• Aucun résultat trouvé

Traitement conservateur d'un second événement intra-mammaire homolatéral : intérêt de la classification d'irradiation partielle de GEC-ESTRO

N/A
N/A
Protected

Academic year: 2021

Partager "Traitement conservateur d'un second événement intra-mammaire homolatéral : intérêt de la classification d'irradiation partielle de GEC-ESTRO"

Copied!
39
0
0

Texte intégral

(1)Traitement conservateur d’un second événement intra-mammaire homolatéral : intérêt de la classification d’irradiation partielle de GEC-ESTRO Lucile Montagne. To cite this version: Lucile Montagne. Traitement conservateur d’un second événement intra-mammaire homolatéral : intérêt de la classification d’irradiation partielle de GEC-ESTRO. Human health and pathology. 2019. �dumas-02436910�. HAL Id: dumas-02436910 https://dumas.ccsd.cnrs.fr/dumas-02436910 Submitted on 13 Jan 2020. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

(2)   .   .    F      . . . . .    4=:1T4!<%3<,43$=,8152%$T<<$% /4!52!.-# !'.!.   :';%3<'%%<;4=<%3=%8=!1,9=%2%3<1 "=1<'$%2'$%",3%$%,"% %@%3$:%$,ho34@%2!:%hfgo :  =",1%  '%1%n4?<goof :'/=;^ni_

(3) 3<%:3%$%QQ43"414*,%48<,43:$,4<+':8,%      E F     E     F.      !6.4,!*529/-0/3# !B . 43;,%=:1%:4)%;;%=:223=%1 . . . . :';,$%3<$=/=:C. 43;,%=:1%:4)%;;%=: %3Z:" . . . . . ;;%;;%=:. 43;,%=:1%:4)%;;%=: ,11%;   . . . . ;;%;;%=:. $2%1%4"<%=::,%Z@% Z  . . . . ;;%;;%=:. 43;,%=:1%:4)%;;%=: %3Z,"+%1 Z

(4) . . . . ,:%"<%=:$%<+&;%. .     . . . .

(5)   

(6) 

(7) 

(8) 

(9) 

(10) 

(11)  

(12)   . . . h.

(13)  

(14) 

(15) 

(16) 

(17) 

(18) 

(19)  

(20) . . .       . . . i.

(21)    

(22) 

(23) 

(24) 

(25) 

(26) 

(27)  

(28) .  . . .     .  .   . . j.

(29) 

(30) 

(31) 

(32) 

(33) 

(34) 

(35)  

(36) .   . . .       . . k.

(37)  

(38) 

(39) 

(40) 

(41) 

(42) 

(43)  

(44) . . .   .   . .     . . l.

(45)  

(46) 

(47) 

(48) 

(49) 

(50) 

(51)  

(52) . . . .        . . m.

(53) 

(54) 

(55) 

(56) 

(57) 

(58) 

(59)  

(60) .   . . .   . n.

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o.

(62)  '-/.!A9=,=:,<'<';,),&:%$T(<:%1=/4=:$T+=,Q                                                  . . gf.

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l^%<81=;_L   5',,5-!N243!%=Z):&:%8:')':'L  4/!,N34<:%),$&1%"+,%3;=",;;%Q            . . gg.

(64)  2%;2,;N  9.4&'A2!%;<+N281=;!%11%:%3"43<:%$%gL%;33'%;3T=:,%3</2,;'<';, !%11%;;3;<4,R(2%=Bj"4,3;$%1 :3"%N2(2%8:&;<4=<%;1%;+,;<4,:%;84;;,!1%;N2(2% 8:&;=3,3<%:3<$3;1:%=;%N:,%33%;4=;;'8:%:L),$'1,<'N<):3"+,;%%<<;843<3',<' )43$$%<4,=3%$%;81=;!%11%;8%:;433%;9=%/%"433,;;%Q  &,/#A243"4=8$%)4=$:%$=iL<4=<%;"%;;4,:'%;$'!:,%),3*;N!,&:%%<*:%;;,3;%< <4=<%;"%11%;9=%1T43@@,@:%L=%;1%!:,3$%)41,%$3;2@,%L6' N1)4:"%<:39=,11%%<=3 +=24=:,3,2,<!1%R/%34=;;4=+,<%%3"4:%81%,3$T33'%;<4=;1%;jL  .%#,'15!N2"4Z,3<%:3%)@4:,<%N^)=<=:%_2&:%8:),<%%<A::,4:$%1T43"414*,% $,*%;<,@%L T$2,:%<438:"4=:;N<8%:;'@':3"%%<<)4:"%,3'!:31!1%Q<4=<%;"%;33'%;4> /T=:,;1"+3"%$%<:@,11%:^%<;=:<4=<$%),:%$%;)411%;;4,:'%;_<%;"5<';L  2%58!452Nhk3;9=%1T43;%"433,<%<34<:%"4281,",<':%;<%,3<"<%Q34; 33'%;843%CN=<%11Z2$%1%,3%;N8,;",3%;N/4=:3'%;!<%=N@"3"%;=;0,4=,:3N;4,:'%; 8441Z+4=;;%@%"1!3$%$=niN:%!43$,;;%2%3<;24=:%=BN2:,*%;;4=,:N%<!,%3$T=<:%; %3"4:%L  2'.!A52!4,9A9 '!!42'.!A2%;),$&1%;"48,3%;$T%B<%:3<%<$T,3<%:3<L%; @"3"%;%34:;%,34=!1,!1%;N$=:%3)4:"%2%3<84;,<,)"4=8$%4142!=;")'N$%;;4=;Z"411%; 8;<4=/4=:;:%3<!1%;N=3;4=<,%32=<=%18%3$3<<4=<%;"%;33'%;R %;=,;),&:%$="+%2,39=% 34=;@43;8:"4=:=L  2/,'.!A2"48,3%$T,3<%:3<N1W:%,3%$=;%,3XN<4=<%;"%;242%3<;:')1%B,43; 8+,14;48+,9=%;^%<;=:<4=<24=:%=;%;L_Q:48"43<%3<%9=%<=;4,;:%@%3=%%<$%84=@4,:<:@,11%: <%;"5<';L<4=<%;"%;)=<=:%;;4,:'%;@%"1'2%3<L  ',A28:,;,%33%$T$48<,43N243:<,;<%8:')':'%^;=:<4=<1%;84:<:,<;$%. _N)=<=:% <+%:,3%%3%=@%N1$4="%=:%<1;%3;,!,1,<',3":3'%;L%;i*:22%;)4:%@%:L  44&'3!4!,'.A34;@4C*%;=BN=B!1*=%;,3,2,<!1%;$%<<+,;%<=B :%2:9=%;"%:!%;$%%14L  52!4/5 /5N"4=81%24$&1%N/T,<%11%2%3<+ <%9=%@4=;:%$%@%3,%D3,#4,;L  4&,'!A34<:%);+,43*=:=N%<1T'<'8:4"+,3%34;"3%L  ./.!A22%B,",3%8:')':'%L           . . gh.

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

(66) !2/-!N2438:%;9=%$,:%"<%=:$%;<%:N/T$2,:%<438:"4=:;%<<43*'3,%L %;=,;<:&; "43<%3<%$%84=@4,:<:@,11%:%<88:%3$:%<%;"5<';L   /-'.N2%:",84=:<4=;<%;%3;%,*3%2%3<;%<<43+=24=:,3'*1!1%L   <;3;4=!1,%:&+!!,A5,'.!!4'.!.4N#/2&A

(67) /3!0&!4/22'.!,3;,9=%1%2 /. '5A84=:1%=:;C28<+,%%<1%=:,$%L  52 !22 N2%:",84=:@4<:%%3;%,*3%2%3<%<@4<:%*:3$%8'$*4*,%Q4=;<:3;2%<<%D @4<:%8;;,43@%"+=23,<'Q T,1%81=;*:3$:%;8%"<84=:@4<:%<:@,1Q  6' ^1)4:"%<:39=,11%N<4=<%;34;$,;"=;;,43;W3B,4*&3%;X;=:1T@%3,:_N5 ^2 "4Z,3<%:3%8:),<%LLL_N-','!.^2438%<,<W,2,XN1

(68)  

(69) <%2_N!,0&'.!^:%@,%3;LLL_%< #-9N2%;;=8%:;"4Z,3<%:3%;$%:$,4<+':8,%Q %;=,;<:&;+%=:%=;%$%@4=;@4,:2%;"5<';L <4=<%;34;;4,:'%;@%3,:%</T%;8&:%"%;!%11%;33'%;<:@,11%:%3;%2!1%L  2%;34=@%=B"4Z,3<%:3%;$%:$,4<+':8,%N@':,<!1%!4:$$%Z N'!22!F,!8'3A

(70) /.4&.!4

(71) !.F&','00!?  2%;"4Z,3<%:3%;$%:$,4<+':8,%W$T$48<,43XN'. !42A1*%3<,11%;;%,3":3'%L  34<:%,28%:<=:!!1%%<),$&1% -:?       . . gi.

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kN@4=;@%D<4=/4=:;;=2T""=%,11,:@%"!,%3@%,113"%%</%@4=;%3 :%2%:",%<:&;;,3"&:%2%3<N  %."3A2%:",84=:<*:3$%,$%N<$,;843,!,1,<'8%:23%3<%N<%;"428'<%3"%;+4:;8,: %<<4=<%;34;"43@%:;<,43;"+4,B$%:4!%;Z$'!<"+%@%=BZ<%3$3"%<143;Z84<,3;L  '/,3!4&'5,4A/%;=,;<4=/4=:;:@,%$%@4=;@4,:$T;<:%,3<%$%*:$%L  %,'!A,'2!A'4/2'A2A!.*-'.!42'B2%:",84=:<4=;"%;;%2%;<:%;8;;'; @4;"5<';L1*:'34<:%,3<%:3<8;<4=/4=:;)",1%N43:%;<%;41,$,:%L<4=<%;"%;*:$%; =B9=%11%;34=;@43;;=:@'"=;L  

(73) /!,9.!4!.5 A2%:",84=:@4<:%,$%8:'",%=;%%<@4<:%8<,%3"%N;3;9=,"%<:@,1 3T=:,<8=!4=<,:L  <4=<%1T'9=,8%$=iN2%:",$%2T@4,:;4=<%3=%8%3$3<"%8:%2,%:;%2%;<:%Q3% 8%3;'%84=:2%;;=8%:;"+%);2/,'.!!4 ...&9=,43<;=*=,$%:2%;8:%2,%:;8;$T,3<%:3%L 2;%":'<,:%;8'",1%5 2!9L  1T'9=,8%$%4=*,3;N84=:2T@4,:$433'1T%3@,%$T(<:%:$,4<+':8%=<%%<84=:1T""=%,1 9=%/T,:%#=$%18:<$%<4=<1%243$%Q%:",=B4"<%=:;2'!'33'!2A&','00!/.&'.A&/-3 2!'4-..A.4/'.!2'.'A!.*-'. /&A !26#-.!4#-92%','!284=:1%=: %3;%,*3%2%3<%<1%=:!,%3@%,113"%Q<4=<%1T'9=,8%$%23,8=1<%=:;%<$%;%":'<,:%;%< . 2'.!N9=,43<:%3$="%;l24,;8:),<;Q3%8%3;'%84=:,/ '!%<34<:%!=:%= 8:<*'Y$,;"=;;,43;%3)122'%;L  1T'9=,8%$%1T N#,'!4

(74) /$$2!9A-',,!!4'&!,A29,/5Al24,;,34=!1,!1%; $3;"%;%:@,"%4>:'*3,<1!433%+=2%=:*: "%@4=;L3<:&;*:3$2%:",!,0&'.! /2&'!,,'.'A84=:;43""428*3%2%3<N;43%3;%,*3%2%3<N;43""%;;,!,1,<'%<;!433%+=2%=: "422=3,"<,@%L28%<,<%/2,'!A;%":'<,:%8:),<%L   1T'9=,8%$%:$,414*,%N=3;%2%;<:%$%:(@%$3;=3%2!,3"%8:),<%L<4=<%;34; 8=;%;")';Y41@,"):,;%Y'!:,%),3*2<%:3,<'Y$,;"=;;,43;<%3=%;Y)4=;:,:%;Y:%3"43<:%@%"1%. . gj.

(75) 8:')%<%<@,;,224!,1,%:;L3<:&;*:3$2%:",,'8A#,'.!A-#,'!A52A,'2!A6' !4 5',,5-!L   1T'9=,8%$%$%:2<414*,%$%1T:"+%<N@4=;2%239=%D$'/L$'"4=@%:<%$=  3T=:,<8;8=2,%=B;%8;;%:L3<:&;*:3$2%:", !.2'N9=,2T""=%,11,%@%"!%="4=8$% !,%3@%,113"%N2%:",84=:<43%3;%,*3%2%3<%<<*:3$%$,;843,!,1,<'L%:",5284=:"%;l 24,;$%!43+%=:<%;"5<';%<84=:</4,%$%@,@:%"43;<3<%L%:",,!8. 2N9=%/T,%3),3 :%<:4=@'%N84=:"%;$%:3,%:;24,;<:@,11%:%3;%2!1%%<<4=;<%;"43;%,1;L8%<,<% #,".!A$% 1T'3%:*,%:%@%3$:%%<=3%%3<%3<%8:),<%L,'6'!4..!A"%;%2%;<:%3T=:,<8;'<'1%2(2% ;3;@4=;N1%;)'%;$%1T  L3%8%3;'%;8'",1%84=: 5',,5-!N1%;%=1"4Z,3<%:3%@4,:=3% =:*%3"%%3<4:;%84=:18,33,3N84=:1$4="%/0&'!N%<1;=8%:%<,::%281#!1%<%2WX '!22!G

(76) !.@H'&!,G2'!@HA/&..!444&'!5L  <4=<%;1%;'9=,8%;$%/4=:;%<$%3=,<N,3),:2,&:%;N,$%;Z;4,*33<%;N N,3),:2,&:%; "44:$,3<:,"%;%<"$:%;$=N$%1T  N$%1T N$=iN$=j%<$=kN2%:",$%:%3$:%2%;/4=:; %<2%;3=,<;$%*:$%;81=;)",1%;%<*:'!1%;*: "%@4;"428'<%3"%;%<@4<:%,3@%;<,;;%2%3< ;3;),11%84=:1%;8<,%3<;L                                   . . gk.

(77) 

(78) 

(79)   

(80)    .  .     . • 

(81) 

(82) 

(83) DDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDCDDDCCDLR •  DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCLS •   DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCCMK  gZ :';%3<<,43$%;8<,%3<%; hZ :';%3<<,43$%;<:,<%2%3<; iZ 1;;,),"<,43$T,::$,<,438:<,%11%$=;%,3""'1':'% jZ =,@, kZ 31C;%;<<,;<,9=%  • DDDDDDDDDDDDDDDDCDDDDDDDDDDDDDDDDDDDDDDDCDDDDDCMN  gZ :"<':,;<,9=%;<=24:1%;%<$%;8<,%3<%; hZ ';=1<<;43"414*,9=%; iZ 4B,",<' •   DDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDCDDDDDCCMT •  DDDDDDDDDDDDDDDDDDDDDDDDDDDDDCDDDDDDDDDDCDDDDNN •  

(84) 

(85)  

(86) DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCCNO • T

(87) DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDCNR • DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNS.                    . . gl.

(88) 

(89) 

(90)   

(91)   . • M. B;%"43$,8;,1<%:1!:%;<<=24:%@%3< • N2  B<+,:$,8;,1<%:1!:%;<<=24:%@%3< • M. P;%"43$"43;%:@<,@%<:%<2%3< •  B""%1%:<%$8:<,1!:%;<,::$,<,43 • 2 P""%1%:<%$8:<,1!:%;<%Z,::$,<,43 • B2%:,"34",%<C)4:$,<,433"414*C • B1,3,"1:*%<41=2% • 

(92) 3@;,@%$="<1":",342 •  ="<1":",342,3;,<= • FP :4=8%=:48'%3$%=:,%<+':8,%4)<+%=:48%34",%<C)4: $,4<+%:8C3$3"414*C • 9B :C • B+,*+$4;%:<% • 

(93) 3<:14!=1:":",342 • B14AZ$4;%:<% •  1C28+4Z@;"=1:,3@;,43 • B2%<;<;,;Z):%%;=:@,@1 • P%$,3 4114AZ=8 •  P2=1<,"<+%<%:,3<%:;<,<,1!:"+C<+%:8C • 43B8<,%3<; • B4@%:11;=:@,@1 • B:%*,431Z):%%;=:@,@1 •  2%$,3$4;%:%)%:%3"%,;4$4;%2%$,3$4;% • %;<:4*%3:%"%8<4: • 8:4*%;<%:43%:%"%8<4: • B;1@*%2;<%"<42C • B;8%",),";=:@,@1 •  BA+41%!:%;<,::$,<,43   . . . gm.

(94)   :%;<"3"%:,;2/4:2<<%:4)8=!1,"+%1<+A,<+A4:1$ZA,$%,3",$%3"%4)gNlmgNgjo 8<,%3<;^8<;_,3hfgh`gaQ,<+3,3":%;,3*,3",$%3"%:<%4)%:1C;<*%!:%;<"3"%:4)hkf8%: gffNfffA42%3N14"1,D%$!:%;<"3"%:;=:*,"123*%2%3<+;!%%3"43;<3<1C%@41@,3*N):42 2=<,1<,3*2;<%"<42CNA+,"+A;<+%*41$;<3$:$=3<,11<%nf;N<4:$,4Z;=:*,"1"43;%:@<,@% <:%<2%3<`haQ +%hfZC%:"=2=1<,@%,3",$%3"%:<%4)h3$,8;,1<%:1!:%;<<=24:%@%3<^h3$

(95) _)<%: ),:;<"43;%:@<,@%:$,4Z;=:*,"1<:%<2%3<,;:4=3$gkrN:,;,3*<+%9=%;<,434);<3$:$4)":% :%*:$,3*<+,;;8%",),";=!848=1<,43`iaQ 4:$%"$%;N;1@*%2;<%"<42C^_+;!%%3"43;,$%:%$ ;<+%431C<+%:8%=<,"1<%:3<,@%1<+4=*+;%"43$"43;%:@<,@%<:%<2%3<^h3$_"43"%8<+; !%%3,3<:4$="%$;,3"%<+%!%*,33,3*4)<+%nf;NA+,"+"43;,;<;4);=:*,"11=28%"<42CA,<+4: A,<+4=<:%Z,::$,<,434)<+%<=24:!%$`jNkaQ+%:%;<3"%:4:0,3* :4=84)<+% :4=8% =:48'%3$%=:,%<+':8,%4)<+%=:48%34",%<C)4:$,4<+%:8C3$3"414*C^ Z_ :%84:<%$<+%:%;=1<;4)"4+4:<4)hgm8<;A+4=3$%:A%3<h3$"42!,3,3*1=28%"<42C81=; ,3<%:;<,<,1!:"+C<+%:8CQ+%kZC%:h3$14"1:%"=::%3"%:<%A;kQlrNA,<+ggr4)*:$%i[j1<% <4B,",<,%;`laQ ;4)<4$CN<+%"+4,"%!%<A%%3h3$3$:%2,3;=3$%:$%!<%!=<!4<+48<,43;"3!% $,;"=;;%$A,<+<+%8<,%3<Q;,"11CN)",3*h3$

(96) N<+%),:;<;<%8,;<4"43;,$%:<+%*=,$%1,3%; :%*:$,3*<+%<=24:)%<=:%;P,)<+%:%,;3,3$,"<,434)2;<%"<42C^A+,"+:%2,3;<+%;2% A+%<+%:,<,;g;<4:h3$

(97) _Nh3$,;$%),3,<%1C:=1%$4=<Q

(98) ),;34<23$<4:CN<%"+3,"1 )%;,!,1,<C4)h3$+;<4!%%@1=<%$Q

(99) 3$%%$N<+%"1,3,"1"43;%9=%3"%;4)<+%),:;<;=:*%:C3$ ,::$,<,43N<+%<4<1$4;%N<+%:%;=1<3<!:%;<;,D%3$<+%"4;2%<,",28"<+@%<4!%<0%3,3<4 "43;,$%:<,43Q%@%:<+%1%;;N<+%8<,%3<T;"+4,"%:%2,3;":=",13$<+%2/4:,<C4)<+%8<,%3<; A3<<4@4,$;2="+;84;;,!1%2=<,1<,3*;1@*%;=:*%:CA,<+4:A,<+4=<!:%;<:%"43;<:="<,43 `maQ =::%3<1CN<+%<:%<2%3<$%",;,43,;2,31C!;%$43<+%;%)"<4:;Q,<<1%$<:%8:4@,$%$!C<+% 1,<%:<=:%)4:+%18,3*8<,%3<;3$8+C;,",3;,3<+%$%",;,43Z20,3*8:4"%;;Q Z3$ 2%:,"34",%<C)4:$,<,433"414*C^_8:484;%$""%1%:<%$8:<,1!:%;<,::$,<,43 ^

(100) _"1;;,),"<,43;!;%$43<+:%%*:4=8;:%8:%;%3<,3**:$=<%14"1Z:%"=::%3"%:,;0`n[gfaQ  . . gn.

(101) +4;%

(102) "1;;,),"<,43;A%:%,3,<,11C=;%$<4$,;"=;;^4:34<_;+4:<%:$/=@3<,::$,<,43)4: 8:,2:C<=24:Q

(103) 34:$%:<420%<+%;1@*%$%",;,438:4"%;;24:%""=:<%NA%8:484;%$<4 %@1=<%<+%,28"<4)

(104) "1;;,),"<,43;881,%$<4h3$

(105) Q +%,24)<+,;;<=$CA;<4$%<%:2,3%A+%<+%:<+%43"414*,"14=<"42%4)8<,%3<;8:%;%3<,3* h3$

(106) "4=1$!%,28"<%$!C<+%,:)),1,<,43<43

(107) "1;;,),"<,43*:4=8Q                  . . go.

(108)    +,;4!;%:@<,431N;,3*1%Z"%3<%:N:%<:4;8%"<,@%;<=$CA;8%:)4:2%$,3<+%3<4,3% ";;*3%%3<%:,3,"%N :3"%N):42hfff<4hfgmQ<A%:%"411%"<%$):428<,%3<;T),1%;Q+,:$

(109) A;"43;,$%:%$;8:,2:C%3$Z84,3<NA+,1%<+%)4114A,3*,<%2;A%:%"43;,$%:%$;;%"43$:C %3$Z84,3<;P:%*,431:%"=::%3"%4""=::,3*,3<+%,8;,1<%:1B,11:C:%^:%*,431Z):%%;=:@,@1\ _O $,;<3<2%<;<;,;:<%;^2%<;<;,;Z):%%;=:@,@1\ _O;8%",),"^_3$4@%:11;=:@,@1^_:<%;Q +,;;<=$CA;88:4@%$!C<+%14"1%<+,";"422,<<%%Q LF4'!.4$!452!3 :*%<848=1<,43A%:%A42%3A+48:%;%3<%$h3$

(110) 4""=::,3*)<%::$,4Z;=:*,"1"43;%:@<,@% <:%<2%3<8%:)4:2%$)4:<+%8:,2:C<=24:Q%"43$

(111) A;"43;,$%:%$;14"1%@%3<4""=::,3* A,<+,3<+%8:%Z<:%<%$!:%;<<1%;<gC%:)<%:<+%g;<

(112) N%B"1=$,3*,3Z!:%;<;0,33$Y4:;=!Z "=<3%4=;2%<;<<,"$,;%;%;Q;%"43$"43;%:@<,@%<:%<2%3<^h3$_"42!,3,3*;1@*% 1=28%"<42C81=;""%1%:<%$8:<,1!:%;<:%Z,::$,<,43^:

(113) _A;8:484;%$"43;,;<,3*,3 2=1<,"<+%<%:,3<%:;<,<,1!:"+C<+%:8C^

(114) _=;,3*%,<+%:14A^_4:+,*+Z$4;%:<%^ _Q B"%8<)4:8<,%3<A,<+)4:21,3$,"<,434);1@*%2;<%"<42C^+,;<414*,"1)"<4:;N2/4:1<% !:%;<<,;;=%<4B,",<C,3$="%$!C<+%),:;<:$,4Z;=:*,"1<:%<2%3<N!:%;<;,D%N4:8<,%3<T;A,;+_N h3$A;8:484;%$;31<%:3<,@%)4:8<,%3<;A+4A%:%:%1="<3<<4:$,"1;1@*%;=:*%:CN ,::%;8%"<,@%4)<+%

(115) "1;;,),"<,43*:4=8;Q43;%9=%3<1CN8<,%3<;A,<+844:8:4*34;<,")"<4:; ^1C28+4@;"=1:,3@41@%2%3<N%B<%3;,@%,3<:Z$="<1"42843%3<N+,*+,lmN844:+,;<414*,"1 $,))%:%3<,<,43QQQ_A%:%1;4"43;,$%:%$;%1,*,!1%"3$,$<%;)4:h3$A,<+:

(116) Q 118<,%3<;:%"%,@%$$%<,1%$,3)4:2<,43"43"%:3,3*<+%:,;0;3$!%3%),<;4)<+,;;1@*%<:%<2%3< 8:4"%$=:%Q MF2!4-!.4$!452!3 +%h3$8:4"%;;+;1:%$C!%%3$%;":,!%$`ggaQ:,%)1CN,<"43;,;<%$,31=28%"<42CA,<+)4=: "1,8;"128%$,3<4<+%1=28%"<42C"@,<C3$43%43<+%8%"<4:1,;2=;"1%QB,11:C1C28+34$% ;;%;;2%3<A;34<8%:)4:2%$)4:8<,%3<A+41:%$C=3$%:A%3<B,11:C$,;;%"<,43<<+%<,2%4) 8:,2:C<:%<2%3<Q%"<4:,2813<<,43)4:

(117) A;8%:)4:2%$8:%Z4:84;<Z48%:<,@%1C)4114A,3* <+%:,;C;<%2*%42%<:,":%"422%3$<,43;`ghNgiaQ . . hf.

(118) 4:!:"+C<+%:8C^8:%Z48%:<,@%,2813<_N<+%2/4:,<C4)<+%,2813<;A%:%8%:)4:2%$,3<A4 813%;^mkr4=<4)hm8<;_Q 4:<+%$%1,3%<,434)<+%N<:*%<@41=2%"4::%;843$,3*<4<+% 2:*,3:%;%"<,434)<+%"@,<C$$,3*hZ"2:$,1;%"=:,<C2:*,3A;;%1%"<%$NA,<+$,;<3"% !%<A%%3"<+%<%:;4)g[gQk"2Q4:%4@%:N2,3,21$,;<3"%4)fQk"2:%*:$,3*<+%;0,33$<+% :,!;A;881,%$N<42,3,2,D%<+%:,;04);0,3<4B,",<C3$8<+414*,"1:,!):"<=:%N:%;8%"<,@%1CQ !4=<k$C;)<%:<+%;=:*%:CN"<+%<%:;A%:%14$%$!Cgoh

(119) :A,:%;Q:%<2%3<813%;A%:% 4!<,3%$):42<A44:<+4*431Z:C),12;NA+,1%<+%$4;%A;8:%;":,!%$43<+%nkr4)<+% :%)%:%3"%,;4$4;%"1"=1<%$43<+%"%3<:1813%Q+%8:%;":,!%$$4;%:3*%$):42if<4kk C^nnr 4)<+%8<,%3<;:%"%,@%$$4;%:3*%$!%<A%%3jf3$kf C_Q 4: !:"+C<+%:8CN<+%3=2!%:4)813%;@:,%$):42g<4jQ+%,2813<A;8%:)4:2%$=3$%: 14"13%;<+%;,N,3";%4)84;<Z48%:<,@%8:4"%$=:%Q84;<Z,2813<A;8%:)4:2%$<+%$C)<%: ;=:*%:CQ+%$%1,3%<,43"43;,;<%$,33%B83;,434)g"2:4=3$<+%"1,8;Q+%$4;% $,;<:,!=<,43A;48<,2,D%$23=11C!C@:C,3*<,2%3$;<4884;,<,434)<+%:$,4Z"<,@%;4=:"%Q+% 8:%;":,!%$$4;%<4<+%)1="<=<%$!%<A%%3hn3$ij C,3n[gf):"<,43;N<A,"%$,1C^lgr4) <+%8<,%3<;:%"%,@%$ij C_N$%1,@%:%$4@%:k"43;%"=<,@%$C;N$=:,3*32!=1<4:C8:4"%$=:%Q $/=@3<<:%<2%3<;^+4:2431<+%:8CN"+%24<+%:8CN4:3<,Z hZ<:*%<%$<+%:8C_A%:%=;%$ ""4:$,3*<44=:"%3<%:*=,$%1,3%;Q NF!,!24! 024',2!34'22 '4'/.,33'$'4'/.%2/503

(120) 34:$%:<48%:)4:2:%8:4$=",!1%31C;,;N!4<+ Z`na3$`gfa

(121) "1;;,),"<,43; A%:%=;%$Q 4A%@%:N$=%<4<+%1"04)B,11:C1C28+34$%:%Z;<*,3*)4:<+%1:*%2/4:,<C4)<+% 8<,%3<;N<+%Z;<<=;A;34<"43;,$%:%$;8:4*34;<,"":,<%:,3$%B"1=$%$):42<+%31C;,;Q

(122) 3$%%$N,)8B;<<=;A;"43;,$%:%$N24;<4)<+%8<,%3<;A4=1$)11,3<4<+%U+,*+Z:,;0V4: U=3;=,<!1%V*:4=8)4: Z3$

(123) "1;;,),"<,43;N:%;8%"<,@%1CQ Z3$ 

(124) "1;;,),"<,43;A%:%%@1=<%$;%8:<%1CQ OF/,,/7F50 <,%3<;A%:%;C;<%2<,"11C%B2,3%$!C<+%:$,<,4343"414*,;<43%243<+)<%:!:"+C<+%:8C<4 %@1=<%%:1C<4B,",<CQ+%3N8<,%3<;A%:%;%%3%@%:Cl243<+;!C<+%;=:*%43N<+%2%$,"14: :$,<,4343"414*,;<A,<+"1,3,"1%B2,3<,43Q<%<4B,",<,%;%@1=<,43=;%$<+%42243 1;;,),"<,43)4:$@%:;%@%3<;jQfQ . . hg.

(125) 4;2%<,":%;=1<;A%:%:%84:<%$!C<+%:$,<,4343"414*,;<3$Y4:<+%;=:*%43=;,3*"4;2%<," ;"4:%$%:,@%$):42<+%;"4:,3*;C;<%2$%;":,!%$!C ::,;%<1Q`gjaP%B"%11%3<N*44$N),:3$844:Q $,414*,";=:@%,113"%A;C%:1C,3@%;<,*<%$!C2224*:2A,<+4:A,<+4=<!:%;< =1<:;434*:8+C%B2,3<,43Q PF44'34',.,93'3 %;":,8<,434)<+%;<=$C848=1<,433$4)<+%$,))%:%3<,3@%;<,*<%$8:2%<%:;A;2$%=;,3* !;41=<%3$:%1<,@%):%9=%3",%;)4:<+%9=1,<<,@%$<3$;=22:,D%$=;,3*$%;":,8<,@%;<<,;<,"; ;="+;2%$,3N%B<:%2%)4:9=3<,<<,@%$<Q<<,;<,"1"428:,;43;A%:%8%:)4:2%$=;,3*<+%h <%;<)4:9=1,<<,@%$<3$343Z8:2%<:,"2<"+%$8,:;,1"4B43<%;<)4:9=3<,<<,@%$<Q @%:11;=:@,@1^_A;$%),3%$!C<+%,3<%:@1!%<A%%3<+%$<%4)h3$;=:*%:C3$$%<+$=%<4 3C"=;%Y<4<+%$,;%;%Q8%",),";=:@,@1^_A;$%),3%$!C<+%<,2%!%<A%%3<+%$<%4)h3$ ;=:*%:C3$$%<+$=%<4!:%;<"3"%:Q+,:$

(126) Z):%%;=:@,@1N:%*,431Z):%%;=:@,@1^i:$

(127) Z _N :%*,431Z):%%;=:@,@1^ _3$2%<;<;,;Z):%%;=:@,@1^ _A%:%"1"=1<%$!%<A%%3<+%$<%4) h3$;=:*%:C3$<+%;%:%;8%"<,@%%@%3<;3$A%:%%;<,2<%$=;,3*<+%813[%,%:2%<+4$Q <,%3<;;<,111,@%<<+%1;<@,;,<A%:%"%3;4:%$<<+%$<%4)1;<)4114AZ=8Q%$,3)4114AZ=8A,<+ okr"43),$%3"%,3<%:@1;A;"1"=1<%$!C:%@%:;%813[%,%:2%<+4$Q 

(128) 3=3,@:,<%31C;,;N<+%;=:@,@1"=:@%;A%:%"428:%$=;,3*<+%14*Z:30<%;<Q

(129) 32=1<,@:,!1% 31C;,;N;;4",<,43!%<A%%3;%@%:18:2%<%:;3$i:$

(130) Z):%%;=:@,@1A;%B8:%;;%$;+D:$ :<,4A,<+okr"43),$%3"%,3<%:@1NA+,"+A;%;<,2<%$A,<+<+%=;%4)4B8:484:<,431Z +D:$;24$%1Q411,3%:,<C!%<A%%3@:,!1%;%3<%:%$,3<+%24$%1A;%@1=<%$=;,3*<+%ST %:;43"4::%1<,43"4%)),",%3<Q

(131) )ufQjfN43%4)<+%<A4@:,!1%;A;"43;,$%:%$;:%$=3$3<3$ +$<4!%:%24@%$):42<+%24$%1Q:484:<,431+D:$;A%:%@%:,),%$)4:11%3<%:%$@:,!1%;Q11 @1=%;,3)%:,4:<4fQfk^<A4Z;,$%$_A%:%"43;,$%:%$;<<,;<,"11C;,*3,),"3<Q<A%:%%3<%:%$3$ ;<4:%$43,":4Z;4)<B"%1c1%Q11;<<,;<,"131C;%;A%:%8%:)4:2%$,3kr18+:,;0=;,3*QiQhQh ;4)<A:%43,3$4A;cQ    . . hh.

(132)  LF 4'!.4. 45-/2$!452!3 %<A%%3hfff3$hfgmNgko8<,%3<;^8<;_8:%;%3<%$h3$

(133) 3$=3$%:A%3<h3$Q 243*<+%2Ngji8<;A%:%31CD%$,34:$%:<4:%;8%"<2,3,2=2)4114AZ=84)hj243<+;)4:<+% 1;<,3"1=$%$8<,%3<Q +%2%$,3<,2%,3<%:@1!%<A%%3;=:*%:C)4:<+%8:,2:C3$;1@*%1=28%"<42CA;giQnC%:; ^gQl[ikQi_Q<,%3<)%<=:%;)4:8:,2:C3$h3$

(134) :%;=22:,D%$,3!1%gQ%$,3*%A;kh C%:;^hj[ni_3$llC%:;^ig[of_)4:8:,2:C3$h3$

(135) N:%;8%"<,@%1CQ:,2:C<=24:;A%:% 24;<1C$%34":",342;^mor_N;,D%;211%:<+3hf22^mjr_N*:$%h^jmr_N84;,<,@%+4:2431 :%"%8<4:;<<=;^nlQor_Q42%$<"43"%:3,3*+,;<414*,"1)"<4:;^,lmN %:h;<<=;QQQ_:%2,;;,3* $=%<4<+%$<%4)<+%),:;<%@%3<Q11<+%8<,%3<;=3$%:A%3<$/=@3<A+41%!:%;<,::$,<,43^

(136) _ A,<+2%$,3$%1,@%:%$$4;%4)kiQn C^jk[ll_Q %"43$

(137) 4""=::%$,34:"14;%<4<+%8:,2:C<=24:9=$:3<,3kgQlr3$iiQlrN:%;8%"<,@%1CQ 4:h3$

(138) N+,;<414*CA;,3@;,@%$="<1":",342)4:ggi8<;^mor_N<=24:;,D%;211%:<+3hf 22)4:ghi8<;^nlr_N+,;<414*,"1*:$%h)4:lk8<;^jnr_N84;,<,@%+4:2431:%"%8<4:;<<=;)4: ghg8<;^ogQlr_3$343Z4@%:%B8:%;;%$ h;<<=;)4:ghg8<;^okQir_Q%*<,@%2:*,3$,;;%"<,43 A;"+,%@%$,3ogrNA+,1%1C28+4Z@;"=1:,3@;,43;A%:%4!;%:@%$,3orQ 43"%:3,3*;C;<%2,"<:%<2%3<;N,3$%9=<,43A,<+<+%+,;<414*,"1)%<=:%;N24;<4)<+%8<,%3<; =3$%:A%3<%3$4":,3%<:%<2%3<^nhr_Q$/=@3<"+%24<+%:8CA;=;%$,3ggrNA+,1%:;<=D=2! A;8:%;":,!%$,3hQnrQ       . . hi.

(139) !1%gP<,%3<;3$<=24:"+:"<%:,;<,";.   MF./,/%',/54/-! 4:<+%A+41%"4+4:<N<+%2%$,3)4114AZ=8A;mg243<+;^lh[nk243<+;_Q,B8<,%3<;$%@%148%$ i:$

(140) )<%:h3$1%$,3*<4lZC%:i:$

(141) Z):%%;=:@,@1:<%4)omQjr^fQoj[g_^ ,*Qg_Q,BZC%:  N N3$:<%;A%:%olQjNofQiNohQo3$ogQhrN:%;8%"<,@%1C^ ,*;QhNi_Q 4=:8<,%3<; 8:%;%3<%$:%*,431:%"=::%3"%N3$$,;<3<2%<;<<,"8:4*:%;;,43A;4!;%:@%$)4:gh8<,%3<;^il 243<+;)<%:h3$)4:gf8<;_Q3"414*,"14=<"42%^2,31C,3<%:2;4)i:$

(142) _A;34<;,*3,),"3<1C ,28"<%$!C<+%!:"+C<+%:8C$4;%:<%^hYhm3$jYggl)4:3$ N:%;8%"<,@%1C_Q  . . hj.

(143) .  . . hk.

(144) ""4:$,3*<4<+%

(145)  Z"1;;,),"<,43Nlf8<;^jhr_Nlg8<;^jir_3$hh8<;^gkr_ A%:%"1;;,),%$;14AZN,3<%:2%$,<%Z3$+,*+Z:,;0*:4=8;Q;,3*<+%hfgl"1;;,),"<,43N ;=,<!1%3$"=<,43:C8<,%3<*:4=8;:%8:%;%3<%$jir3$jhrN:%;8%"<,@%1C^=3;=,<!1%*:4=8 gkr_Q 4:<+% Z"1;;,),"<,43NlZC%:i:$

(146) Z):%%;=:@,@1:<%;A%:%gffNokQn3$ohQorN :%;8%"<,@%1CN)4:14AZN,3<%:2%$,<%Z3$+,*+Z:,;0*:4=8;^tfQffi_Q 4:<+%"1;;,),"<,43NlZ C%:i:$

(147) ):%%;=:@,@1:<%;A%:%gffNolQh3$ohQorN:%;8%"<,@%1CN)4:;=,<!1%N"=<,43:C3$ =3;=,<!1%:,;0*:4=8;^tfQffj_Q4;,*3,),"3<$,))%:%3"%;A%:%4!;%:@%$,3<%:2;4) N N 3$!%<A%%3<+%<+:%%

(148) :,;0*:4=8;^!1%h_Q243*<+%;,B8<,%3<;A+48:%;%3<%$ i:$

(149) Nk8<;!%143*%$<4<+%+,*+Z:,;0Y=3;=,<!1%*:4=8A+,1%<+%:%2,3,3*8<,%3<A;"1;;,),%$ ;,3<%:2%$,<%:,;0Y"=<,43:C^!1%i_Q+%)%<=:%;4)<+%i:$

(150) :%;=22:,D%$,3!1%iQ.  .  . . hl.

(151)  .   ;<. 4:<+%A+41%"4+4:<N43%8<,%3<8:%;%3<%$i:$

(152) <kj243<+;Q:,2:C<=24:^g

(153) _A;3 ,3@;,@%$="<1":",342NA+,1%<+%h3$

(154) 4""=::%$gjl243<+;1<%:A,<+3,3@;,@%$="<1 ":",342;;4",<%$A,<+1C28+4Z@;"=1:,3@;,433$84;,<,@%;=:*,"12:*,3;Q+,:$

(155) A;3 ,3@;,@%$="<1":",342Q114)<+%<+:%%!:%;<%@%3<;88%:%$,3<+%;2%:%Q+,;8<,%3< !%143*%$<4<+%+,*+Z:,;0Y=3;=,<!1%*:4=8Q;%"43$8<,%3<+$i:$

(156) mg243<+;)<%:<+% h3$

(157) Q+%<+:%%<=24:;A%:%,3@;,@%14!=1:":",342^<,2%,3<%:@1!%<A%%3g;<3$h3$

(158) t lh243<+;_Q+%CA%:%1114"1,D%$,3<+%;2%9=$:3<Q!,)4"1<=24:A;4!;%:@%$43<+% h3$

(159) 1=28%"<42C;8%",2%3Q+%i:$

(160) A;;<,11!,)4"1Q+,;8<,%3<!%143*%$<4<+% ,3<%:2%$,<%Z:,;0Y"=<,43:C*:4=8Q 4=:4<+%:;i:$

(161) ^+,*+Z:,;0Y=3;=,<!1%*:4=8_A%:%4!;%:@%$ <niNohNoi3$ggj243<+;Q

(162) 34:$%:<4),3$;,*3,),"3<8:4*34;<,")"<4:;)4:i:$

(163) N$,))%:%3<@:,!1%;:%1<%$<4<+%h3$

(164)  A%:%31CD%$,3=3,@:,<%31C;,;^*%N<=24:;,D%N+,;<414*,"1*:$%N2:*,3;<<=;N1C28+4Z @;"=1:,3@;,43N0,lmN

(165) Z:,;0*:4=83$<,2%,3<%:@1!%<A%%3g;<3$h3$;=:*%:C_Q C28+4@;"=1:,3@;,43^tfQffo_N84;,<,@%2:*,3;^tfQfffg_3$+,*+Z:,;0Y=3;=,<!1%*:4=84) <+%

(166) "1;;,),"<,43^tfQffg_A%:%<+%<+:%%;,*3,),"3<8:4*34;<,")"<4:;)4:i:$

(167) Q

(168) 3 2=1<,@:,<%31C;,;N+,*+Z:,;0Y=3;=,<!1%

(169) *:4=8A;<+%431C;,*3,),"3<8:4*34;,;)"<4:)4: i:$

(170) ^tfQffo_N1%$,3*<4"43;,$%:<+<8<,%3<;!%143*,3*<4<+%+,*+Z:,;0*:4=8+@%oQll :%1<,@%:,;0)4:$%@%148,3*i:$

(171) Q  . . hm.

(172) NF/8''4902/$',! 243*<+%gji8<;N<+%2B,2=2"4281,"<,43:<%4!;%:@%$)<%:h3$^<<+%1;<)4114AZ=8_A; iir^jm8<;_Nhlr^im8<;_NhQnr^j8<;_3$fQmr^g8<_)4:*:$%;gNhNi3$jN:%;8%"<,@%1CQ+% 4!;%:@%$"4281,"<,43;"43;,;<%$2,31C,3"=<3%4=;^ihQkr_3$;=!Z"=<3%4=;),!:4;,;^ifQgr_N A+,1%<%13*,%"<;,^nQjr_3$+C8%:Z8,*2%3<<,43^gmr_A%:%1%;;):%9=%3<Q3%8<,%3<8:%;%3<%$ *:$%j=1"%:<,43Q%*:$,3*"4;2%<,"4=<"42%N%B"%11%3<Y*44$:%;=1<A;34<,"%$)4:ghh8<; ^nkr_NA+,1%844::%;=1<A;4!;%:@%$)4:l8<;^jQlr_QB"%11%3<"4;2%<,":%;=1<;A%:%4!<,3%$)4: lhr3$mjr)4: 3$"4+4:<N:%;8%"<,@%1CQ                . . hn.

(173)    +%<:%<2%3<"+4,"%,3";%4)h3$

(174) +;!%%3=3$%:$%!<%)4:<+%8;<)%AC%:;NA,<+ 34"1%:%;<!1,;+%$*=,$%1,3%;Q1@*%2;<%"<42CA;<+%+,;<4:,"1<:%<2%3<N!;%$43 :%<:4;8%"<,@%3$"428:<,@%;%:,%;Q,<+<+%%2%:*%3"%4)"43;%:@<,@%<:%<2%3<)4:8:,2:C !:%;<<=24:N<+%84;;,!,1,<C4);%"43$!:%;<8:%;%:@<,438:4*:%;;,@%1C*,3%$,3<%:%;<`jaQ;3 314*C<4<+%%;;%3<,1:41%4)$/=@3<:$,4<+%:8C)<%:!:%;<"43;%:@<,@%<:%<2%3<)4: 8:,2:C<=24:;N<+%"43"%8<4)$/=@3<:%Z,::$,<,434)<+%<=24:!%$)<%:;1@*%1=28%"<42C !%"2%23$<4:C8:<4)<+%h3$`iNgkaQ44=:034A1%$*%N<+%:%+;!%%3348+;%

(175)

(176)

(177) <:,1 3$. "428:,3*@%:;=;h 3$<+%1,0%1,+44$4)<+%%2%:*%3"%4);="+<:,1:%2,3;9=,<% =3"%:<,3!%"=;%4)2%<+4$414*,"13$%<+,"1"43;,$%:<,43;`glaQ;%$43;%@%:141$ "428:<,@%;%:,%;N<+%i:$

(178) )<%:,;!4=<gf[gkr^:3*,3*):42i<4ihr_A,<+%9=,@1%3< :%;=1<;4!<,3%$)<%:h3$s:

(179) `gkaQ4:%:%"%3<1CN<+% Z:%;<3"%:4:0,3*. :4=8:%84:<%$<+%:%;=1<;4);1@*%1=28%"<42Cs:

(180) A,<+i:$

(181) "<=:,1:<%;<k3$gf C%:;4)kQlr3$mQhrN:%;8%"<,@%1C`laQ+%"+4,"%!%<A%%3<+4;%<A4;1@*%<:%<2%3<;NA+,"+ ;%%2;<4"+,%@%"428:!1%14"1"43<:41N,;2,31C!;%$43+,;<48<+414*,"1)"<4:;Q

(182) )<+%C1%$ <4"43;,$%:Nh3$2=;<!%:=1%$4=<Q3<+%4<+%:+3$N,3<+%!;%3"%4)!$ +,;<48<+414*,"18:4*34;,;)"<4:;N!:%;<;,D%)<%:<+%8:,2:C"43;%:@<,@%<:%<2%3<3$<+% "=<3%4=;3$;=!"=<3%4=;"43;%9=%3"%;4)<+%),:;<,::$,<,43;+4=1$!%<0%3,3<4""4=3<,3 4:$%:<4$,;"=;;h3$s:

(183) G ,*QjHQ ,311CN<+%8<,%3<T;"+4,"%:%2,3;":=",1)<%:)=113$ $%<,1%$%B813<,434)<+%:,;03$!%3%),<;4)%"+;1@*%<:%<2%3<Q . . . ho.

(184)

(185) 34=:;<=$CN:%*:$,3*<+%43"414*,"14=<"42%;4)<+%A+41%"4+4:<N<+%lZC%:i:$

(186) Z N  N N3$:<%;A%:%omQjNolQjNofQiNohQo3$ogQhrN:%;8%"<,@%1CQ

(187) 3 =,B%<1Q;<=$CNil 8<;A+48:%;%3<%$h3$

(188) ^2,31C;<*%;

(189) 3$

(190)

(191) _=3$%:A%3<h3$^;1@*%1=28%"<42Cs Z 

(192) :

(193) _`gmaQ+%=<+4:;:%84:<%$gfZC%:14"1"43<:41:<%4)noQjrA,<+gfZC%:4@%:11 ;=:@,@1:<%4)olQmrQ+% Z;<=$C:%84:<%$;,2,1:14"1"43<:41A,<+kZC%:"<=:,1 i:$

(194) Z):%%;=:@,@1:<%4)ojQjr`laQ+%=<+4:;:%84:<%$kZC%:"<=:,1 N3$:<%;4) nnQoNofQk3$nnQmrN:%;8%"<,@%1CNA+,"+A%:%9=,<%;,2,1:<44=::%;=1<;)<%:lC%:;4))4114AZ=8Q

(195) 3<+%;%<A4;<=$,%;N<+%:%Z,::$,<,434)<+%<=24:!%$A;8%:)4:2%$A,<+2=1<,Z"<+%<%: ,3<%:;<,<,1!:"+C<+%:8C!;%$434: A+,"+:%2,3;"=::%3<1C<+%24;<88:4@%$:%Z ,::$,<,43<%"+3,9=%Q 4A%@%:N$,))%:%3<:

(196) <%"+3,9=%;+@%!%%3$%;":,!%$`gn[hhaQ:42!%<<%<1Q:%84:<%$<+% :%;=1<;4)"4+4:<4)gn8<;A,<+h3$

(197) A+4=3$%:A%3<h3$"42!,3,3*;1@*%1=28%"<42C 81=;!11443Z$%@,"%!;%$!:"+C<+%:8C^ij C,3gf):"<,43;4@%:k$C;_Q)<%:2%$,3)4114AZ =84)ioQl243<+;N<+%=<+4:;4!;%:@%$ggr4)i:$

(198) `gnaQ

(199) 3<:48%:<,@%kf0@Z:C:$,4<+%:8C ^

(200) _+;1;4!%%3,3@%;<,*<%$Q:=;Z,%)%3!"+%:%<1Q8%:)4:2%$

(201) )4:gm8<;3$:%84:<%$N )<%:2%$,3)4114AZ=84)im243<+;NggQmr4)i:$

(202) `goaQ

(203) 3<+%;2%ACN+,3*%<1Q4!;%:@%$ i:$

(204) Z :<%4)gffr,3;211"4+4:<4)gh8<;^ Pgj243<+;_`hfaQ4:%:%"%3<1CN=;,3*kf 0@

(205) :

(206) <%"+3,9=%N+3*:/+%<1Q8:%;%3<%$%3"4=:*,3*:%;=1<;,3"4+4:<4)jg8<;^  "14;%<4kC%:;_A,<+:<%4)i:$

(207) Z "14;%<4ofr`hgaQ1%"<:43!%2

(208) :

(209) A; ,3@%;<,*<%$!C13$,34%<1QA+4<:%<%$ho8<;A,<+kZC%:14"1"43<:41:<%4)ohQir`hhaQ %"%3<1CN<+%43"414*,"14=<"42%3$<4B,",<C:%;=1<;4)<+% gfgj8:4;8%"<,@%<:,1A%:% :%84:<%$<<+%hfgn2%%<,3*Q

(210) 3<+,;8:4<4"41N:

(211) =;%$i"43)4:2<,431%B<%:31!%2 :$,<,43<%"+3,9=%$%1,@%:,3*<4<1$4;%4)jk C,3gk):"<,43;^<A,"%$,1C_Q

(212) 3"4+4:<4)lk8<; A,<+2%$,3)4114AZ=84)iQljC%:N<+%=<+4:;4!;%:@%$h3$!:%;<"43;%:@<,43:<%N  3$4)ojQnrA,<+lQor4)1<%*:$%i<:%<2%3<Z:%1<%$"4281,"<,43:<%Q %*:$,3*<+%43"414*,"14=<"42%""4:$,3*<4<+% Z

(213) "1;;,),"<,43NA% :%84:<%$lZC%:i:$

(214) Z):%%;=:@,@1:<%;4)gffNokQn3$ohQor)4:14AZN,3<%:2%$,<%Z3$+,*+Z :,;0*:4=8;N:%;8%"<,@%1CQ+% Z

(215) 8+;%

(216)

(217)

(218) "428:%$

(219) @%:;=;

(220) )4:;%1%"<%$ 8:,2:C%:1CZ;<*%!:%;<"3"%:^14AZ3$,3<%:2%$,<%Z:,;0*:4=8;_`hiaQ+%=<+4:;:%84:<%$kZ C%:14"1:%18;%:<%^h3$

(221) _4)gQjjrA+,"+88%:;9=,<%"428:!1%A,<+4=:h3$:%;=1<;^34 3$431C43%i:$

(222) )4:14AZ3$,3<%:2%$,<%Z:,;08<,%3<N:%;8%"<,@%1C_Q . . if.

(223) +4;%:%;=1<;1%$<4"43;,$%:<+<N,3";%4)14AZ3$,3<%:2%$,<%Z:,;0!:%;<"3"%:N1=28%"<42C 81=;

(224) Z

(225) "+,%@%%B"%11%3<14"1"43<:41:<%;A+<%@%:<+%;<<=;4)!:%;<<=24:^8:,2:C4: h3$

(226) _Q4:%4@%:N:%"%3<1C<<+%hfgn33=12%%<,3*N<+% Z:%84:<%$<+% :%;=1<;4)8:48%3;,<C;"4:%Z2<"+%$31C;,;"428:,3*^hgk8<;_@%:;=;h3$^hgk8<;_=;,3* 

(227) Q,<+ 4)lk243<+;N34;,*3,),"3<$,))%:%3"%A;4!;%:@%$!%<A%%3<+%<A4;1@*% <:%<2%3<;,3<%:2;4) NN 4:i:$

(228) Q 4:+,*+Z:,;0*:4=88<,%3<;NA%:%84:<%$lZC%:i:$

(229) Z):%%;=:@,@1:<%4)ohQor ;,*3,),"3<1C14A%:"428:%$<414AZ3$,3<%:2%$,<%Z:,;0*:4=8;^tfQffi_A+,1%<+%:%1<,@%:,;0 4)i:$

(230) A;oQllQ+,;;=!*:4=84)8<,%3<;<%3$;<4+@%24:%**:%;;,@%$,;%;%^84;,<,@% 2:*,3;N1C28+4Z@;"=1:,3@41@%2%3<N%B<%3;,@%

(231) N2=1<,)4"1,<C4:1:*%<=24:;,D%QQQ_1%$,3*<4 "43;,$%:h3$)4:+,*+Z:,;0*:4=8A,<+"=<,43Q 4A%@%:N,))4:g;<

(232) +,*+Z:,;08<,%3<;N<+% :%"422%3$<,43A4=1$!%

(233) ,3;<%$4)

(234) N,3";%4)h3$

(235) N2=<,1<,3*<:%<2%3<^_ ;+4=1$!%$,;"=;;%$;<+%431C1<%:3<,@%<4h3$Q"<=11CN%%%<1Q$%;":,!%$<+%$%1%<%:,4=; ,28"<4)2;<%"<42C^%@%3A,<+;=:*,"1:%"43;<:="<,43_:%*:$,3*!4$C,2*%N;%1)Z"43),$%3"% 3$9=1,<C4)1,)%`mNhjaQ;<%"<42CA;%@%3;;4",<%$A,<++,*+%::<%4)=3%2814C2%3<`hkaQ +%:%)4:%N,3";%4)h3$

(236) 3$2,31C)4:+,*+Z:,;0*:4=88<,%3<;N$,;"=;;,433$,3)4:2<,43 *,@%3<4<+%8<,%3<:%*:$,3*<:%<2%3<48<,43;3$<+%,:84<%3<,14=<"42%;,;":=",1Q3 ,3$,"<,434)h3$2=;<1;4!%":%)=11C%B2,3%$:%*:$,3*8<,%3<;A,<+1C28+4Z@;"=1: ,3@41@%2%3<3$84;,<,@%;=:*,"12:*,3;NA+,"+88%:%$<4!%8:4*34;,;)"<4:)4:i:$

(237) ,3 =3,@:,<%31C;,;Q @%:11;=:@,@1:%;=1<;4)<+%A+41%"4+4:<:%%3"4=:*,3*A,<+lZC%::<%4)ogQhrN A,<+lZC%: 3$:<%;4)ofQir3$ohQorN:%;8%"<,@%1CQ+,1%<+%;%:%;=1<;:%"428:!1% <4<+%kZC%:^nnQor_N ^ofQkr_3$^nnQmr_:<%;:%84:<%$,3<+%h3$ Z;<=$C `laNkZC%:)4:14AZ3$,3<%:2%$,<%Z:,;08:,2:C<=24::%84:<%$,3<+% Z

(238) 8+;%

(239)

(240)

(241)  <:,1N88%:+,*+%:^omQir_`hiaQ

(242) 34=:;<=$CN24;<4)<+%8<,%3<A+48:%;%3<%$2%<;<<," $,))=;,43!%143*%$<4<+%14AZ:,;0*:4=8A,<+lZC%: 4)nkQiNoiQg3$okQhr)4:14AZN ,3<%:2%$,<%Z3$+,*+Z:,;0*:4=8;N:%;8%"<,@%1CQ

(243) 3<+%14AZ:,;0*:4=8N11<+%2%<;<<,"8<,%3<;^n 8<;_$,;81C%$;C;<%2,"$,;%;%$=:,3*<+%),:;<jn243<+;4))4114AZ=83$kfr^j8<;_A,<+,3<+% ),:;<hC%:;Q+%2%"+3,;24)<+%;%%:1C:%18;%;,314AZ:,;08<,%3<;,;34<"1%:1C%1=",$<%$3$ 3%%$;<4!%31CD%$,31:*%:"4+4:<Q . . ig.

(244) =:;<=$C8:%;%3<;;42%A%03%;;%;;="+;,<;:%<:4;8%"<,@%3<=:%N<+%1,2,<%$3=2!%:4) 8<,%3<;3$)4114AZ=8NA+,"+1,2,<<+%31C;,;4)<+%43"414*,"14=<"42%%;8%",11C)4:14AZ:,;0 8<,%3<;,3<%:2;4) Q 4A%@%:N""4:$,3*<44=:034A1%$*%N<+,;,;<+%),:;<31C;,;4)<+%=;%4) 

(245) "1;;,),"<,43,3<+%<+%:8%=<,"$%",;,438:4"%;;,3";%43h3$

(246) Q                   . . ih.

(247)   +%3"43;,$%:,3*h3$

(248) N<+%$%!<%;<,11:%2,3;43+4A<4"43;,$%:<+,;%@%3<P<:=% :%"=::%3"%4)<+%g;<

(249) 4:3%A^,3$%8%3$%3<_%@%3<M+%"43"4:$3"%4)<+%14"1"43<:41:<%; )4:14AZ3$,3<%:2%$,<%Z:,;0*:4=8;N:%84:<%$!C<+% Z

(250) 8+;%

(251)

(252)

(253) ^8:,2:C<=24:_3$ 4=:;^h3$

(254) _;=**%;<;<+<<+%9=%;<,4388%:;1%;;":=",1:%*:$,3*14"14=<"42%A+,1%<+% "43<:414);C;<%2,"$,;%;%:%2,3;":,<,"1,;;=%Q

(255) 3";%4)h3$

(256) N;%"43$"43;%:@<,@%<:%<2%3<A,<+

(257) Z:

(258) "3!%8:484;%$;;)%3$ %)),",%3<1<%:3<,@%<4;1@*%2;<%"<42CQ

(259) 34:$%:<4:%),3%<+%<+%:8%=<,"$%",;,43N<+% Z 

(260) "1;;,),"<,43"4=1$!%=;%$;84<%3<,1$%",;,4320,3*3$8:4*34;,;<441)4:;%"43$ "43;%:@<,@%<:%<2%3<A+,1%8<,%3<,3)4:2<,43:%2,3;)=3$2%3<12,31C)4:+,*+Z:,;08<,%3<;Q 4281,3"%A,<+%<+,"1;<3$:$; 43)1,"<4),3<%:%;<P  ,;"43;=1<3<)4:

(261) 4283CQ+%4<+%:"4Z=<+4:;$%"1:%<+<<+%C +@%34"43)1,"<4),3<%:%;<Q <+,"188:4@1P+,;;<=$CA;88:4@%$!C<+%3<4,3%";;*3%3"%:%3<%:%<+,"; "422,<<%%Q '34/$54&/23B=",1%43<*3%] 4"%1C3 1]:,%Z@%+3$]%3=$"+,88]1%B3$%:Q 10]'2C,3/]<+,%= =<+,%:] %3Z,"+%1 334=3Z%@, %"%,@%$Phf4@%2!%:hfgnY""%8<%$Pg8:,1hfgoY=!1,;+%$431,3%Pj8:,1hfgob8:,3*%: ",%3"%s=;,3%;;%$,NN8:<4)8:,3*%:<=:%hfgo :%;<3"%:%;%:"+3$:%<2%3<^hfgo_gmlPgjo[gkm+<<8;PYY$4,Q4:*YgfQgffmY;gfkjoZgoZ fkhhgZD             . . ii.

(262)      gQ %:1C N<%1,:4@Z 4="+%:N4:<%<Z,%=1%3< %<1^hfgk_%8:,3<4)P"3"%:,3",$%3"%3$ 24:<1,<C8<<%:3;,3=:48%P;<,2<%;)4:jf"4=3<:,%;,3hfghQ=: 3"%:kgPghfg[ghfh  hQ1%C%:N%1"+ ^hfgi_))%"<4)<+:%%$%"$%;4);":%%3,3*2224*:8+C43!:%;<Z"3"%: ,3",$%3"%P%$,<4:,1"422%3<Q!;<%< C3%"41=:@lnPjjf[jjh iQ ,;+%:N3$%:;43N:C3< %<1^hffh_A%3<CZC%:)4114AZ=84):3$42,D%$<:,1"428:,3* <4<1)4:<+%<:%<2%3<4),3@;,@%!:%;<"3"%:Q3*1 %$ijmPghii[ghjg jQ=:<D N21:,"N:3$43% %<1^gonn_%;=1<;4)A,$%%B",;,43)4:222:C:%"=::%3"% )<%:!:%;<Z"43;%:@,3*<+%:8CQ3"%:lgPgolo[gomh kQ=1:$N 4=;;%<N:=3%1%<1^gook_;%4)8%:,48%:<,@%4:;81,<Z"4=:;%,3<%:;<,<,1 !:"+C<+%:8C<%"+3,9=%;)4:;1@*%,::$,<,434),;41<%$14"1:%"=::%3"%;)<%: "43;%:@<,@%23*%2%3<4)!:%;<"3"%:Q2 1,33"41gnPijn[ikh lQ 334=3Z%@, N%;"+N 1 %<1^hfgi_""%1%:<%$8:<,1!:%;<,::$,<,43A,<+,3<%:;<,<,1 !:"+C<+%:8C;;%"43$"43;%:@<,@%<:%<2%3<)4:,8;,1<%:1!:%;<<=24=::%"=::%3"%P 2=1<,"%3<:,";<=$C4)<+% Z:%;<3"%:4:0,3* :4=8Q$,4<+%:3"41 gfnPhhl[hig mQ%% N,*343%N%1%<1^hfgn_""=:"C4)8:%$,"<,43;4)8<,%3<;A,<+!:%;<"3"%: 4))=<=:%A%11Z!%,3*)<%:,22%$,<%!:%;<:%"43;<:="<,43Q =:*Q+<<8;PYY$4,Q 4:*YgfQgffgY/2;=:*QhfgmQlggh nQ41*:N3,2!%:*%3N6<<%:%<1^hfgf_<,%3<;%1%"<,43)4:""%1%:<%$8:<,1Z!:%;< ,::$,<,43^

(263) _)<%:!:%;<Z"43;%:@,3*;=:*%:CP:%"422%3$<,43;4)<+% :4=8% =:48'%3$%=:,%<+':8,%Z=:48%34",%<C)4:+%:8%=<,"$,414*C3$3"414*C^ Z _!:%;<"3"%:A4:0,3**:4=8Q$,4<+%:3"41ojPhlj[hmi oQ2,<+N:<+=:N="++41D%<1^hffo_""%1%:<%$8:<,1!:%;<,::$,<,43"43;%3;=; ;<<%2%3<):42<+%2%:,"34",%<C)4:$,<,433"414*C^_Q

(264) 3< $,<3"41,41 +C;mjPonm[gffg gfQ. 4::%N ::,;N%43:$,%<1^hfgm_""%1%:<%$8:<,1!:%;<,::$,<,43P%B%"=<,@% ;=22:C)4:<+%=8$<%4)3%@,$%3"%Z!;%$"43;%3;=;;<<%2%3<Q:"<$,< 3"41mPmi[mo   . . ij.

(265) ggQ 334=3Z%@, N;<%11, N1%;=%<1^hfgg_%"43$"43;%:@<,@%<:%<2%3<)4:,8;,1<%:1 !:%;<"3"%::%"=::%3"%=;,3*+,*+Z$4;%:<%,3<%:;<,<,1!:"+C<+%:8CP8:%1,2,3:C"1,3,"1 :%;=1<;3$%@1=<,434)8<,%3<;<,;)"<,43Q:"+C<+%:8CgfPgmg[gmm  ghQ+;;*3%N=<:%,BN;+%<1^goom_

(266) 3<:4$="<,43Q 

(267) 3<422$,<3,<;%; 4;ifPgQ+<<8;PYY$4,Q4:*YgfQgfoiY/,":=Y4;ifQgQg  giQ +!=%:N3$!%:*N+@=$: %<1^hffj_%)%:%3"%;Q 

(268) jPok[gff   gjQ ::,; N%@%3%N@%3;;43 N %1123^gomo_31C;,;4)"4;2%<,":%;=1<;)4114A,3* 8:,2:C:$,<,43<+%:8C)4:;<*%;

(269) 3$

(270)

(271) ":",3424)<+%!:%;<Q

(272) 3< $,<3"41,41 +C;kPhkm[hlg  gkQ 334=3Z%@, ZN

(273) +:,N4=:$,^hfgi_4"1<:%<2%3<48<,43;)4:,8;,1<%:1!:%;< <=24=::%"=::%3"%Q3"%::%<%@ioPmim[mjg   glQ:42!%<<N 334=3Z%@, ^hfgm_:%<2%3<4);%"43$,8;,1<%:1!:%;<<=24:%@%3<P 3%%$)4:3%A<C8%4)%@,$%3"%)4:@4,$,3*2;<%"<42CQ=: =:*3"41jiPnjo[nkf  gmQ =,BN%/:"%*=, N%114

(274) %<1^hfgf_B%:%;,;3$!:"+C<+%:8C;;1@*%<:%<2%3<)4: 14"1:%"=::%3"%)<%:"43;%:@<,@%<:%<2%3<)4:!:%;<"3"%:P:%;=1<;4)<%3ZC%:8,14< ;<=$CQ

(275) 3< $,<3"41,41+C;mnPnfj[ngf   gnQ:42!%<<N 11N =1,3^hfgj_43*Z<%:2)4114AZ=84)!:%;<8:%;%:@<,43!C:%Z %B",;,433$!11443!:"+C<+%:8C)<%:,8;,1<%:1!:%;<<=24::%"=::%3"%Q:"+C<+%:8C giPjnn[joh  goQ:=;Z,%)%3!"+%:N=%:N"+%$%<1^hffm_

(276) 3<:48%:<,@%:$,4<+%:8C^

(277) _,;3 48<,43)4:8<,%3<;A,<+14"1,D%$!:%;<:%"=::%3"%;)<%:8:%@,4=;%B<%:31Z!%2 :$,4<+%:8CQ3"%:mPg[m   hfQ+3*:/+ N %,1233 N1<%:%<1^hfgn_:%;<"43;%:@,3*;=:*%:C,3"42!,3<,43 A,<+,3<:48%:<,@%:$,4<+%:8C)<%:8:%@,4=;%B<%:31!%2<+%:8CP348<,43<4@4,$ 2;<%"<42CQ:%;<3"%:%;:%<glnPmio[mjj  hgQ+,3N $%/N!"0%<1^hfgm_@1=<,434)8:<,1!:%;<:%Z,::$,<,43A,<+ ,3<:48%:<,@%:$,4<+%:8C)<%:8:,4:<+4:",":$,<,43P;,3*1%Z,3;<,<=<,43:%84:<4) 4=<"42%;3$<4B,",<CQ :43<3"41mPg[l  . . ik.

(278) hhQ13$,34 N =%3D,N%1*,4,%<1^hfgm_$/=@3<,3<:48%:<,@%:$,4<+%:8C)4: ;%1%"<%$!:%;<"3"%:;,38:%@,4=;1C,::$,<%$A42%3P%@,$%3"%)4:%B"%11%3<)%;,!,1,<C3$ )@4:!1%4=<"42%;Q%84:<;:"<3"41$,4<+%:hhPhmm[hni  hiQ<:3$N<< N ,1$%!:3$< %<1^hfgl_kZC%::%;=1<;4)""%1%:<%$8:<,1!:%;< ,::$,<,43=;,3*;41%,3<%:;<,<,12=1<,Z"<+%<%:!:"+C<+%:8C@%:;=;A+41%Z!:%;< ,::$,<,43A,<+!44;<)<%:!:%;<Z"43;%:@,3*;=:*%:C)4:14AZ:,;0,3@;,@%3$,3;,<= ":",3424)<+%)%21%!:%;<P:3Q3"%<inmPhho[hin   hjQ%% N%1N =+%<1^hfgm_=1,<C4)8<,%3<$%",;,43;!4=<!:%;< :%"43;<:="<,43)<%:2;<%"<42CQ =:*gkhPmjg[mjn  hkQ3*N 43*N%33%$C%<1^hfgn_:%$,"<4:;4)=3%2814C2%3<)<%:!:%;<"3"%: ;=:*%:CP;C;<%2<,":%@,%A3$2%<Z31C;,;4)4!;%:@<,431;<=$,%;Q 1,33"41 ilPgnln[gnmo                              . . il.

Références

Documents relatifs

To test whether the vesicular pool of Atat1 promotes the acetyl- ation of -tubulin in MTs, we isolated subcellular fractions from newborn mouse cortices and then assessed

Néanmoins, la dualité des acides (Lewis et Bronsted) est un système dispendieux, dont le recyclage est une opération complexe et par conséquent difficilement applicable à

Cette mutation familiale du gène MME est une substitution d’une base guanine par une base adenine sur le chromosome 3q25.2, ce qui induit un remplacement d’un acide aminé cystéine

En ouvrant cette page avec Netscape composer, vous verrez que le cadre prévu pour accueillir le panoramique a une taille déterminée, choisie par les concepteurs des hyperpaysages

Chaque séance durera deux heures, mais dans la seconde, seule la première heure sera consacrée à l'expérimentation décrite ici ; durant la seconde, les élèves travailleront sur

A time-varying respiratory elastance model is developed with a negative elastic component (E demand ), to describe the driving pressure generated during a patient initiated

The aim of this study was to assess, in three experimental fields representative of the various topoclimatological zones of Luxembourg, the impact of timing of fungicide

Attention to a relation ontology [...] refocuses security discourses to better reflect and appreciate three forms of interconnection that are not sufficiently attended to