[PDF] Top 20 The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
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The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
... least in part, by perturbations of cell metabolism and that targeting these metabolic dependencies may be promising therapeutic avenues in EVI1-positive ...indicate a higher ... Voir le document complet
34
Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML
... thank the Saint-Louis Hospital’s Tumor Biobank (Daniela Geromin, Carole Albuquerque) for managing patient AML ...from the US National Cancer Institute (NCI) (NIH R35 CA210030; KS), the Children’s ... Voir le document complet
10
Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
... metabolism is also involved in other crucial metabolic pathways such as the pentose phosphate path- way (PPP) coupled to NADPH production, glutathione/ redox recycling, and nucleotide ... Voir le document complet
18
Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells
... be a useful strategy to treat mt p53 tumors and potentially improve the prognosis of cancer ...patients. In this study, we unveil different mechanisms that eliminate p53-R248Q, one of the most ... Voir le document complet
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CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia
... improving the knowledge of this AML subgroup pathophysiology appears as an essential task for the next ...involvements in cell proliferation and drug resistance remain to be ...performed in ... Voir le document complet
19
Isolated granulocytic sarcoma of the pancreas: A tricky diagnostic for primary pancreatic extramedullary acute myeloid leukemia
... and the Wirsung duct (6 mm), above a 28 × 20 mm irregular, hypoechoic and hypodense mass of the pancreatic head, without any lymph node or vascular invasion or distant secondary lesion ...on ... Voir le document complet
6
Transplant Outcomes for Secondary Acute Myeloid Leukemia: Acute Leukemia Working Party of the European Society for Blood and Bone Marrow Transplantation Study.
... with a diagnosis of ...blasts in bone marrow]), transplant-related factors in- cluding conditioning regimen (myeloablative conditioning [MAC] or reduced- intensity conditioning [RIC]), donor type ... Voir le document complet
9
H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations
... Through a series of CRISPR-Cas9 and RNAi experiments targeting UTX/JMJD3, it was demonstrated that sensitivity by GSK-J4 in RUNX1 mut AML cells observed in vitro was most likely due to an off- target ... Voir le document complet
89
Targeting primary acute myeloid leukemia with a new CXCR4 antagonist IgG1 antibody (PF-06747143)
... evaluated the ability of PF-06747143 to induce cell death by ADCC on AML primary BM malignant cells, in presence of an NK effector cell line, NK92 158 ...V. A significant dose-dependent cytotoxic ... Voir le document complet
14
View of Specific pulmonary involvement in acute myeloid leukemia: from diagnosis to treatment
... Score) a été développé en 2005 à partir de 95 patients atteints de LAM hyperleucocytaire [13] et pourrait prédire l ’existence d’un syndrome de leucostase ...perfusion a été évaluée et montre un pattern ... Voir le document complet
8
Gut microbiota diversity after autologous fecal microbiota transfer in acute myeloid leukemia patients
... of the intestinal microbiota by intensive chemother- apy and antibiotics is well established in patients with hematologic malignancies 5 , 6 , 8 , and our results confirm these findings with a ... Voir le document complet
12
Inhibition of the proteasome and proteaphagy enhances apoptosis in FLT3‐ITD‐driven acute myeloid leukemia
... inhibition in FLT3-ITD mutant driven MOLM-14 leukemic cells To mechanistically understand the regulation of the crosstalk between UPS and ALS in leukaemia, we investigated the role of ... Voir le document complet
24
en fr Targeting NPM1c in Acute Myeloid leukemia NPM1C, une cible dans le traitement des leucémies aigues myéloides
... Hiba A. El Hajj, PhD 1,5 BACKGROUND: Nucleophosmin 1 (NPM1) is a nucleocytoplasmic shuttling protein mainly localized in the ...NPM1 is frequently mutated in acute ... Voir le document complet
241
Development of gene expression-based risk score in cytogenetically normal acute myeloid leukemia patients.
... role in hematopoietic stem cells (HSC) proliferation and differentiation ...MSI2 in mice created a pre-leukemic phase [21] and its overexpression was found during transition from chronic to ... Voir le document complet
10
The impact of HLA-matching on reduced intensity conditioning regimen unrelated donor allogeneic stem cell transplantation for acute myeloid leukemia in patients above 50 years—a report from the EBMT acute leukemia working party
... represent the most frequent stem cell source for allo-SCT in Europe and are used in more than 50 % of RIC allo-SCT for AML patients ...[15]. In the absence of HLA-matched URD, a ... Voir le document complet
15
Acute lymphoblastic leukemia in children
... Le nombre (n = 13 soit 16,5 %) d’échecs thé- rapeutiques (rechutes et patients réfractaires : plus de 25 % de blastes après l’induction) que nous avons observé est bas mais le taux de “r[r] ... Voir le document complet
7
en fr Checkpoint kinase 1 : its novel functions during normal myeloid differentiation ans its role as prognostic marker and therapeutic target in acute myeloid leukemia Etude de nouvelles fonctions de la protéine checkpoint kinase 1 (Chk1) au cours de la différenciation myéloïde normale et leucémique
... interaction a déjà été décrite dans un contexte de mitose classique, sur des cellules HeLa, et coïncide avec un pic d’activité de Chk1 et de ...cette kinase assure une bonne maturation des centrosomes et la ... Voir le document complet
235
Stable Isotope Labeling Highlights Enhanced Fatty Acid and Lipid Metabolism in Human Acute Myeloid Leukemia
... including acute myeloid leukemia (AML) cells, grow and divide faster and more efficiently than normal cells, which increase their demand for energy, biosynthetic precursors, and macromolecular ... Voir le document complet
19
Prophylactic donor lymphocyte infusion in patients with high-risk acute myeloid leukemia: ready for prime time?
... DLI in patients with high-risk acute leukemia has been reported by Liga et ...ago. In that study, patients were given allo-HCT following a low-dose (10 –20 mg total dose) ... Voir le document complet
3
Use of Tyrosine Kinase Inhibitors to Prevent Relapse After Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia: A Position Statement of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
... to the posttrans- plant use of imatinib was performed by a German group German multicenter study group for adult acute lympho- blastic leukemia ...therapy. In the prophylactic ... Voir le document complet
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