[PDF] Top 20 Coupled seasonal and intraseasonal variability in the South China Sea
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Protective immunity against Trypanosoma cruzi
... “sterile immunity” after inoculation is serological ...T. cruzi infection that includ- ed wild T. cruzi isolates as well as TCC and Tulahuen ...T. cruzi infection, 25/28 for Tula- huen ... Voir le document complet
16
Recombinant Yellow Fever Viruses Elicit CD8(+) T Cell Responses and Protective Immunity against Trypanosoma cruzi
... T cell epitope, TEWETGQI, induced specific IFN-c producing-cells but only partial protection of mice after a T. cruzi challenge. In this study, we have used the previously described YF virus platform of insertion ... Voir le document complet
8
CD8(+) T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?
... T. cruzi escapes from the parasitophorous vacuole and enters the cytosol, where it diferentiates into amastigotes and begins its ...in immunity against experimental infection with T. cruzi has ... Voir le document complet
10
Immune responses to gp82 provide protection against mucosal Trypanosoma cruzi infection
... protection against systemic BFT ...protected against this initial infecting ...gp82-specific immunity is likely to have been irrelevant in recognizing this ... Voir le document complet
22
Vaccination with epimastigotes of different strains of Trypanosoma rangeli protects mice against Trypanosoma cruzi infection
... with Trypanosoma rangeli, a non-pathogenic parasite that shares many antigens with Trypanosoma ...protected against infection with virulent ...T. cruzi. The goal of the present work was to ... Voir le document complet
147
Perforin and Gamma Interferon Expression Are Required for CD4(+) and CD8(+) T-Cell-Dependent Protective Immunity against a Human Parasite, Trypanosoma cruzi, Elicited by Heterologous Plasmid DNA Prime-Recombinant Adenovirus 5 Boost Vaccination
... during certain chronic viral infection, perforin-mediated down- regulation of T-cell responses is critical to avoiding autoimmu- nity and immune-pathological damages (40). To date, the most predictable immunological ... Voir le document complet
31
DNA sequences encoding CD4+ and CD8+T-cell epitopes are important for efficient protective immunity induced by DNA vaccination with a Trypanosoma cruzi gene
... cells was performed essentially as described previously (15). The hybridomas producing rat IgG anti-CD4 (GK1.5) or anti-CD8 (2.43) were purchased from the American Type Culture Collection. Ascites were produced in BALB/c ... Voir le document complet
18
Cytokines in innate and acquired immunity to Trypanosoma cruzi infection
... to Trypanosoma cruzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mecha- ...T. cruzi replication by the innate and specific immune systems of ... Voir le document complet
9
Immunization with cDNA expressed by amastigotes of Trypanosoma cruzi elicits protective immune response against experimental infection
... that the presence of genes related to asp-2 in the Y strain of T. cruzi is restricted to the cDNA of amastigotes and epimastig- otes (Fig. 1A). In contrast, Northern blot analysis reproducibly revealed the ... Voir le document complet
7
Novel protective antigens expressed by Trypanosoma cruzi amastigotes provide immunity to mice highly susceptible to Chagas' disease
... Using the immune sera of plasmid DNA-vaccinated mice, we confirmed that in fact most of the antigens selected were stage-specific amastigote antigens. Only one ORF/antigen was not expressed by amastigotes (par-2). Three ... Voir le document complet
18
Swimming against the current: genetic vaccination against Trypanosoma cruzi infection in mice
... In the past, vaccination studies have failed because researchers have in most cases focused on inducing pro- tective antibodies. Essentially, these studies confirmed that antibodies alone are unable to completely ... Voir le document complet
14
Advances in nanocarriers as drug delivery systems in Chagas disease
... T. cruzi, the improvement of these membrane mimic systems as immu- nogenic vehicles for parasite molecules could eventually contribute to the development of an effective ... Voir le document complet
Freqüência do parasitismo encefálico em camundongos experimentalmente inoculados com diferentes cepas de Trypanosoma cruzi.
... FREQÜÊNCIA DO PARASITISMO ENCEFÁLICO EM CAMUNDONGOS EXPERIMENTALMENTE INOCULADOS COM DIFERENTES CEPAS. DE TRYPANOSOMA CRUZI[r] ... Voir le document complet
3
Phenotypic Screening In Vitro of Novel Aromatic Amidines against Trypanosoma cruzi
... T. cruzi, pre- vious studies identified diamidines located in different intracellu- lar compartments, including the nucleus, kinetoplast, and acido- calcisomes, suggesting the site(s) of cellular insult (primary ... Voir le document complet
30
Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruzi
... T. cruzi are considered sibling species, for some drugs such as nifurimox it appears that they have similar susceptibility (Marinkelle ...T. cruzi (EC Grisard, un- published observations) and this ... Voir le document complet
10
Inserção de DNA de Trypanosoma cruzi no genoma de célula hospedeira de mamífero por meio de infecção.
... A h ib rid iz a ç ã o in situ so b re cro m o sso m o s, com so n d a d e D N A b io tin ila d o d e T. cruzi, m o stro u a p re s e n ç a de D N A c o m p le m e n ta r à so nd a. O s po n to s flu o resc en te ... Voir le document complet
71
Protective immunity against Trichinella spiralis infection induced by a multi-epitope vaccine in a murine model.
... of protective immunity against Schistosoma mansoni infection that was comparable to the immunity induced by an intact protective antigen ...combining protective epitopes from ... Voir le document complet
2
Cross-talk between the Immune System and Tuberculosis Pathogenesis; a Review with Emphasis on the Immune Based Treatment
... For many years, B cells have been thought to have little impact in protection against TB. Animal studies have revealed a beneficial role of B cells through interactions with players of the cellular immunity ... Voir le document complet
13
In vitro antiparasitic activity and chemical composition of the essential oil from Protium ovatum leaves (Burceraceae)
... leaves against trypomastigote forms of Trypanosoma cruzi and the promastigote forms of Leishmania amazonensis were ...promising against trypomastigote forms of T. cruzi (IC 50 = ... Voir le document complet
361
In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
... tested against cultures of the parasite Trypanosoma ...activity against the epimastigotes and blood tripomastigotes was exhibited by N1, followed by N3, N4 and finally ...activity against ... Voir le document complet
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