Protein degradation
BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways
... end, proteasome inhibitors such as Bortezomib together with HDAC inhibitors have demonstrated synergistic cytotoxicity in several cancers, for example, ovarian, breast and colon carcinoma. 11–13 Although we similarly ...
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BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways
... The Protein Quality Control ...and protein misfolding ...and degradation of proteins is crucial (Figure 1): to this end, eukaryotic cells have developed a network of constitutive and inducible ...
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ClpXP, an ATP-powered unfolding and protein-degradation machine
... Early studies revealed that the peptidase activity of ClpP was inhibited by diisopropyl fluorophosphate [5,78,79] , which covalently modi fies the active site of serine proteases. In addition, the first crystal structure of ...
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Chronic oxidative stress promotes H2 AX protein degradation and enhances chemosensitivity in breast cancer patients
... , 2012; Kocylowski et al, 2015) and suggests for the first time a connection between RNF168 and K119 ubiquitination under chronic oxidative stress, which mechanism will be interesting to delineate in future work. ...
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A Targeted Protein Degradation Cell-Based Screening for Nanobodies Selective toward the Cellular RHOB GTP-Bound Conformation
... A GST-RBD pull-down was performed for each F-Ib to control RHO-GTP level lines RHOB-GTP, RHOAGTP, and RHOC-GTP, and the total level of RHO proteins was revealed by loading 2% of input li[r] ...
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Controlled degradation by ClpXP protease tunes the levels of the excision repair protein UvrA to the extent of DNA damage
... and degradation was measured by western after inhibition of protein synthesis, rather than by pulse ...natural degradation motifs often enhances protein degradation (Prakash et ...
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The current landscape of coronavirus-host protein-protein interactions
... in protein export were targeted together with components of the unfolded pro- tein response/endoplasmic-reticulum-associated protein degradation (ERAD) ...
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Analysis of protein contacts into Protein Units.
... each protein shows that only 29% of these PUs have a relative accessibility higher than 35% (rather accessible) and 9% more than 50% (very ...each protein, 50% have a relative accessibility still higher ...
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Protein beta-turn assignments.: Protein beta-turn assignments
... Abstract: A classical way to analyze protein 3D structures or models is to investigate their secondary structures. Their predictions are also widely used as a help to build new 3D models. Thus, hundreds of ...
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Degradation of elastomeric parking garage membranes
... This publication could be one of several versions: author’s original, accepted manuscript or the publisher’s version. / La version de cette publication peut être l’une des suivantes : la version prépublication de ...
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Mannoside recognition and degradation by bacteria
... mucin protein have been found to be retained in the endoplasmic reticulum (ER) if unmannosylated (Perez-Vilar, Randell & Boucher, ...viral protein sGP, which is the first reported example of viral ...
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Degradation de l'insecticide phenylcarbamate Elocron par une pseudomonade du sol
... principal .... Le aouèi ,principal d.. yl de dlvelopper de. eDfll'eDlls.eat ear eile contribue. de cllarad.tioD ne.. rûkuto et al.. but de traacber cette qûeattoD ec.. d[r] ...
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Protein enriched pasta : impact of protein network structure on the in-vitro protein digestibility
... acids. Protein enriched (17%) pasta with better amino acid profile were produced using 35% faba bean flour or 5% egg white ...their protein network was studied from the macro to the supramolecular scales ...
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Comparative Analysis of Protein -Protein Interface Methods
... Comparative Analysis of Protein - Protein Interface Methods A.G. de Brevern 1 and J. Esque 2 1 Laboratoire DSIMB, INSERM, U 1134, Univ Paris Diderot, Univ. Sorbonne Paris Cité, INTS, Laboratoire ...
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Structure-based algorithms for protein-protein interactions
... the protein at two distinct stages of minimization to re- duce the number of degrees of freedom: coarse-grained and full-atom ...the protein-protein complex being optimized is an ...
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Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum
... different protein complexes involved in the different ERAD ...well-characterized degradation of MHC-I HC by the HCMV proteins US11 and US2 involve different protein complexes and distinct ...
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Compacting local protein folds with a Hybrid Protein: Compacting local protein folds
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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Designing helical peptide inhibitors of protein–protein interactions
... MDM2 and MDMX MDM2 and MDMX bind to a short helical region of the tumor suppressor p53 and inhibit its function both directly, by blocking activation activity, and by promoting ubiquitination that leads to ...
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Large-scale prediction of protein-protein interactions from structures
... ¿From a technical point of view, we face two issues to implement this strategy. First, we must be able to manipulate protein 3D structures in the context of a machine learning algorithm. For this we borrow an idea ...
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Electrochemical degradation and mineralization of glyphosate herbicide.
... intensity of 4.77A and the theoretical response proposed for TOC degradation was 90.28 % whereas the residual concentration was 0.69 mg L -1 for the glyphosate. According to the results mentioned above, the ...
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