Randomized controlled clinical trials
The safety of medications used to treat peripheral neuropathic pain, part 1 (antidepressants and antiepileptics): review of double-blind, placebo-controlled, randomized clinical trials
... many clinical trials included in this review had a poor description of the safety of the assessed ...placebo-controlled, randomized clinical trials have been included in this ...
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Randomized placebo-controlled cross-over designs in clinical trials : a gold-standard to be reassessed
... We propose an alternative solution, based on the observations made a number of years ago by Fedele and colleagues 11 . In their study, the authors noted a positive treatment effect during placebo trials which, ...
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The Safety of Medications used to Treat Peripheral Neuropathic Pain, Part 2 (Opioids, Cannabinoids and Other Drugs): review of Double-Blind, Placebo-Controlled, Randomized Clinical Trials
... The Safety of Medications used to Treat Peripheral Neuropathic Pain, Part 2 (Opioids, Cannabinoids and Other Drugs): review of Double-Blind, Placebo-Controlled, Randomized Clinical Trial[r] ...
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View of Efficacy of inhaled corticosteroids for patients with asthma: a descriptive review of randomized controlled trials
... improved clinical outcomes, such as the FEV1, for patients with asthma, leading to improved disease ...the clinical setting and thus would improve external ...
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How to use frailtypack for validating failure-time surrogate endpoints using individual patient data from meta-analyses of randomized controlled trials
... a clinical trial was quite difficult, mainly due to a lack of power and the difficulty to verify an assumption related to the relation between the treatment effects upon the true and the surrogate ...between ...
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Efficacy of Oral Vitamin Supplementation in Inflammatory Rheumatic Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
... of randomized controlled trials assessing the effect of oral vitamin supplementation on symptoms and disease activity in patients with rheumatoid arthritis (RA), spondyloarthritis (SpA) and psoriatic ...
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Early Aspirin Discontinuation Following Acute Coronary Syndrome or Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
... Future trials are warranted to compare the performance of all commercially available P2Y 12 inhibitors, used in clinical practice in the setting of early aspirin ...all trials with patients ...
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Micropolitics of poverty : how randomized controlled trials address global poverty through the epistemic and political fragmentation of the world
... pharmaceutical trials: US-based companies run trials in Eastern Europe, where they are less constrained by regulations ...in clinical trials, because the latter are presumably more benign and ...
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Levosimendan in the light of the results of the recent randomized controlled trials: an expert opinion paper
... 36 ]. Repetitive infusions of levosimendan in patients with advanced chronic heart failure Patients with symptomatic advanced heart failure despite optimal medical treatment are sometimes unable to be discharged because ...
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Randomized trials are the real hope for Covid-19 treatment
... 2. Cucherat M et al. From single-arm studies to externally controlled studies. Methodological considerations and guidelines. Therapie 2020 ; 75 : 21-27. 3. Kalil AC. Treating COVID-19—Off-Label Drug Use, ...
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Clinical impact of the disposable ventouse iCup® versus a metallic vacuum cup: a multicenter randomized controlled trial
... more trials with all the disadvantages inherent to this: an increase in the num- ber of subjects to be included and especially no result as to the overall effectiveness (or not) of the new cup for several ...
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Covariate-Adaptive Optimization in Online Clinical Trials
... 6. Conclusions In this paper, we introduced a covariate-adaptive optimization algorithm for the problem of online allocation of subjects in randomized controlled trials. Our method leverages robust ...
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Randomized clinical trials of oral vitamin D supplementation in need of a paradigm change: The vitamin D autacoid paradigm
... D clinical trials are based on 25D status and not 1,25D ...of randomized controlled trials concluded that vitamin D supplementation could increase circulating 1,25D concentrations, but ...
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Delayed pain decrease following M1 tDCS in spinal cord injury: A randomized controlled clinical trial.
... longitudinal trials should also evaluate the long-term e ffects of tDCS on acute patients su ffering from neuropathic pain after a SCI, or as a prophylactic ...
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Evaluation of benazepril in cats with heart disease in a prospective, randomized, blinded, placebo‐controlled clinical trial
... The manuscript was prepared after consultation of the CONSORT statement for reporting of randomized clinical trials. 14 2.1 | Study design All cats were client-owned animals and therefore were fed, ...
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Inpatient trunk exercises after recent stroke: An update meta-analysis of randomized controlled trials
... trunk training in the relatively early post-stroke phase. Considering that trunk stability is a core component of balance, coordination, and performance of daily activities, it is possible that such gains have a ...
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Inadequate description of educational interventions in ongoing randomized controlled trials.
... registering clinical trials, by placing key protocol information about the trial in the public do- main, has been promoted to prevent misconduct in trials, specifically selective reporting ...
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Repeated stimulation of the posterior parietal cortex in patients in minimally conscious state: A sham-controlled randomized clinical trial
... sham-controlled randomized clinical trial Patients in unresponsive wakefulness syndrome (UWS e recov- ery of eyes opening while no behavioral sign of consciousness [1]) and in minimally conscious ...
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Impact of a targeted monitoring on data-quality and data-management workload of randomized controlled trials a prospective comparative study
... Workload and cost analysis Across the six studies, 140 hours were devoted by the CRA to the targeted SDV versus 317 hours for the full SDV, with a mean±SD of 23±15 and 53±24 hours per study respectively (p=0.001). ...
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Primary Thromboprophylaxis in Ambulatory Pancreatic Cancer Patients Receiving Chemotherapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
... It has been suggested that PC patients receiving chemotherapy may require higher doses of anticoagulant for VTE prevention since dalteparin was administered at therapeutic doses in the FRAGEM trial [ 25 ]. On the other ...
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