Chapitre 4 : Structures de l’AS 71-82 en solution
4.2 Conclusions
Réussir à caractériser le peptide AS71-82 en solution revêt une grande importance avant de pouvoir s’intéresser aux structures que celui-ci adopte lors d’interactions avec des membranes modèles. Cette particularité de l’AS71-82, d’être soluble dans l’eau, permet d’affirmer que les changements structuraux observés en présence de membranes modèles, et détaillés dans les chapitres suivants, sont bien provoqués par ces interactions. La conformation désordonnée de l’AS71-82 en solution rappelle celle de sa protéine parent, AS35- 37. De plus, la plasticité structurelle de l’AS
71-82 est un argument supplémentaire en faveur du fait qu’il représente un bon modèle38.
groupes de recherche39-42, venant là encore renforcer l’idée qu’AS
71-82 constitue un bon modèle pour appréhender les comportements structuraux et dynamiques de l’AS.
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