[PDF] Top 20 Redefining and measuring transplant conditioning intensity in current era: a study in acute myeloid leukemia patients

... components, and thus it is likely that the TCI has at least the same validity as the original RIC/MAC ...inherent in retrospective registry-based studies by studying a large patient cohort, by ... Voir le document complet

... adult patients (ages > 18 years) with a diagnosis of sAML. Patients with sAML were defined as patients di- agnosed with AML who had an antecedent MDS, MPN, overlap MDS/MPN, other malignant ... Voir le document complet

... approach in patients with primary induction failure (PIF) or patients who relapsed, and failed to achieve a second ...5–11 In this setting, conventional myeloablative ... Voir le document complet

... of a significant differ- ence at 2 years, in terms of NRM, which was quite low in both groups ...(16.7% and 15.2% for PTCY and ATG groups, ...the study, we could not compare the ... Voir le document complet

... of patients diagnosed with acute myeloid leukemia (AML) has improved, disease recur- rence remains the leading cause of treatment failure, with only a minority of patients who ... Voir le document complet

... performed a retrospective registry-based study comparing outcomes after T-replete haplo-SCT for patients with acute myeloid (AML) or lymphoid leukemia (ALL) after RIC (n = 271) ... Voir le document complet

... Blood and Marrow Transplantation (EBMT). The EBMT registry is a voluntary working group of more than 500 transplant centers; its participants are required once a year to report all consecutive ... Voir le document complet

... grafts and in vivo T cell depletion based either on ATG [32] or post-transplant cyclophos- phamide [33] has been demonstrated in the past 10 ...graft, a myeloablative ... Voir le document complet

... (OS), leukemia-free survival (LFS), relapse incidence (RI) and non-relapse mortality ...OS and LFS were calculated using the log-rank test and Kaplan–Meier graphical ...RI and NRM ... Voir le document complet

... included in the study cohort received a maximum of 2 cycles of induction therapy to obtain CR1 ...as a single fraction or 800 cGy or less if fractionated (2) <9 mg/kg busulfan oral (or ... Voir le document complet

... two in good and intermediate risk AML within the Spanish CET- LAM group with a specific interest in evaluation of minimal residual disease and in vivo purging by gemtuzumab ... Voir le document complet

... HL60 and MOLM14 IDH1 WT or R132H transfected with shRNA control or targeting CEBPα (n ≥ 4, independent ...activity in HL60 and MOLM14 IDH1 WT and R132H transfected with shRNA control or ... Voir le document complet

... be a useful strategy to treat mt p53 tumors and potentially improve the prognosis of cancer ...patients. In this study, we unveil different mechanisms that eliminate p53-R248Q, one of ... Voir le document complet

... occurred in Feb- ruary 2018; 6 months after high dose ...diagnosis. In the Czech Republic there is limited access to novel agents for treatment of ...t(11;14) and requested venetoclax free of charge ... Voir le document complet

... prospective study of prophylactic DLI in patients with high-risk acute leukemia has been reported by Liga et ...ago. In that study, patients were given allo-HCT ... Voir le document complet

... the study population From Table 1 , IC, LIT and BSC represented respectively 32, 38 and 30% of the 592 patients included study ...sample. In total, 68% of the study sample ... Voir le document complet

... the patients and ARF episodes were compared between hospital survivors and nonsurvivors using the Wilcoxon rank-sum test or the Fisher ’s exact test as ...of in- hospital mortality, baseline ... Voir le document complet

... Secondary acute myeloid leukemia (sAML) describes patients (pts) with a history of malignant or non-malignant disease or AML secondary to environmental, occupational or therapeutic ... Voir le document complet

... 5% and 10% of GFP- positive ...pelleted and frozen down to constitute the day 0 time point, and cells were maintained in culture and split every two days to keep at least 6×10 6 cells ... Voir le document complet

... Results and Discussion 2.1. Lipid Metabolism is Dysregulated in IDH1 Mutant Cells We first compared the proteome of IDH1 mutant HL60 cells to the one of IDH1 WT ...cells. A list of proteins that are ... Voir le document complet