• Aucun résultat trouvé

Thérapies ciblées anticancéreuses orales et adaptation posologique chez la personne âgée‎ : revue de littérature

N/A
N/A
Protected

Academic year: 2021

Partager "Thérapies ciblées anticancéreuses orales et adaptation posologique chez la personne âgée‎ : revue de littérature"

Copied!
163
0
0

Texte intégral

(1)

HAL Id: dumas-01323871

https://dumas.ccsd.cnrs.fr/dumas-01323871

Submitted on 31 May 2016

HAL is a multi-disciplinary open access

archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.

L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

Thérapies ciblées anticancéreuses orales et adaptation

posologique chez la personne âgée : revue de littérature

Quentin Le Pallec

To cite this version:

Quentin Le Pallec. Thérapies ciblées anticancéreuses orales et adaptation posologique chez la personne âgée : revue de littérature. Sciences pharmaceutiques. 2016. �dumas-01323871�

(2)

!

"

" # $ %

!

"

&

" # $ %

# $

% & ' ("

!

"

# )

* ""

& +

#

,

"

% -

"

*

(3)

!

"

" # $ %

!

"

&

" # $ %

# $

% & ' ("

!

"

# )

* ""

& +

#

,

"

% -

"

*

(4)

! " #

$ $ %#" &

! " ' ( ) # * +, $ # + ) - . " * ) " / " )+ / 0 1 ) 2 ) 3 3 4 / $ -& ) " ) " ) ( )+ )+ "( 1) ) 15 * " # 6 " 7 " 0 " / ( 2 +, " + ) -# $ % & ' ( )) "(8 ) 4" ) " " * "( ) 1 " # - & ) " / * ) 3 " ) " / * 2 ) ) ) -' $ $( " ) * & ) (+ 2 1) # $* ) "( )) " ) 7 1) 1 - & ) + / 1 ) " / -* + (+ 2 " 1) # $* "( " " / " " ) ) 2 1 " ) # $- 9 / " ) " / * ) 3 " + 1 14 ) ) * ) ( 1 " # " +, , & ) "( )) " 2 1 " # $ " +, * * "(8 ", * " ( " " # $ " 2 3 ( :) * # " +, #( ), +

(5)

-) ) " ) * # 2 " " ( % ) -+ , #-." & - . ( " ) 7 "( " * "( 5 ) , * " ) ) - ) )+ 3* 1 -; )+ 2 " )12 % <= 8 " " >?- &8 # " ( ) % # -/ 0 1 * + - @ ) / -1 ) #( ) # "(+ )( 1 / A) * ( ( " " " 7 - & ) 1 * ( " )+ # - B ) )( " +, 0!- '( ) ( " / > ; 7 +, / " " 1 * / 1 " 2 " , " / "-# $ & $ & ! ( C 1 45 * 1 , ) "( " ) " " " +, - 9 1 ) ) 1 " ) # $ 2 " 8 ( D ) $ , ( ( 2 1 !-2 ) / " " / * "( ) ) 5" ) 81 !* 8 ( "

(6)

-3 3 + $ 1 " " ,) * "( ) 2 " # -1 4 4 1 5 3 1 " / , * 2 " ( " ) 1" - '(8 > 4 $ - - - -- - - . 6 . ) * < + ) ? " / "> = C " # ) # " %4!-4 $ $ $ - & ( " )) * 1 " ) 7 1 1) , ( - 9 ) " " ) ) & " * )+ ( / 1 " * -" / * ( ( / " 2 * " " 2 * " ) ) * ) ) 3 ) ) 5 "

(7)

-/ 0 % 1 " #

% # 0

%

#

-! $!

%

%0 %# %

%#

%%

! % !

(!2 % % $

(!2 % ! '

% %" $ " "

(8)

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

(9)

& + K; K 4/ 4 / & J P + K; ;+ / + " 4 O / & J ) K; 4 ;+ / + " / & B ) K; ; " / & @ " K; + / 1 )+ / ) & K , K; ; " / & O+ $ > = 9JH Q 1 & = K; 4 )+ / & J L = K; & " ) & B = K; I / " ) & ) = K; " $)+ & & )+ = . * / K@ + / &- Q = K; +$ / & + = . * / K; 9 / & ' = K; + / & E = K; $)+ " & ' " A K; / & J ) + ;@ K /

& R )4& + ? K; & " ) "S / )

& ) + ? K; ' 4 = / & A K; )$ / + / & = ) > K; + 1 )+ / ) & T K; ;+ / 2 1 & K > K@ B " ) / " & O+ $ A K@ H+ / & 4& K; +$ / & K A K@ & " ) & / , :C K; ;+ / I 2 1 & F C K; ;+ / ) " & @ " K; K / * $ / * )$ / 1 &- ' " K; / & ;+ + = K; " & I K@ & " ) & 4 K; E 4 + 4 $ / / & R U) K; Q$ ) / 4 E & G + K; " & = K; B " / & K; K 4/ 4 /

(10)

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

(11)

E @ & T > > : > = K; @ ) / V = / & ; > = K; @ )+ & = > F ?> K; ;+ / = ) & Q " > K; K / & & K; " & + K; +$ / & G + ? K; @ )+ / ) & & U K; 1 & G + ? K; )+ /

& & K; & " 2 )1 )

& G / + A 9JH I / & T K; B " / * ) " & 4@ 1 9JH @ / ) & H )+ : 9JH +$ / & O+ C K; = / & & A K; @ )+ / ) & ;+ 1 9JH +$ / " H " )1 & & + K; / & ) = : > K; Q 1 & 4; > : + K; = = & ' C 9JH / & O+ $ D > 9JH ; ) 1

(12)

: & O+ $ > ;+ O+ 1 & 4 ) > + ) / & H " 94 K! @ +$ & 2 ! + ) / & I > @ )+ & R U) 94 K! / & = 2 ! O 3 ) / & & )+ = > O 3 ) / & I F : +$ / & ;+ O 3 ) /

& & 1 : 94 K! & ) /

& B + = + ) / & H 94 K! + ) ) & 4& = + ) / & + ;+ $1 E & ; ) > > ;+ Q & & $ > + ) / & J " ) > + ) Q & " = +$ / & ; > G 1 1 & & ; + : > R / 1 + ) 1 ) " & B C + @ & ; ) > @ )+ & B ) @ +$ & + + ) / & I > + ) / & ' : > + ) / & " + P + ) / & J L ;+ E / & Q = = &;94 K! /

(13)

& # = > ;+ $1 & & 4R = @ & K @ +$ + 1 & R 11 = / 4 I / & K / @ / & G = ;+ / & O + = C: ;+ $1 & & + " B > + ) / & & P B > + ) / & ;+ 1 ;+ + 1 & J " ) C = @ )+ & ; ) = : A + ) :) & 4J L + ) :) & & + " = / : & G " ? @ ) / = & G $ > : C C @ )+ & K = Q & ; = ;+ / & H $ C B > /

(14)

> A & ; ) > > ;+ Q & O+ $ > ;+ + 1 & H " @ +$ & & 4; + : > R / 1 ) " & B + @ & 4 ) > + ) "$ & I > @ )+ & R U) / & & )+ = > O 3 ) / & J L ;+ / & I F: +$ /

& & 1 : & ) /

& B + = + ) /

& & + " B > + ) /

& H + ) )

(15)

@ = & 4R 9JH & " ) / : & B > 9JH & " ) Q & + = ? 9JH & " ) / : & ) > 9JH & " ) / & B + 9JH & " ) / & F 9JH & " ) /

(16)

= : & G / "! +$ / 'B ! & + ! G) ) " & " ) & G "! Q I 2 1 & G + "! @ )+ / ) 9 I ! & Q T > = : ? "! @ )+ / ) 9&H G & ; "! ) ) )! & ) = "! Q 1 ) + 9&H ! & ) = "! ;+ / B3 & : "! +$ / 9 I ! & J " ) A G) ) " / / * + + & I "! @ )+ 9&H ! % & = 0 1! " " "" ) 0 1! " )$ % - & ) 0 ) 2 " % 0 ! " %! " 3 & 0 4 " & 3 2 ! %5 % 5 "

(17)

!(

" $!2. "

A/ ) ) --- R A/ %--- %--- R $ " ) 1 )+ C 1 A/ --- --- R( ) %---W - - - ; " " ( ) %---X - & " 5) 1 + ) ) 1 (A/ %--- %--- 1 )+ C # A/ %--- %--- ' 1 )+ C # A/ %--- - -W & )+ C # A/ %--- %---X B 1 )+ C A/ %---W Q , "( ) ) %--- X -W- ;$) ) "( ) %--- X -W- - ' / 1 " )$) ) %--- X -W- - " ) M " )$) ) %---W- -W G 1 " " Q %---W- -X R( %---W- ; ) ) %---W- - ; ) " ) ) ) --- W -W- - E ) /, /, " %--- X -W- -W ) "( ) / , %--- -X R ) ) )+ C A/ %---R O+ ) " ( :) ---W - R ) ) + 1 %---WW - - R =BQJ ) %---WX - - R BQJ4H %---W - -W H ) )4YIO %---W - -X R 'QJ4H %---W - - RY %---X - - @) 4 %---X - - @H J %---XW - - R Y %---XX - - ) + 1 %---X - - - R G++ %---X - - - &OEH %---X - - -W JROW %---X - - -X ;GJ4 H %---X - - - R ) 3 " /, %---X - R ) " ( :) %--- %--- R + " @) 4 %--- %--- %--- R( 1 QRI=B;Z! %--- %--- %--- R " 1 G HF;BRZ! %--- %--- %---W R 1 O GIQ Z! %--- W - - -X R 1 @EG9RIJZ! %--- X - - R + " =BQJ4H %--- %--- %--- R 1 G9OB OZ!

(18)

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

(19)

%

'

"

"# !2 %"

I 1 % R " " "( " ) "( , 9 " W!---I 1 % ;$) ) ) 1 " " ) M "( , H ) )+ ) ) !---I 1 W% B3 " " & Y "( , H ' W !---I 1 X% G)+ 5 " ( "( , @ / " !---I 1 % G)+ 5 " ( )1 O * IOY YI! ) )1 O$ P "( , H ' / !---WW I 1 % I ) 1 " =BQJ4H " / 1 ) "( , Y PP !---W I 1 % G)+ / " ( )1 1 " (BQJH "( , P !---W I 1 % I ) 1 " )4Y " 2 1 ) "( , G !---W I 1 % R " ] 'QJH / " "( , @ !---W I 1 % I ) 1 " " 2 RY " 2 1 ) "( , G+ ^ G X!---X I 1 % R " ] )1 @) 4 "( , _ / W!---X I 1 % ; @H J ) " 1 +$ / "( , R !---XW I 1 W% G)+ 5 " Y`GO O "( , G+ R !---XX I 1 X% ] ) ) " G ) K "/ + / "( , E^ _ 7 ! ---X I 1 % I ) 1 " OEH "( , ' ) $ X!---X I 1 % G / 3 ) " ( )1 1 " JRO4W "( , G^ " !---X I 1 % ;GJ4 H* )1 + 1 ) 7 "( , K & )' " !---X I 1 % G)+ " ( )1 " ) 3 " /, H! " " ) 2 " ) 7 ( 0 ( C " 0 # " ) " ! "( , R

(20)

!---8

" %% HI

# !%

838

!

" %% HI

&

R * ) "( " * " " )+ ] " 5 ( / 1 " " ! ) )) 1 " " / " 1 ( )+ ) 3 ) !- ; 7 )) 1 D / " " 5) +$ * 3* ( 1 " + / 5 " ), -' 1 * ) A/ " 8 1 53 ( " " ) ( 1 * A/ 0 ) 2 " ) * 8 A/ " , 1" * ) - "( + ) " " / , " )1 (+ * * !- 3 * " 8 ) ) ) * " ) 3 % ) 1 A/ ) ) ) " ( ) " " " ) * " ) " - ) * "( " * /, " ) 3-G ) " ) A/ " " $ + / " " - R(A/ ( ) 4 " ) 1 2 ) " " ) * ( +$ + / " # A/ * ) 5) ` "( + 1 * " ) * )+ 2 " - R " 1 * ( ( )+ 1 " * ( )) D 0 " ) ) 3 " ) "( " ) 7 1 ) " 1 - R " " ( 1 1 " 1 1 " " ) ! ( , W* WX + 2 !0 ) "( 3 )+ 1 ( , W XX + -, 3 1) " ) ) 1 A/ * 2 " + / )+ +$ *

(21)

+$ )+ * " , 4" " * )---! ) " )

-83838

!

*$

!2 % - J

!2 %# HI

; " 5 ) ( " 1 " 3 " ) " , ( " 1 "( 3) 2 " " ) (E&G!- B ) 2 ) )+ ] , ( " " ) ) ) 2 " " / ) " 1 " - ; ) ", ( 4" " " ) 1" * " " $ " ) 1 W!* " "( ) ", " ) ) -; 4) )+ # A/ - R(A/ L * " + / ( )) D " ) " " ) 1 " X!- ) " " ) * " "( ] " / - ;+ C A/ * "(+ 1 / ) " ) ) 1 / 3 " ) 3 / -I " ) ) 3 " 12 "(+ 1 + / 1) / 3 )+ ( " $)+ - ; ( "+ " 1 ! * ) / 1 " 5 , " ] 3 -R "( )) " / * " / " ) !* " ) ) ) " $ " ) 1 )+ C 1 A/ - R / " / ) a a b " ) </ ? b / " ! " 5 ) ] " )1 ! " ) 2 " , / )+ C 1 * " ) 1) " * 1 4 8 ! " ( " ) 1 !- ;+ C A/ * 1 ( W c " /, 8 ! ) + 1 - R / " ) c " + 1 / ) " " c " " -R ) 1 # , " A/ " $ " W* " ) X " $ X 0 5 X* 4" " !- ; , " "( 1) ) 3 3 "

(22)

$ + ) * ) " $ " ) 1 * ) ) + / (A/ * " ) ) / 12* 2 / 0 " :) "( ) 1

-83836

0 (" 1!% &

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

(23)

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

(24)

836

K !2 %" -! $! % 2L

"

" 4 0HI &

R + ) ) 1 " 5 ) ( " " " " " ) " ( / * * d ) ) " , ( ( " " ! " " 0 + / 0 / 1 !* " ) 2 / ) " " ) )12* ) "( " ) !- ;( " 1, " " ) 1 " " !* + )+ )+ )+ " * ) )( ) "( )1 " ) ) )$ )+ !-; ) * "( " 1 1 * ) 1 )+ C # A/ " # , ", " " * / " , " " ) " " + ) ) 1 "( " ) * " / ) % 1 % / " " ) " , " " / 12 ) ) 1 / * " 1 1 % " ] " ) ) +$" ` 4 ! # ( ) + 1 "" 67 ! 8 8 ! 9 " .6:;/

(25)

1 % 1 + 1 ) " )1 " + I " + II 1 % 3) 1 " " ) " ( / * / " 1 8 1 " )$) 4+ 1 ! ; / " 1 " + ) ) 1 " 5 ) (A/ !* ) 3 1 A/ # "( " ) 2

-83638

("

2 % - J

" ) # HI &

R " ) ) " / 12* ) d " ) ( 1 "( ) )12* ) " 5) 1 +$ / ) ) " / 12 )+ C # A/ " 5 ) 1 "( ) )12 ! !% " )1 +$ ! % + / " / " ! ) (A/ ) ) " " ) " 1 * 1)+ / ) )+ !* 8 " :) "( " ) ) 3 ) ! " )1 " ) 1 ) " / " ) +$ )+ +$" / ) " " 1 " 2 / " ( ) " ) 1 " ) )12 1 " 1 1 / ( 3 1 ) )12 " 1 " 1 G ) " * ( / " + ) " ( :) * " ) "( / " " ( 1 , d ) % ( " 1 " 2 / ) " " / " 1 " 2 / 1 " ) )12- ; 7 8 " 2 ( 1 " 2 1 / " R- -!* ( ( / " ) / 4 " )+ " ) " / 12 ) )12 ! 1 " ( " " 1 * ( ] ) / " , / 4 1 " " " ( 1 " ) )12*

(26)

" - ' 3 ) ) 3 # 3 " ] " 2 / 4 1 , d L K " Y " " ) ! )12 6 " ) 7 " ) ) 1 ;+ C # A/ * " 1 " ) 1 ) " " ) ( / 1 " K / * 2 ( 1 " ) - R ) " $ ) " 2 2 " ( ) 8 " , 1 - ) 2 1 " ( ) ) ) / ( 3 1 " 1 " ) !- & ) K / , " 2 / 4 8 * ) L ( ) " " / 1 * 2 " ) " 2 " 5 " -R( 1 ) " 1 (A/ " 1 ) ) 1 +$ ) 4)+ " ) * " :) )+ C # A/ - ; " ) " " " ) * ) , " 5 ) 2 )1 " ) )12 2 )+ / " ) ) 1 / " c !- B d ) 1 ) ) " ( )1 C$ 1 1 * + 1 % ] " /

!-83636

"# ( 2 % - J

" ) # HI &

; 7 " " ) )12 " ( / ) " 3 3 % 1 1 -R 1 * ) ( " * ( 3 ) " /* 1 ) ) * $ M ) " + 1 * " ) )$ * " 7 " ) " + * 14) * " " 1 7 ( # " - R ) )12 ) ) ) ) 1 * 2 )1 + ) / )1 ) ) 1 3 - '( 6 ( ) ) 2 * " ) D " / " ( 6 / " # " " ) !* "( ] "

(27)

-R / " ) % ( % " * 53 2 " ) " ) " ) 1 ! +$" + !- ;+ C # A/ 3 " "( " ( )1 + 1 ! " $ +, ! " 2 "( " 1 , ( + 4/ $) ) " % " / 2 ( ) ) ) ) 1 1 2 ) " ( 0 3 ) ) 1 + 1 "( ) )12* " ) " (e 4 / $) -) " =R'R* R'R* K'R! ) , + 5 / ) 2 )1 " ) + * 8 / ! R "( ) )12 ) " ) 2 )1 " d ) ) ) 1 1 " ) * ) ) 1 1 " ) ! "( , - ) , * ( : " ) )12 " !* ) 3 1 - ; 7 : " 3 " ) 11 " 53 1 " 3 ) )12 @ % ( : " @* " ) @ " " 53 1 ) ) % ) ) 1 / " 2 )1 " @ / * " ) " 3 ) # 3 " f 14 d U" g " + 3 ! ' 8 ) ) " 1 * , d ) (A/ * ( / " 1 " 1 !* + ) ) 1 " 1 " " ) ) 1 / ) )12! ) " ) (+ / " 1 " ( / - I "( 1 53 1 1 "( ) )12 2 2 % ) ) 1 / 2 * ="

(28)

" ) 53 1 1 2 - I " ) d ) * ) ) " ) ) , +$" + + "( ) ) +$" + " " 1 2 ) " ] " :) 1 * ( "( ) + !-;+ C # A/ * $ " 1 " 1 * ) " 5 " " 1 % ( / 1 " / " ) )+ C # A/ * 2 "( / 1 " =" " ) + "( " )1 " ) " ) +$" + -B 5 * 1 A/ # ( ! " c " 1 " !* ) d ) =" ) ) ) ) 3 / / + )$) 3 !- R " 1 " + 1 D / 1 " 2 )1 ) ) " ) "( " " ] 3 )+ C ) 1 - R( / " 8 ) / 5 " 3 )+ C 1 A/ - ' ) 4) 8 ( / "( " 2 1/ / + ! 1 " )1

-8363M

#!(

"$ - J

" ) # HI &

R ) " " ) " ) + 2 !-I ( / " ( / 7 " " 2 )1 " ) ) " / ! "( )1 "( ) - O ) " 5) 1 )+ 1 " "( C$ " + I " + II-R " + 1 2 1 ! " " ) +$" * 5 " ( 2 ) " ) ) 1 / -R " )1 " + I* ( / " )1 " 2 )1 1 * "# )1 "( / " 3$" 1 * " )1 * +$" $ - ) )1 "( 3$" 1 ) ) $ " C$ ) )$ )+ X ! X ) " ) "( ) * ) + * " ) C$ !- I ( / "( 2 "( C$ * / 4 C$ * " 3 " 2 " ] " " + ) / 1

(29)

!-R ) C$ ;F W X ;$ )+ X W X! / " 1 " " ) - 9 ( 2 ) 3) 2 )$ )+ * " 8 ) 8 " ) + " ( )1 "( )$ )+ " ) $ " " 2 1 " - G " 15 " " " ) % ;F ' " )1 !* ;F ; ` ; * B 0 " 2 1 )+ " " ] ) )12 -' ) " " ) * + ) # ;F W X )12 )12 " " / ) , - I ) " ) " ) D ) 3 " ) + " ) )$ )+ " (A/ d ) ( )1 C$ 1 + 1 -) (A/ * + 1 * " 1 " d 3 / + 1 ) !* ) d ) " ) " ) # ( 3 + )$ 2 1 * " ) )1 1 " ) " + ) !-; 7 "!-; 1 " d 3 / + 1 ) ) " ) 2 ] " / % " / )1 " , 1 " ) 2 )1 1 * * ) "( 7 " " ) ) 1 3 -' 8 + 1 )+ C # A/ " # # W!* ) ) ) ) ) " 1 " " / + 1 ! " 1 " ) ) + 1 " ) )12 - ; 7 " , / ) :) "( 3 )1 "( ) % 2 )1 " / " " ) " -; 7 ) ) + 1 2 )1 " ) ) ) ) C$ 1 " 2 2 )1 "( " ) ! " ) ) ) ) "( 1 $ , !- R 2 ) ( d L ) ) " * 3 ( "# " % " )1 ` + 1 C$ 1 $ + / 1 % ) # A/ * " ) " ) * " )

(30)

8 " " "( ] " ! 53 1 % ) " " ) ) 1 / * ) 7 2 )1 1 " 5 2 ; ) )1 " + II " ) # / !* ) 4) d ) (A/ - I ( / " )1 " / ) ) # / # "( ) " / ) 9QO 9' 4/ ) $ 4 2 ! ) " 2 ) # / * # " " ) +$ 1 * )---!- & # * ) )1 " + II 1 " 2 ! )1 ! " ) , -R ) 15 ( )) " 2 ( 2 ) " (A/ ) ) " " ) ) d " ! X!* 2 ) " " ] ) / 5) 1 ) # # ( )1 C$ 1 -R D " )1 + ) ) 1 " )1 + 1 )$ )+ !* $ " ) 1 * " 1 " " / + 1 , " 5 - ' 8 ( 2 " ) ( ) + ) / 1 * * " "

-8363N

$ %!2 % - J !

" %% HI

&

R " , + " "( ) )12 " ( / * 3) 1 - B ) ) 2 "( ) " % ( ( / " ) )+ / * " )12 )12 - B # * ) + 1 " ) +$" * ) 4) 2 " - R( ) "( 1 * " ) ) # / " * $ 1 " )$) 4+ 1 ! " 2,) -* ( 1 ! " * ) 1 * ( / " 5 1 / * " ) 1 ) " 1 - R 5 1 / " " 1 " " / " 53 1 " ) 3 1 * ) " " - R , / ) * " $ * 8 " ) 7 2 L ) " / - R( / , , / * " ) ( ( / "( 1 "( " ) *

(31)

) ) ) ) , ` ! !-; + , 2* 2 / " " ) ) 1 " ) ) " -( * ) 1 * + , " )12* 2 " " ) 3 - R( ) # * ) $ , ( $ ) 11 ! 3 " ) " ) " ! % ) $ / " : * ( 1 " * ) 8 5 ) ( )1 + 1 "( " ) ) ) D / 1 " "( )) 1 !- ; + , 2 " / "( 1 " ) )12 * " " " +$ ) 4)+ % Y * ) " ) 8 " # ( , " " ( 1 !-) (A/ * ( 1 8 " 5 " 2 L " 1 ) $ " 1 " 5 1 / " 1 " ) 1 " + - I ) +$ / " " " 5 1 / =! " ` " ) 1 " (A/ " X !- R + , +$ / * / $ 1 * " ) " , 2 - ; 2 * " )+$ " ) (A/ * " 8 8 7 " / ) " 2 1 " ) / - R / ) 7 " / * " 2 1 " 1 5 3 " / $ ) ) ) " 1 - ; 7 + / ) ) "( 7 )+ " * ) " , (+$ -' $ , 4 / 4 " )+ (A/ ) * ) " +$ +$ " - ; d ) ) (+ " " * " ) ) 1 " ( " 5 1 " 2 " ) ) 1 " / 1 " 1 " " !-; $ , / M " " / 1 " -; " ] ) ) ( / ) "( 1 " " )

(32)

//, " ) A/ ) ) " ) )12 " ( 1 " !- R ) ) " ) 1 "( " " 5 1 * ( 1 "( ) 5) 1 " " ] " "( : ) - ; 7 ) ) ) ) ) 2 " ; )P h Q % f X 4 A/ ! 3 " ` ) 1 i `R!g 3 P ) P b * W )+ C (+ * P b * X )+ C 2 ! ! & )+ C A/ ) 7 " , ) 2 " 5) 1 2 + ! 2 * ) % -W j ) 1 /`" !4 - Xj A/ 4 - W 3 * X 3 2 * 3 * !-G ) ) * ) " " ( $ 7 3 5 " ( " 1 " / % " " / ( " 3 " - I ) " ) ) ) + 3 3 % " ! " 1 1 " ) ) 1 " -R ) " "( 1 ) !* )+ ) +$" " / ) 5 " / " ' !- ) 1 )1 " + I " + II* ) " " ) " * 8 2 ) ) # / 3 - R ) " ! 3) ( 1 -R " ) ) # / 3 $ " , 1 -) * " 3 ( ] 3 % " 2,) ) " / 12 )$) 4+ 1 % ( 1 * ) K* ) "( C$ * 7 " ) )12* " 4 " ) )12 / ) ) 4) " ) " ) ) 1 / W

(33)

83M

= %."

0 % !%

&

" " + ) " ( :) * ) " (+ " " "( ) ) " ( / 5 " ) " M " ) + 1 " " ) " " / 1 )

-83M38

*

!

0 %

% $! &

R )$) ) * ) " " "( ) , " 3 ) 5 * " / " + * " ( " % Q Q ! % ( / "( + 8 5 " + " ) ) " 1 ) 1 G % + " $ +, Q % ) " + " ) ) " 1 , + * ) 1 ( + " " " ) -& % " ) ) + * + * ( + * + 0 " )$ " , + Q , + &* ) ) " ) " Q * + " ) ) * " - R 1 " " Q d ) " 2 ) /, -) 1 " ) , " 3 ) 5 * )$) ) 3 8 / ( / ) " ) ) ) !-83M3838 $ %# # I !2 % * ! & R , " )$) * 8 ) " " )1 !* ) " ) M ( 1 ( % " 1 ! !- R ) ) M ( " / 3 " 2 1 " 2 ) /, * ( : * ) " )1 " + Q -R C$ # " / 1 " )$) ) O $) " B % Y ' " " ;$) !* 2 )1 ( 2 X

(34)

` )$) ! )1 - ; ;"P ) $ + + $ 1 " ) * ) " 4 + P % 2, / + + " ( " 4 + + ! ) + ! ) " 1 " ) D ) ) "( ) " - R + + $ 1 " ) * " )+ / " ) 2 1 " ) " 2 )1 " )1 * + 1 ---!- B ) " ) " 3 )+ ) $1 % ( 53 ( O 2 / + + ( 53 ) B Q * ;"PX ;"P W ! )$) " $ '* ) 4) 7 / " + Q + + $ 1 )1 1 " H !* " ) 1 " 2 ) B J 2 ) " ) 1 * ) )1 " /, 2 1 Q `G ) 1 " )$) + G!-R " 1 Q `G* $ ) 1 " )$) B ;"P - R ) 3 2 * + + $ H * 1) " ) )1 1 -B + G* ) 3 )$) `;"P " ] 3 % 1 " ) 1 " ( ) " 3$ % ) ! )) 1 " )$) @ " ) 1 " ) Q * + " 1 " * $ 1 "( ;"P "( )$) " $ * ) ) " - R " / " Q &* )$) @ ( )) ;"P W !% ) 3 2 ( 1 / ) & 1 1 / J ) !* ) 4) 1 " " * d ) + , " ) % ) " 1 " )+ " / 1 " ( ) " $ 1 " ! / " ( )1

(35)

2 1 " 2 1 R( )1 " P )$) 4" " / W ! "( ) " + " )$) ) 0 )1 ) + ) " ) ;"P- B * )$) * 1 ( )1 " ;"P* ( " ) ) , C$ 1 % 3 P 7 )1 1 -; ;"P 8 )1 + + "( " + + $ 1 )1 ) * ;") 1 " " 53 1 " ( O " ;"P* ) 4) + + $ + !- ;") )1 ;"P * X0 ;") @ ; )1 ;"P - '( )1 " ;"P 3 * ( / " P * " + + $ 1 )1 ) * B "P )1 1 / B ! 2 ) 3 2 ;"P `)$) K )1 ;"PX ;"P -R + " ;"P " 3 / * "( )M B "P + ! ) ;"P* 8)+ 53 1 " )$) !* )$) 8)+ 53 1 "( O ! / " ) ) 3 ;"P`)$) - B ) " / ) "( P " + + $ 1 + ) ;"P % _ -83M3836 %#" %# P * ! & I ( 3 " ) M " )$) ) * * )+ + * ( # )12 # 8 % "" <7 3 " "" " " " ! 1" 8 ! 9 .6=>/

(36)

/ , " " 3 ) 5 $ 8 / 1 * ) - ; ) " ) * 7 " " ) " " ( ' " " ) 1 * 11 " )+ 1" " )+ ) " ) 5 - ; ) " ) W ! " ) / " ( " + * ) 1 " 2 ) " 1 " ( ' " , " ) ( " ) -R " ) " ) M 1 Q `G* ( / "( / + )P ! % ( ' " / , " ) 1 3 !* $ 1 " ) " ) - R ) + Q -R ) " ) 2 "( % P 3 / ) "!* 3 / ) "!* ( ' ( $ -O * " 3 G 4O+ P + )P B ! ! 1) 5) ! " + & G( $ " 2 ) " ( ' Q * $ )1 1 " P O& " ;+P - G( )1 1 " W* )1 ) "( + " ;"P % ) " !- W " " ) 1 " ) " 1 " ( ' - ' 8 O&4;+P * " " / " 1 " ;") * )1 ) " ;"P * X Q 1 Q `G-R 1 Q `& ) " ) " ) WW!* ( / "( ) 1 + )P !* ( $ " ) 1 ) 4) ( * ) Q - I $ " 3 ) ) % 1 )$ " ;") ; ;+P )1 OH* " ) " "( 7 " $ " ;") ; % ;"P 1 " W ) ) " * " ) ) / " )$) @ R " " ) " " ) ) ( 7 )+ " )+ 2 1 * ( / " ) ) "( 1)

(37)

+ )P !* 3 ) 1 + 4 + WX!- I 2 & " * )1 P )+ " 3 ) , ! 7 )+ 2 1 - ; 7 ) 3 4;") + 1 / 3 ! " "( + ( )1 " ) ) 3 - * ($ "( )1 1 " * C$ " $ * )+ / " $ ) + )+ 1" k -83M383M 2 "#! =7 & R ) Q * 2 ) " ) 1 B J )12 H 1 ) " !* " )$ " " )$) - R( )1 1 " )$) 2 " ) " 2 ) /, !* / 2 ) " ) ) f = " = ^ + ) !* = ) " + = ^ + ) ! *lg ) 3 ) - ;( "( ) ) ) " " ) 2 ( # " ) 7 1 - R " ) 2 ) ) D ) ) " " / 3 ) -R B ) )1 $ B !* " / "* " * 3 ) ( 4 + + $ )1 1 Q !" ) = ! * ) " 1 ( )1 1 ( ) / "( " " )1 " / - ; " ) ) ) % H 2 )1 ( )12 )12- B )1 " ) HOY* G * ( ) ) " ( )1 * " )+ / " ) 2 1 " H - ; 4) : / = = 4 + + ! ( )1 - G )1 1 " ( )1 1 " " 4Y / )1 " Y !-R & 4Y " )1 ) ) " W !* $ / " ) ) ) " "( )1 1 ) " ( " "( )1 1 % BBB & 4Y 4Y 4Y ! % )1 ( )1 "( 1 Q 3 ) ) H !* ( / " 4 + P -BB & 4Y 4Y ! % )1 ) " * + + $ O$ O+ " & Y

(38)

B & 4Y ! % 4 + P + + $ " 2 ) " ) 1 ) & 4Y * " $ )) " ) ! - ; 4) ( " ) + 1 " " ) 2 ( # " ) " +, - I 3 2 " H J W !* , " 15 2 H J4 ;4 H J* " 3 @4H J ) + 1 ! 4H J " 2 )1 / ) !- R H J* 2 )1 H QO * 2 ) 3 ) ) 7 " , - " " 2 L 8 ) )1 - B 2 + + $ 1 " ) " $ & YY % &BY ` - ; 7 " , )1 O ` 3 ) / " B ! W !* "( ) " ) " 2 ) " ) 1 * " P * " + + * " $ M " ( " ) 4 1 !-H HOY )1 )1 7 ) 1 " 2 ) " 1 " " Q - R ) MB + + 1"$ 4 W4 O !* O# Y @! $ $ / 2 $) ! W !- R IWY " ) 2 1 " M I O 4 + + !* ) " / 7 + + $ 1 " P B8 + + 1"$ 4 " B ! W !- R P @ B>! P * + + + $ 1 ` "" ;7 ? !" & @ 8 ! 9 * # .;:/

(39)

) 3! ) 3 ) " OG; OG; " M ) "(8 / / 12 W ! " ) 3 $ 8 $ 3!-I ( / "( " $ = =O )1 1 / !* ( )1 + 1 Q - ( / )+ " > !* ) 2 1 Q' - ' ) / OG; ` * H+ )+ / " ) 2 1 QO )1 OEH;

-I 3 " 3 ) 3 OEH % OEH; OEH; X !* " OEH

8 )1 / $ ) " 2 !* ) ) 3 $) ) OEH; * 6 OEH $) 1 2 !- OEH; M " $ +, " * * ( + / " / " 1 " )$ "( ) $ !0 OEH; " M " ) ( / 1 " )$ 7 - OEH; M ) " 15 " / " )$) ) % ) ) 3 1 " 2 ) " ) 1 N P $ 1) 1 1 ) XB! ( )1 1 " P G Y $ ) 4 !* $ " ) / 1 " " )1 " )$) ' 2 / Q `G!* ` $ 3 " ) ) ! 2 ( / / , -; 7 " / 1 IWY` P ` OEH " ) ) " / 1 " ) * )( " " / * " 5) 1 "( / / 1 "( " " )$) ) ) " + / " $ ) ) -83M383N 0! # " & I ( / " / "( ) * )( ) " / 1 " 2 1 ) * " , " ) 2 )1 - R / " ) ) 1 " ) * ] ) " , ( * / ) ) -R( * ( " ) )+ 2 / 1 " $ " ) ) ) ) + / " ( ) * ($ " $ " " ) ) " )$ a) a ) ) " ], " )

(40)

!-R ) 3 / " ) " 2 @) 4 ) " 14 1 f@) 4 * @) 4[R @4; R$ + !g " 4 1 @ 3* @ P* @ "* @ "!- ; d ) " ) ( * / 2 "(+ + 4" , " , ) !0 ( $ " " , 4 1 14 1 * $ )1 1 " ) -B ) " ) ) 1 " 2 ) 4 1 X !* )+ " * " )$ * )$ )+ ; - ; )$ )+ ; X ! )$ " ) !<4 1) )1 1 / ) ! C$ /, " % ) - R ) 3 2 " ) ( ( )1 1 ) ) " "( ) ) W !- R ) W " ] ) " ) )+ ( * ) )1 " )$ 4 " ) / " " " @) 4 " " ) ) " 2 / 1 " ( ' % )1 " !-"" A7 % !" B "8 ! ! 8 ! 9 ) 4 " .6:C/

(41)

; 7 " " ) )+ " ( 8 1 W ) " ) * ( $ " " 5) 1 " ( ' " ) 1 " /, ) " 7 1 " )$ )+ ; " )+ " @ 3* @ "!- W 2 " / " # " ) ) * ) " " ) 2 1 " ) 3 ;"P`)$) " ) / " )$) ) / ' " 2 ) 3 ) ( -R ) " / + , " ( * 3 3 , 6 ( " ) )+ " / " 1) 3 ) " ) ) ) !- I ( / " ) * " ) !" 1 1 / / ! 2 1 * ) 4) ( )1 !" !" / "! XW!* ) ) 3 ) " " ) )$ " 2 L )1 ) )1 ) ) " " ) -R( )1 " ) / " 2 @) 4 " 3 + 2 ! X !* 3 ) 2 )1 + ( )1 1 " ) " ) 3 ) )1 - ; 3I * ( " ) )+ * + " 3 % G& ;`' )+ " " 1 " )$ )+ ; F 'I ) " ) !* ) 2 ) / 3 " (

-83M36

!%

" &

I ($ " ) ) ) $ * ) 4) " " " ] $ ) * / " 1 ) ) 1 " 1 ) "( / - ) ) ) ) 1 3 ) ) ) " 15 - R ) * " ) ) * " )) " ' " ) M " )$) ) ( + , " " / + !-G( $ )) 1 " " 5) 1 " ( ' * ) " " 1 / 1 1 * " 1 ! / 1 ( ' * " +$ 1 3 !- ; " 5) 1 " / 1 "

(42)

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

(43)

8)+ " -; , 3 " , ) ) 1 " ) * 2 2 1 ) * ) ) ) " ) * / 1 " 1 " 5 # )1 ) X !- ' 8 ) ) "( 1 * ( / " ) 1 * 2 " " 3 1 " ] " ) "( / -I ( 3 " 3 $ " % < " ? % 2 "( " ) ) ) " ) " ) 4 < " ? % " + / )+ / / $ + 1 " ) ) ) ! R " , " , ) ) ) ) % ( / / , - 9 * 4" " m "( / " ) 1 " ) D * "( 3$/, - B 1 "(+$ 3 * ) ) ) $ + 1 KIJ " $ +, " =BQJ ) =BQJH " ) " + - * $ / A) =BQJ X !* 1 1 " 2 1 " ) " + * ( / " ) 3 ) " C$ " $ 3 4 !* / " 2 / A) " ) "( "+ " $ / - ; , 1 2 " 3 3 / / 7 ( ) 3$/, - R 4 / / , ) " + ) * ) ) 4) 8 1 ) 1 " )+ + ) 1 " ( )1 ) ( ' * " C$ ) "

!-83M3636 % I.% " # I.% " " "" " # $ " &

9 ) ) + $ " ) " )

"( 1 " ( ' X !* " 1 " /, " 15 ) ) /, ( / " 4 ) /, /, ) " "

/ )$) ) ! " /, " * ! " 1

(44)

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b ) " 2 ) " ) ) " ) )+ ! )1 " , ) 1 1 " ) ) )1 $ 4P ( ) % GH; !0 ) ) * 4 ) ) $ )1 " P % @;H4 Q % ) /, H G X !* K4H G 4H G

(45)

/, ) " 4 + P " $ H J W !* " 1 " * ) ) "

/, ? * $ !* W! " 2

&F;* 4&F; R4&F;* ) " 2 ) " ) 1 $) 1 4 3 " ) ) " ) ! /, P 4@ P 4 P / ) ) ! W! " 15 ) 2 * " J ( ) 2 ) 3 " / 1 " ) 1 ( " ) /, * " " /, 2 / / " )$) ) * 3 ) " / " ) / " /, ( * 7 ) M / 12 " )+ ) ( $ " 2 % ( / " /, " X! 14 ) /, 0 7 " ) 8 )$) ) ) " ( - O # ( " ) /, * ) 14 ) /, 8 )1 " " 3 , ) ) " "(+ C$/ 1 * % 2 C$/ $!* " ) 2 -K " ) = =, " ! " 15 /, H@ ! ) " H * " " )1 " )$) ) - I )+ C 2 ] " 1 2 * ) c " 2 " $ ) 7 + / ] * ) " 2 ) " ) /, : - I 2 ( , - I " " " " /, H " " 1 )+ W* " ) 2 ) " ) M " H - I $ " )$) ) )+ 1 )+ - 9 " $ ) ) , ) 2 " QGO* " " ) " H@ * 2 ( 1 " 1 )+ " ) 7 + / ( / -'( /, " " 15 * ) 9M W! ) " W !* / ) " ( )1 ;"P`)$) " ( - ; 7 4 1 * /, " 5 * ) " # " * ) 4) )1 / / " 2 )1 ) / " 5) 1 " " ) " )

(46)

!- ' /, ) " " " 1 " ( ' ) 4) " 2 ) 3 " " )$) ) Q Q ! > ` > ! ) !* $ " ) ) " - ( " 15 )+ /, @H; " 1 * ) / " ) ) " - R 1 " @H; " ) ) -83M363M "" " 0 % I %." & R( 1 "( ) ) " / " ! " * $ ( 1 1 * 1 / - R , " 2 1 ) " " * ) " 1 " ( ' * 3$" 12 2 1 " " ) 3 , )12 ( ' !* " 1 / 1 3 % +$ 1 ! "( ;$ " 1 " ( ' ) " /, !- ; " 5) 1 " ( ' / " ( )1 1 " 4 ) /, ) /, ` ( )1 1 " QGO* " ) ) / , - I 2 " ) ) " ) " 4+ ) "( ' * ) " 1 " ) * )( ( )) 1 " 1 / " ( / " ) ) 1 "( ) -R " 3 , " 1 ) " + " 2 1 " ) M ( / * 6 ) ( " "( / 1 ) ) /, ! "( / 1 * 3 * + * )! )+ D " , ) M 6 ) " " " " 2 ) /, - I $ 2 1 "( / " / " ) " ] ) * ( " 1 " " " " 1 -B 5 , " , * / * D " ) ) % ) " 1 ) " ) " ) )+ " + / ) ) ) ) " ( 4 " !* ) ) )+ 2 3 ) 5 - R ) / "( ) ) )+ * ) 7 1 3 " ) - & " # " ) ) ) 5 )+ + 1 * ) / " ) ) ) 4

(47)

" / ! " " - ; ) " * + , "( / / , 7 ) 5 "( " ) ) * " 7 " 1 " " "( 1 ) ) 1 /

-83N

!%

- J !

" %% HI

&

R ) ) * ( 1 1 " !* " " " ( ) " ) / " - B * $ W 3 ) " ) ) " / 1 % )+ C (+ ) , 1 ) ) " * " ) ) " ) " ) ! )+ C 2 ) 8 " 5 ) ) " * ) ) ) ) ) ) " ! G ( ! 1 1 " ! ) ! !* " 3 ) " ) ) )+ " A/ " * , "( 1 " 3 ) J ) - ' 8 * ) " A/ * " W c " ( ] )12 " 3 ) !-R " ) ) 8 ", * )( 4 4" ( "(+ )+ 3 2 * )+ " 1 " ) " " " " X % ) ) ) 2 " * ) " ), )+ C + ) , ) ) ) " " W " ), -)+ C 2 * W " ), " 3 ) ) * " ) " ) ) " * " ) ) " ) " " " ) ) ) ) )+ C 2 ! R )+ ] " (I ; ) A/ * " ! " ), )+ C " " "( ) ) " WW " " !-; 7 ) " ) ) ) " " 3 2 ) ) 3 % ( )) " 1 ( / 1 " ) " - R( ) " $ " * * ( " *

(48)

-;+ C 1 A/ * " ) 5 "( 1 !* ) ) ) " " 5) 1 + ) ) 1 (A/ * ) / - RS 8 "( 1 / / = % + = ) ! ! 7 " ) " " )+ / "( ) ) * ) " " 1 / 2 / " 1 "( " 3 - ; 7 1 " / " " * ) "( ) * ( " " " ] , % R 2 )1 ) " )1 " 1" % )1 1 2 $ / % !- ; " 3 , 7 "( $ ( " " ) " 1 4 4 " )1 * 2 / 3 ! ) " 7 1 " ( " " ) 2 ) ) ) * $ 2 ) !- G ) " 3 , ] ) " , / 1 * 1) " -R ) " (A/ * ) ( :) ) " * 8 3 ) ) " - ' " ) " * " " " 1 ) * ) d )+ 3 " 1 -R $ " ) 1 ) ) " ! 1 "( ) " / (+ 1 ! " 1 "( )1 " ) d ) ) 1 " 12 ) ) -R 1 % A/ )+ " 1 " 3 ) + / ! / * " ) ) ) - I "( 1 ) 1" : !* " " " " c ) " 3 " R ) / 12 7 "( " " ) " 1 d ) ( ) " - I $ ) "( 1 ) / 12 " , $ d ) ( ) - ; " 3 , " 8 " , / , !

(49)

R ) " $ " / " ) * " * " * " * 2 / * )+ * 2 1/ ! d ) / 1 ( ) " " " " " ) B " , ) " ) * ) ) )+ C A/ )+ / 1) , * ) " 2 " , " ] 1 (A/ ) !* ) ) " ) ) " < " " ? / !- ' ) ) ) * ) ) ) / " ) ) ] 2 ! )+ C ( " " A/ * ) ( / A/ )+ !- ; 7 1 " 2 1 / " ) ) 1 (A/ d )+ / )+ C 1 A/ * ) " 8 ) !-' / + ) " 3 " + / ) ) ) " ] ) )+ C A/ 1 # * 5 " "( ) ] " < " " ?- B * " ) ) $ U" / T* )+ C A/ ) ) / 1 " / + U 1 ( 1/, ;'WX ) ) " ) ) ) " " ) ) " " ) + U 1 - B 5 * ( / 1 " ( 3 " /, 8 1 / ) ! " ) ) )) 3 )+ + !-; " 3 , d " , / 1 1) " " * " 8 " ) " R$ + 4K "/P ) / ) * ) 7 2 * "( ) 1 / " )$ P )+ C 1 A/ S )) ) ( / ) 7 + / " ( P " # " ( d 1 " " ) " 1 !- R ) 1 / "( P W! )+ C A/ " )1 1 " $ + )$ * 1 ) / " , ) 1 ( * ) " ) )+ 1 + / -B 5 * ) ] " < " " ? 8 2 A/ * ) " ) ) " )+ C 2 A/ 6 " " , 1 ) " 2 1 , " ] ) !- B $ " W

(50)

" * 2 ( 1 8 1 ) $ " ) )

5 1 / 1 X! + ) "$ "

$ " :) ) ) " :) 7 " ) " 2 3$/

(51)

6

" - !

" (

"

"

% ( " 4 0 Q %

R )+ + 3 " * " ) 2 "( 2 % " ) " / " * " 3 / C " $ ! 3 " ) / / ) !- G ) 7 " ) * , 2 " )$ 3 D % " ( C - R " )+ + 2 1 " ) ) 3 , " " + !* # "( " # ) - R( 1 )+ )+ " 3 ( 3 ) " )$ 3 3 % ) ) [BRE' Z! ( " " "( ] " -' "( " C "( * " 3 ) $ " ) ) 2 " * ( / " )$ 3 $ )1 ) 1 ) 1 " " ) )1 ) 5 ) ) ) ! ) + ) - G ) * " ] ) ! % " 14) ) 3* 3 3 1 1 ! :3 a a* 1 # ) * " 2 ) " " d )+ * " ) " 3 ) ! " ) " * " / '-;-I :3 a a 2 3) 1 ; 7 " , ) + ) ! ) D " # ) * ) "( / " " - ; ) ) + , * # 1 " + ) " - I ( / " ) ) D ) * $ ) ( 3 - I " * + 2 ) " )+ + * 5 " ) 3 )$ 3 ) * $ " ) 2 " 1 " * "( 6 ( ) " ) D ) " ) * " " * 5 "( ] " "( , " 1 ( ) )) " " ) -W

(52)

638

"

% ! " ( " #- !

2L

" &

R ) " ) " ) " +, * " * ( / / " P * # " O$ P W !* " G 4O+ P * ) # " ) ) " - ; ) / " ) ) !* "( + / " $ ) ) * 4 3 )+ C 1 " ) + / 0 "( 6 # ) " " ) " ) ) + 1 - I ( / " )+ + " * " + ) - ; " , ( )1 " ) * " 3 ) * 8)+ " `" / " +$ / * ( )1 P ) !-R( )1 " P " ) ( , / , " / " ) % $ 2 1 "( + " , ! " # " ) ! + + $ 1 " " O$ " " ) * " WW "" C7 % !" B "8 , ,@ . @ / " ! D ,3 ' 8 ! 9 * # 4 .6=6/

(53)

)+ / " ) 2 1 " ) * " " 53 1 " ) " " / 3 " )$) ) - ; ) 2 " " / "* ) " " 2 1 "( " , - R 1 " + + $ 1 " " ) " ) " / A) ( O * ) 4) / " " ) 5 * 7 2 "( " / + + -R " ) " * 8)+ ( O "( 3 ) M ) !* 53 " ) " " ( O ) " " ] 2 " ) !* ) ( O 2 " +$" /, ) 1 )$ " ) % 7 + + $ 1 " ) + + $ 1 " ) " / 1 ) - 9 " "( )1 ) ) * 53 " ) +$" + " HOY* )+ / ) 2 1 " " ) " ) " ) 2 P )1

-63838

=

# " "

#

" &

R =BQJ ( ) * ) * 2 " / $) " ) " =BQJ4 # '* $ )+ ) : $ " = : ) " + = ^ + ) ) ! " !-' 3 # ) 7 2 = ) = ^ + ) !- I 3 $ " =BQJ4H* ) 3 3 2 ) " ) " + * " ) $ M # " ( / / , ( +$ / "( / ! !* ( / " ) )1 O$ P - R $ W M " $ + / / , * ) ) 2 ) " ) " + $ + 1 - R $ +, " 2 ) " ) ) ) 2 2 ) KIJ ! = 8 " = ^ + ) ! " " ) " 1 +$ / * ) -WX

(54)

R =BQJ4H $ " ) / 3 * ( ) 5 " ) " + * 8 2 " " ] 1 - ; $ " ) ) " ) / / 12 " ) =BQJ4H !* " ) "( " " ) 2 1 " 3 3 " , " ) - G ) 3 / " =BQJ @* IQJ0 "( 6 " ) / "- * =BQJ4H M " ( d 1 * / 1 " )$ 0 ) " =BQJ @ # M " " " ) " / " ) " + $ ) " -R ) " $ =BQJ4H $ " ) ) " * ) # 2 ) " ) " + * " * ( / / , !- R / " ) =BQJ " $ * ( )1 ) ) ) " " / 3 ) " ( )1 1 " + + ; R;! 7 ( )) 1 " 4 )$ 4= $) =! "(I W-' " =BQJ ) )1 H G`H J`BHY W !0 ) W "" E7 !" -F0 " 4 " "" " 8 ! 9 @ '' " .6::/

(55)

) $ M " / 1 " ) ) ) 7 ) ) * 2 1 " ) " + * 7 / 2 " , " " 3 3 " ) " " ) ) 7 1 " !- B 5 ) =BQJ4H M " ) * 2 2 1 " " $ d ) # )1 ) - R =BQJ4H " ) ) + 1 / ( ( / "( + ( / / , " ) -B 5 " $ " =BQJ4H* $ W " $ + / / , !* ) # 2 ) " ) " + - I M " ( / / , 8 ( " ) " =BQJ4H ) =BQJ4H W / A) =BQJ ; 2 " + " , $ M " ( )1 " ) " + ) -R M " =BQJH " ) 2 " ) ) X !* ) ) " ) " ) + 1 / ) / " 8 ) " , ) ) ) ) % ) " , 2 * ) 4 8 2 ) ) ) ) * 7 "( (

-63836

" = : " &

I ( / "( / " 2 " ) ) * ) ) " 8 " / " $ * " ) / " 8 + 1 - ' 8 =BQJ4H * ) ) 2 " % " 3 ) / "* " * 5 " ) ," ( )1 C$ 1 - I 3 $ "(BQJ4H* 8 KBH B @ W! % KBH BQJ4H B @ % " 15 * (BQJ* " ) " )+ )+ * " ) "( / " * ) -KBH KBHW B @W! KBHX B @X! W

(56)

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

(57)

] ) ) " / 1 ) R;* IWY` P ! " & Y % H G`H J`&BY`BHY W !-* " 5) 1 " ( 3 " /, B @* 5) 1 " /, ) " $ " ) ) " " 2 1 " ) ) ) - ' ) ) " * ) " 4 3 " ) 2 ) " ) " ) KBH 0 / KBH! " + ) ` 14) ) " / ) KBH - I" ) ) )+ * 6 ) ) 7 2 ) KBH " ) ( )+ % 1 >

!-6383M

#

:B &

; ) " 15 " ) " ( ) /, 4P K "$4 \ )P X J G ) = !* )+ C (K ) " /, )4P 0 ( / " ) " 2 ) " ) ) " ) )+ b ) ) Y R Y R / "! !- ; ) 3 2 ) " 1 ) * " ) )+ C " B B )P " ! % " (+ U, * / 1 " * 2 1 " " ] ) 1 " ) ) " 1 " ( / ) - B 5 ) ) M " 1 1 * ) " 7 ( )) " " ) " ; # $ M " ) M " 1 !-W "" =7 !" 0@ " ! " "" " 8 ! 9 % " .6:E/

(58)

I ( / "( ) )1 O$ P * 2 )1 " 8 , ) " $ - ( 3 2 " ) ) * " " 3 " ], ) "( 1" ! " 3 ) Q Y!* ) " / " ] ) " Q Y- ; ) " * ) )4YIO 2 / "* 2 " , 0 ) ) " " 1 " ) ( 1 1 " " / 1 ) -R 1 " /, ) " ) )4YIO ! ) " ( )1 1 ) 1 1 " ) " * ( / " ($ 53 8 )12- I " ) / " $ " ) ) " M " )4YIO ! ! % ) $ U" / T* / 4 1 = % = 4 1 !* * ) ) " 1)

!-6383N

"

= : " &

I ( / "( 1 / " ) * " " 3 % 'QJ4H + 'QJ4H 8 * ) " ) " 2 ) " ) ) " " 7 - R / " " % 'QJ4 * @* ; '0 3 L )1 2 " " , " / " * 53 ) W "" G7 H #-F " " 4 8 ! 9 ) " .6:</

(59)

" - R 'QJ4H + $ " 'QJ* ) 8 'QJ @ ' !- ; ) ) * 2 2 " " , * $ )+ / " ) 2 1 " " ) 7 # " " GK G ) K /$ ! )1 "( )$ " / 1 ) IWY* H * R;!-R 'QJ " ( / / , " "( 2 )1 +$ / (A/ " * ) " $ ) ) " 'QJ 3 ) - ;+ C ( " * $ M " ) M " " " " 1 11 'QJ4H 8 ! " ) ) 1 ) 3 5 * $ ) + * ) + / * ) / " -' 1 ) " 'QJ4H 1) 2 1 " ) ) ) * ) ( )1 " 'QJ ) ) * $ " ) d ) " ) ) 4 " ) - I ( / "( 5) 1 / )+ /, ) " ) " 1 )+ / " 0 ) ) ) )1 4) " 'QJ4 H - ; 7 )1 1 + / " $ " + / ) QIGO * " 5 )

-63839

B &

I ( / "( ) + 1 * ) ) ) C 1 ! 3 ) )1 ) 7 P * "( ) " " * " ) " / ( $ ) ) C 1 - G B 1) $ + B !* " 2 "( / ) / !* " / RY* $ " 1 )+ ) /, # - RY P M " 2 1 " 1 3 " ( $ / , * " / )+ /, ) " RY "( * $ )1 1 " P + ) " " ] + / -X

(60)

B " 15 " $ + / " ) * 2 $ + 4+ "/P ) O + $ " 3 4 $ % RYn " 1)! RY4* 7 " " / " )+ + $ - ' ) " " ) " +, * )( / B&RX4 RY* * ) " ) ) ) )+ 1 ) !* ) (+ ) ! "( ) )+

-6383; > : ( &

I " ) 1 " /, > ( % + / " 4 @R* ) /, )+ C ! " /, > > P / ! )1 )+ * ) 7 " 2 " R&;0 /, " 2 ) " ) 7 ) ;+ + " + " " ) !- ; " ) " " ) $ 4P * )1 " , ) 1 1 " )$ 2 @;H !-G M ) / ) " 15 W! ) ) 7 2 " " , ( + + $ 7 # " " GK * 3 " " / 1 ) - " " ) ) QH@ * 2 ) 3 @;H4 `QH@ " 2 ! 7 ( )1 1 " Q' 4H QO 4H % ) ) X "" 6>7 !" " ! @ " ! " "" " 8 ! 9 % I % " .6:A/

(61)

( )1 1 " " & P / /, -' 8 ) 3 1 @) 4 `QH@ `G )1 IWY` P * " M " " )1 " / ( " * * ( )1 " 2 ) " ) 1 F P+ " ' ) E! " ) "( 1 ) -B 5 * "( ) 2 @) 4 " " / OEH W!* " "( / 1 " )1 " " ) " " 4 4 " )$ P % " " $ / " ) " )1 2 ) 1 !* )1 " P + B! " "( )$ P * )1 " , ) - R( )1 1 " GO O " / ) " ( " ) 2 * * ) " 5) 1 ) ) " * 2 1 -; 7 P 8 ) " ) + * ) ( / " , + " a) a % ( 1 !-X "" 667 H ! ) 0 *" 8 ! 9 J * 4 " .6=;/

(62)

6383R >

&

; 7 ) + 1 2 1 " 2 " H J " ) " / + !* ) 7 " , " " / 3 ) - I) * ( / "( ) 2 ) " ) * " )$ * ) 2 )1 " H QO 4H !* ( " " & P * " ) ] ) " H W !* " " / 3 " ) * " ) ) 2 1 - * ( / "( O$ P * "( G 4O+ P * " "( )1 " ) ) " 1 * " ` 8)+ " ( O " , ) ( $ " 2 " / + + -@H J "( " ) + 1 " * ) " / " # " % 1 = B X ! = ) ) " Q 1 !* ) 7 " , ( " 1 c " 1 " @H J = * " W c = B! " - B " 5 )1 " P " "( )1 1 " + + $ 1 * ) " 2 )1 ) 1 1 * $ " ) 1 ) /, -" 3 1 ) )+ = * ( / " = Y = '* ) " @H J 1 ) / * " ) + 1 * 8 ) )+ 2 + @H J = B-XW "" 6<7 ! ) F " ! 3 " 4 2 8 ! 9 " .6:G/

(63)

; 7 1 " @H J " , ) ! " "( ) ) X! * ) ) ) ) * ) ) ) +$ U" * ) ;@

;-6383S

" + B" &

I ( / "( 2 " P * Y * " P ) " ) % ) " 4 ) O$ P * 3 ) " )$ P - B " % Y * * W OFY O$ Y !* 3 ) " $ I II " )$ P -R M " ) 1 ) 7 " )1 " / " 2 * " P - R "( / " ) )+ / " ) 2 1 " ) 4) * )1 Y* )1 " $ GO O* ( / " Y`GO O- ( " " $ GO O 3 % GO O * * W* X* * @ ! + + $ 1 )1 2 " , / " $ * ) 1 !-B " M " " 1 " / " " )$ P ) * Y M " " " ) )+ + U 1 $ + U" - " 1 " Y * W! XX "" 6;7 % !" B " 5 @K%, , 8 ! 9 % .6:6/

(64)

" + / 7 # / / $ + U" % $/ 1 & " " = C!* + )$ + 1 * $ 5 * ) 1 " Y Y = J! !- ; 7 1 2 ) 2 " "( $ " $ 2 12 ) )$ $ * ) $ )$ )+ * ) $ U" )+ ;+ + " + /

12!-6383T

# " ( " #- !

2L

" &

I) ) + 1 ( $ 2 ) M " P * ) " " ) ) " ) + ) * " ) " / " ! " + ) ) " / + ) " -6383T38 ! 1 -- & R K "/ + / ) "( ) BHI=B'QBZ!* 2 # - " H ) ! $ + " % ) " ) Q!- I 3 /, " / " O;K % G++ % G ) + "/ + /* " ) + 1 '++ % ' + "/ + / I++ % I " + "/ + / ; 7 )1 " / " ) O;K* )1 G&E0 ) 7 " , 7 ( )1 1 " 2 = = ) / !* # ( $ )1 " " ) 1 !-; 2 ) ) * $ ) ) 2 1 ) $ +, " ) )$) !* ) / 1 " $ +, " @) 4 !* $ +, " =BQJ-X

(65)

; 7 G ) K "/ + / ) M " " $ * " $ , 3 ) ( $ " " " ) 7 ) 1 + ) + ) " 1 " " 3 + +, ) 3!- ' 8 ( 4 )1 " G ) K "/ + / ( / " " ] $ " ) ) 0 ) ) ) -6383T36 & ' ) " " ) " +, * " OEH # )12 + 1 / + ) " -Q + " OEH $ " 1 " # " / ] "( ) )$) # ) " ) ) ) * ( JI IOEHZ B ! $ - ' ) " 1 +$ / OEH " / " ] )1 " ) ) ) 1 " * 2 1 ) * d !-X "" 6A7 H " % 4 4 8 ! 9 $I J L .6:=/

(66)

O 1 "( " ( )1 1 " OEH " ) )+ 1 ) / " ) 7 " , * " )1 1 ) 1 - I ( / " 1 " 4 ) /, H * IWY* IJXB ) " /, OG; ` * + + " % + /!- ' 8 ( 1 " OEH 4 8 " / 1 " )1 - G ) 3 OEH; )+ ( * "( + * 3 ) " " * + ( )1 P " OEH 8 ) + " ) )1 O$ P - ; 2 " ) ) 7 " " " ) "( 6 1 " )+ OEH; X !* " 8 )+ IWY-6383T3M M & @ , * "( ) * ) " " ( " )1 " ) " " / " + " O$ P * ) ) M &G P $ P W! )1 " & Y* P - ; ) 3 " ) )+ + U 1 " ) " " ] ) 1 !0 3 2 ) " ) $ + U" ) := $ / 4= )$ )$ % ( / " / )$ " ;J94& " ) + / !- ; ) "( ) "( 8 " + / T " ) $ + U" $ U" !* ) , / " ) + )) -X "" 6C7 !" " ,$ 8 ! 9 # 3 .6=A/

(67)

6383T3N :8 & B 5 * " , ) ) :8 $ 1 1 / ) ) !* ) " ;GJ* )$ P " * " ] ) 1 2 1 " )$ ) + / / (+ " ) + / !- ; ) 8 2 * " " ) -X "" 6E7 % 4 ? "" " D "8 F ,0; 8 ! 9 %I " .=G/ "" 6:7 %F06 " ! 2 *" 2 L 8 ! 9 & # " .G>/

(68)

G ) ) 1 / " + / ) ) ) * " 2 )1 ! " / !- ; ) 3 ) )1 " P * 2 )1 " ) 3 ) " 0 "( 4 3 " " 3 ) ) - G 4 3 " " 5) 1 " ) 1 " 2 ) " ) ) !* 2 1 " ( / / , * " 5 ) 4 ) / 1 " ( )1 " ) + / " ) / 1 " ( d 1 !* d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

(69)

R( )1 " ) ) * ( ] ) " , % " / " ) * 7 " ) " " )+ ) + % + )P ! ) * D 2 1 "( " , " ) P $ + " $ 1 + * " $ W!- B 5 ) " , " ) " " /, * / " /, ) ) 3 ) " ) 5) 1/ !- 9 " ) / " /, * 3), " 1 1 " ) 7 ( / " ) " ) ) 1 " X!- ' 8 * " ) $ " ) ) " " " " /, * * ) " ) 3 " /, $ +, " / " " ) )

-636

" $

"

"

% ( " 4 0 Q % &

B / * ( / "( + $ " 1 ) * " " ) ) * ) " ) " * ) ) " ) ) ( ( / " " ) 1 " " !* " "" 6=7 % "8 ! ? 49 . / L . "8 * M *" "8 N " M O " !! / 8 ! 9 .6=</

(70)

/ + O+ * ( )1 + ) ) ) " " - ' * ( / "( " " " )+ C A/ ) ) ) ) * + " " " )+ ) -'-&-B! ) * ) " 1 1) , : * : + 1 * A/

!-63638

" %- ( #

"

> : ( &

6363838 0 $!2% ( U= VG & I ( / + " , + ) 1 " )+ f g " !* O$ P !* ( ) @) 4 * 4 3 ) " ) $ U" + ! ;+ - " + 12 -W!- I + " ) ( )1 )+ ) 1 1 " ) 7 P * % )( + " ) Y G;J4H!* " ;GJ4 H* " " 3 $ " 'QJ4H- R " ) 1 " ) 7 ) " ) 1 % R&; +n " ( " " ( 2 0 + )+ * )) ) 1 ) / T $ + 1 ! +n " ( " " ( 2 $ " $ $ ` $ 2 12 ` ! 1 " /, " 'QJ4H ) + + ! ) 1 " /, ) " 'QJ4H $ " $ + ! " ) QIGO ) 4 3 " Y * ) ` 1 K5 ) ! ) -! $! % 2L % 1 % " " ( 1 " c * d ) " , / 5) 1 - R ) ) ) " " " " " ) 4) - I ) " " " ) ) "( 1 / 4 1 * ) / " "( - I

(71)

"( / " " $ " ( ( $ " " :) -' 1 % c 3 1 " ) ) 1 ) * ) ( ( + 4/ $) ) " & % ( )1 " ;$ )+ X W X ;F W X!0 " 3 * 4" +$ )12 ) , -)( + " ;F ' ; . 1 % # " 2,) 0 c " " " 4 " c " 2,) Wc " -!2 %" ! 2 . " & ) (A/ $ / 1 " " " 1 " ) * 2 * c-' 8 * " ( "( d ) / 5) 1 ( )1 " ) -;+ C ( : " , !* ) ) 1 ( " * " ( ( "( 1 ) " 0 ($ " " 4 3 1 -I" )+ C ( : + 1 * ) " ;+ "4 /+-6363836 !"!2% ( U ? VG & G ( / ) 1 2 " 1 " @) 4 " R&; +n " R R +n!* + ) ) 2 ) ( 1 * 8 ) 1 )+ / " ) ) - ' 8 * / ) / " ) ) ) * " 1 @) 4 * ) 7 ) ( # - B ) * " 3 1 QRI=B;Z )+ * ) " ) + ) * 7 " ) ) " ) " ) ) ) !-R " 1 && " ! + " ( ) @) 4 !* ) ( 1 * ) @) 4 * "( + ( )1 " ) Y 4 3 * ) 'QJ4H 8 - G " ) 1 ) " ( 1 * / $ ) "( ) "

(72)

) ( 1 % R&; +n " / 1 R&; +n + * ) " ) ) ) ( 1 R R +n ) "( ) ) -! $! % 2L & 1 % " ) ) " ) ) 1 " 4+ + , ( " 1 - R " 5 ( ! " " 1 * " , ) / 5) 1 0 " ) " " ) " ) " + " 0 " ) ) ) -' 1 % ) " " 1 ="! " * ) 7 ) 2 " " ) 1 3 4 ) 0 c 3 1 & % # ;F W X0 ) , " ( )1 + 1 . 1 % , " 1 "( " " 4 * c " " " # * # " 2,) c! 2 " Xc!-!2 %" ! 2 . " & ; " 1 , * ($ ) d ) "( : ) * ( " - ) * )+ C ( : + 1 " , * " " 1 " ) ) 1 3 * " ( G; - "( " * " 3 / ) " )+ C 1 $ 2 )1 + 1 ) + 1 " , 2 ) -636383M % 2% ( U = VG & I ( / ) " , ) ! && " ! ) @) 4 * W

(73)

1 ( 1 * $ / " ) "( )1 " @;H4 * )+ 1 ) 7 " , - I 8 ) " ) L " " ( 1 !* " 3 " ) 1 " 1 - * ) 7 ) ," ) # ( " ) 1 % R&; +n + )+ --! $! % 2L & 1 % $ * ) " c 2 / - ; " ) " ) ) 1 ( G; / ) " " * 8 " 3 + , ! # - I " ) ) " " O GIQ Z " + " * "( / " " " " " ) ) ) , ) 2 " ) " -' 1 % 1 2 3 1 ) 3 " " c & % 1 ;F W X0 ) , " ( )1 + 1 * ) 7 " , " , 2 ( )1 " ( 2 ;F ; -. 1 % * " c "( " " 4 * Xc " " )1 " 2,) -!2 %" ! 2 . " & ' 1 4 3 * ($ ) ) " 1 ) ) 1 : -& )+ C " 1 ] "( : ) + 1 /, , * " 5) 1 " ) ) 1 3 " ( G; ) * " "( / 1 - I " ) " " ) ( " 2 )1 + 1 -636383N ( " 2% ( U> VG & R " , ) " :) !* ) ( ) @) 4 X

(74)

) * " P " 2 G ) , 2 'QJ4H Y - ; 7 ) * ) # " , 1 ! "( R&; +n && " " W!* " ) 1 % R&; + )+ * )) ) 1 0 )+ C " 1 " ) " + " O$ P ) ) " ) " ) --! $! % 2L & 1 % 1 ) ) ) 1 3 + , - ; 7 " , ) " * / ) " ) ) 1 1 ( G; " 1 -' 1 % 2 3 1 c 3 !* ) " 1 1 3) ) =" " 1 " ( " " R $ -& % )$ )+ W X* 2 ) , " ] 3$)+ * " +$ * 3$" ! ( $ , "( )1 + 1 -. 1 % ) " 4 "( 1 " WX + * Xc "( " " @EG9RIJZ ) " # % c " " ) , ! " 2,) * Wc " ) " c " 2 )+ / !-!2 %" ! 2 . " & I ($ " ) " 1 1 (A/ " 1 * ) " " 4 4 " 2 1 "( ] " -;+ C ( : / * ($ " " ] ) "( 3 1 " ) -) * ) "( : ) " , * $ / 1 " ( G; " 1 * ) //, " 1 " / ) " " / )+ C # X /* W / # ( 7 -;+ C 1 " 2 )1 + 1 * , / * ( ( / " ) ) 1 3 * " ( ) * " 4 "

(75)

" ) / - 9 7 + 1 1 ( 3 1 " ) * $ # 1 "( " 2 1 "

-63636

" %- ( #

"

"

= : &

; ) ) " * ( / / "( + " 1 P * 2 " ) ) 3) ) " =BQJ- R " ) 1 + 1 ) * ) " ( / " " * )+ / $ U" -6363638 " % 2% ( U VG & I ( / "( 1 ) && " " # ! * ) "( ) =BQJ* + 4 / / , !* " " " * ) ) - R 2 "( + 4 / / , " ) " " * " " ] " -* 1 ) + " ) " $ * W " =BQJ* " 3 $ " ) " 'QJ- ; ( 1 * ) ) Y * ;GJ4 H* JRO4W ) " 2 ) + " / / !- G " ) 1 % QIGO , )+ ) "( 1 ) "( ) "( ) ) " ! ; ) " 1 % 1) ) ! O " ) " ) % ) 1) " ) ! ) 1 -! $! % 2L & 1 % d ) * G9OB OZ 8 " + " - R ) " ) ) 1 + , -' 1 % ) / " " " 1 " W * ) 7 ) / 1 " " ] 1 - ' , " 1 " " # , * ) 7 ) ( )) ) $ / 1 " ) ) 1 " ) , " )12- ; 7 )

(76)

) " 2 3 1 % c!-& % ;F W X* " ) )12 % " +$ 4 1 " , "( 1 " ( )1 + 1 " " ) ! ( )1 " " ;F W X . 1 % # 2 )+ / " " +$ 4 1 " * 3) " , " c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

(77)

P ) " 1 )+ C " 1 )+ + " 1 $ / ) " " -! $! % 2L & 1 % d ) * ) " =EOHIB OZ " 2 / ) ) 1 3 " C " /* G;- 3 1 " ) ) ) ] " !* ) " " " " 3 + + , - R ) 8 ) ) -' 1 % c 3 1 " 4 / $) & % # 2 ;F W X* )( ) , " ( )1 + 1 . 1 % ) " 2,) * Xc " " " " !2 %" ! 2 . " & ;+ C ( : * ($ " ) 1 1) , "( * " 2 ) 1 " ) 7 " ( 1 " C - ; " * ( $ " )+ C " $ " " ) ) 2 W ` * ) "(8 " -;+ C ( : + 1 * 1 * ( : ) /, * / " 1 ) )+ C $ 2 )1 + 1 / 2 # !- B )+ / )+ C ( : + 1 " 2 " " ( " " / # - ; 7 ) ( "( ) " )+ C " 1 ] "( : ) + 1 , -636363M 1!% #!% ( U VG & O , ) ) ) ( / / , " =BQJ && " " 2 !* " + $ " =BQJ4H % )

(78)

!-B * + ( )1 " (BQJ4H )12 ) / " 1 " HBO " 2 " " 1 "( !- HBO ) " P * ) " ) /, )4H * ( 7 P "( )1 ) 1 1 " " 1 2 - R " / " ) " + * ( 1 =BQJ 2 " 4 3 (BQJ / 2 " , )+ - I ," ( " ) 1 ) # % ) $ " " #+$ U" ! ) * 1 0 ) 5) 2 1 HBO ) / 1 --! $! % 2L & 1 % 2 ) 8 " " " ( / C ( $ " " " / 11 - R ) " ) ) 1 1 7 X + , - R " ( )) "( " 1 * ( "( / 7 , " 3 "( 1 1 - R ( 3 ) "( d ) ( 1 " " ) -' 1 % ) 7 ) , / " * ) =" " ( " " X R-' " " 3 * 3 1 c* ( ( + 4/ $) ) " -& % ) ;F W X 2 " +$ " 4 3$/ d 2 "( 3$" -. 1 % , " 1 "( " " 4 * ) " " 4 / # !* c " " ) " XXc " 2,) c " -!2 %" ! 2 . " & ;+ C ( : * / 1 " ( 3 1 ) ) "( : ) " , - " " * 1 1 ( ) )+ C ) 1 -I " 8 )+ C 1 $ : ) + 1 )

(79)

1 * 2 RG * # " " )+ C ( :) ) ( " ) "( !-636363N 0!' 2% ( U ? VG & + " ) =BQJ " !* ( / " ) )+ ) ) W!- B ( " ) 1 ) * ) / ) $ " =BQJ4H- G 1 " )+ " " * ," ) # ( " ) 1 % H;; ) , )+ ) "( 1 )$ P -! $! % 2L & 1 % " " 2 ) " c* ) " ) ) 1 , " 7 X + - R " " ( 3 1 ( d ) I RFO Z " ) 8 " + " " 3 2 # " ) " 4 !-' 1 % " ( 3 1 3 1 1 c* ) ( ( + 4/ $) ) " - G " " 1 " R-& % # ;F W X` * " " / ;F ; - I 3 " " $ / ) " (9QO 9' Q ) $ O 2 !- = )$ )+ $ 2 1 " 2 3$" ) " ) 3$ - R )1 , 2 ) , -. 1 % " 2,) ) * , " 1 "( " " 4 * Wc " ) ) " ) , !-!2 %" ! 2 . " & ;+ C # A/ * ($ "( d ) " A/ ( # " / "(I RFO Z- B )+ * 1 1 " 2 )1 ) ) 1 1 * 2 RG ` ) ) 2 R` 3) " ) - & ( ) "( 3) 1 " ) , * "( : ( ) # / ( ) )+ C ( :

Références

Documents relatifs

To test whether the vesicular pool of Atat1 promotes the acetyl- ation of -tubulin in MTs, we isolated subcellular fractions from newborn mouse cortices and then assessed

Néanmoins, la dualité des acides (Lewis et Bronsted) est un système dispendieux, dont le recyclage est une opération complexe et par conséquent difficilement applicable à

Cette mutation familiale du gène MME est une substitution d’une base guanine par une base adenine sur le chromosome 3q25.2, ce qui induit un remplacement d’un acide aminé cystéine

En ouvrant cette page avec Netscape composer, vous verrez que le cadre prévu pour accueillir le panoramique a une taille déterminée, choisie par les concepteurs des hyperpaysages

Chaque séance durera deux heures, mais dans la seconde, seule la première heure sera consacrée à l'expérimentation décrite ici ; durant la seconde, les élèves travailleront sur

A time-varying respiratory elastance model is developed with a negative elastic component (E demand ), to describe the driving pressure generated during a patient initiated

The aim of this study was to assess, in three experimental fields representative of the various topoclimatological zones of Luxembourg, the impact of timing of fungicide

Attention to a relation ontology [...] refocuses security discourses to better reflect and appreciate three forms of interconnection that are not sufficiently attended to