[PDF] Top 20 Natural killer cells promote early CD8 T cell responses against cytomegalovirus
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Natural killer cells promote early CD8 T cell responses against cytomegalovirus
... help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination ...While natural ... Voir le document complet
14
Dok1 and Dok2 proteins regulate natural killer cell development and function
... infected cells in the induction of the antiviral type I interferons responses in these animals (Supplementary Fig ...NK cells accumulate in the spleen upon MCMV infection in both WT and DKO animals ... Voir le document complet
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Identification of druggable inhibitory immune checkpoints on Natural Killer cells in COVID-19
... immune responses arising in the course of SARS-COV-2 infection may help to propose therapeutic ...of Natural Killer (NK) cells in antiviral immune responses, 2 we analyzed NK ... Voir le document complet
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Increased Degranulation of Natural Killer Cells during Acute HCV Correlates with the Magnitude of Virus-specific T cell Responses
... T cell responses despite active viral ...3). Natural killer (NK) cells are the most important effector population of the innate immune ...NK cell subsets can be distinguished ... Voir le document complet
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Natural Killer Cell Sensing of Infected Cells Compensates for MyD88 Deficiency but Not IFN-I Activity in Resistance to Mouse Cytomegalovirus
... by CD8 T cells depends on the local effector-to-target ratio in infected tissues [ 50 ], the enhanced susceptibility of BALB/c MyD88 -/- mice to MCMV infection likely resulted in part from their failure to ... Voir le document complet
24
XCR1 + dendritic cells promote memory CD8 + T cell recall upon secondary infections with Listeria monocytogenes or certain viruses
... immune responses have demonstrated that the effectiveness of NK cell activation influences CD8 + T cell responses such as occurring during acute infections with mouse ... Voir le document complet
19
Regulatory role of natural killer T cells in diabetes
... iNKT cells not only play an active role in the antiviral response, but also play a major role in the protection against diabetes [46] ...iNKT cells activate conventional DCs (cDCs), which produce ... Voir le document complet
13
en fr [The CD8+ T cell innate function in the war against cancer]. Les fonctions innées des lymphocytes T CD8 dans la lutte contre le cancer
... natural killer T cells », découvertes au début des années 1990. Elles possèdent un TCR semi-invariant reconnaissant des antigènes glycolipidiques présentés par la molécule non classique du complexe ... Voir le document complet
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Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human
... from CB, adult and fetal MNCs. CD56 + CD36 + cells were purified by cell sorting. RNA extraction and microarray. Total RNA was isolated from purified CD56 + NK cells (> 95% purity) from different ... Voir le document complet
13
P11-05. Induction of CD8+ T cell mediated immune responses through skin and mucosa: identification of immunostimulatory versus tolerogenic dendritic cells
... to CD8+ T cells, but were unable to prime ...T cells, indicating a tolerogenic role for ...CTL responses is accompanied by the recruitment of inflammatory monocytes at the site of immunization ... Voir le document complet
2
Invariant natural killer T cells and TGF-ß attenuate anti-GBM glomerulonephritis
... T cell population, the invariant nat- ural killer T (iNKT) cells, in the development of this ...iNKT cells constitute a distinct population of mature T lym- phocytes positively selected by the ... Voir le document complet
12
Intestinal epithelial cells instruct myeloid cell-mediated T-cell responses
... dendritic cells (DC), eosinophils and mast cells. If all these immune cells were present in other tissues at such concentrations, they would be regarded as an abnormal chronic inflammatory ... Voir le document complet
85
High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors
... positive cells were identified using the 20d5 clone which also recognizes NKG2C and NKG2E, however, since mouse resting NK cells only express NKG2A, we considered 20d5 reactive cells as NKG2A ... Voir le document complet
23
Homéostasie des cellules natural killer
... cellules natural killer (NK) sont des lymphocytes de l’immunité innée qui jouent un rôle important dans les réponses antivirales et antitumorales ainsi que dans la défense contre les bactéries ou les ... Voir le document complet
6
Rôle des cellules Natural Killer dans l'asthme allergique
... 19 conduisant ainsi à sa dégradation lysosomale et donc à une absence d’expression à la surface cellulaire. En revanche, l’ubiquitinylation et la dégradation de MULT-1 sont réduites en réponse à un stress induit par une ... Voir le document complet
312
Ito Cells Are Liver-Resident Antigen-Presenting Cells for Activating T Cell Responses
... NKT cells account for up to 50% of liver lymphocytes; however, the factors rendering liver tissue a preferential location for NKT cells remained elusive ( Kro- nenberg and Gapin, 2002 ...liver cell ... Voir le document complet
14
CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network
... specific CD8 + T cells were primed in the draining lymph node and infiltrated the tumor but failed to control tumor growth ...T cells and tumor infiltration but had only a transient control in tumor ... Voir le document complet
16
Deciphering anti-HCMV HLA-E-restricted unconventional CD8 T-cell responses in seropositive HCMV+ hosts
... HLA-E-restricted, CD8 T lymphocytes directed against a strain-specific viral peptide but that display potential autologous and allogeneic ...Human cytomegalovirus (HCMV) causes severe illness and ... Voir le document complet
2
Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity.
... T cell function and survival, is also required for efficient anti-tumor immune ...surveillance. Natural killer (NK) cells, which express PKC θ, play a prominent role in this process, mainly by ... Voir le document complet
13
Rencontre avec un pathogène : les cellules natural killer se souviennent-elles ?
... Sun et al. montrent que les NK LY49H + qui persistent dans la rate après l’infection par MCMV prolifèrent de façon similaire aux NK de souris naïves. C’est là une différence importante avec les cellu- les T mémoires qui ... Voir le document complet
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