[PDF] Top 20 Ion Channels as Promising Therapeutic Targets for Melanoma
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Ion Channels as Promising Therapeutic Targets for Melanoma
... use ion channel modulators in therapy is recent but might be compensated by the active development of these modulating agents in other medical disciplines ...of ion channels modulators in anticancer ... Voir le document complet
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SFPH proteins as therapeutic targets for a myriad of diseases
... Unc-1 plays a central role in the regulation of the anesthetic re- sponse, while unc-24 controls the correct localization of unc-1. Subsequently, it has been shown that unc-1 physically interacts with a homolog of ... Voir le document complet
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From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules
... dangerous for humans because of their possible accumulation in the alimentary chain or their use as biological weapons ...ligands for studying structural or functional properties of their molecular ... Voir le document complet
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Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives
... these channels. They emerge from these studies as interesting targets for drug development in a variety of neurological and psychiatric disorders including pain, stroke, epilepsy, anxiety, depression ... Voir le document complet
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From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules
... dangerous for humans because of their possible accumulation in the alimentary chain or their use as biological weapons ...ligands for studying structural or functional properties of their molecular ... Voir le document complet
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Ion channels as effectors of cyclic nucleotide pathways: functional relevance for arterial tone regulation
... these channels is observed in situations of hypoxia, metabolic inhibition, ...pivotal for adapting local blood flow and nutrient supply to organs relative to demand (Cole & Clement-Chomienne, 2003; ... Voir le document complet
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Small Hsps as Therapeutic Targets of Cystic Fibrosis Transmembrane Conductance Regulator Protein
... 4.2. HspB1 (Hsp27) Mammalian HspB1, also called Hsp27, which was for decades the most investigated small Hsp, has been extensively studied in the context of CF. Various basal levels of HspB1 constitutive ... Voir le document complet
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The gating mechanism in cyclic nucleotide-gated ion channels
... Mutant channels I323C were blocked both in the open and closed states by extracellular but not by intracellular MTSET ...mutant channels was either not state-dependent or could not be distinguished from ... Voir le document complet
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Ion kinetic effects on the ignition and burn of ICF targets
... formalism for thermal species. Then, we extend the ion kinetic mod- eling to suprathermal α-particles produced by fusion re- ...full ion kinetic simulation of a realistic ICF configuration with the ... Voir le document complet
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Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets
... site for cancer metastases, particularly for prostate, breast, kidney, lung and thyroid primary ...mechanism for metastatic progression, we report on the gene expression profile of bone-seeking ... Voir le document complet
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Hippo/YAP Signaling Pathway: A Promising Therapeutic Target in Bone Paediatric Cancers?
... 3.2. Angiogenesis Angiogenesis may be defined as the formation of new blood vessels from pre-existing vascularization. Since angiogenesis is a highly regulated process during development, it is not surprising that an ... Voir le document complet
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Myeloid-Derived Suppressor Cells in Hematologic Diseases: Promising Biomarkers and Treatment Targets
... unique for MDSCs have not been identi fied so ...assay for MDSC definition (Fig. 2). Recently, guidelines for the standardization and harmonization of the functional assays were published by a working ... Voir le document complet
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Voltage-gated ion channels and gating modifier toxins.
... K channels would then resemble the Na and Ca channels in having an associated subunit with a single transmembrane V V V segment and short intracellular and extracellular ...of Ion Channel Structure ... Voir le document complet
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Vasopressin receptors and pharmacological chaperones: From functional rescue to promising therapeutic strategies.
... constitute promising future therapeutic candidates for cNDI clinical studies ...Like for PC-based approaches, V2R rescue and intracellular receptor activation by OPC51803 and both VA compounds ... Voir le document complet
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VIP and PACAP analogs regulate therapeutic targets in high-risk neuroblastoma cells
... major therapeutic target. This therapeutic relevance was demonstrated in a mouse model of NB that overexpresses MYCN in cells derived from neural ... Voir le document complet
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Advances in Pathophysiology of Calcific Aortic Valve Disease Propose Novel Molecular Therapeutic Targets
... anti-inflammatory phenotype defined by its RNA expression profile ( 15 ). Thus, aortic side of AoV demonstrates protection against repetitive insult in normal AoV. As consequence, VECs are releasing nitric-oxide (NO), a ... Voir le document complet
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Voltage- and cold-dependent gating of single TRPM8 ion channels
... account for the voltage dependence at 20°C, further analysis was performed on recordings at 30°C showing that the same basic kinetic mechanism was also able to describe the gating at ... Voir le document complet
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Ion channels in death and differentiation of prostate cancer cells.
... importance for understanding of what drives PCa to ...quest for molecular basis of SOC and for molecules underlying the process of capacitative calcium ...candidates for PCa ... Voir le document complet
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HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours
... following the manufacturer ’s protocol. RNA samples were run on two lanes of a HiSeq2500 using RAPID onboard clustering and single read 50 cycles. All samples were run at 16.6% per lane to achieve 25 million clusters. ... Voir le document complet
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Epigenetic control of gene function in schistosomes: a source of therapeutic targets?
... of new drugs ( Swinney and Anthony, 2011 ) although a more recent analysis of discovery of first-in-class drugs suggests a grow- ing predominance of target-based approaches ( Eder et al., 2014 ). Drug discovery is not a ... Voir le document complet
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