Cognitive atlasing: From images to concepts and vice-versa: Behavioral profiling across large-scale activation data to understand cognitive information processing

Behavioral profiling across large-scale

activation data to understand cognitive

information processing

Sarah Genon

Cognitive Neuroinformatics Group

1) Region of Interest:

Dorsal Premotor Cortex:

Interface between prefrontal and primary motor

Genon et al., 2017, Cerebral Cortex

2) Connectivity matrix

3) Clustering/factorization

Connectivity-based parcellation (CBP)

Functional organization of the human

hippocampus

Plachti et al., in press

study c study a study b

Vos de Wael et al, 2018

First gradient Second gradient

The human hippocampus

Hippocampus organization based on local microstructure

Local microstructure

Ding & Van Hoesen, 2015

Lateral medial DG DG Sub Sub CA1 CA2 CA3 CA3 CA2 CA1 Amunts et al., 2006 Lateral medial

Connectivity-based parcellation

2k

3k

 Not one map of the brain

 Beyond regions and network: gradients/organizational dimensions

Amunts et al., 2006 Plachti et al., in press

Characterizing brain organization

anterior

posterior

medial lateral

Local microstructure _{Connectivity markers}

What do these organizational dimensions reflect in terms of

Relating brain organization to behavioral

functions with activations databases

Genon et al., 2018

BrainMap:

> 3200 papers (> 16380 experiments)

horse

horse

Green

M

What is her name?

1. Caroline Ravin 2. Stéphanie Dupont 3. Stéphanie Rufon 4. Caroline Martin Neurosynth: > 11400 papers

Activation database behavioral conditions 25 + 32 = ? Similar to 2-back? M Font color? green

What was her name? 1. Linda 2. Susan 3. Helen Are you? self-confident activation peaks ζSame or different ? ζ ζ Brain region

?

Behavioral profiling

Right PMd

Flexion/extension

Isometric force

Finger tapping

Drawing

Sequence recall/learning

Visual pursuit/tracking

Visual attention/distractor

Saccades

Antisaccades

Imagined movement

Mental rotation

N-back (working memory)

Card Sorting (abstract rules)

Genon et al., 2017, Cerebral Cortex

lateral posterior intermedi

ate lat 1 intermediate lat 2 anterior lateral anterior rostral Cognition.Memory.Explicit Cognition.Language.Semantics Cognition.Memory Emotion Emotion.Happiness Emotion.Fear Emotion.Disgust Emotion.Sadness

Plachti et al., in press

Associated behavioral functions in activations databases

Emotion-cognition gradient Navigation Context Scenes, pictures Episodic memory Autobiographical Face Emotion* Anxiety Fear** Threat

lateral posterior intermediate lateral anterior lateral anterior rostral

* emotional valence , ** fearful faces

Self-world centric gradient

Characterizing the anterior-posterior gradient of the

human hippocampus

Behavioral profiling

• Limited spatial precision

• Publication bias

• …

Conclusions and perspectives:

Behavioral profiling of parcellation maps

 As a proof of concept, behavioural profiling across activation data of the PMd rostro-caudal organization highlights a cognitive-motor

gradient.

 Behavioural profiling along the hippocampus longitudinal axis supports a cognitive-motor gradient and further suggests a self-word centric gradient

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Cognitive Neuroinformatics Lab

WashU Aris Sotiras