergen-like Protein-4 (HpVAL-4) monomers reveals

extensive structural similarity. Supplementary Fig. S3. The secondary structure alignment of Heligmosomoides

polygyrus Venom Allergen-like Protein-4 (HpVAL-4) with Ostertagia ostertagi activation-associated secreted protein-1

(OoASP-1) reveals conserved secondary structure motifs and variations in loop regions. Supplementary Fig. S4. The

secondary structure alignment of Necator americanus Ancylostoma secreted protein-1 (Na-ASP-1) reveals conserved

secondary structure motifs and variations in loop regions.

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Chain A

2 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 EFGCDGTLEQNDTTREVFLRFHNDVRKFI ALGI YP NKVGVLGPAKNMYQLKWSCDLEEEAHESIYSCSYNPLLL HPQSYSKLLSVD LPDT GFCCPADLNQTDEARKIFLDFHNQVRRDI AGAS PLLNLAVQMRNVLGPAKNMYRMDWDCNLEAKAKAMIWPCT TPLPIDTS IPQNLAQWLLFQNSQEN 1 5 10 15 20 25 30 35 41 45 50 55 60 65 70 75 80 85 90 95 100 4g2u(A)

Chain A

92 95 100 105 110 115 120 125 130 135 140 145 150 155 160 165 170 175 180 185 DVVGATLEMWTEFMR I YGV NTKTNSYNPSFSQFANMAYSKNTKVGCSYKKCG GDTLVTCVYELGVKLPSHPQMWENGPTCVCVAYTDSICNDNNL EVLTQTPWSWVTASLRNLQPDTEANIYNWQIRPLSNIANWQNLKVGCAHKVCKFPTGTNMVVSCAYGGEV LQDNEVVWDKGPTCMCNAYPNSFC CNNL 101 105 110 115 120 125 130 135 140 145 150 155 160 165 170 175 180 185 190 195 4g2u(A)

Chain A

187 CEY CDT I AAATLRNQPC 199 205 210 4g2u(A) HpVAL-4 HpVAL-4 HpVAL-4 OoASP-1 OoASP-1 OoASP-1

Supplementary Fig. S3.

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Chain A

2 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95 EFGCDGTLEQNDTTREVFLRFHNDVRKFIALGIYPNKVGVLGPAKNMYQLKWSCDLEEEAHESIYSCS YNPLLLHPQSYSKLLS VDLP DTDVVGAT SFGCSNS G I TDSDRQAFLDFHNNARRRVAKGLEDSNSGKLNPAKNMYKLSWDCAMEQQLQDAIQSCPSGFAGIQGVAQNTMSWSSSGGYPDPSVKIEPT 24 30 35 40 45 50 55 60 65 70 75 80 85 90 95 100 105 110 115 120 3nt8(A)

Chain A

98 105 110 115 120 125 130 135 140 145 150 155 160 165 170 175 180 185 LEMWTEFMRI YGVNTKTNSYNP SFSQFANMAYSKNTKVGCSYKKCGGDTLVTCVYELGVKLPSHPQMWENGPTC VCVAYTDSICNDNNLCE LSGWWSGAKKNGVG PDNKYTGGGLFAFSNMVYSETTKLGCAYKVCGTKLAVSCIYNGVGYITNQP MWETGQACQTGADCSTYKNSGCED GLCTKGPD 123 130 135 140 145 150 155 160 165 170 175 180 185 190 195 200 205 210 215 3nt8(A)

Chain A

VPETNQQCPSNTGMTDSVRDTFLSVHNEFRSSVARGLEPDALGGNAPKAAKMLKMVYDCEVEASA I RHGNKCVYQHSHGEDRPGLGEN I YKTSVLKFDKN 220 225 230 235 240 245 250 255 260 265 270 275 280 285 290 295 300 305 310 315 3nt8(A) HpVAL-4 HpVAL-4 NaASP-1 NaASP-1 OoASP-1

Supplementary Fig. S4.

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