Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes.
Texte intégral
(2) Hal author manuscript J Biol Chem 19/06/1998; 273(25): 15804-10. . βγ
(3)
(4)
(5)
(6) α
(7)
(8)
(9)
(10)
(11) . !"# %$&'
(12) )(*
(13) +-,. .*/10235460798;:)<>=*460@?*ACBD/10@4FE1GF79BD/)H4I/)=J2ALK:1GM46079NO/1?*E%PQACRSG64PQ/)T*7U<WVX8;YZ0@0/132AN[V46GM46\\*7^]_/GF7)<5A`a/)b. Hal author manuscript. c /1dWY0%<5/10CAZef7
(14) /10g.*:)TZ/%Ph<W4I710g.*/)=*G60@4F713ij8kGF/ml1V7no. p o qros. o R;o tuo `wvDx y A p 0LPh<W4z<>=< c Y=*4P{8=*?0C/132Av_0@4|H*713-P}4|<5:9NO/)=*G .*/)TZ/)<W4F713A*K~Xvt;/10?=J714MGFAC8;/)<W4M710%< c xA*x U* xALYC=*GIYC= PQ7K97m27)b. inserm-00110175, version 1. t=*00@460?_<W4|<WGF7C. α. A 3/10Cl
(15) 7o. i5/
(16) 23710C713}?4Fl^37ml
(17) 71\<5Y3l
(18) YC=*\GM460?_<5Y\. n^<5YDuVY&l
(19) Y3}37%P5\*YZ0C2710l
(20) 7XP5VY=*GF2XT*7/
(21) 223Q7%PPQ7
(22) 2 N[VY07@}xx L@ . y. [/)b}xx L@{ xx y. *. @. . RS/146GWP/)=*G60@4F7133Q/10?=J714MG>o460LPQ713}god>3. . 35VY.
(23) . $ $. p 0a\37
(24) /
(25) 246\*Y*l "<57%PQA/1G6\V/. i}/
(26) 23710C713}?4Fl . 37
(27) l
(28) 7\<5YZ3. . . iW^t^gPW<W46X=*GF/)<W4IYZ0. α. . . 271\*710C2710%< 37
(29) /13/0?*7170%< YZdS/
(30) l)<W460rl %<5YP *7GF7)<5Y0o V4P4Pkl1V/3/
(31) l)<571354 "7
(32) 2. Hal author manuscript. <WV7. dWY3}/)<W4IYZ0aYd_/ml)<W460. . 4M0/%PQ7. \. 3}VCYZ. 2V7"P}4FY0.
(33). ONO/%PQ7. . . h\\ . Ph<W3Q7%PPd>4|TZ713P. . . /10C2. A<WV7a7)b4PW<5710lm7.
(34) 4
(35). Ydg/. 7)HZ710%<P. . < 3QY P GIih\VYP}\VCYZ3 @GF/U<W4FYZ0 T*7460?. . <W4M?VG. /. YLi. /D3Q/1\4F2rl
(36) 71G6G P}\3Q7
(37) /
(38) 2460@?*A. . <WVC7'460Cl137
(39) /%PQ7'460. fo VC7%P7l
(40) 71G6G|=*GI/13. T.
(41) 4
(42). GF7m/
(43) 2LP_<5Y. . l
(44) Y0%<W3QYZGF7m2. YLi}27\*7102710"<rl
(45) Y=*\G6460@?YZd. α. ih^t. YZd^<WVC7 T. <5Y. <WV7 \ . [Y*l
(46) /1G P5/1G6G. 3}VY. 460. \37
(47) /m246\*YLl %<57"P{/"P \3Y\*Y PQ7
(48) 2o p 0. inserm-00110175, version 1. /10C2. _V@4Fl1V. 460C2%=Jl)<W4FY0. α. ^ . . PW<5/)TG YZd. . iW\37
(49) /
(50) 246\*Y*l "<57%P;}/l
(51) 71G6G[l1GIYZ0C7273}4|H*7m2 7)b\3Q7%PPQ7%P<WV7gV%=*/10. l
(52) 71G6GP}\37
(53) /m2460?*A. α. dWY3}/)<W4FY0. K. d>3Y. <WV7xx% . i}/
(54) 23710C713}?4Flg37
(55) lm71\<5YZ35 Yd&/
(56) l)<W4M0. Ph<W3Q7%PP. d>4|T*713-P. α /10C2. . . \3Q7
(57) /
(58) 246\*YP7l
(59) 71GMGGM4607. i}/
(60) 2370713}?4Il
(61) i}271\*710C2710%< 460l13Q7
(62) /%P7. 460. . < @3YP @GFi. . Yd \\ uAD7137 /)T*YG64P5V7
(63) 2 T r\37)<W37m/)<W710"<kYZd<WV7\3Q7
(64) /
(65) 246\*Y*l "<57%P u4|<WV <WV7 Kx 7)b*Y*710 D7
(66) A /D<5Yb460guV4Fl1Vr46_\*/463Pk\ 3}VY /
(67) l)<W4zH4|< gT r^BXNOih3}4zT*YP @GF/)<W4FY0o KY0%HZ713P7G CA K9x 7)bZYL710 @. 7 V/m2'0Y 71d>dW7
(68) lU<kYZ0g<WV7 α i5/
(69) 23710C713}?4Fl
(70) i5271\*710270%<460Cl137
(71) /"P74M0 < @3YP @GFih\VCY P5\VY3 @GF/)<W4FY0 /10C2 P5V46d<;Yd Rt! ` 4|<5Y?*710 lU<W4|H*/)<57m2 N[3YC<57460" 4M0/%PQ7oG6\V/ i}/
(72) 23710C713}?4FlgPh<W46 =*GF/)<W4FY0 /GPY GF7
(73) 2 <5Y /10g4M0l137m/%P7_460#^
(74) BXN$%X
(75) {N 7)b*l1VC/10?*7uYZ0 \ 3}VY A /%PD71G6G /"P<5Yr/10 460Cl137
(76) /"P7X460<WV7_/YC=*0"<SYZd \ 3}VCYZw4M0 <WVC7 \*/13h<W4Il)=*GF/)<57 d>3/
(77) l)<W4FY0 YZd ^ \3Q7
(78) /
(79) 246\*Y*l ". <57%PUo.<5/)TCGF7 <W3Q/10LP5dW7
(80) l)<W4FY0 Yd α ^ α i5K9 5/DTGIYLl * 73^Yd'
(81) βγi}/
(82) l)<W4FY0QA \37
(83) /m246\*YLl%. <57"P9u4|<WVg<WV7 Kij<573}_460C/1G 2Y/1460 Yd β^t& β^t&u Ph<W3QYZ0@?G 460V@4|T4|<57m2<WV7 i}/
(84) 2370713}?4Il
(85) i}271\*710C2710%<4M0l137m/%P7460_<@. 3Y P@ GFih\VYP}\VCYZ3 GI/)<W4FY0 /02 P5V46d< YZd α Rt& A9u4|<WVCYC=<uY*246d>4Fl
(86) /)<W4IYZ0aYd <WVC7'<. 3QY P GIih\VYP}\VCYZ3@ GF/U<W4FYZ0aYd \\ /02 P}\37
(87) /m2460? YZd \37
(88) /m246\*YLl%. <57"PUo V7%PQ7 3Q7%Ph=*G|<P P5VY <WV/U< α i}/
(89) 2370713}?4Il
(90) i}271\*710C2710%< 37
(91) Y3}?*/10@4" /)<W4IYZ0 Yd /ml)<W460 l ". <5Y(* 71GF7)<5Y0'3Q7*%) =*4637%P<WV7 /
(92) l)<W4|HZ/)<W4FY0 Yd \ 3}VCYZ 460'\3Q7
(93) /
(94) 246\*Y*l " <57%PUoJKYZ0"H*713PQ71G <5Y <WV7/
(95) l)<W4zH*/)<W4FY0 Yd <WVC7 \ 3/%P ` ^N$ \*/)<WV"/ C. A{<WV7 α i}/m2371073}?4Fl /ml)<W4|H*/U<W4FYZ0 Yd \ 3}VY i}271\*702710"<\*/)<WV%D/ * P iPh=T=*0@4|<PYd V7)<5713QYC<W3}4M713}4Fl+
(96) \3Y<571460LPfo /137^4M0271\*710C2710%<OYd<WV7 βγ \VYP}\VCYZ3 GI/)<W4FY0.
(97) x. 1 . G6\V/. Hal author manuscript. <WV7g/ml)<W4FY0. i}/
(98) 23710C713}?4Fl . . ih^tk. α.
(99). /137. ih\3Y<571460Ci}l
(100) Y=*\GF7
(101) 2. YZdkl
(102) /U<57
(103) l1VYGF/1u4607%P }71\460C71\V3}4M07
(104) A 0Y371\460C71\V35460714M0. uV4|<57_/m246\*Y PQ7 <W4P-Ph=J7
(105) A. /10C2. 3Q7
(106) l
(107) 71\<5Y3P. \37m/
(108) 246\*Y*l "<57%PUo. α. ih^t. P TZ71GFY0?<5Y<WV7. p 0. /
(109) 246\*Y*l "<57%P. . α. 271\*710C2710%< l
(110) Y=*\G6460?<5Yg/
(111) 2710 G G*l lGF/%P7. α. ih^t . P. . . i PW=T< @\*7 /102. 7
(112) 24I/)<57. 37
(113) lm71\<5YZ3-P^_V@4Fl1V. /Du4F273Q/10?*7. . G646\*YG *P}4Pa<WV3Y=*?V. Uo p 0. /
(114) 246\*Y*l "<57%P. . Yd. fo p 0u\37
(115) /
(116) 246\*Y*l "<57%PQA PW<W46X=*GF/)<W4IYZ0Yd . YZd<W4PPh=J7"P. /137 7)b\37"PP7m2460_T*Y<WV. 460@V4|TC4|<W4FY0. D7
(117) 24F/)<57. /.
(118) 4Fi. inserm-00110175, version 1. α. iW^tXPO?*710713Q/)<57%P. YZdk/
(119) lU<W460Ph<W3Q7%PPd>4zT*713P;/10C2. <WV7460l13Q7
(120) /%P7460.
(121) 4%
(122) XY*i}271\*710C2710%<D460l13Q7
(123) /%P7 460 l
(124) 71G6Gk\3YZGM46dW713/)<W4IYZ0Jo V@4Pg7d>dW7
(125) l)<_D/%P /%PPQYLl14I/)<57
(126) 2 u4|<WVa3/1\4F2a/102 <W3/10*P}4F70%<g<@. 3YP}460C7 \VYP}\VCYZ3 @GF/U<W4FYZ0 YZd <WVC7 \ /102 \ ` 4|<5YZ?*70ih l)<W4zH*/)<57
(127) 2 N[3YC<57460 460/%PQ7%P j` ^N Rt! /02 Rt! }xk371d>GF7
(128) lU<W460?'<WVC7
(129) 4
(130) Y*ih7
(131) 24F/U<57
(132) 2'lmYC=*\G64M0? YZd <WV7 ih^t P <5Y <WV7 α P}D/1G6GX
(133) {NO/%P7\ 3/%Pa UoG6\VC/ i}/
(134) 2370713}?4IlX/
(135) lU<W4|H*/)<W4IYZ0 Yd<WV73/%P ` ^N \*/)<WV%D/ 4PD7
(136) 24F/)<57
(137) 2 i PW=T=*04z<P_Yd9<WVC7 VC7)<5713Y<W3}46D713}4Fl#
(138) \3Y<571460LPu/%Pu271DYZ0*Ph<W3/)<57m2 T <WV7r/)T46GM4|< Yd9<WV7gKi T <WV7 βγ <5713}u460/1G*2Y/14M0YZd ^t! }/ ijTC46024M0?\3Y<571460{<5Y_TGFY*l _ <WV4P/
(139) l)<W4|HZ/)<W4FY0& A Uo β βγ \37
(140) /m246\*YLl%. <57"PAPh<W46 =*GF/)<W4FY0 Yd α iW^tXP 4P /GPY /%PPQYLl4F/)<57
(141) 2 u4|<WV PW<W3}4 460@?
(142) 4
(143) YLi p 0 271\*710C2710%<k37m/13}3/10@?*71710"<;YZdk/
(144) l)<W4M0 l ". <5Y P * 71GF7)<5Y0o[ V4P4P l1V/3/
(145) l)<571354" 7
(146) 2'T / 3/1\4I2 P5\37
(147) /
(148) 24M0? YZd /. <WV7glm71G6GP <WV7. Y0'<WVC71463?3Y_4M0?. . Ph=TJPh<W3/)<>=*DAO<WVC7. . < @3Y P @GFih\VYP}\VCYZ3 GI/)<W4FY0. l
(149) 71GMG|=*GF/13r7)HZ710%<P. . 0CYCu0. /137. Yd <5Y. <WVC7 TZ7. \\. . . <W46?V@G. dWYZ3}D/)<W4FY0 dWY*l
(150) /1G . l
(151) Y0%<W3YGF7
(152) 2. . . . . TZ71GFY0?460@?. y Uou VC7%P7 <5Y. <WV7. 3Q/%Pi. @7 d>3Y
(153) }/ <5YCbC460 _V@4Fl1V P}\*7
(154) l14Md>4Fl
(155) /1G6G TGFY*l <WVC7 /
(156) l)<W4IYZ0&Yd'\ 35VY T. l
(157) /)<5/G *P}460@?g4|<P^BXNOih3}4zT*YP @GF/)<W4FY04PS/)TCGF7;<5YTCGFY*l <WVC7X/
(158) lU<W4|H*/)<W4IYZ0 Yd l
(159) 71GMGLY<W46G64z< AJl
(160) 71G6G*Y3}\VYGFY?. /10C2 l
(161) 71G6Gk?3YX<WVCA^?*710713Q/)<57
(162) 2 T P7)HZ713/1G;/1?*YZ0@4Ph<P /
(163) l)<W4M0? <WV@3YC=*?V
(164) ih\3Y<571460 l
(165) YC=*\GI7
(166) 2 3Q7
(167) l
(168) 71\<5Y3P Ph=JlV/%P G*. PQYZ\VCY P5\V/)<W4F24Il/
(169) l14F2AP}\V@460?*YP}460C7 ih\VYP}\VC/)<57/10C2u<WV@3YXT460& A Uo ih^t Pg460 KYZ0*P}4F27135460? <WV7 YZ35\VYGFYZ?4Il
(170) /1Gul1V/10@?*7%Pr?*71073/)<57
(171) 2 T PW<W46X=*GF/)<W4IYZ0Yd<WV7 α \37
(172) /m246\*YLl%. <57"PA'7 /10/1GL PQ7
(173) 2 h46a<WV7 460"H*YG|H*7710%< Yd \ 3}VCYZ 460 α i}/
(174) 2370713}?4Il
(175) i}271\*710C2710%< 37
(176) Y3}?*/10@4" /)<W4IYZ0 Yd /ml)<W460 l " <5YP* 71GF7U<5YZ0 /10C2 <@ 3YP@ GFiW\VYP}\VY3@ GF/)<W4IYZ0 Yd \\ h464M <WV7 Ph=*\*73}dW/1_46G A\. . @A. 3}VY. . Uo p <. . 460C/%P7 h\\ T /10CYC<WVC713
(177) ONO/%PQ7. /
(178) 2VC7%P}4FY0. VC/%P_\*/13W<W4Fl)=*GF/135G. 7)bC4Ph<5710Cl
(179) 7 YZd[/^d=*0lU<W4FYZ0C/1G*l
(180) Y=*\G6460@?DTZ7)<>D7
(181) 710 Yd. βγ. α. ^ . i Ph=T@=*04|<P . Yd. .
(182). \3YC<57460LP460<WV@4P. ih\37
(183) /m246\*YLl %<57"Pr}/. l
(184) 71GMG. l1GFY07. α. ih^t. T*7
(185) 710. P/10C2D\. l
(186) Y=*\G6460@? o p 0<WVC7 2713}4zH*7
(187) 2. d>3Y. 271Y0LPW<W3/)<57
(188) 2. <WV7. . <WVC/)<<WV7. Kx. 7)bZYL70. 35VYh4M4646{<WV7^\=<5/U<W4|H*7^460"H*YG|H*7710%<. \3Q7%P710"< xx% . PW<>=J2 D7 . 271Y0LPW<W3/)<57. \37
(189) /
(190) 24M\*Y PQ7. l
(191) 71G6GG64M07. <WVC/)<5A 460. . PW<5/)TG.
(192) . 7)bC\37%PP5460?<WV7V%=*/0 /
(193) l)<W4M0. . l "<5Y *71GI7)<5YZ0. α. K. 4M0%H*YG|HZ7%P. <W3/10*P2%=Jl)<W4IYZ0_\*/U<WV%D/ Jo. i}/
(194) 2370713}?4Il 37ml
(195) 71\<5Y3}A <WV7. /
(196) l)<W4zH*/)<W4FY0. Yd. \ . α. . i}/
(197) 2370713}?4Il
(198) i}271\*710C2710%<O37
(199) Y3}?*/10@4 "/)<W4FY0. 3}VCYZ. . 4M0271\*710C2710%<WG. Yda/.
(200). βγ. YZd. ihD7
(201) 24F/)<57
(202) 2. Hal author manuscript inserm-00110175, version 1.
(203) . ' 1 Q# +.
(204) + . . 1F
(205) F g + 5
(206) 1 . Hal author manuscript. VC7. l
(207) 71G6GP. K. 737'?3Y_0. . /)<ux y.
(208). . 3/
(209) 24IYZG64M?*/102. inserm-00110175, version 1. L@ . . T4M02460@?. . d>YG _? . . R`. Ph=*\\GF7710%<57m2. /%P \37UH4FY= P}G D27%PQl13}4|TZ7
(210) 2 y Uo"G6\V/. . YCT@<5/14607m2. ?*710C7D4M0<WV7uxx% . BX`. . 4|T*lmYLi c 4MdW79<57
(211) l1V0CYZGIYZ?4F7"PA"q D7137\3Q7)H4FY= P}G. 460. . T r\*7135/1070%< <W3/0LP}dW7ml)<W4FY0rYZd <WV7_V%=*D/10.
(212). . \3Q7
(213) /
(214) 246\*YP7_lm71G6GG64M07XdWYG6GFY7m2T. . /0/1G *P54P. α. ^ . 3Q7
(215) l
(216) 71\<5Y3a2710LP54|<. 460. K. α. . α. 2Y0Y3l
(217) /1G6d_PQ713h=*. . α. ^ . \3Q7
(218) /
(219) 246\*Y*l "<57%P. i}/m2371073}?4Fl_37
(220) l
(221) 7\<5YZ3. . @iP71GF7ml)<W4FY0. . i}/
(222) 23710C713}?4Fl. \3Y<571460Jo_.<5/)TGI7. . . _4|<WV. }xUo_P 27)<5713}_4M07
(223) 2T. ^ . . \37
(224) /m246\*YLl %<57"P. 7)bC\37%P-P}4FY0YZd<WV7al
(225) /13hTZYCb GIij<5713}_4M0/1Gu2YZD/1460YZd. β. D/%P. &. ^t. u4|<WV /\ S7
(226) Y β^t!uK H*7ml)<5YZ3QA dWYG6GFYD7
(227) 2T <WV7u2YC=TCGF7P7GF7
(228) l)<W4FY0
(229) * 7
(230) YLl460o\ S7
(231) Y ^t!u K HZ7
(232) l)<5Y3 D/%PSYCT@<5/1460C7
(233) 2DT. β Ph=TZl1GFY0460@? /10 R l
(234) Yt p i.*/1G p d>3/1?710"<gd>3Y \t!ui ^t! HZ7
(235) l)<5Y3r rh?*710C713Y= Pg?46d< d>3Y B_3fo β 7
(236) 2 T R l
(237) Yt p i VY p o V7XH*/G64F24|< YZd <WV7 c YVLP794M0%<5Y'\*l)B;q xo
(238) S7
(239) Y HZ7
(240) l)<5Y3^ p 0%HC4|<W3Y?*710G6460C7
(241) /13}4 " l
(242) Y0LPW<W3h=Jl)< /"P{H*713546d>4F7
(243) 2XT P7 % ) =J710l14M0? o . β. . !. ^t ui}K gD/%P. YCT@<5/14607m2. . T. <W3/10LP5dW7
(244) l)<W4FY0YZd.
(245) ++-rr 1F}
(246) r. \3Y<571460*P. 460. . v. <WV3QYZXTC460. }K/1G|TC4FYLlV71_. \3Q7
(247) /
(248) 246\*Y*l "<57%P. . D7137_7)bC\37%P-P7
(249) 2g/%PS?G|=<5/)<WV@4FYZ0C7. RkPl1VC713}4Fl1V@4F/lmYZG64;h?*710C713Y= P. P7\V/13YP7XTZ7
(250) /
(251) 2LPk/%P\37UH4FY= P}G. ^ . m(r. @7. t;7
(252) l
(253) YXT460C/10%< Kxg7)b*Y*710. α. ?46d<Dd>3YZ. 27%Pl3}4|T*7m2w. l1GF7m/)H*/1?*7&/10C2. . B_3fo GF/10~D/1G6G6.
(254). .*ij<W3/10*P}dW713Q/%P7_ .* d= P}4FY0 /10C2. @7/%PS371GF7m/%P7
(255) 2. UoJK9xg7Ub*Y*710. l
(256) Y0l
(257) 70%<W3/)<57m2. \=*3}4Md>4F7
(258) 2aYZ0. . T. lm710%<W3}4Il
(259) YZ0Ci}x. d>3QYZ. h_4FlmYZ0. ?G|=<5/U<WV4FY07. . 8;7)H*7135GC. A. <WVC7 T*7m/
(260) 2LPT p 0l
(261) A. .Zfo. m(r 1
(262) 6(J+-
(263) $ 1
(264) +Q(* r u#
(265) + K71G6GP 713Q7'\37)<W37m/)<57
(266) 2 Y3_0Y<_4z<WV Kxi}7)bZYL710 @. 7gdWYZ3H*/1354FYC= P \*71354FYL2 YZd<W467
(267) A /%P5V7
(268) 2 <>u4Fl
(269) 7_460 N 8u. /10C2 VCYZY?*710C714" 7
(270) 2g460r7)b@<W3/
(271) l)<W4IYZ0 T@=*d>dW713k o ` Ph=Jl13YP7mA ` 3}4Pi>~K c A xX` ` ?*K G A ` RB A X` BDA ` \V710 . GM7)<WV @ GPW=*G6dWY0 @ G6d>G|=JY3}4F27
(272) A X` T*70"/1u4F24607mA \~ y o fo^BXNOih354|T*YP@. GF/)<W4IYZ0_D/%PSl
(273) /13}3}4I7
(274) 2 Y=< 460 /^<5YC<5/GZHZYZG|=*D7XYd µGJl
(275) YZ0"<5/1460@460? X`w~D71\*7%P \~ *o A ` ` ?*K G A X` <WV @. _4F2460C7
(276) A A 27
(277) YbC l1VCYZGF/U<57
(278) A X` q^BDA µK 4!UN#" q^BDA ?aYd l
(279) 71GMG VYY?*7107
(280) /U<57 /102 o ? YdKx 7)b*Y*710. D7o V7g37
(281) /
(282) l)<W4IYZ0 D/%Pul
(283) /13}3}4I7
(284) 2Y=< /)< µ µ.
(285) . K. x . dWY3x y. Ko[ . VC7. . Hal author manuscript. . A . . /102<573}_460C/)<57
(286) 2T. \3Y<571460LP;460'<WV7. o @A . \~. _460. .CB. .*A. X` . /
(287) 224z<W4FYZ0. YZd . \*7G6GF7)<D7137g24P-PYG|H*7
(288) 2. . RBD . A . . .Bg.*ih\*YG C/
(289) l13 GI/1_4F27. . µ. 460. . G Yd y. @. µ. <W3}4Fl1V@GFY3YL/ml
(290) 7)<W4Fl_/ml14F2dWY3
(291) . GYd c /m71__G64{T@=*d>dW713. . ih713Ql
(292) /1\<5Y*7)<WV/10CYZG;/102. ?*7GFAPh<5/1460C7
(293) 2. u4|<WV. ?G Cl
(294) 713QYZG6. . KYLY/%P-P}4F7. . . T3546G6G64F/0%<TCG|=J7. . /)=<5Y3/
(295) 24FY?3/1\V@4F7
(296) 2o@ VC7^460%<570LP}4z< Yd<WV7XP}\*Y<P{D/%P/10C/1G "7
(297) 2X= P5460?. 1 #
(298) J 6(J++. . K71G6G P}\3Q7
(299) /
(300) 2460@?/ml)<W4|H4z< 'D/%P. inserm-00110175, version 1. 37U<W3/
(301) l)<57
(302) 2 T P73h=* 371d>35460?*710Cl @ T*71dWY37/
(303) 224|<W4FY0rYd \37)HC4FY= P}G. D/%P27)<573}_460C7
(304) 2. /%PX<WVC7'3/)<W4IY. 27)<573}_460C7
(305) 2 PW<5/13hH*/U<W4FYZ0. /10. /1G6\VC/. T*7)<>D7
(306) 710. . /%Pk\37)HC4FYC= P5G. juV4FlV. D/%P. ti. ). . 3}4PQij~DK c. PQ71\*/13/U<57
(307) 2 @ A. 23}4F7
(308) 2. Y0 /102. . 27%PQl13}4|TZ7
(309) 2. y UoL8k3}4I71d>G CA l
(310) 71G6GP9D7137. . l
(311) /13/
(312) lU<5713}4PQ7
(313) 2. T. /10. 460Cl137
(314) /%PQ7
(315) 2. l
(316) 71G6G. \3YZ\*Y3h<W4FY0gYd 37)<W3Q/
(317) l)<57
(318) 2gl
(319) 7G6GP. <WV7g0%=* T*713uYZdk371d>3}4M0?*710"< l
(320) 71GMGPu/102. l
(321) 71GMGP \37"P710"<460g/Xu4Fl13YPl
(322) Y\*7Xd>4F7GF2oR/
(323) lVH*/G|=J7_l
(324) Y3}37%P5\*YZ0C2<5Y. /10C2. /)<. p /1?*7 %=J/10%<PQYZd<>D/137o. /10. i}/
(325) 2370713}?4Il_/1?*Y04PW<-oL V7 . X` . _460. <WVC7 D7
(326) /10. <WV7. <5YC<5/1G0%=*. T*713uYZd. YZdO/)< GI7
(327) /%Ph<Od>4|H*7_P7\*/13/)<57. d>4F71GI2LPUo . . l)<W460. . d>46GI/1710"<P^737H4PW=J/1G64 7
(328) 2. /%P\37)HC4FY= P}G. 27%Pl3}4|T*7m2. l)=*G|<>=*3Q7 \GF/U<57%P 713Q7;D/%P}VC7
(329) 2D<>u4Fl
(330) 7^u4|<WV_N8u.g/02_d>4|b*7m2DdWY3
(331) N 8u.oL 4|b*7
(332) 2 N 8u.. dWYZ3. l
(333) 71G6GPD7137DD/%P5V7
(334) 2. <>u4Fl
(335) 7__4z<WV. . u460o%NO71357
(336) /)TC46G64 "7m2 . d>G|=JY37%PQl
(337) 71460. N 8u.. . /10C27Ub*/1_4M07
(338) 2X= P}4M0?. u 1
(339) 1 Qr{ h(J+Q(*F # + # f(* m'
(340) + 46_. =*0Y\37
(341) l146\4z<5/)<57
(342) 2. u4|<WV @. µ. G. /0. u4|<WV. .
(343) . . \37)HC4FY= P}G. µ. /10"<W46\VYP}\VCYZ3 GI/)<57
(344) 2. . . \*YG C/
(345) l13 @GF/1u4F27. . . !. uA^Rt ui. jN. i PQ71\V/13QY PQ7. . . p 0lo. /
(346) 2VC7%P}4FY0. dWYG6GFY7
(347) 2. . T. /10C2 . dWY3}/1GF27V C27^460. ui . 354|<5YZ0. . YZd. l
(348) 71G6GPD7137D<WVC710. \3Y<571460*P. D7137. /10"<W4|T*Y*2. VCYZ3PQ713/
(349) 24P}V. . . <WV70. Ki. D7137. /102a37%Ph= P5\*71027m2. P71\*/13Q/)<57
(350) 2&YZ0. <W3Q/10LP5dW713}37
(351) 2. j . \3YC<57460LP. K VC71_4Flm/1G p 0loul
(352) YZ0h=*?*/)<57
(353) 2. A 3/0LP2%=JlU<W4FYZ0aGF/)TZYZ3Q/)<5YZ354F7%P}. 460C/%P7.
(354) @ 0"`. 460. 7%PW<5713}0CijTGFY<_D7137. P5\VY3 @GF/)<57
(355) 2. T*7
(356) /m2LP.46?/. ?*71G>od<5713a71GF7ml)<W3Y\VY37%P}4PAg\3YC<57460LPD7137. u4|<WV&/10&/10"<W4FihdWY*l
(357) /1G. 8k4FY<57
(358) l1V0CYZGIYZ?4 CA. . < @3YP @GFih\VCY.
(359). u460o V7 . . y Uo'8k3}4F71d>G CA. G \3Y<571460. /10"<W4|T*Y*2. dWY3. \GF/"Ph<W4Fl. /1071\4Md>G|=JYZ3Q7%Pl
(360) 70l
(361) 7^_4Il13YPl
(362) Y\*7o. YZd_< @3YP @GFih\VCY P5\VY3 @GF/)<57
(363) 2. c /
(364) 71_uG64T@=*d>dW713Uo 3QY P GIih\VYP}\VCYZ3 @GF/U<57
(365) 2. 460Cl)=T*/)<57m2. . Y0. l
(366) 71GMGP 713Q7;D/%P}VC7
(367) 2D<>u4Fl
(368) 7^u4|<WV_N8u.g/02_460lU=T*/)<57
(369) 2Xu4|<WV. 7)b@<5710LP54|H*71G XD/%P}VC7
(370) 2X_4z<WVXN 8_.. 27%PQl13}4|TZ7
(371) 2. jHH u4|<WV A . /102r\*713}7
(372) /UT46G64 "7
(373) 2. l
(374) /1353}4F7
(375) 2wY=</%P. xfo{K71G6GP?3Y_0. _460_4M0xA y. 4PY<WV4FY*l C/10/U<57gj p K i}l
(376) Y0h=*?*/U<57
(377) 2'\V/G6GFY4F2460gN8u.. p _X=*0CYZ\3Q7
(378) l146\4|<5/U<W4FYZ0. . . . \*73YCb C2/%P7
(379) iWGF/)T*7GF7
(380) 2. <5Y A. . . 460. .Bg.*i. 04z<W3YLlm71G6G|=*GFYP7/102. µ. . ? >uGFAg.L/0%<5/. . P7ml
(381) YZ0C2/13. K 3h=. . /10"<W4Fih3/)T@T4|<.
(382) y. p uX=*0Y<57
(383) l1VJo fo 27)<57
(384) lU<W4FYZ0. 460. @. X`. Hal author manuscript. 7)b@<5710LP54|H*7D/%P}VC7%P460. β. O8u.*. T@=*d>dW713. . 27U<57
(385) l)<. . D7137. ih713Ql
(386) /1\<5Y*7)<WV/10CYZGIA. . H4Ph=J/1G64 "7
(387) 2. T. 710@V/10Cl
(388) 7
(389) 2. lV71_4MG|=*_460C7%Pl
(390) 70l
(391) 7. . X`. . !. Rt. .*A . A . µ. 3}4Ph~Dl1G q. \~. o. /
(392) K GFA A. . . . dWYZGMGFYCD7
(393) 2. . T. {7m710i. fo . . ? >uGFA.*/10"<5/K 3h= _8k4FY<57
(394) l1V@0YGFYZ? CA p 0lo. . VC7. `. *o A
(395) @ X`. \~. }Ki U A . o . ). .CB. 3}4PQij~DK c. u4|<WVr/10"<W4FijRt. < @3Y P @GFih\VYP}\VCYZ3 GI/)<57
(396) 2. . &. V7XTGFY</%P <WVC710g460Cl)=T*/)<57m2 <5Y. T*/10C2LP. c 46dW7'.*l14F70l
(397) 71fod<57139 ui527)<57
(398) l)<W4FY0A<WVC7DTCGFYC<S/%P Ph<W3546\\*7
(399) 2'dWY3kx . jR K c A{713P5V/1. K. /)<. p _X=*0Y37
(400) /ml)<W4|H*7. 460%<570LP}4z<. Yd'<WV7. T*/10C2LP. D/%P. 7
(401) /%PW=*37
(402) 2. = P5460?. p /?*7 %=J/0%<PYd<>/37o. inserm-00110175, version 1. u 1
(403) 1 Qr. #%$. . K71G6GP713Q7XG *P7
(404) 2
(405) X`. q. . /
(406) K GFA. \*/13h<W4Il)=*GF/)<57. 7Ub<W3/
(407) lU<W4FYZ0_T@=*d>dW713 . . c *PQ/)<57%P.
(408) + r )
(409) +
(410) 1F}1 . 4M0. 0i5YLl)< @G. GF7)=*\*7\<W460Uo. . α F. . β. 713Q7. y o A
(411) @ . * A. . l
(412) 710"<W3}46d=*?*7
(413) 2. `wq. /
(414) l1GIA . . PQYL24z=*. X`. . . Yd. c YCu3. . /10C/1G *P}4P= P5460? 4. /10%<W4|TZYL2 Dh?46d<[d>3Y. X`. `. ?*K G . . o . q A. {N A A. X`. @ .
(415) `. j. . . D/%P460lU=T*/)<57
(416) 2 .<-o c YC=*4PQA `. . dWY3. x. _460. . <5Y. 4M0't p N[. PQ71\*/13/U<57. T=*d>dW713; A { `. . . Y0. A . . .Bg.*A. K A. µ. . ? >_G /102. 3}4PQij~DK c q. Y04F27U<NOi. . µ. l "<5YPYG64Fl.
(417) A ? <5Y<WV7. . ?*7G^dWY3D7%Ph<571350ijTCGFYC< 3h= 8k4FY<57
(418) l1V0CYZGIYZ?4 CA p 0l@o QA/10C2 /10%<W4. .Bg.*ih\*YG C/
(419) l13 @GF/_4F27. _GFA.L/0%<5/gK ?. 1 .
(420) X{N$
(421) ^BXN. Ph<5/13WH*7
(422) 2. T=*d>dW73. Ph=Jl3Y PQ7
(423) A {N A o. dWY3. y o QA . . \V70 @G67)<WV @GPh=*G6dWY0 @G6d>Gz=JYZ3}4I271k/102rl
(424) 710"<W3}46d=*?*7
(425) 2r/)<. P71\*/3/)<57
(426) 2. /10"<W4|T*Y*2. PQ713h=*. Y04I27)<XNOi *. . W\~. PY*24|=*&Y3h<WVYH*/10C/
(427) 2/)<57
(428) A A. aV. dWYZ3. 3Q/)<W4FY. Yd. *). /10C2. . X` Va/)<. kl
(429) Y0h=*?*/U<57
(430) 2. . lmYZ0"<5/14604M0?. !
(431). X`. R. .
(432) ;B. NOA. X`. _4|<WV.
(433) . K. . X`. X`. q. . A. \. 3}VCYZ . . Ph=TPQ7 %=J710"<WG. Y3h<WVY\VYP}\VC/)<57 dWY3SxVoCK97G6GP 737DPW<W46X=*GF/U<57
(434) 2Du4|<WV 460. R X . \V710 GM7)<WV @GPW=*G6dWY0 @G6d>G|=JY3}4F27
(435) A. 37%Ph= P5\*71027m2.
(436). y A A X`. X`. A b?. 27U<5713}_460C/)<W4FY0YZd<WV7.
(437) Uo;K97G6GPg737. h\~. Bu3{tY=JY<WUo. u 1
(438) ' r VC7. . . 3}4P ~DK c. D/)<5713}4F/G>oN{3QYC<5714M0gl
(439) Y0l
(440) 70%<W3/)<W4IYZ0*PD7137_27)<573}_460C7
(441) 2g/
(442) l
(443) l
(444) Y32460@?. U g/10C2. /10%<W4FiW3}VY. A. X` . /)<. d>3/
(445) lU<W4FYZ0r713Q7. RBD . 27
(446) Yb Cl1VCYZGF/U<57
(447) A. <5Yr71G646_4M0/)<57X0CYZ0rPYG|=T4MG64 "7
(448) 2. α. ijBDih?G|=JlmYZ\ @3/10CY P54F27
(449) A. d>3/ml)<W4FY0LPUoNO/13h<W4FlU=*GF/)<57. h\~. 7)<WVCYL2. . X` . GI/)T*71GI7
(450) 2. . X`. v. U x . 3}4PQij~DK c / N. . y A. /%P. h\~ . `wq. . 7%P-P710"<W4F/1G6G _4|<WV. o . /%P. 27%Pl1354|T*7
(451) 2. x N#". . DK 4 >_G. . dWY3{H*/1354FYC= P[<W467%P/02_G *P7
(452) 2. y A A /) [A.
(453) @. . X` <W3}4z<5YZ0. q. /
(454) K GFA. ui A. X` X`. \VC710 @G6D7)<WV @GPW=*G6dWYZ0 @G6d>G|=JY3}4F27o@ VC7XPYG|=TGI7l
(455) 71G6G*7)b@<W3/
(456) l)<. µ. G\3Y<571460. u4|<WVr/_Y= P7/10"<W4Fih3}VCYZ.
(457) XiP71\VC/13YP7 TZ7
(458) /
(459) 2LP-.Z4M?/ K V71u4Fl
(460) /1GKY ozA /10%<W4zT*Y*2 r. A .*/10%<5/mi}l13h= X8k4FY<57
(461) l1V@0YGFY?4 CA.
(462) . p 0CloUo. x N ". GI/)T*71GI7
(463) 2.
(464) ;B. N. /02.
(465) X{N&713Q7. 71G|=<57
(466) 2. BA o. .B. <WV7. 46_X=*0CYLl
(467) Y_\GF7Ub*7%P_4z<WV. /. T=*d>dW713.
(468) ^BXN /102 o X`
(469) X{N {/)< Ko d<5713 7)b<5710*P}4|HZ7 D/%P}VC7%P
(470) ON$
(471) ^B N D7137P71\*/3/)<57
(472) 2T <WV460 GF/ 73 lV3Y/)<5Y?3/1\V a. j8;/ *7135d>GF7)b N R p ij l
(473) 71G6Gz=*GFY PQ7g c K \GF/)<57"PA{8/*713}d>GF7)bC460 ` ~ N h\~Dxo /10C2 /)=<5Y3/
(474) 24FY?3/1\V@4F7
(475) 2o V7 460"<5710LP54|< Yd<WV7XP5\*YC<P{D/%P/0/1G "7m2u= P5460? p D/1?*7 % ) =J/10%<PYd<>D/137o l
(476) Y0%<5/14M0460@?*A X`. RB . A. . . `. . . d>3Y. .*A o X`. Hal author manuscript inserm-00110175, version 1.
(477) . u
(478) +F + m(r g. W mm g^ #. Hal author manuscript. r1 # %( p 0. P}\3Q7
(479) /
(480) 2460@?*A\\. y UoO VC7%P7rl
(481) 71G6Gz=*GF/13. . 7)HZ710%<P. . \*/13h<W4Il)=*GF/13}G. \. . 0Y_0r<5Y "fo p 0. 3}VCYZ. inserm-00110175, version 1. . <WV/U< 460g\3Q7
(482) /
(483) 246\*Y*l "<57%PA. . . Y32713^<5Y. . YZd\37
(484) /m246\*YLl %<57. <5Yb460_uV4Fl1V46u\*/1463P <WV7d=*0lU<W4FYZ0. Yd{\. p 0. <5YC<5/G. . 3}VCY. ^ . α. 3}4|TZY P @GF/)<W4FY0rYZdS/10. ). . α. ^ . G *P/)<57. o . . µ. j 46?=*37. . _G ?. . ^ . . @7GF7
(485) 2. Kxi}7)bZYL70. o 8k27YZ0*Ph<W3/U<W460?'<WVC7. . VY=*3P.
(486) . @7. . Y3}\VYGFY? j 4M?=*37 . . . . l1VC/13/
(487) l)<573}4 "7
(488) 2. T. VY=*3P. . . /10C2. . T '<WVC7. dWYZ35/)<W4FY0. . 37
(489) Y3}?*/10@4 "/)<W4IYZ0. YZd. . \37
(490) /m246\*YLl %<57"P{_4z<WV 4|HZ7. µΜ h\\ . v. . . . . j 46?=*37. l
(491) Y3}37%P5\*YZ0C2460?. <5Y. <WV7. YZd. 37
(492) 2%=Jl)<W4IYZ0r460g<WV7. @7_<5Y. YdKxi}7)bZYL70. <WVC7. 4M0%<5/
(493) l)<. Yd. α. <WVC7. ^ . \37m/
(494) 246\*Y*l "<57%P . /)TPQ710l
(495) 7. P}\37m/
(496) 2460?. 460l13Q7
(497) /%P7. . VY=*3P . 4|<5Y?*710. . Yd /1GMY PW< . . x%8kUoLv. \*707)<W3/U<57460"<5Y. 7)bV@4|T4z<57
(498) 2. µ. `. . N[3YC<57460. . . 4M0%<5/
(499) l)<. /. U x ih4602%=Jlm7
(500) 2. α. . . 37U<W3/
(501) l)<57
(502) 2. /1GPY. 460/"P7. ^ . Yd <WV7. . α. ^ . ! . Yd. α. \37
(503) /
(504) 246\*Y*l "<57%P. i. α. j 46?=*37 . l
(505) 71GMGP}\3Q7
(506) /
(507) 2460@?. . /102 ^ . u4|<WV. #460C/%P7 460_<WVC7;<@. 3YP @GFi. dWY*l
(508) /1G /m2V7%P54FYZ0. GF7
(509) 2_<5Yg/10460l37
(510) /%PQ7 Rt. u4|<WV. Yd <WV7P5\*7
(511) l146d>4Fl. YZd 37U<W3/
(512) l)<57
(513) 2. P73h=*i PW<5/13hH*7m2. . l)<W4|HZ/)<57
(514) 2. ^ . /
(515) l)<W460Ph<W37%P-Pgd>4|TZ713PrjHC4Ph=J/G64 "7
(516) 2. 4M0'<WV7< @3YP @GFih\VCY P5\VY3 @GF/)<W4FY0. . α. . Yd. o &KY0%<W3YG6Uo* V7PQ/17PW<W46X=*GF/U<W4FYZ0 `. \. /YC=*0"<kYd<WV7. D7137 /)TZYZGM4P}VC7
(517) 2 T y VY=*3P \37)<W3Q7
(518) /)<W710"< ?> uG*YZd[Kx7)b*Y*710 D7j 46?=*37"P ALxKa/10C2x%BuUo µ <W37
(519) /U<W710%<. <5Y. N. 3}VCY\3Y<571460*PUo. Yd^/ml)<W460PW<W37%PP;d>4|T*713-P j 46?=*3Q7. GF7
(520) 2'<5Y/10. \VYP}\VCYZ3Q/)<W4FY0wYd. GF7
(521) 2. x N#"h^B. <WVC7. /
(522) l)<W460&l "<5YP *71GI7)<5YZ0. _460"=<57%P. U x . U x . @7mA/. 7Ub*Y*710. B/_lmYZ3}3Q7%P}\*Y02460@? . p KihGF/)TZ71GF7
(523) 2g\V/G6GFY4F2460kj 46?=*37xUoZ 46d<57
(524) 710g_4M0%=<57%P <W37m/)<W710"<u4|<WV /
(525) 2370713}?4Il/?*YZ0@4Ph<v. i. α. P}\37
(526) /m2460?*APh<W37"PP. lm/)<5/1G *P7m2. \37)<W37
(527) /U<W710%<. . . 460'<WVC7. /)TZYC=< . <5Y. /)TC46G64|<. . PQ713h=*iPh<5/13hHZ/)<W4FY0A. <>DY. 3}VCY. \37
(528) /
(529) 246\*Y*l "<57%P{D/%P{<57"Ph<57
(530) 2o . Kxi}7Ub*Y*710. Ar Uog.*7)HZ710%<. d<5713. i}/
(531) 23710C713}?4Flmih7
(532) 24F/U<57
(533) 2. α. α. . \3Q7
(534) /
(535) 246\*Y*l "<57. \37
(536) /
(537) 246\*Y*l "<57%P/02_^BXNOih354|T*YP @GF/)<57^\ . AY0 . . . DYZ3}\VCYZGIYZ? CA{<WV7g71d>dW7
(538) lU<YdkKx. \VYP}\VCYZ3 @GF/U<W4FYZ0u460. . \3Y<571460*Paj 46?=*3Q7. BD/DT*/02. . . {N /"P7%P Yd <WV7. 4M0%H*YG|HZ71710"<Yd3}VY. =*0@4 %=J7 T*/02g7)bCV4|TC4|<W460?r/ YZGI7
(539) l)=*GF/13714M?V%<SYd. \37
(540) /m246\*YLl %<57"P^_4z<WV . . 3}VY .
(541). l
(542) Y0%<W3YGF7
(543) 2'T r<WV7'P5/1G6G. 27)<5713}_4M07<WV7. Ph<W4MX=*GF/)<W4FY0. Ph<W37"PPd>4|TZ713 dWY3}/)<W4FY0. . T*7<W4M?VG. /
(544) 2370713}?4Il
(545) i}271\*710C2710%<;371?=*GF/U<W4FYZ0. d>4|TZ713P dWY3}/)<W4IYZ0/02_\\. i5/
(546) 23710C713}?4Fl. α. &< @3Y P @G\VCY P5\VY3 @GF/)<W4FY0r/10C2'/
(547) lU<W460 . /37.
(548) a
(549) )(* . /D\3Q7)H4FY= PPh<>=J2 CA7271Y0LPW<W3/)<57
(550) 2. \3YY<57%P3/1\4F2. dW/1_4MG. αQ
(551)
(552) 1Q m m
(553) . /%PPQYLl4F/)<57
(554) 2. _4z<WV. /. <WV7T46\VCY P5\VY3 @GF/)<57
(555) 2g}Y0< @3YP}4M07_/10C2<WV37mYZ0@4607X3Q7%P}4F2%=J7"P}/10C2g/
(556) l)<W4|HZ7 dWY3}. P5V46d< YZd.
(557) . &. Rt. j 4M?=*37 . . o8. K9Y0%<W3QYZG6fo9.*7)HZ710%<. <>DY. VCYC=*3-P_\37)<W3Q7
(558) /)<W710"<uYZd. α. ^ . \37m/
(559) 246\*Y*l "<57%PXu4|<WV . _GYZd Kx 7Ub*Y*710 @7 GF7
(560) 2 <5Y / yL i 37m2%=Jl)<W4FY0 Yd v U x ih4M02%=Jl
(561) 7
(562) 2 < @3YP @G \VYP}\VCYZ3. GI/)<W4FY0 YZd\\ j 46?=*37 AK9x^u4|<WVCYC=<;/1G|<573/)<W4FY0 Yd v U x ih460C2%=Jl
(563) 7
(564) 2 P5V46d< /10C2u<@. 3YP@ G\VCY P5\VY3 @GF/)<W4FY0Yd Rt! j 46?=*37 8;A*KxUo ^ \37
(565) /m246\*YLl%. <57"PA /
(566) lU<W4|H*7 \ 3}VY \3QYC<5714M0LP /137 VC7%P7&37%Ph=*Gz<P 37)HZ7
(567) /1GF7m2 <WV/U<5A'460 α 37*% ) =*4M37
(568) 2 <5Y 7
(569) 24F/)<57 α i}/m2371073}?4Fl
(570) i}27\*7102710"<uh46 P5\37
(571) /
(572) 24M0? Sh4646u/
(573) l)<W4M0 PW<W37%P-PXd>4zT*713P dWY3}/)<W4IYZ0 /10C2W464646{<@. 3YP@ GFih\VCY P5\VY3@ GF/)<W4FY0Yd<WV7^dWY*l
(574) /1G*/
(575) 2VC7%P}4FY0 460C/%P7@o . µ. ?. Hal author manuscript inserm-00110175, version 1. . h$u #
(576)
(577) + Q r ' J m+ 1# %$ VC7 /
(578) 2370713}?4Il. /)T*YH*7. 37ml
(579) 71\<5Y3Pu/102. i}/
(580) 23710C713}?4Fl. α. 3Q7%Ph=*G|<P. Ph=*??*7%PW<57
(581) 2 \. PW<W46X=*GF/)<W4IYZ0rY0. . p 0. 3}VYo Y .
(582) $N
(583). /10C2u<WVC7l
(584) /1\*/
(585) l4|< Yd ;B. ON. /1DYC=*0"<rYd. l %<5YPYG|=TCGF7d>3/ml)<W4FY0. . \37
(586) /m246\*YLl %<57"P _4|<WV. µ. `. v. U x . \. <5Y. j 4M?=*37. . 8kUo. K9Y0%HZ713PQ71G CA. T3/10C7
(587) A/%PO0Y<{DYL246d>4I7
(588) 2XT VC7'460@d>G|=J710lm7.
(589). <57%PW<57
(590) 2. µ \. `. v. T. . 3}VCYZ . <WV7&/1Y=*0%<. v . 71. 37)HZ7
(591) /1GF7m2. YZd. U x .
(592). i ^B. N. GF7
(593) 2. <5Y. u4|<WV. U x . i}/
(594) 23Q7107135?4Fl. α. /02. <WV77)b4PW<5710lm7. Yd. /. 460. dWYGF2.
(595). 4. A. α. <WV7. \*/13h<W4Il)=*GF/)<57. i. α. \GF/"P}/XD71XT3Q/107. . Yd . . V. D/%PrGFYCD713. PQ713h=*iPh<5/13hHZ7
(596) 2. . 4Pa7)b*lG|= P}4|HZ71G. <W37
(597) /U<W710%<Oj 46?=*37. . . d>3/
(598) l)<W4IYZ0. <WVC7/1Y=*0%< YZd3}VY&460. _V@4Fl1V. V. Y0. dWYZGF2. lmYC=*\G64M0?.
(599) ^B N %
(600) X{N. T*7)<>D7
(601) 710. . ^ . <WV7_\*/13h<W4Il)=*GF/)<57
(602) . GFY*l
(603) /1G64PQ7
(604) 2. 7)b*lV/10@?*7'Y0. α. ^ . <WV7_\3Y\*Y3h<W4FY0rYZd\ /1d<5713. α. /%P. <W37m/)<W710"<-o 460. \GF/"P}/. 8kUo. PQ713h=*iPh<5/13hHZ7
(605) 2. <W3/10LP54F710"< 460Cl137
(606) /"P7_460. d=*0l)<W4FY0/G. l "<5Y PQYZG*<5Y. 460l37
(607) /%PQ7gYCHZ713 l
(608) Y0%<W3YG6^T*7dWYZ37. Ph<W4MX=*GF/)<W4FY0. /'/)bC46X=*w460Cl137
(609) /"P7. T*7)<>D7
(610) 710. <WV7g460d>G|=J70l
(611) 7rYZd<WV7. d>3Y. oUo{.<W46X=*GI/)<W4FY0rYZd. o. /%PPQ/ Jo{.<W46X=*GI/)<W4FY0rYZd /3/1\4F2. 3}VY . 35VY . YZd. {N iWGFYL/m2460?. . V @\*Y<WV7%P54PA 7r/10/G *P7
(612) 2. /_460l13Q7
(613) /%P7_460. d>3/
(614) lU<W4FYZ0Jo V4Pu71d>dW7
(615) lU<^D/%P 0Y<XP546?04Md>4Fl
(616) /10"<. d=*0Cl)<W4FY0/1GrlmYC=*\G64M0?. 3}VYo . j 46?=*37 GF7
(617) 2. Yd/. <57%Ph<k<WV4P. 7)bZl1V/10@?*7YZ0u\. . <5Y'<WV7. 7)bC4Ph<5710Cl
(618) 7. <WV7 <W3Q/10LP5GFYLlm/)<W4FY0gYd \. lmYZ0"<W3YZGDl
(619) 71G6GPQAX<WV7. l
(620) Y_\*/137m2. <WV7.
(621) . . . i
(622). 3}VY. D/%P. \37
(623) /m246\*YLl %<57"P _4|<WV . _4M0%=<57%Puj 4M?=*37. α. \. 3}VY. ON. H*713-Ph= P. fo VC7%P7g37%PW=*G|<P. i}/
(624) 2370Y*l
(625) 71\<5Y3P. /102. \ . 3}VCYZ. i. . \3Y<571460*PUo. . βγ
(626)
(627)
(628) . #
(629) +. . +. 1 Q. . +
(630) . . h(J+Q(*F # + # f(* . . Q#. }m.
(631) . 7. . VC/)H*7. \3Q7)H4FY= P}G. 460. \37
(632) /m246\*YLl %<57"P. . l "<5YP *71GF7U<5YZ0. P5VY_0. . Hal author manuscript. \=<5/)<W4|HZ7. 460@d>G|=J710lm7. YZd. . . \37
(633) /m246\*YLl %<57"P D7137 <W3h=*0Cl
(634) /)<57
(635) 2. Ph<5/UTG. /. l
(636) 71G6G. Ph=T@=*04|<PQA/"P9TZ/%P7
(637) 2. inserm-00110175, version 1. !. Yd{\. P5V46d<SYd{Rt . 3/%P. \3YC<57460LP Ph=T@=*04|<P. βγ <5Y. . TGIYLl. \. <WV7&/
(638) l)<W4FY0. YZd. YZ0g<WV7460V@4|T4|<W4IYZ0. YZd<WV7. y Uo p 0. l
(639) 71GMG^lGFYZ0C7%P. /ml)<W460. 271DYZ0*Ph<W3/)<W4M0?w<WV7. YZ3Q27139<5Y. 27)<57135_4607_<WV7. 4M0. <WV4P'3Q71?=*GF/)<W4FY0A. Yd. β. !. ^t. .
(640). Ph=T=*0@4|<PaYd. βγ. YZd. β. !. . ^t ui}K QA/. \3Y<571460*P_VC710. . 7)bCV4|TC4|<W460?. ^ . α. /'TGFY*l */
(641) 27. .
(642). Yd. . βγ. i}/
(643) 23Q7107135?4Fl
(644) i}271\*702710"<< @3YP @GFih\VCY P5\VY3 @GF/)<W4FY0. α. !.
(645). /
(646) l)<W4zH*/)<W4FY0. 3Q7%Ph=*G|<. \3QYC<5714M0LP. <WV7. YZd{Rt &\3YC<57460LPS37%Ph=*Gz<W460?gd>3Y. . . dW/_46G.
(647). . 3/%PRt!&\*/)<WV"/ 'PW=Jl1Vg/"P<WV/U<. AL4|<P5VY=*GF2XT*79TGIYLl *7m2uT X<W3Q/10LP5dW7
(648) l)<W4FY0Yd. /
(649) l)<W4zH*/)<W4FY0gYd{<WV7. . Y. YZdr/ml)<W4|H*/U<57
(650) 2. UoS VC7P71GF7ml)<W4FY0aYZd<WV7. o* V7_/
(651) lU<W4|H*/)<W4IYZ0 .
(652) 4
(653). Yd <WV7. /. <W3Q/10LP5dW7
(654) l)<57
(655) 2'u4|<WV'<WV7gKij<573}_460C/1G2YZD/1460. 0Y_0. \3YC<57460. YH*7137Ub\37%P-P7
(656) 2a460. /10C2.
(657). <WVC7. i}/m2371073}?4Fl
(658) i}27\*7102710"<. α. D/%P&\*713h<>= P-P}4P<5YCbC460i PQ710LP54|<W4|HZ7
(659) A.
(660). 460"H*YG|H*71D710%<;Yd9VC7)<5713Y<W3}46D713}4Fl. <WV/)<. β.
(661) /. βγ. !. i5271\*710270%<S/
(662) l)<W4zH*/)<W4FY0.
(663). ^t ui}KoKY0%H*73P71G. βγ. . ih4M0271\*710C2710%<. 460C2%=Jl
(664) 7
(665) 2DT ?3YX<WVdW/
(666) lU<5YZ3PSl
(667) Y0%<5/4607
(668) 2460_<WV7. P73h=*AP}VY=*GF2_0Y< T*7/1Gz<57137
(669) 2o 8;/%P7
(670) 2gY0<WV@4Pl3}4|<5713}4I/ <>Yrl
(671) 71GMG l1GFY07%P }l1GFY07 D7137_P71GF7ml)<57
(672) 2o. T4M02460@?. . 0G D37%Ph=*Gz<P YT<5/4607
(673) 2__4z<WVl1GFY07. . /%PPQ/. α. <WVC7. /)TZYC=<. . α. ^ . . /%P. . l
(674) Y_\*/13Q7
(675) 2. . /
(676) l
(677) lmYZ_\*/04F7
(678) 2. T. . Yd9Rt&. /10. <5Y. 0CYZ0Cij<W3/10*P}dW7
(679) l)<57m2. /1G6YPh<l
(680) YZu\GF7)<57. . 7. . /
(681) l)<W4zH*/)<W4FY0. YZd \ . <57%PW<57
(682) 2. /)T*YH*7. v. . YdP}\37
(683) /m2460? <5Y. . d>YZG >_?. U x . YZd<WV7P5V46d<57
(684) 2 . TZ7271\*702710"<. j 46?=*37. /%PalmYZ_\*/37
(685) 2. _4z<WV.
(686) .
(687). . TGIYLl */m27. βγ. . _460. 0Y0ij<W3Q/10LP5dW7
(688) l)<57
(689) 2. \\. . . Y0. <WV7. . . 3}VCYZ. YZdRt. . V@4PD/%P j 46?=*3Q7. y fo. . H4I/u<W3Q7
(690) /)<W710"<u4|<WV. . i}/
(691) 2370713}?4Il
(692) i}271\*710C2710%<. α. α. ^ . Yd\\. @ AC<WVC7 . /ml)<W4|H*/U<W4FYZ0Jo p 0alGFYZ0C7. 7)bC\*Y PW=*37^<5Y. < @3YP @GFih\VCY. . y Uo. !. dWY3}. \3YZDYC<57
(693) 2. < @3YP @GFiW\VYP}\VY3 @GF/)<W4IYZ0 YZ0a\. \3QYC<5714M0Uo p 0rl1GFY07. <W3Q7
(694) /)<W710"</%P;37
(695) 2%=Jl
(696) 7
(697) 2. \37m/
(698) 246\*Y*l "<57%P . @. <W3/10LP5dW7
(699) l)<W4FY0j 46?=*37 y Uo. Yd. /10C2. . @ AJ<WVC7X460Cl137
(700) /%PQ7_Yd. U x . !. . v. 246d>dW71370%<T*7)<>D7
(701) 710rl1GIYZ0C7. iW7
(702) 24F/)<57m2D\*/U<WV%D/ *PUo
(703) [YZ3{<WVC/)< 7XPW<>=J24F7
(704) 2A460l1GIYZ0C7. . l1GFY07. ^ . α. `. P5V46d<kYd Rt. ^t ui}K. 460d>Gz=J710l
(705) 7. \37
(706) /m246\*YLl %<57P}\37
(707) /m2460?g?*710C713/)<57m2DT 246d>dW713Q710%<. . L@ . !. /02. 3}VCYZ. 271\*710C2710%<;371?=*GF/U<W4FYZ0 271Y0LPW<W3/)<57
(708) 2. <WV7. β. HJP. . 24P/\*7
(709) /13710Cl
(710) 7. . /%P[=*0/1d>dW7
(711) lU<57
(712) 2XT. <WV710. 4602%=Jlm7
(713) 2'T . KYZ0"H*713-P71G CA<WVC7D< @3YP @GFih\VCY P5\VY3 @GF/)<W4FY0 dW7)<5/1G*lm/1G6d P713W=*. . \3Q7
(714) /
(715) 246\*Y*l "<57%P; yL@ . < @3YP @GFiW\VYP}\VY3 @GF/)<W4IYZ0. . @ S7)bCV4|TC4|<W460?rP}46u46GF/13 T*71VC/)H*Y463. i}/
(716) 23710C713}?4Fl37
(717) l
(718) 7\<5YZ3;2710LP54|< g/"P^0CYC<P546?04Md>4Fl
(719) /10"<WG. /10C2'0Y0ij<W3Q/10LP5dW7
(720) l)<57
(721) 2 @. lGFYZ0C7. /137^\3Q7%P710"<57
(722) 2o"_P27)<5713}u4607
(723) 2XT _3/m24FYZGM46?*/102. @. . /02 . . `. v. . U x . . i}/m2371073}?4Fl
(724) i. uAl
Documents relatifs
To test whether the vesicular pool of Atat1 promotes the acetyl- ation of -tubulin in MTs, we isolated subcellular fractions from newborn mouse cortices and then assessed
Néanmoins, la dualité des acides (Lewis et Bronsted) est un système dispendieux, dont le recyclage est une opération complexe et par conséquent difficilement applicable à
Cette mutation familiale du gène MME est une substitution d’une base guanine par une base adenine sur le chromosome 3q25.2, ce qui induit un remplacement d’un acide aminé cystéine
En ouvrant cette page avec Netscape composer, vous verrez que le cadre prévu pour accueillir le panoramique a une taille déterminée, choisie par les concepteurs des hyperpaysages
Chaque séance durera deux heures, mais dans la seconde, seule la première heure sera consacrée à l'expérimentation décrite ici ; durant la seconde, les élèves travailleront sur
A time-varying respiratory elastance model is developed with a negative elastic component (E demand ), to describe the driving pressure generated during a patient initiated
The aim of this study was to assess, in three experimental fields representative of the various topoclimatological zones of Luxembourg, the impact of timing of fungicide
Attention to a relation ontology [...] refocuses security discourses to better reflect and appreciate three forms of interconnection that are not sufficiently attended to